Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 45, 2008, Pages 17414-17419

  Choo, Andrew Y ^a   Yoon, Sang Oh ^a   Sang, Gyun Kim ^a   Roux, Philippe P ^b   Blenis, John ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

Author keywords

Cap dependent translation; mTORC1; Rapamycin resistance

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; RAPAMYCIN;

5' UNTRANSLATED REGION; ARTICLE; CATALYSIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; CARRIER PROTEINS; GENE EXPRESSION REGULATION; MICE; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; RIBOSOMAL PROTEIN S6 KINASES; SIROLIMUS; TRANSCRIPTION FACTORS;

EUKARYOTA; MAMMALIA; RAPTORES;

EID: 56249147509     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0809136105     Document Type: Article

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