PI 3-kinase related kinases: 'Big' players in stress-induced signaling pathways

DNA Repair

Volumn 3, Issue 8-9, 2004, Pages 883-887

  Abraham, Robert T ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

ATM; Kinases; mTOR; Signaling pathway

Indexed keywords

ATM PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE;

CARCINOGENESIS; CARDIOVASCULAR DISEASE; CELL GROWTH; CHEMICAL ANALYSIS; CYTOPATHOLOGY; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; DNA REPAIR; ENZYME REGULATION; EUKARYOTIC CELL; GENE EXPRESSION; GENOME ANALYSIS; MAMMAL CELL; MOLECULAR WEIGHT; NONHUMAN; PATHOPHYSIOLOGY; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN MOTIF; REVIEW; SIGNAL TRANSDUCTION; STRESS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID MOTIFS; ANIMALS; CELL CYCLE PROTEINS; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; HUMANS; MODELS, GENETIC; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EUKARYOTA; MAMMALIA;

EID: 3242882820     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2004.04.002     Document Type: Review

References (33)

1. Hunter T. When is a lipid kinase not a lipid kinase? When it is a protein kinase. Cell. 83:1995;1-4
2. Tibbetts R.S., Abraham R.T. PI3K-related kinases - roles in cell-cycle regulation and DNA damage responses. Signal. Netw. Cell Cycle Control: Mol. Basis Cancer Other Dis. 5:2000;267-301
3. Zakian V.A. ATM-related genes: what do they tell us about functions of the human gene? Cell. 82:1995;685-687
4. Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer. 3:2003;155-168
5. McMahon S.B., Van Buskirk H.A., Dugan K.A., Copeland T.D., Cole M.D. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell. 94:1998;363-374
6. Vassilev A., Yamauchi J., Kotani T., Prives C., Avantaggiati M.L., Qin J., Nakatani Y. The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. Mol. Cell. 2:1998;869-875
7. Abraham R.T. Identification of TOR signaling complexes: more TORC for the cell growth engine. Cell. 111:2002;9-12
8. Kim D.H., Sarbassov D.D., Ali S.M., King J.E., Latek R.R., Erdjument-Bromage H., Tempst P., Sabatini D.M. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell. 110:2002;163-175
9. Hara K., Maruki Y., Long X., Yoshino K., Oshiro N., Hidayat S., Tokunaga C., Avruch J., Yonezawa K. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. 110:2002;177-189
10. O'Connell M.J., Walworth N.C., Carr A.M. The G2-phase DNA-damage checkpoint. Trends Cell Biol. 10:2000;296-303
11. Melo J., Toczyski D. A unified view of the DNA-damage checkpoint. Curr. Opin. Cell Biol. 14:2002;237-245
12. Zou L., Cortez D., Elledge S.J. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev. 16:2002;198-208
13. Cortez D., Guntuku S., Qin J., Elledge S.J. ATR and ATRIP: partners in checkpoint signaling. Science. 294:2002;1713-1716
14. Perry J., Kleckner N. The ATRs, ATMs, and TORs are giant HEAT repeat proteins. Cell. 112:2003;151-155
15. Bosotti R., Isacchi A., Sonnhammer E.L. FAT: a novel domain in PIK-related kinases. Trends Biochem. Sci. 25:2000;225-227
16. Matsuoka S., Rotman G., Ogawa A., Shiloh Y., Tamai K., Elledge S.J. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc. Natl. Acad. Sci. U S A. 97:2000;10389-10394
17. Tibbetts R.S., Cortez D., Brumbaugh K.M., Scully R., Livingston D., Elledge S.J., Abraham R.T. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. 14:2000;2989-3002
18. Cortez D., Wang Y., Qin J., Elledge S.J. Requirement of ATM-dependent phosphorylation of BRCA1 in the DNA damage response to double-strand breaks. Science. 286:1999;1162-1166
19. Stewart G.S., Wang B., Bignell C.R., Taylor A.M., Elledge S.J. MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature. 421:2003;961-966
20. Abraham R.T., Wiederrecht G.J. Immunopharmacology of rapamycin. Annu. Rev. Immunol. 14:1996;483-510
21. Jacinto E., Hall M.N. Tor signalling in bugs, brain and brawn. Nat. Rev. Mol. Cell Biol. 4:2003;117-126
22. Sabers C.J., Martin M.M., Brunn G.J., Williams J.M., Dumont F.J., Wiederrecht G., Abraham R.T. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J. Biol. Chem. 270:1995;815-822
23. Brown E.J., Albers M.W., Shin T.B., Ichikawa K., Keith C.T., Lane W.S., Schreiber S.L. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature. 369:1994;756-758
24. Sabatini D.M., Erdjument-Bromage H., Lui M., Tempst P., Snyder S.H. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell. 78:1994;35-43
25. Gingras A.C., Raught B., Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 15:2001;807-826
26. Edinger A.L., Linardic C.M., Chiang G.G., Thompson C.B., Abraham R.T. Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells. Cancer Res. 63:2003;8451-8460
27. Ui M., Okada T., Hazeki K., Hazeki O. Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. Trends Biochem. Sci. 20:1995;303-307
28. Walker E.H., Pacold M.E., Perisic O., Stephens L., Hawkins P.T., Wymann M.P., Williams R.L. Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol. Cell. 6:2000;909-919
29. Sarkaria J.N., Tibbetts R.S., Busby E.C., Kennedy A.P., Hill D.E., Abraham R.T. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res. 58:1998;4375-4382
30. Kaufmann W.K., Heffernan T.P., Beaulieu L.M., Doherty S., Frank A.R., Zhou Y., Bryant M.F., Zhou T., Luche D.D., Nikolaishvili-Feinberg N., Simpson D.A., Cordeiro-Stone M. Caffeine and human DNA metabolism: the magic and the mystery. Mutat. Res. 532:2003;85-102
31. Sarkaria J.N., Busby E.C., Tibbetts R.S., Roos P., Taya Y., Karnitz L.M., Abraham R.T. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res. 59:1999;4375-4382
32. Yamashita A., Ohnishi T., Kashima I., Taya Y., Ohno S. Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. Genes Dev. 15:2001;2215-2228
33. Cortez D. Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases. J. Biol. Chem. 278:2003;37139-37145