Effects of knockout of the protein kinase C β gene on glucose transport and glucose homeostasis

Endocrinology

Volumn 140, Issue 10, 1999, Pages 4470-4477

  Standaert, M L ^a   Bandyopadhyay, G ^a   Galloway, L ^a   Soto, J ^a   Ono, Y ^a   Kikkawa, U ^a   Farese, R V ^a   Leitges, M ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYGLUCOSE; GLUCOSE; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVITY; GENE TRANSLOCATION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; HORMONAL REGULATION; HORMONE ACTION; INSULIN RESISTANCE; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0033305732     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.10.7073     Document Type: Article

References (18)

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3. A carboxy-terminal deletion mutant of protein kinase Cβ2 inhibits insulin-stimulated 2-deoxyglucose uptake in L6 rat skeletal muscle cells
4. Evidence for involvement of protein kinase C (PKC)-ζ and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes
5. Activation of protein kinase C (α, β, and ζ) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-ζ in glucose transport
6. Protein kinase C-ζ as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport
7. Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells
8. Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity
9. Tumor-promoting phorbol esters increase the K(m) of the ATP-binding site of the insulin receptor kinase from rat adipocytes
10. Overexpression of protein kinase C isoenzymes α,β1, λ, and ε in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling
11. Protein kinase C: Mediator or inhibitor of insulin action?
12. Immunodeficiency in protein kinase Cβ-deficient mice
13. Effects of insulin on diacylglycerol-protein kinase C signaling in rat diaphragm and soleus muscles and relationship to glucose transport
14. Effects of insulin on diacylglycerol/protein kinase-C signalling and glucose transport in rat skeletal muscles in vivo and in vitro
15. Effects of phorbol esters on insulin-induced activation of phosphatidylinositol 3-kinase, glucose transport, and glycogen synthase in rat adipocytes
16. Effects of transiently expressed atypical (ζ, λ), conventional (α, β) and novel (δ, ε) protein kinase C isoforms on insulin-stimulated translocation of epitope-tagged GLUT4 glucose transporters in rat adipcocytes: Specific interchangeable effects of protein kinase C-ζ and C-λ
17. Protein kinase C is not required for insulin stimulation of hexose uptake in muscle cells in culture
18. Phorbol ester only partially mimics the effects of insulin in glucose transport and glucose-transporter distribution in 3T3/L13/L1 adipocytes