Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 37, 2004, Pages 13489-13494

  Roux, Philippe P ^a   Ballif, Bryan A ^a   Anjum, Rana ^a   Gygi, Steven P ^a   Blenis, John ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHORBOL ESTER DERIVATIVE; PHOSPHOTRANSFERASE; RIBOSOME PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; EMBRYO; GENE ACTIVATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TUBEROUS SCLEROSIS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; ENZYME ACTIVATION; HUMANS; MAP KINASE SIGNALING SYSTEM; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; ONCOGENE PROTEIN P21(RAS); PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN BINDING; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; REPRESSOR PROTEINS; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SERINE; TETRADECANOYLPHORBOL ACETATE; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR PROTEINS;

MAMMALIA;

EID: 4544384577     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0405659101     Document Type: Article

References (29)

1. Cheadle, J. P., Reeve, M. P., Sampson, J. R. & Kwiatkowski, D. J. (2000) Hum. Genet. 107, 97-114.
2. Carbonara, C., Longa, L., Grosso, E., Borrone, C., Garre, M. G., Brisigotti, M. & Migone, N. (1994) Hum. Mol. Genet. 3, 1829-1832.
3. Green, A. J., Smith, M. & Yates, J. R. (1994) Nat. Genet. 6, 193-196.
4. Ito, N. & Rubin, G. M. (1999) Cell 96, 529-539.
5. van Slegtenhorst, M., Nellist, M., Nagelkerken, B., Cheadle, J., Snell, R., van den Ouweland, A., Reuser, A., Sampson, J., Halley, D. & van der Sluijs, P. (1998) Hum. Mol. Genet. 7, 1053-1057.
6. Manning, B. D. & Cantley, L. C. (2003) Trends Biochem. Sci. 28, 573-576.
7. Kwiatkowski, D. J. (2003) Cancer Biol. Ther. 2, 471-476.
8. Martin, K. A. & Blenis, J. (2002) Adv. Cancer Res. 86, 1-39.
9. Richardson, C. J., Schalm, S. S. & Blenis, J. (2004) Semin. Cell Dev. Biol. 15, 147-159.
10. Manning, B. D. & Cantley, L. C. (2003) Biochem. Soc. Trans. 31, 573-578.
11. Inoki, K., Zhu, T. & Guan, K. L. (2003) Cell 115, 577-590.
12. Tee, A. R., Anjum, R. & Blenis, J. (2003) J. Biol. Chem. 278, 37288-37296.
13. Roux, P. P. & Blenis, J. (2004) Microbiol. Mol. Biol. Rev. 68, 320-344.
14. Tee, A. R., Fingar, D. C., Manning, B. D., Kwiatkowski, D. J., Cantley, L. C. & Blenis, J. (2002) Proc. Natl. Acad. Sci. USA 99, 13571-13576.
15. Schalm, S. S. & Blenis, J. (2002) Curr. Biol. 12, 632-639.
16. Roux, P. P., Richards, S. A. & Blenis, J. (2003) Mol. Cell Biol. 23, 4796-4804.
17. Shimamura, A., Ballif, B. A., Richards, S. A. & Blenis, J. (2000) Curr. Biol. 10, 127-135.
18. Chou, M. M. & Blenis, J. (1996) Cell 85, 573-583
19. Tee, A. R., Manning, B. D., Roux, P. P., Cantley, L. C. & Blenis, J. (2003) Curr. Biol. 13, 1259-1268.
20. Gygi, S. P., Rochon, Y., Franza, B. R. & Aebersold, R. (1999) Mol. Cell. Biol. 19, 1720-1730.
21. Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J. & Cantley, L. C. (2002) Mol. Cell 10, 151-162.
22. Richards, S. A., Dreisbach, V. C., Murphy, L. O. & Blenis, J. (2001) Mol. Cell. Biol. 21, 7470-7480.
23. Peng, X. D., Xu, P. Z., Chen, M. L., Hahn-Windgassen, A., Skeen, J., Jacobs, J., Sundararajan, D., Chen, W. S., Crawford, S. E., Coleman, K. G. & Hay, N. (2003) Genes Dev. 17, 1352-1365.
24. Kwiatkowski, D. J., Zhang, H., Bandura, J. L., Heiberger, K. M., Glogauer, M., el-Hashemite, N. & Onda, H. (2002) Hum. Mol. Genet. 11, 525-534.
25. Potter, C. J., Huang, H. & Xu, T. (2001) Cell 105, 357-368.
26. Tapon, N., Ito, N., Dickson, B. J., Treisman, J. E. & Hariharan, I. K. (2001) Cell 105, 345-355.
27. Romanelli, A., Martin, K. A., Toker, A. & Blenis, J. (1999) Mol. Cell. Biol. 19, 2921-2928.
28. Downward, J. (2003) Nat. Rev. Cancer 3, 11-22.
29. Han, S., Santos, T. M., Puga, A., Roy, J., Thiele, E. A., McCollin, M., Stemmer-Rachamimov, A. & Ramesh, V. (2004) Cancer Res. 64, 812-816.