Critical role of T-loop and H-motif phosphorylation in the regulation of S6 kinase 1 by the tuberous sclerosis complex

Journal of Biological Chemistry

Volumn 279, Issue 20, 2004, Pages 20816-20823

  Shah, O Jameel ^a   Hunter, Tony ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; CELLS; MUTAGENESIS; PATHOLOGY; TUMORS;

BIOCHEMICAL CHANGES; PHOSPHORYLATION; SERINE KINASES;

ENZYMES;

GENE PRODUCT; GUANOSINE TRIPHOSPHATASE; PROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN TSC 1; RHEB PROTEIN; S6 KINASE; S6 KINASE 1; TARGET OF RAPAMYCIN KINASE; THREONINE; TUBERIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL PROTECTION; CHEMICAL ANALYSIS; COMPLEX FORMATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; METAZOON; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; T WAVE; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR GENE;

AMINO ACID SEQUENCE; ANDROSTADIENES; ANIMALS; CELL LINE; CHEMOKINES, CC; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INSULIN; MICE; PEPTIDE FRAGMENTS; PHOSPHORYLATION; RABBITS; RATS; REPRESSOR PROTEINS; RIBOSOMAL PROTEIN S6 KINASES; SIROLIMUS; TRANSFECTION; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; MAMMALIA; METAZOA;

EID: 2442700142     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400957200     Document Type: Article

References (53)

1. Gomez, M. R. (1988) Tuberous Sclerosis, 2nd Ed., Raven Press, New York
2. Hyman, M. H., and Whittemore, V. H. (2000) Ach. Neurol. 57, 662-665
3. Povey, S., Burley, M. W., Attwood, J., Benham, F., Hunt, D., Jeremiah, S. J., Franklin, D., Gillet, G., Malas, S., Robson, E. B., Tippett, P., Edwards, J. H., Kwiatkowski, D. J., Super, M., Mueller, R., Fryer, A., Clarke, A., Webb, D., and Osborne, J. (1994) Ann. Hum. Genet. 58, 107-127
4. The European Chromosome 16 Tuberous Sclerosis Consortium (1993) Cell 75, 1305-1315
5. van Slegtenhorst, M., de Hoogt, R., Hermans, C., Nellist, M., Janssen, B., Verhoef, S., Lindhout, D., van den Ouweland, A., Halley, D., Young, J., Burley, M., Jeremiah, S., Woodward, K., Nahmias, J., Fox, M., Ekong, R., Osborne, J., Wolfe, J., Povey, S., Snell, R. G., Cheadle, J. P., Jones, A. C., Tachataki, M., Ravine, D., Sampson, J. R., Reeve, M. P., Richardson, P., Wilmer, F., Munro, C., Hawkins, T. L., Sepp, T., Ali, J. B. M., Ward, S., Green, A. J., Yates, J. R. W., Kwiatkowska, J., Henske, E. P., Short, M. P., Haines, J. H., Jozwiak, S., and Kwiatkowski, D. J. (1997) Science 277, 805-808
6. Potter, C. J., Huang, H., and Xu, T. (2001) Cell 105, 357-368
7. Gao, X., and Pan, D. (2001) Genes Dev. 15, 1383-1392
8. Kwiatkowski, D. J., Zhang, H., Bandura, J. L., Heiberger, K. M., Glogauer, M., el-Hashemite, N., and Onda, H. (2002) Hum. Mol. Genet. 11, 525-534
9. Rennebeck, G., Kleymenova, E. V., Anderson, R., Yeung, R. S., Artzt, K., and Walker, C. L. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 15629-15634
10. Yang, J., Cron, P., Thompson, V., Good, V. M., Hess, D., Hemmings, B. A., and Barford, D. (2002) Mol. Cell 9, 1227-1240
11. Yang, J., Cron, P., Good, V. M., Thompson, V., Hemmings, B. A., and Barford, D. (2002) Nat. Struct. Biol. 9, 940-944
12. Han, J. W., Pearson, R. B., Dennis, P. B., and Thomas, G. (1995) J. Biol. Chem. 270, 21396-21403
13. Pearson, R. B., Dennis, P. B., Han, J.-W., Williamson, N. A., Kozma, S. C., Wettenhall, R. E. H., and Thomas, G. (1995) EMBO J. 14, 5279-5287
14. Weng, Q.-P., Andrabi, K., Klippel, A., Kozlowski, M. T., Williams, L. T., and Avruch, J. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 5744-5748
15. Sugiyama, H., Papst, P., Gelfand, E. W., and Terada, N. (1996) J. Immunol. 157, 656-660
16. Weng, Q.-P., Kozlowski, M., Belham, C., Zhang, A., Comb, M. J., and Avruch, J. (1998) J. Biol. Chem. 273, 16621-16629
17. Dennis, P. B., Pullen, N., Pearson, R. B., Kozma, S. C., and Thomas, G. (1998) J. Biol. Chem. 273, 14845-14852
18. Dennis, P. B., Pullen, N., Kozma, S. C., and Thomas, G. (1996) Mol. Cell. Biol. 16, 6242-6251
19. Kim, D.-H., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D. M. (2002) Cell 110, 163-175
20. Hara, K., Maruki, Y., Long, X., Yoshino, K., Oshiro, N., Hidayat, S., Tokunaga, C., Avruch, J., and Yonezawa, K. (2002) Cell 110, 177-189
21. Nojima, H., Tokunaga, C., Eguchi, S., Oshiro, N., Hidayat, S., Yoshino, K., Hara, K., Tanaka, N., Avruch, J., and Yonezawa, K. (2003) J. Biol. Chem. 278, 15461-15464
22. Isotani, S., Hara, K., Tokunaga, C., Inoue, H., Avruch, J., and Yonezawa, K. (1999) J. Biol. Chem. 274, 34493-34498
23. Vanhaesebroeck, B., and Alessi, D. R. (2000) Biochem. J. 346, 561-576
24. Pullen, N., Dennis, P., Andjelkovic, M., Dufner, A., Kozma, S. C., Hemmings, B. A., and Thomas, G. (1998) Science 279, 707-710
25. Alessi, D. R., Kozlowski, M. T., Weng, Q.-P., Morrice, N., and Avruch, J. (1997) Curr. Biol. 8, 69-81
26. Biondi, R. M., Komander, D., Thomas, C. C., Lizcano, J. M., Deak, M., Alessi, D. R., and van Aalten, D. M. F. (2002) EMBO J. 21, 4219-4228
27. Biondi, R. M., Kieloch, A., Currie, R. A., Deak, M., and Alessi, D. R. (2001) EMBO J. 20, 4380-4390
28. Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J., and Cantley, L. C. (2002) Mol. Cell 10, 151-162
29. Inoki, K., Li, Y., Zhu, T., Wu, J., and Guan, K. L. (2002) Nat. Cell Biol. 4, 648-657
30. Zhang, Y., Gao, X., Saucedo, L. J., Ru, B., Edgar, B. A., and Pan, D. (2003) Nat. Cell Biol. 5, 578-581
31. Garami, A., Zwartkruis, F. J., Nobukuni, T., Joaquin, M., Roccio, M., Stocker, H., Kozma, S. C., Hafen, E., Bos, J. L., and Thomas, G. (2003) Mol. Cell 11, 1457-1466
32. Inoki, K., Li, Y., Xu, T., and Guan, K. L. (2003) Genes Dev. 17, 1829-1834
33. Tee, A. R., Manning, B. D., Roux, P. P., Cantley, L. C., and Blenis, J. (2003) Curr. Biol. 13, 1259-1268
34. Shah, O. J., Kimball, S. R., and Jefferson, L. S. (2000) Biochem. J. 347, 389-397
35. Brunn, G. J., Williams, J., Sabers, C., Wiederrecht, G., and Abraham, R. T. (1996) EMBO J. 15, 5256-5267
36. Jaeschke, A., Hartkamp, J. Saitoh, M., Roworth, W., Nobukuni, T., Hodges, A., Sampson, J., Thomas, G., and Lamb, R. (2002) J. Cell Biol. 159, 217-224
37. Schalm, S. S., and Blenis, J. (2002) Curr. Biol. 12, 632-639
38. Weng, Q.-P., Andrabi, K., Kozlowski, M. T., Grove, J. R., and Avruch, J. (1995) Mol. Cell. Biol. 15, 2333-2340
39. Cheatham, L., Monfar, M., Chou, M. M., and Blenis, J. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 11696-11700
40. Moser, B. A., Dennis, P. B., Pullen, N., Pearson, R. B., Williamson, N. A., Wettenhall, R. E. H., Kozma, S. C., and Thomas, G. (1997) Mol. Cell. Biol. 17, 5648-5655
41. Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., and Cohen, P. (1997) Curr. Biol. 7, 261-269
42. Romanelli, A., Martin, K. A., Toker, A., and Blenis, J. (1999) Mol. Cell. Biol. 19, 2921-2928
43. Gilbert, J. R., Guy, V., Kumar, A., Wolpert, C., Kandt, R., Ayelsworth, A., Roses, A. D., and Pericak-Vance, M. A. (1998) Neurogenetics 1, 267-272
44. Niida, Y., Lawrence-Smith, N., Banwell, A., Hammer, E., Lewis, H., Beauchamp, R. L., Sims, K., Ramesh, V., and Ozelius, L. (1999) Hum. Mutat. 14, 412-422
45. Dabora, S. L., Jozwiak, S., Franz, D. N., Rosberts, P. S., Nieto, A., Chung, J., Choy, Y. S., Reeve, M. P., Thiele, E., Egelhoff, J. C., Kasprzyk-Obara, J., Domanska-Pakiela, D., and Kwiatkowski, D. J. (2001) Am. J. Hum. Genet. 68, 64-80
46. Choy, Y. S., Dabora, S. L., Hall, F., Ramesh, V., Niida, Y., Franz, D. N., Kasprzyk-Obara, J., Reeve, M. P., and Kwiatkowski, D. J. (1999) Ann. Hum. Genet. 63, 383-391
47. Zhang, H., Nanba, E., Yamamoto, T., Ninomiya, H., Ohno, K., Mizuguchi, M., and Takeshita, K. (1999) J. Hum. Genet. 44, 391-396
48. Jones, A. C., Shyamsundar, M. M., Thomas, M. W., Maynard, J., Idziaszczyk, S., Tomkins, S., Sampson, J. R., and Cheadle, J. P. (1999) Am. J. Hum. Genet. 64, 1305-1315
49. Nellist, M., Verhaaf, B., Goedbloed, M. A., Reuser, A. J. J., van den Ouweland, A. M. W., and Halley, D. J. J. (2001) Hum. Mol. Genet. 10, 2889-2898
50. Aicher, L. D., Campbell, J. S., and Yeung, R. S. (2001) J. Biol. Chem. 276, 21017-21021
51. Neshat, M. S., Mellinghoff, I. K., Ran, C., Stiles, B., Thomas, G., Petersen, R., Frost, P., Gibbons, J. J., Wu, H., and Sawyers, C. L. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 10314-10319
52. Podsypanina, K., Lee, R. T., Politis, C., Hennessy, I., Crane, A., Puc, J., Neshat, M., Wang, H., Yang, L., Gibbons, J., Frost, P., Dreisbach, V., Blenis, J., Gaciong, Z., Fisher, P., Sawyers, C., Hedrick-Ellenson, L., and Parsons, R. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 10320-10325
53. Mills, G. B., Lu, Y., and Kohn, E. C. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 10031-10033