mTORC1 links protein quality and quantity control by sensing chaperone availability

Journal of Biological Chemistry

Volumn 285, Issue 35, 2010, Pages 27385-27395

  Qian, Shu Bing ^a   Zhang, Xingqian ^a   Sun, Jun ^a   Bennink, Jack R ^b   Yewdell, Jonathan W ^b   Patterson, Cam ^c,d  

^a Department of Obstetrics Gynecology   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d 8200 Medical Biomolecular Research Bldg ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR FUNCTION; COMPLEX 1; ENERGY STATUS; ENVIRONMENTAL CUES; INTRACELLULAR PROTEINS; MAMMALIAN TARGET; MOLECULAR CHAPERONES; NUTRIENT AVAILABILITY; NUTRIENT LEVELS; PLAUSIBLE MECHANISMS; PROTEIN MISFOLDING; PROTEIN QUALITY; PROTEIN SYNTHESIS; QUANTITY CONTROL; STRESS-INDUCED; TIGHTLY-COUPLED; UBIQUITIN-PROTEASOME SYSTEM;

BIOINFORMATICS; MAMMALS; NUTRIENTS; QUALITY CONTROL; SIGNALING;

PROTEINS;

CELL PROTEIN; CHAPERONE; CYCLOHEXIMIDE; GELDANAMYCIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HEAT SHOCK TRANSCRIPTION FACTOR 1; INITIATION FACTOR 2ALPHA; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN RAPTOR; PROTEIN RICTOR; PROTEIN S6; PYRUVATE DEHYDROGENASE KINASE; PYRUVATE DEHYDROGENASE KINASE ISOENZYME 1; RAPAMYCIN; S6 KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; HEAT SHOCK RESPONSE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUTRIENT AVAILABILITY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN MISFOLDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

CELL LINE; HUMANS; MOLECULAR CHAPERONES; MULTIPROTEIN COMPLEXES; PROTEIN BIOSYNTHESIS; PROTEIN FOLDING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 77956260496     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.120295     Document Type: Article

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