Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

Genes and Development

Volumn 22, Issue 2, 2008, Pages 239-251

  Deyoung, Maurice Phillip ^a   Horak, Peter ^a   Sofer, Avi ^a   Sgroi, Dennis ^a,b   Ellisen, Leif W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Hypoxia; mTOR; REDD1; Tuberous sclerosis; Tumor suppressor

Indexed keywords

HAMARTIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN 14 3 3; TARGET OF RAPAMYCIN KINASE; TUBERIN;

ANIMAL EXPERIMENT; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN SECRETION;

ANIMALS; BREAST NEOPLASMS; CELL HYPOXIA; CELLS, CULTURED; HUMANS; MICE; MICE, NUDE; MODELS, BIOLOGICAL; NEOPLASM TRANSPLANTATION; PROTEIN KINASES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

MAMMALIA;

EID: 38349056675     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1617608     Document Type: Article

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