Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

Genes and Development

Volumn 20, Issue 20, 2006, Pages 2820-2832

  Yang, Qian ^a,b   Inoki, Ken ^a,b   Ikenoue, Tsuneo ^a,b   Guan, Kun Liang ^a,b,c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Akt; mTOR; Rictor; Sin1; TORC; TSC

Indexed keywords

LINSIDOMINE; PROTEIN KINASE B; RAPAMYCIN;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DROSOPHILA; GENE; HUMAN; HUMAN CELL; IN VIVO STUDY; LETHALITY; MAMMAL CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RICTOR GENE; SIGNAL TRANSDUCTION; TORC1 GENE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; CYTOSKELETON; DROSOPHILA; HELA CELLS; HUMANS; MICE; MICE, KNOCKOUT; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EUKARYOTA; MAMMALIA;

EID: 33751079895     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1461206     Document Type: Article

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