-
1
-
-
0032518467
-
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
-
D.R. Alessi, M.T. Kozlowski, Q.P. Weng, N. Morrice, and J. Avruch 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro Curr. Biol. 8 1998 69 81
-
(1998)
Curr. Biol.
, vol.8
, pp. 69-81
-
-
Alessi, D.R.1
Kozlowski, M.T.2
Weng, Q.P.3
Morrice, N.4
Avruch, J.5
-
2
-
-
14144254701
-
Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors
-
B.A. Ballif, P.P. Roux, S.A. Gerber, J.P. Mackeigan, J. Blenis, and S.P. Gygi Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors Proc. Natl. Acad. Sci. USA 102 2005 667 672
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 667-672
-
-
Ballif, B.A.1
Roux, P.P.2
Gerber, S.A.3
MacKeigan, J.P.4
Blenis, J.5
Gygi, S.P.6
-
3
-
-
0032698075
-
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
-
A. Bonni, A. Brunet, A.E. West, S.R. Datta, M.A. Takasu, and M.E. Greenberg Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms Science 286 1999 1358 1362
-
(1999)
Science
, vol.286
, pp. 1358-1362
-
-
Bonni, A.1
Brunet, A.2
West, A.E.3
Datta, S.R.4
Takasu, M.A.5
Greenberg, M.E.6
-
4
-
-
0032539664
-
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
-
P.E. Burnett, R.K. Barrow, N.A. Cohen, S.H. Snyder, and D.M. Sabatini RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1 Proc. Natl. Acad. Sci. USA 95 1998 1432 1437
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 1432-1437
-
-
Burnett, P.E.1
Barrow, R.K.2
Cohen, N.A.3
Snyder, S.H.4
Sabatini, D.M.5
-
7
-
-
3042818799
-
Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
-
M.N. Corradetti, K. Inoki, N. Bardeesy, R.A. DePinho, and K.L. Guan Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome Genes Dev. 18 2004 1533 1538
-
(2004)
Genes Dev.
, vol.18
, pp. 1533-1538
-
-
Corradetti, M.N.1
Inoki, K.2
Bardeesy, N.3
Depinho, R.A.4
Guan, K.L.5
-
8
-
-
18544375193
-
Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin
-
H.C. Dan, M. Sun, L. Yang, R.I. Feldman, X.M. Sui, C.C. Ou, M. Nellist, R.S. Yeung, D.J. Halley, and S.V. Nicosia Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin J. Biol. Chem. 277 2002 35364 35370
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 35364-35370
-
-
Dan, H.C.1
Sun, M.2
Yang, L.3
Feldman, R.I.4
Sui, X.M.5
Ou, C.C.6
Nellist, M.7
Yeung, R.S.8
Halley, D.J.9
Nicosia, S.V.10
-
9
-
-
0021523971
-
Protein synthesis and memory: A review
-
H.P. Davis, and L.R. Squire Protein synthesis and memory: a review Psychol. Bull. 96 1984 518 559
-
(1984)
Psychol. Bull.
, vol.96
, pp. 518-559
-
-
Davis, H.P.1
Squire, L.R.2
-
10
-
-
0036712905
-
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
-
X. Gao, Y. Zhang, P. Arrazola, O. Hino, T. Kobayashi, R.S. Yeung, B. Ru, and D. Pan Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling Nat. Cell Biol. 4 2002 699 704
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 699-704
-
-
Gao, X.1
Zhang, Y.2
Arrazola, P.3
Hino, O.4
Kobayashi, T.5
Yeung, R.S.6
Ru, B.7
Pan, D.8
-
11
-
-
0038433304
-
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
-
A. Garami, F.J. Zwartkruis, T. Nobukuni, M. Joaquin, M. Roccio, H. Stocker, S.C. Kozma, E. Hafen, J.L. Bos, and G. Thomas Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2 Mol. Cell 11 2003 1457 1466
-
(2003)
Mol. Cell
, vol.11
, pp. 1457-1466
-
-
Garami, A.1
Zwartkruis, F.J.2
Nobukuni, T.3
Joaquin, M.4
Roccio, M.5
Stocker, H.6
Kozma, S.C.7
Hafen, E.8
Bos, J.L.9
Thomas, G.10
-
12
-
-
0003669985
-
-
2nd Edition Raven Press New York
-
M.R. Gomez Tuberous Sclerosis 2nd Edition 1988 Raven Press New York
-
(1988)
Tuberous Sclerosis
-
-
Gomez, M.R.1
-
14
-
-
0037163033
-
Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)
-
E.A. Goncharova, D.A. Goncharov, A. Eszterhas, D.S. Hunter, M.K. Glassberg, R.S. Yeung, C.L. Walker, D. Noonan, D.J. Kwiatkowski, and M.M. Chou Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM) J. Biol. Chem. 277 2002 30958 30967
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 30958-30967
-
-
Goncharova, E.A.1
Goncharov, D.A.2
Eszterhas, A.3
Hunter, D.S.4
Glassberg, M.K.5
Yeung, R.S.6
Walker, C.L.7
Noonan, D.8
Kwiatkowski, D.J.9
Chou, M.M.10
-
15
-
-
0041333070
-
Tuberous sclerosis-associated neoplasms express activated p42/44 mitogen-activated protein (MAP) kinase, and inhibition of MAP kinase signaling results in decreased in vivo tumor growth
-
B. Govindarajan, M.C. Mizesko, M.S. Miller, H. Onda, M. Nunnelly, K. Casper, D. Brat, C. Cohen, and J.L. Arbiser Tuberous sclerosis-associated neoplasms express activated p42/44 mitogen-activated protein (MAP) kinase, and inhibition of MAP kinase signaling results in decreased in vivo tumor growth Clin. Cancer Res. 9 2003 3469 3475
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 3469-3475
-
-
Govindarajan, B.1
Mizesko, M.C.2
Miller, M.S.3
Onda, H.4
Nunnelly, M.5
Casper, K.6
Brat, D.7
Cohen, C.8
Arbiser, J.L.9
-
16
-
-
0028289473
-
Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients
-
A.J. Green, M. Smith, and J.R. Yates Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients Nat. Genet. 6 1994 193 196
-
(1994)
Nat. Genet.
, vol.6
, pp. 193-196
-
-
Green, A.J.1
Smith, M.2
Yates, J.R.3
-
17
-
-
0842325813
-
Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions
-
S. Han, T.M. Santos, A. Puga, J. Roy, E.A. Thiele, M. McCollin, A. Stemmer-Rachamimov, and V. Ramesh Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions Cancer Res. 64 2004 812 816
-
(2004)
Cancer Res.
, vol.64
, pp. 812-816
-
-
Han, S.1
Santos, T.M.2
Puga, A.3
Roy, J.4
Thiele, E.A.5
McCollin, M.6
Stemmer-Rachamimov, A.7
Ramesh, V.8
-
18
-
-
3342958797
-
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
-
L.S. Harrington, G.M. Findlay, A. Gray, T. Tolkacheva, S. Wigfield, H. Rebholz, J. Barnett, N.R. Leslie, S. Cheng, and P.R. Shepherd The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins J. Cell Biol. 166 2004 213 223
-
(2004)
J. Cell Biol.
, vol.166
, pp. 213-223
-
-
Harrington, L.S.1
Findlay, G.M.2
Gray, A.3
Tolkacheva, T.4
Wigfield, S.5
Rebholz, H.6
Barnett, J.7
Leslie, N.R.8
Cheng, S.9
Shepherd, P.R.10
-
19
-
-
0029831886
-
Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions
-
E.P. Henske, B.W. Scheithauer, M.P. Short, R. Wollmann, J. Nahmias, N. Hornigold, M. van Slegtenhorst, C.T. Welsh, and D.J. Kwiatkowski Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions Am. J. Hum. Genet. 59 1996 400 406
-
(1996)
Am. J. Hum. Genet.
, vol.59
, pp. 400-406
-
-
Henske, E.P.1
Scheithauer, B.W.2
Short, M.P.3
Wollmann, R.4
Nahmias, J.5
Hornigold, N.6
Van Slegtenhorst, M.7
Welsh, C.T.8
Kwiatkowski, D.J.9
-
20
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
K. Inoki, Y. Li, T. Zhu, J. Wu, and K.L. Guan TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling Nat. Cell Biol. 4 2002 648 657
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
21
-
-
0043127125
-
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
K. Inoki, Y. Li, T. Xu, and K.L. Guan Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling Genes Dev. 17 2003 1829 1834
-
(2003)
Genes Dev.
, vol.17
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.L.4
-
22
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
K. Inoki, T. Zhu, and K.L. Guan TSC2 mediates cellular energy response to control cell growth and survival Cell 115 2003 577 590
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
23
-
-
0033582748
-
Gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle
-
N. Ito, and G.M. Rubin gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle Cell 96 1999 529 539
-
(1999)
Cell
, vol.96
, pp. 529-539
-
-
Ito, N.1
Rubin, G.M.2
-
24
-
-
1342322145
-
Translational control by MAPK signaling in long-term synaptic plasticity and memory
-
R.J. Kelleher 3rd, A. Govindarajan, H.Y. Jung, H. Kang, and S. Tonegawa Translational control by MAPK signaling in long-term synaptic plasticity and memory Cell 116 2004 467 479
-
(2004)
Cell
, vol.116
, pp. 467-479
-
-
Kelleher III, R.J.1
Govindarajan, A.2
Jung, H.Y.3
Kang, H.4
Tonegawa, S.5
-
25
-
-
0033559663
-
Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice
-
T. Kobayashi, O. Minowa, J. Kuno, H. Mitani, O. Hino, and T. Noda Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice Cancer Res. 59 1999 1206 1211
-
(1999)
Cancer Res.
, vol.59
, pp. 1206-1211
-
-
Kobayashi, T.1
Minowa, O.2
Kuno, J.3
Mitani, H.4
Hino, O.5
Noda, T.6
-
26
-
-
0036501277
-
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
-
D.J. Kwiatkowski, H. Zhang, J.L. Bandura, K.M. Heiberger, M. Glogauer, N. el-Hashemite, and H. Onda A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells Hum. Mol. Genet. 11 2002 525 534
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 525-534
-
-
Kwiatkowski, D.J.1
Zhang, H.2
Bandura, J.L.3
Heiberger, K.M.4
Glogauer, M.5
El-Hashemite, N.6
Onda, H.7
-
28
-
-
0030828764
-
The GAP-related domain of tuberin, the product of the TSC2 gene, is a target for missense mutations in tuberous sclerosis
-
M.M. Maheshwar, J.P. Cheadle, A.C. Jones, J. Myring, A.E. Fryer, P.C. Harris, and J.R. Sampson The GAP-related domain of tuberin, the product of the TSC2 gene, is a target for missense mutations in tuberous sclerosis Hum. Mol. Genet. 6 1997 1991 1996
-
(1997)
Hum. Mol. Genet.
, vol.6
, pp. 1991-1996
-
-
Maheshwar, M.M.1
Cheadle, J.P.2
Jones, A.C.3
Myring, J.4
Fryer, A.E.5
Harris, P.C.6
Sampson, J.R.7
-
29
-
-
0036342294
-
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
-
B.D. Manning, A.R. Tee, M.N. Logsdon, J. Blenis, and L.C. Cantley Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway Mol. Cell 10 2002 151 162
-
(2002)
Mol. Cell
, vol.10
, pp. 151-162
-
-
Manning, B.D.1
Tee, A.R.2
Logsdon, M.N.3
Blenis, J.4
Cantley, L.C.5
-
30
-
-
0028141496
-
Transformation of mammalian cells by constitutively active MAP kinase kinase
-
S.J. Mansour, W.T. Matten, A.S. Hermann, J.M. Candia, S. Rong, K. Fukasawa, G.F. Vande Woude, and N.G. Ahn Transformation of mammalian cells by constitutively active MAP kinase kinase Science 265 1994 966 970
-
(1994)
Science
, vol.265
, pp. 966-970
-
-
Mansour, S.J.1
Matten, W.T.2
Hermann, A.S.3
Candia, J.M.4
Rong, S.5
Fukasawa, K.6
Vande Woude, G.F.7
Ahn, N.G.8
-
31
-
-
0034887907
-
Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions
-
Y. Niida, A.O. Stemmer-Rachamimov, M. Logrip, D. Tapon, R. Perez, D.J. Kwiatkowski, K. Sims, M. MacCollin, D.N. Louis, and V. Ramesh Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions Am. J. Hum. Genet. 69 2001 493 503
-
(2001)
Am. J. Hum. Genet.
, vol.69
, pp. 493-503
-
-
Niida, Y.1
Stemmer-Rachamimov, A.O.2
Logrip, M.3
Tapon, D.4
Perez, R.5
Kwiatkowski, D.J.6
Sims, K.7
MacCollin, M.8
Louis, D.N.9
Ramesh, V.10
-
32
-
-
0025969093
-
Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)
-
D.M. Payne, A.J. Rossomando, P. Martino, A.K. Erickson, J.H. Her, J. Shabanowitz, D.F. Hunt, M.J. Weber, and T.W. Sturgill Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase) EMBO J. 10 1991 885 892
-
(1991)
EMBO J.
, vol.10
, pp. 885-892
-
-
Payne, D.M.1
Rossomando, A.J.2
Martino, P.3
Erickson, A.K.4
Her, J.H.5
Shabanowitz, J.6
Hunt, D.F.7
Weber, M.J.8
Sturgill, T.W.9
-
33
-
-
0034997845
-
Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions
-
G. Pearson, F. Robinson, T. Beers Gibson, B.E. Xu, M. Karandikar, K. Berman, and M.H. Cobb Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions Endocr. Rev. 22 2001 153 183
-
(2001)
Endocr. Rev.
, vol.22
, pp. 153-183
-
-
Pearson, G.1
Robinson, F.2
Beers Gibson, T.3
Xu, B.E.4
Karandikar, M.5
Berman, K.6
Cobb, M.H.7
-
34
-
-
0032213545
-
Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles
-
T.L. Plank, R.S. Yeung, and E.P. Henske Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles Cancer Res. 58 1998 4766 4770
-
(1998)
Cancer Res.
, vol.58
, pp. 4766-4770
-
-
Plank, T.L.1
Yeung, R.S.2
Henske, E.P.3
-
35
-
-
0033565503
-
Immobilized gallium(III) affinity chromatography of phosphopeptides
-
M.C. Posewitz, and P. Tempst Immobilized gallium(III) affinity chromatography of phosphopeptides Anal. Chem. 71 1999 2883 2892
-
(1999)
Anal. Chem.
, vol.71
, pp. 2883-2892
-
-
Posewitz, M.C.1
Tempst, P.2
-
36
-
-
0035805162
-
Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size
-
C.J. Potter, H. Huang, and T. Xu Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size Cell 105 2001 357 368
-
(2001)
Cell
, vol.105
, pp. 357-368
-
-
Potter, C.J.1
Huang, H.2
Xu, T.3
-
37
-
-
0036714127
-
Akt regulates growth by directly phosphorylating Tsc2
-
C.J. Potter, L.G. Pedraza, and T. Xu Akt regulates growth by directly phosphorylating Tsc2 Nat. Cell Biol. 4 2002 658 665
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 658-665
-
-
Potter, C.J.1
Pedraza, L.G.2
Xu, T.3
-
38
-
-
0032578998
-
Phosphorylation and activation of p70s6k by PDK1
-
N. Pullen, P.B. Dennis, M. Andjelkovic, A. Dufner, S.C. Kozma, B.A. Hemmings, and G. Thomas Phosphorylation and activation of p70s6k by PDK1 Science 279 1998 707 710
-
(1998)
Science
, vol.279
, pp. 707-710
-
-
Pullen, N.1
Dennis, P.B.2
Andjelkovic, M.3
Dufner, A.4
Kozma, S.C.5
Hemmings, B.A.6
Thomas, G.7
-
39
-
-
0033521535
-
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E
-
S. Pyronnet, H. Imataka, A.C. Gingras, R. Fukunaga, T. Hunter, and N. Sonenberg Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E EMBO J. 18 1999 270 279
-
(1999)
EMBO J.
, vol.18
, pp. 270-279
-
-
Pyronnet, S.1
Imataka, H.2
Gingras, A.C.3
Fukunaga, R.4
Hunter, T.5
Sonenberg, N.6
-
40
-
-
4544384577
-
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
-
P.P. Roux, B.A. Ballif, R. Anjum, S.P. Gygi, and J. Blenis Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase Proc. Natl. Acad. Sci. USA 101 2004 13489 13494
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 13489-13494
-
-
Roux, P.P.1
Ballif, B.A.2
Anjum, R.3
Gygi, S.P.4
Blenis, J.5
-
41
-
-
0038643484
-
Rheb promotes cell growth as a component of the insulin/TOR signalling network
-
L.J. Saucedo, X. Gao, D.A. Chiarelli, L. Li, D. Pan, and B.A. Edgar Rheb promotes cell growth as a component of the insulin/TOR signalling network Nat. Cell Biol. 5 2003 566 571
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 566-571
-
-
Saucedo, L.J.1
Gao, X.2
Chiarelli, D.A.3
Li, L.4
Pan, D.5
Edgar, B.A.6
-
42
-
-
0035133659
-
The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells
-
G.C. Scheper, N.A. Morrice, M. Kleijn, and C.G. Proud The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells Mol. Cell. Biol. 21 2001 743 754
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 743-754
-
-
Scheper, G.C.1
Morrice, N.A.2
Kleijn, M.3
Proud, C.G.4
-
43
-
-
0036490552
-
Isolation and mass spectrometry of transcription factor complexes
-
G. Sebastiaan Winkler, L. Lacomis, J. Philip, H. Erdjument-Bromage, J.Q. Svejstrup, and P. Tempst Isolation and mass spectrometry of transcription factor complexes Methods 26 2002 260 269
-
(2002)
Methods
, vol.26
, pp. 260-269
-
-
Sebastiaan Winkler, G.1
Lacomis, L.2
Philip, J.3
Erdjument-Bromage, H.4
Svejstrup, J.Q.5
Tempst, P.6
-
44
-
-
0037103769
-
The Src-family tyrosine kinase inhibitor PP1 interferes with the activation of ribosomal protein S6 kinases
-
O.J. Shah, S.R. Kimball, and L.S. Jefferson The Src-family tyrosine kinase inhibitor PP1 interferes with the activation of ribosomal protein S6 kinases Biochem. J. 366 2002 57 62
-
(2002)
Biochem. J.
, vol.366
, pp. 57-62
-
-
Shah, O.J.1
Kimball, S.R.2
Jefferson, L.S.3
-
45
-
-
4544343980
-
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
-
O.J. Shah, Z. Wang, and T. Hunter Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies Curr. Biol. 14 2004 1650 1656
-
(2004)
Curr. Biol.
, vol.14
, pp. 1650-1656
-
-
Shah, O.J.1
Wang, Z.2
Hunter, T.3
-
46
-
-
0034284131
-
Docking domains and substrate-specificity determination for MAP kinases
-
A.D. Sharrocks, S.H. Yang, and A. Galanis Docking domains and substrate-specificity determination for MAP kinases Trends Biochem. Sci. 25 2000 448 453
-
(2000)
Trends Biochem. Sci.
, vol.25
, pp. 448-453
-
-
Sharrocks, A.D.1
Yang, S.H.2
Galanis, A.3
-
47
-
-
3142594193
-
The LKB1 tumor suppressor negatively regulates mTOR signaling
-
R.J. Shaw, N. Bardeesy, B.D. Manning, L. Lopez, M. Kosmatka, R.A. DePinho, and L.C. Cantley The LKB1 tumor suppressor negatively regulates mTOR signaling Cancer Cell 6 2004 91 99
-
(2004)
Cancer Cell
, vol.6
, pp. 91-99
-
-
Shaw, R.J.1
Bardeesy, N.2
Manning, B.D.3
Lopez, L.4
Kosmatka, M.5
Depinho, R.A.6
Cantley, L.C.7
-
48
-
-
0038304516
-
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
-
H. Stocker, T. Radimerski, B. Schindelholz, F. Wittwer, P. Belawat, P. Daram, S. Breuer, G. Thomas, and E. Hafen Rheb is an essential regulator of S6K in controlling cell growth in Drosophila Nat. Cell Biol. 5 2003 559 565
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 559-565
-
-
Stocker, H.1
Radimerski, T.2
Schindelholz, B.3
Wittwer, F.4
Belawat, P.5
Daram, P.6
Breuer, S.7
Thomas, G.8
Hafen, E.9
-
49
-
-
0035805180
-
The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation
-
N. Tapon, N. Ito, B.J. Dickson, J.E. Treisman, and I.K. Hariharan The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation Cell 105 2001 345 355
-
(2001)
Cell
, vol.105
, pp. 345-355
-
-
Tapon, N.1
Ito, N.2
Dickson, B.J.3
Treisman, J.E.4
Hariharan, I.K.5
-
50
-
-
0037108750
-
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
-
A.R. Tee, D.C. Fingar, B.D. Manning, D.J. Kwiatkowski, L.C. Cantley, and J. Blenis Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling Proc. Natl. Acad. Sci. USA 99 2002 13571 13576
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 13571-13576
-
-
Tee, A.R.1
Fingar, D.C.2
Manning, B.D.3
Kwiatkowski, D.J.4
Cantley, L.C.5
Blenis, J.6
-
51
-
-
0042701991
-
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
-
A.R. Tee, B.D. Manning, P.P. Roux, L.C. Cantley, and J. Blenis Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb Curr. Biol. 13 2003 1259 1268
-
(2003)
Curr. Biol.
, vol.13
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
Cantley, L.C.4
Blenis, J.5
-
52
-
-
0029935418
-
Regulation of transcription by MAP kinase cascades
-
R. Treisman Regulation of transcription by MAP kinase cascades Curr. Opin. Cell Biol. 8 1996 205 215
-
(1996)
Curr. Opin. Cell Biol.
, vol.8
, pp. 205-215
-
-
Treisman, R.1
-
53
-
-
3242719457
-
Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development
-
T. Ueda, R. Watanabe-Fukunaga, H. Fukuyama, S. Nagata, and R. Fukunaga Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development Mol. Cell. Biol. 24 2004 6539 6549
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 6539-6549
-
-
Ueda, T.1
Watanabe-Fukunaga, R.2
Fukuyama, H.3
Nagata, S.4
Fukunaga, R.5
-
54
-
-
0030879277
-
Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34
-
M. van Slegtenhorst, R. de Hoogt, C. Hermans, M. Nellist, B. Janssen, S. Verhoef, D. Lindhout, A. van den Ouweland, D. Halley, and J. Young Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34 Science 277 1997 805 808
-
(1997)
Science
, vol.277
, pp. 805-808
-
-
Van Slegtenhorst, M.1
De Hoogt, R.2
Hermans, C.3
Nellist, M.4
Janssen, B.5
Verhoef, S.6
Lindhout, D.7
Van Den Ouweland, A.8
Halley, D.9
Young, J.10
-
55
-
-
7144255533
-
Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products
-
M. van Slegtenhorst, M. Nellist, B. Nagelkerken, J. Cheadle, R. Snell, A. van den Ouweland, A. Reuser, J. Sampson, D. Halley, and P. van der Sluijs Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products Hum. Mol. Genet. 7 1998 1053 1057
-
(1998)
Hum. Mol. Genet.
, vol.7
, pp. 1053-1057
-
-
Van Slegtenhorst, M.1
Nellist, M.2
Nagelkerken, B.3
Cheadle, J.4
Snell, R.5
Van Den Ouweland, A.6
Reuser, A.7
Sampson, J.8
Halley, D.9
Van Der Sluijs, P.10
-
56
-
-
0032981328
-
Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo
-
A.J. Waskiewicz, J.C. Johnson, B. Penn, M. Mahalingam, S.R. Kimball, and J.A. Cooper Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo Mol. Cell. Biol. 19 1999 1871 1880
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 1871-1880
-
-
Waskiewicz, A.J.1
Johnson, J.C.2
Penn, B.3
Mahalingam, M.4
Kimball, S.R.5
Cooper, J.A.6
-
57
-
-
0029021621
-
Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity
-
R. Wienecke, A. Konig, and J.E. DeClue Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity J. Biol. Chem. 270 1995 16409 16414
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 16409-16414
-
-
Wienecke, R.1
Konig, A.2
Declue, J.E.3
-
58
-
-
0035072833
-
A motif-based profile scanning approach for genome-wide prediction of signaling pathways
-
M.B. Yaffe, G.G. Leparc, J. Lai, T. Obata, S. Volinia, and L.C. Cantley A motif-based profile scanning approach for genome-wide prediction of signaling pathways Nat. Biotechnol. 19 2001 348 353
-
(2001)
Nat. Biotechnol.
, vol.19
, pp. 348-353
-
-
Yaffe, M.B.1
Leparc, G.G.2
Lai, J.3
Obata, T.4
Volinia, S.5
Cantley, L.C.6
-
59
-
-
0347988005
-
Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR
-
H. Zhang, G. Cicchetti, H. Onda, H.B. Koon, K. Asrican, N. Bajraszewski, F. Vazquez, C.L. Carpenter, and D.J. Kwiatkowski Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR J. Clin. Invest. 112 2003 1223 1233
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1223-1233
-
-
Zhang, H.1
Cicchetti, G.2
Onda, H.3
Koon, H.B.4
Asrican, K.5
Bajraszewski, N.6
Vazquez, F.7
Carpenter, C.L.8
Kwiatkowski, D.J.9
-
60
-
-
0038141979
-
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
-
Y. Zhang, X. Gao, L.J. Saucedo, B. Ru, B.A. Edgar, and D. Pan Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins Nat. Cell Biol. 5 2003 578 581
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 578-581
-
-
Zhang, Y.1
Gao, X.2
Saucedo, L.J.3
Ru, B.4
Edgar, B.A.5
Pan, D.6
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