-
1
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA (1996) Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15: 6541-6551
-
(1996)
EMBO J
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
2
-
-
14144254701
-
Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors
-
Ballif BA, Roux PP, Gerber SA, MacKeigan JP, Blenis J, Gygi SP (2005) Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. Proc Natl Acad Sci USA 102: 667-672
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 667-672
-
-
Ballif, B.A.1
Roux, P.P.2
Gerber, S.A.3
MacKeigan, J.P.4
Blenis, J.5
Gygi, S.P.6
-
3
-
-
0032560796
-
Akt activation by growth factors is a multiple-step process: The role of the PH domain
-
Bellacosa A, Chan TO, Ahmed NN, Datta K, Malstrom S, Stokoe D, McCormick F, Feng J, Tsichlis P (1998) Akt activation by growth factors is a multiple-step process: the role of the PH domain. Oncogene 17: 313-325
-
(1998)
Oncogene
, vol.17
, pp. 313-325
-
-
Bellacosa, A.1
Chan, T.O.2
Ahmed, N.N.3
Datta, K.4
Malstrom, S.5
Stokoe, D.6
McCormick, F.7
Feng, J.8
Tsichlis, P.9
-
4
-
-
0034161251
-
Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA
-
Biondi RM, Cheung PC, Casamayor A, Deak M, Currie RA, Alessi DR (2000) Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA. EMBO J 19: 979-988
-
(2000)
EMBO J
, vol.19
, pp. 979-988
-
-
Biondi, R.M.1
Cheung, P.C.2
Casamayor, A.3
Deak, M.4
Currie, R.A.5
Alessi, D.R.6
-
5
-
-
0035882103
-
The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB
-
Biondi RM, Kieloch A, Currie RA, Deak M, Alessi DR (2001) The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. EMBO J 20: 4380-4390
-
(2001)
EMBO J
, vol.20
, pp. 4380-4390
-
-
Biondi, R.M.1
Kieloch, A.2
Currie, R.A.3
Deak, M.4
Alessi, D.R.5
-
6
-
-
0037102153
-
High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site
-
Biondi RM, Komander D, Thomas CC, Lizcano JM, Deak M, Alessi DR, van Aalten DM (2002) High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site. EMBO J 21: 4219-4228
-
(2002)
EMBO J
, vol.21
, pp. 4219-4228
-
-
Biondi, R.M.1
Komander, D.2
Thomas, C.C.3
Lizcano, J.M.4
Deak, M.5
Alessi, D.R.6
van Aalten, D.M.7
-
7
-
-
0031952597
-
Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK
-
Dalby KN, Morrice N, Caudwell FB, Avruch J, Cohen P (1998) Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK. J Biol Chem 273: 1496-1505
-
(1998)
J Biol Chem
, vol.273
, pp. 1496-1505
-
-
Dalby, K.N.1
Morrice, N.2
Caudwell, F.B.3
Avruch, J.4
Cohen, P.5
-
8
-
-
33751583820
-
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
-
Engel M, Hindie V, Lopez-Garcia LA, Stroba A, Schaeffer F, Adrian I, Imig J, Idrissova L, Nastainczyk W, Zeuzem S, Alzari P, Hartmann RW, Piiper A, Biondi RM (2006) Allosteric activation of the protein kinase PDK1 with low molecular weight compounds. EMBO J 25: 5469-5480
-
(2006)
EMBO J
, vol.25
, pp. 5469-5480
-
-
Engel, M.1
Hindie, V.2
Lopez-Garcia, L.A.3
Stroba, A.4
Schaeffer, F.5
Adrian, I.6
Imig, J.7
Idrissova, L.8
Nastainczyk, W.9
Zeuzem, S.10
Alzari, P.11
Hartmann, R.W.12
Piiper, A.13
Biondi, R.M.14
-
9
-
-
0037107414
-
A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation
-
Frodin M, Antal TL, Dummler BA, Jensen CJ, Deak M, Gammeltoft S, Biondi RM (2002) A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation. EMBO J 21: 5396-5407
-
(2002)
EMBO J
, vol.21
, pp. 5396-5407
-
-
Frodin, M.1
Antal, T.L.2
Dummler, B.A.3
Jensen, C.J.4
Deak, M.5
Gammeltoft, S.6
Biondi, R.M.7
-
10
-
-
0242612949
-
A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1
-
Frodin M, Jensen CJ, Merienne K, Gammeltoft S (2000) A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1. EMBO J 19: 2924-2934
-
(2000)
EMBO J
, vol.19
, pp. 2924-2934
-
-
Frodin, M.1
Jensen, C.J.2
Merienne, K.3
Gammeltoft, S.4
-
11
-
-
33748320817
-
RSK and MSK in MAP kinase signalling
-
Hauge C, Frodin M (2006) RSK and MSK in MAP kinase signalling. J Cell Sci 119: 3021-3023
-
(2006)
J Cell Sci
, vol.119
, pp. 3021-3023
-
-
Hauge, C.1
Frodin, M.2
-
12
-
-
0035413608
-
Dynamics of cAMP-dependent protein kinase
-
Johnson DA, Akamine P, Radzio-Andzelm E, Madhusudan M, Taylor SS (2001) Dynamics of cAMP-dependent protein kinase. Chem Rev 101: 2243-2270
-
(2001)
Chem Rev
, vol.101
, pp. 2243-2270
-
-
Johnson, D.A.1
Akamine, P.2
Radzio-Andzelm, E.3
Madhusudan, M.4
Taylor, S.S.5
-
13
-
-
0026342401
-
Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase
-
Knighton DR, Zheng JH, Ten Eyck LF, Ashford VA, Xuong NH, Taylor SS, Sowadski JM (1991) Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science 253: 407-414
-
(1991)
Science
, vol.253
, pp. 407-414
-
-
Knighton, D.R.1
Zheng, J.H.2
Ten Eyck, L.F.3
Ashford, V.A.4
Xuong, N.H.5
Taylor, S.S.6
Sowadski, J.M.7
-
14
-
-
0033571416
-
Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase
-
Kobayashi T, Deak M, Morrice N, Cohen P (1999) Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Biochem J 344 (Part 1): 189-197
-
(1999)
Biochem J
, vol.344
, Issue.PART 1
, pp. 189-197
-
-
Kobayashi, T.1
Deak, M.2
Morrice, N.3
Cohen, P.4
-
15
-
-
0036007421
-
Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K
-
Kozma SC, Thomas G (2002) Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K. Bioessays 24: 65-71
-
(2002)
Bioessays
, vol.24
, pp. 65-71
-
-
Kozma, S.C.1
Thomas, G.2
-
16
-
-
1842426795
-
Distinct activation mechanisms of protein kinase B by growth-factor stimulation and heat-shock treatment
-
Matsuzaki H, Yamamoto T, Kikkawa U (2004) Distinct activation mechanisms of protein kinase B by growth-factor stimulation and heat-shock treatment. Biochemistry 43: 4284-4293
-
(2004)
Biochemistry
, vol.43
, pp. 4284-4293
-
-
Matsuzaki, H.1
Yamamoto, T.2
Kikkawa, U.3
-
17
-
-
17644422193
-
MSK1 activity is controlled by multiple phosphorylation sites
-
McCoy CE, Campbell DG, Deak M, Bloomberg GB, Arthur JS (2004) MSK1 activity is controlled by multiple phosphorylation sites. Biochem J 387: 507-517
-
(2004)
Biochem J
, vol.387
, pp. 507-517
-
-
McCoy, C.E.1
Campbell, D.G.2
Deak, M.3
Bloomberg, G.B.4
Arthur, J.S.5
-
18
-
-
24644488646
-
Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif
-
Messerschmidt A, Macieira S, Velarde M, Badeker M, Benda C, Jestel A, Brandstetter H, Neuefeind T, Blaesse M (2005) Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif. J Mol Biol 352: 918-931
-
(2005)
J Mol Biol
, vol.352
, pp. 918-931
-
-
Messerschmidt, A.1
Macieira, S.2
Velarde, M.3
Badeker, M.4
Benda, C.5
Jestel, A.6
Brandstetter, H.7
Neuefeind, T.8
Blaesse, M.9
-
19
-
-
0030848939
-
Dual requirement for a newly identified phosphorylation site in p70s6k
-
Moser B, Dennis P, Pullen N, Pearson R, Williamson N, Wettenhall R, Kozma S, Thomas G (1997) Dual requirement for a newly identified phosphorylation site in p70s6k. Mol Cell Biol 17: 5648-5655
-
(1997)
Mol Cell Biol
, vol.17
, pp. 5648-5655
-
-
Moser, B.1
Dennis, P.2
Pullen, N.3
Pearson, R.4
Williamson, N.5
Wettenhall, R.6
Kozma, S.7
Thomas, G.8
-
20
-
-
0035413601
-
Protein kinase C: Structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions
-
Newton AC (2001) Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem Rev 101: 2353-2364
-
(2001)
Chem Rev
, vol.101
, pp. 2353-2364
-
-
Newton, A.C.1
-
21
-
-
0037337159
-
Regulation of the ABC kinases by phosphorylation: Protein kinase C as a paradigm
-
Newton AC (2003) Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J 370: 361-371
-
(2003)
Biochem J
, vol.370
, pp. 361-371
-
-
Newton, A.C.1
-
22
-
-
0034651539
-
Multiple pathways control protein kinase C phosphorylation
-
Parekh DB, Ziegler W, Parker PJ (2000) Multiple pathways control protein kinase C phosphorylation. EMBO J 19: 496-503
-
(2000)
EMBO J
, vol.19
, pp. 496-503
-
-
Parekh, D.B.1
Ziegler, W.2
Parker, P.J.3
-
23
-
-
23844445836
-
Colorectal cancer: Mutations in a signalling pathway
-
Parsons DW, Wang TL, Samuels Y, Bardelli A, Cummins JM, DeLong L, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Lengauer C, Velculescu VE (2005) Colorectal cancer: mutations in a signalling pathway. Nature 436: 792
-
(2005)
Nature
, vol.436
, pp. 792
-
-
Parsons, D.W.1
Wang, T.L.2
Samuels, Y.3
Bardelli, A.4
Cummins, J.M.5
DeLong, L.6
Silliman, N.7
Ptak, J.8
Szabo, S.9
Willson, J.K.10
Markowitz, S.11
Kinzler, K.W.12
Vogelstein, B.13
Lengauer, C.14
Velculescu, V.E.15
-
24
-
-
2942530310
-
ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functions
-
Roux PP, Blenis J (2004) ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 68: 320-344
-
(2004)
Microbiol Mol Biol Rev
, vol.68
, pp. 320-344
-
-
Roux, P.P.1
Blenis, J.2
-
25
-
-
0037205409
-
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site
-
Saitoh M, Pullen N, Brennan P, Cantrell D, Dennis PB, Thomas G (2002) Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site. J Biol Chem 277: 20104-20112
-
(2002)
J Biol Chem
, vol.277
, pp. 20104-20112
-
-
Saitoh, M.1
Pullen, N.2
Brennan, P.3
Cantrell, D.4
Dennis, P.B.5
Thomas, G.6
-
26
-
-
0036333737
-
Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
-
Scheid MP, Marignani PA, Woodgett JR (2002) Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. Mol Cell Biol 22: 6247-6260
-
(2002)
Mol Cell Biol
, vol.22
, pp. 6247-6260
-
-
Scheid, M.P.1
Marignani, P.A.2
Woodgett, J.R.3
-
27
-
-
2942617368
-
The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein
-
Smith KJ, Carter PS, Bridges A, Horrocks P, Lewis C, Pettman G, Clarke A, Brown M, Hughes J, Wilkinson M, Bax B, Reith A (2004) The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein. Structure (Camb) 12: 1067-1077
-
(2004)
Structure (Camb)
, vol.12
, pp. 1067-1077
-
-
Smith, K.J.1
Carter, P.S.2
Bridges, A.3
Horrocks, P.4
Lewis, C.5
Pettman, G.6
Clarke, A.7
Brown, M.8
Hughes, J.9
Wilkinson, M.10
Bax, B.11
Reith, A.12
-
28
-
-
0032568921
-
Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies
-
Weng Q-P, Kozlowski M, Belham C, Zhang A, Comb MJ, Avruch J (1998) Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies. J Biol Chem 273: 16621-16629
-
(1998)
J Biol Chem
, vol.273
, pp. 16621-16629
-
-
Weng, Q.-P.1
Kozlowski, M.2
Belham, C.3
Zhang, A.4
Comb, M.J.5
Avruch, J.6
-
29
-
-
18744373865
-
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP
-
Yang J, Cron P, Good VM, Thompson V, Hemmings BA, Barford D (2002a) Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP. Nat Struct Biol 9: 940-944
-
(2002)
Nat Struct Biol
, vol.9
, pp. 940-944
-
-
Yang, J.1
Cron, P.2
Good, V.M.3
Thompson, V.4
Hemmings, B.A.5
Barford, D.6
-
30
-
-
0036295728
-
Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation
-
Yang J, Cron P, Thompson V, Good VM, Hess D, Hemmings BA, Barford D (2002b) Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation. Mol Cell 9: 1227-1240
-
(2002)
Mol Cell
, vol.9
, pp. 1227-1240
-
-
Yang, J.1
Cron, P.2
Thompson, V.3
Good, V.M.4
Hess, D.5
Hemmings, B.A.6
Barford, D.7
|