mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif

Journal of Biological Chemistry

Volumn 286, Issue 16, 2011, Pages 14190-14198

  Wu, You Tong ^a,b   Ouyang, Weiming ^a,c   Lazorchak, Adam S ^a   Liu, Dou ^a   Shen, Han Ming ^b   Su, Bing ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AKT ACTIVATION; CONTROL-CELL; GROWTH FACTOR; HUMAN DISEASE; HYDROPHOBIC MOTIFS; MAMMALIAN TARGET; NEGATIVE FEEDBACK; POLYUBIQUITINATION; PROTEASOMAL DEGRADATION; PROTEIN DEGRADATION; PROTEIN KINASE; PROTEIN KINASE B; UBIQUITINATION;

ACTIVATION ANALYSIS; ANTIBIOTICS; DEGRADATION; ENZYMES; FEEDBACK; HYDROPHOBICITY; MAMMALS; PROTEIN FOLDING;

PHOSPHORYLATION;

LYSINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PROTEASOME; PROTEIN KINASE B; SERINE;

ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME STABILITY; HUMAN; HUMAN CELL; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN MOTIF; UBIQUITINATION;

AMINO ACID MOTIFS; ANIMALS; CELL LINE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MICE; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; SERINE; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 79954600448     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.219923     Document Type: Article

References (39)

1. Manning, B. D., and Cantley, L. C. (2007) Cell 129, 1261-1274
2. Restuccia, D. F., and Hemmings, B. A. (2009) Science 325, 1083-1084
3. O'Reilly, K. E., Rojo, F., She, Q. B., Solit, D., Mills, G. B., Smith, D., Lane, H., Hofmann, F., Hicklin, D. J., Ludwig, D. L., Baselga, J., and Rosen, N. (2006) Cancer Res. 66, 1500-1508
4. Elghazi, L., and Bernal-Mizrachi, E. (2009) Trends Endocrinol. Metab. 20, 243-251
5. Woodgett, J. R. (2005) Curr. Opin. Cell Biol. 17, 150-157
6. Peterson, R. T., and Schreiber, S. L. (1999) Curr. Biol. 9, R521-R524
7. Yang, Z. Z., Tschopp, O., Hemmings-Mieszczak, M., Feng, J., Brodbeck, D., Perentes, E., and Hemmings, B. A. (2003) J. Biol. Chem. 278, 32124-32131
8. Tschopp, O., Yang, Z. Z., Brodbeck, D., Dummler, B. A., Hemmings-Mieszczak, M., Watanabe, T., Michaelis, T., Frahm, J., and Hemmings, B. A. (2005) Development 132, 2943-2954
9. Easton, R. M., Cho, H., Roovers, K., Shineman, D. W., Mizrahi, M., Forman, M. S., Lee, V. M., Szabolcs, M., deJong, R., Oltersdorf, T., Ludwig, T., Efstratiadis, A., and Birnbaum, M. J. (2005) Mol. Cell. Biol. 25, 1869-1878
10. Cho, H., Thorvaldsen, J. L., Chu, Q., Feng, F., and Birnbaum, M. J. (2001) J. Biol. Chem. 276, 38349-38352
11. Altomare, D. A., Lyons, G. E., Mitsuuchi, Y., Cheng, J. Q., and Testa, J. R. (1998) Oncogene 16, 2407-2411
12. Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., and Cohen, P. (1997) Curr. Biol. 7, 261-269
13. Toker, A., and Newton, A. C. (2000) J. Biol. Chem. 275, 8271-8274
14. Jacinto, E., Facchinetti, V., Liu, D., Soto, N., Wei, S., Jung, S. Y., Huang, Q., Qin, J., and Su, B. (2006) Cell 127, 125-137
15. Frias, M. A., Thoreen, C. C., Jaffe, J. D., Schroder, W., Sculley, T., Carr, S. A., and Sabatini, D. M. (2006) Curr. Biol. 16, 1865-1870
16. Sarbassov, D. D., Guertin, D. A., Ali, S. M., and Sabatini, D. M. (2005) Science 307, 1098-1101
17. Facchinetti, V., Ouyang, W., Wei, H., Soto, N., Lazorchak, A., Gould, C., Lowry, C., Newton, A. C., Mao, Y., Miao, R. Q., Sessa, W. C., Qin, J., Zhang, P., Su, B., and Jacinto, E. (2008) EMBO J. 27, 1932-1943
18. Efeyan, A., and Sabatini, D. M. (2010) Curr. Opin. Cell. Biol. 22, 169-176
19. Ikenoue, T., Inoki, K., Yang, Q., Zhou, X., and Guan, K. L. (2008) EMBO J. 27, 1919-1931
20. Chen, C., Liu, Y., Liu, R., Ikenoue, T., Guan, K. L., Liu, Y., and Zheng, P. (2008) J. Exp. Med. 205, 2397-2408
21. Plas, D. R., and Thompson, C. B. (2005) Oncogene 24, 7435-7442
22. Martin-Berenjeno, I., and Vanhaesebroeck, B. (2009) Cancer Cell 16, 449-450
23. Liu, Q., Sasaki, T., Kozieradzki, I., Wakeham, A., Itie, A., Dumont, D. J., and Penninger, J. M. (1999) Genes Dev. 13, 786-791
24. Padmanabhan, S., Mukhopadhyay, A., Narasimhan, S. D., Tesz, G., Czech, M. P., and Tissenbaum, H. A. (2009) Cell 136, 939-951
25. Gao, T., Furnari, F., and Newton, A. C. (2005) Mol. Cell 18, 13-24
26. Song, J. J., and Lee, Y. J. (2005) J. Cell Biol. 170, 61-72
27. Du, K., and Tsichlis, P. N. (2005) Oncogene 24, 7401-7409
28. Cheng, J., Zhang, D., Kim, K., Zhao, Y., Zhao, Y., and Su, B. (2005) Mol. Cell. Biol. 25, 5955-5964
29. Lazorchak, A. S., Liu, D., Facchinetti, V., Di Lorenzo, A., Sessa, W. C., Schatz, D. G., and Su, B. (2010) Mol. Cell. 39, 433-443
30. Shiota, C., Woo, J. T., Lindner, J., Shelton, K. D., and Magnuson, M. A. (2006) Dev. Cell 11, 583-589
31. Ikeda, F., and Dikic, I. (2008) EMBO Rep. 9, 536-542
32. Adhikari, A., and Chen, Z. J. (2009) Dev. Cell 16, 485-486
33. Yang, W. L., Wang, J., Chan, C. H., Lee, S. W., Campos, A. D., Lamothe, B., Hur, L., Grabiner, B. C., Lin, X., Darnay, B. G., and Lin, H. K. (2009) Science 325, 1134-1138
34. Suizu, F., Hiramuki, Y., Okumura, F., Matsuda, M., Okumura, A. J., Hirata, N., Narita, M., Kohno, T., Yokota, J., Bohgaki, M., Obuse, C., Hatakeyama, S., Obata, T., and Noguchi, M. (2009) Dev. Cell 17, 800-810
35. Xiang, T., Ohashi, A., Huang, Y., Pandita, T. K., Ludwig, T., Powell, S. N., and Yang, Q. (2008) Cancer Res. 68, 10040-10044
36. Adachi, M., Katsumura, K. R., Fujii, K., Kobayashi, S., Aoki, H., and Matsuzaki, M. (2003) FEBS Lett. 554, 77-80
37. Oh, W. J., Wu, C. C., Kim, S. J., Facchinetti, V., Julien, L. A., Finlan, M., Roux, P. P., Su, B., and Jacinto, E. (2010) EMBO J. 29, 3939-3951
38. Rosen, N., and She, Q. B. (2006) Cancer Cell 10, 254-256
39. Sale, E. M., and Sale, G. J. (2008) Cell. Mol. Life Sci. 65, 113-127