Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition

Molecular Cell

Volumn 38, Issue 5, 2010, Pages 768-774

  Yip, Calvin K ^a   Murata, Kazuyoshi ^c   Walz, Thomas ^a,b   Sabatini, David M ^c,d,e   Kang, Seong A ^c,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

PROTEINS; SIGNALING

Indexed keywords

FK 506 BINDING PROTEIN; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; RAPAMYCIN; S6 KINASE; S6 KINASE 1; UNCLASSIFIED DRUG;

ARTICLE; CRYOELECTRON MICROSCOPY; ELECTRON MICROSCOPY; HUMAN; IN VITRO STUDY; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; PROTEIN STRUCTURE;

ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE; COMPUTER SIMULATION; CRYOELECTRON MICROSCOPY; HUMANS; MODELS, MOLECULAR; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; PROTEINS; SIROLIMUS; TACROLIMUS BINDING PROTEIN 1A; TRANSCRIPTION FACTORS;

MAMMALIA; RAPTORES;

EID: 77953091045     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2010.05.017     Document Type: Article

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