Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

Cell

Volumn 110, Issue 2, 2002, Pages 177-189

  Hara, Kenta ^a   Maruki, Yoshiko ^a   Long, Xiaomeng ^b   Yoshino, Ken ichi ^a   Oshiro, Noriko ^a   Hidayat, Sujuti ^a   Tokunaga, Chiharu ^a   Avruch, Joseph ^b   Yonezawa, Kazuyoshi ^a  

^a KOBE UNIVERSITY   (Japan)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; INITIATION FACTOR 4E; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN; PROTEIN RAPTOR; RAPAMYCIN; RNA; S6 KINASE; SEPHAROSE; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; CONTROLLED STUDY; ENZYME ACTIVITY; EUKARYOTIC CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PHENOTYPE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EUKARYOTA; RAPTORES; TOR;

EID: 0037178781     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(02)00833-4     Document Type: Article

References (57)

1. 3-phosphoinositide-dependent protein kinase-1 (PDK1): Structural and functional homology with the Drosophila DSTPK61 kinase
2. 3-phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
3. The p70 S6 kinase integrates nutrient and growth signals to control translational capacity
4. TOR controls translation initiation and early G1 progression in yeast
5. Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation
6. The genetics of Caenorhabditis elegans
7. A mammalian protein targeted by G1-arresting rapamycin-receptor complex
8. Control of p70 s6 kinase by kinase activity of FRAP in vivo
9. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
10. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4EBP1
11. Alpha 4 associates with protein phosphatases 2A, 4, and 6
12. RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex
13. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
14. Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases
15. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
16. Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicellular clusters
17. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
18. Regulation of 4E-BP1 phosphorylation: A novel two-step mechanism
19. Hierarchical phosphorylation of the translational initiator 4E-BP1
20. Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region
21. Regulation of eIF-4E BP1 phosphorylation by mTOR
22. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
23. Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
24. Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k
25. PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints
26. Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); A novel nuclear target of Akt
27. Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
28. PHAS/4E-BP1s as regulators of mRNA translation and cell proliferation
29. Characterization of S6K2, a novel kinase homologous to S6K1
30. TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation
31. Distinct regulatory mechanism for p70 S6 kinase β from that for p70 S6 kinase α
32. Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies
33. B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A
34. Alpha4 protein as a common regulator of type 2A-related serine/threonine protein phosphatases
35. Characterization of the phosphoproteins and protein kinase activity in mTOR immunoprecipitates
36. Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
37. Bidirectional modulation of insulin action by amino acids
38. Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycin associated protein
39. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase
40. RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast tors
41. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
42. Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases
43. TOR, a central controller of cell growth
44. The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease
45. Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells
46. Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase
47. Novel WD-repeat protein Mip1p facilitates function of the meiotic regulator Mei2p in fission yeast
48. The WD repeat: A common architecture for diverse functions
49. MRNA 5′ cap-binding protein eIF4E and control of cell growth
50. Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro
51. Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidyl inositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation
52. Specific interference by ingested dsRNA
53. Amino acid availability regulates p70 S6 kinase and multiple translation factors
54. The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine
55. Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling
56. ATM-related genes: What do they tell us about functions of the human gene?
57. Regulation of cellular growth by the Drosophila target of rapamycin dTOR