FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions

Journal of Biological Chemistry

Volumn 275, Issue 10, 2000, Pages 7416-7423

  Peterson, Randall T ^a,b   Beal, Peter A ^b,d   Comb, Michael J ^c   Schreiber, Stuart L ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b HARVARD UNIVERSITY   (United States)

^c NEW ENGLAND BIOLABS   (United States)

^d UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SERINE;

ARTICLE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CONTROLLED STUDY; DEPHOSPHORYLATION; DNA DAMAGE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FAMILY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANDROSTADIENES; ANIMALS; HUMANS; IMMUNIZATION; JURKAT CELLS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BIOSYNTHESIS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RABBITS; SERINE; SIROLIMUS;

EUKARYOTA;

EID: 0034629365     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.10.7416     Document Type: Article

References (41)

1. Dennis, P. B., Fumagalli, S., and Thomas, G. (1999) Curr. Opin. Genet. Dev. 9, 49-54
2. Brown, E. J., Beal, P. A., Keith, C. T., Chen, J., Shin, T. B., and Schreiber, S. L. (1995) Nature 377, 441-446
3. Beretta, L., Gingras, A. C., Svitkin, Y. V., Hall, M. N., and Sonenberg, N. (1996) EMBO J. 15, 658-664
4. Brown, E. J., and Schreiber, S. L. (1996) Cell 86, 517-520
5. Barbet, N. C., Schneider, U., Helliwell, S. B., Stansfield, I., Tuite, M. F., and Hall, M. N. (1996) Mol. Biol. Cell 7, 25-42
6. Brunn, G. J., Hudson, C. C., Sekulic, A., Williams, J. M., Hosoi, H., Houghton, P. J., Lawrence, J. C., Jr., and Abraham, R. T. (1997) Science 277, 99-101
7. Zheng, X. F., Florentino, D., Chen, J., Crabtree, G. R., and Schreiber, S. L. (1995) Cell 82, 121-130
8. Burnett, P. E., Barrow, R. K., Cohen, N. A., Snyder, S. H., and Sabatini, D. M. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 1432-1437
9. Gingras, A. C., Gygi, S. P., Raught, B., Polakiewicz, R. D., Abraham, R. T., Hoekstra, M. F., Aebersold, R., and Sonenberg, N. (1999) Genes Dev. 13, 1422-1437
10. Scott, P. H., Brunn, G. J., Kohn, A. D., Roth, R. A., and Lawrence, J. C., Jr. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 7772-7777
11. Dennis, P. B., Pullen, N., Kozma, S. C., and Thomas, G. (1996) Mol. Cell. Biol. 16, 6242-6251
12. Cheatham, L., Monfar, M., Chou, M. M., and Blenis, J. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 11696-11700
13. Weng, Q. P., Andrabi, K., Kozlowski, M. T., Grove, J. R., and Avruch, J. (1995) Mol. Cell. Biol. 15, 2333-2340
14. Peterson, R. T., Desai, B. N., Hardwick, J. S., and Schreiber, S. L. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 4438-4442
15. Westphal, R. S., Coffee, R. L., Jr., Marotta, A., Pelech, S. L., and Wadzinski, B. E. (1999) J. Biol. Chem. 274, 687-692
16. Jiang, Y., and Broach, J. R. (1999) EMBO J. 18, 2782-2792
17. Hara, K., Yonezawa, K., Weng, Q.-P., Kozlowski, M. T., Belham, C., and Avruch, J. (1998) J. Biol. Chem. 273, 14484-14494
18. Kuruvilla, F. G., and Schreiber, S. L. (1999) Chem. Biol. 6, R129-R136
19. Smith, J. A., Francis, S. H., and Corbin, J. D. (1993) Mol. Cell. Biochem. 127-128, 51-70
20. Kamps, M. P., and Sefton, B. M. (1989) Anal. Biochem. 176, 22-27
21. Songyang, Z., Blechner, S., Hoagland, N., Hoekstra, M. F., Piwnica-Worms, H., and Cantley, L. C. (1994) Curr. Biol. 4, 973-982
22. Keith, C. T., and Schreiber, S. L. (1995) Science 270, 50-51
23. Vanhaesebroeck, B., Higashi, K., Raven, C., Welham, M., Anderson, S., Brennan, P., Ward, S. G., and Waterfield, M. D. (1999) EMBO J. 18, 1292-1302
24. Brunn, G. J., Williams, J., Sabers, C., Wiederrecht, G., Lawrence, J. C., Jr., and Abraham, R. T. (1996) EMBO J. 15, 5256-5267
25. Iiboshi, Y., Papst, P. J., Kawasome, H., Hosoi, H., Abraham, R. T., Houghton, P. J., and Terada, N. (1999) J. Biol. Chem. 274, 1092-1099
26. Hansen, B. S., Vaughan, M. H., and Wang, L. (1972) J. Biol. Chem. 247, 3854-3857
27. Thomas, G., and Hall, M. N. (1997) Curr. Opin. Cell Biol. 9, 782-787
28. Gingras, A. C., Kennedy, S. G., O'Leary, M. A., Sonenberg, N., and Hay, N. (1998) Genes Dev. 12, 502-513
29. Burgering, B. M., and Coffer, P. J. (1995) Nature 376, 599-602
30. Chan, D. W., and Lees-Miller, S. P. (1996) J. Biol. Chem. 271, 8936-8941
31. Brunn, G. J., Fadden, P., Haystead, T. A. J., and Lawrence, J. C., Jr. (1997) J. Biol. Chem. 272, 32547-32550
32. Peterson, R. T., and Schreiber, S. L. (1998) Curr. Biol. 8, R248-R250
33. Belham, C., Wu, S., and Avruch, J. (1999) Curr. Biol. 9, R93-R96
34. Blunt, T., Gell, D., Fox, M., Taccioli, G. E., Lehmann, A. R., Jackson, S. P., and Jeggo, P. A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 10285-10290
35. Concannon, P., and Gatti, R. A. (1997) Hum. Mutat. 10, 100-107
36. Alessi, D. R., Kozlowski, M. T., Weng, Q. P., Morrice, N., and Avruch, J. (1998) Curr. Biol. 8, 69-81
37. Pullen, N., Dennis, P. B., Andjelkovic, M., Dufner, A., Kozma, S. C., Hemmings, B. A., and Thomas, G. (1998) Science 279, 707-710
38. Peterson, R. T., and Schreiber, S. L. (1999) Curr. Biol. 9, R521-R524
39. DiComo, C. J., and Arndt, K. T. (1996) Genes Dev. 10, 1904-1916
40. Chen, J., Peterson, R. T., and Schreiber, S. L. (1998) Biochem. Biophys. Res. Commun. 247, 827-832
41. Murata, K., Wu, J., and Brautigan, D. L. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 10624-10629