-
1
-
-
21244458013
-
Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site
-
Ali, S. M., and D. M. Sabatini. 2005. Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site. J. Biol. Chem. 280:19445-19448.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 19445-19448
-
-
Ali, S.M.1
Sabatini, D.M.2
-
2
-
-
0038321436
-
Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes
-
Bouzakri, K., M. Roques, P. Gual, S. Espinosa, F. Guebre-Egziabher, J. P. Riou, M. Laville, Y. Le Marchand-Brustel, J. F. Tanti, and H. Vidal. 2003. Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes. Diabetes 52:1319-1325.
-
(2003)
Diabetes
, vol.52
, pp. 1319-1325
-
-
Bouzakri, K.1
Roques, M.2
Gual, P.3
Espinosa, S.4
Guebre-Egziabher, F.5
Riou, J.P.6
Laville, M.7
Le Marchand-Brustel, Y.8
Tanti, J.F.9
Vidal, H.10
-
3
-
-
0031453135
-
The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus
-
Brunn, G. J., P. Fadden, T. A. Haystead, and J. C. Lawrence, Jr. 1997. The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus. J. Biol. Chem. 272:32547-32550.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 32547-32550
-
-
Brunn, G.J.1
Fadden, P.2
Haystead, T.A.3
Lawrence Jr., J.C.4
-
4
-
-
0030881836
-
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
-
Brunn, G. J., C. C. Hudson, A. Sekulic, J. M. Williams, H. Hosoi, P. J. Houghton, J. C. Lawrence, Jr., and R. T. Abraham. 1997. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science 277:99-101.
-
(1997)
Science
, vol.277
, pp. 99-101
-
-
Brunn, G.J.1
Hudson, C.C.2
Sekulic, A.3
Williams, J.M.4
Hosoi, H.5
Houghton, P.J.6
Lawrence Jr., J.C.7
Abraham, R.T.8
-
5
-
-
0032539664
-
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
-
Burnett, P. E., R. K. Barrow, N. A. Cohen, S. H. Snyder, and D. M. Sabatini. 1998. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc. Natl. Acad. Sci. USA 95:1432-1437.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 1432-1437
-
-
Burnett, P.E.1
Barrow, R.K.2
Cohen, N.A.3
Snyder, S.H.4
Sabatini, D.M.5
-
6
-
-
0347318052
-
The AMP-activated protein kinase cascade-a unifying system for energy control
-
Carling, D. 2004. The AMP-activated protein kinase cascade-a unifying system for energy control. Trends Biochem. Sci. 29:18-24.
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 18-24
-
-
Carling, D.1
-
7
-
-
0032779156
-
Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM
-
Carvalho, E., P. A. Jansson, M. Axelsen, J. W. Eriksson, X. Huang, L. Groop, C. Rondinone, L. Sjostrom, and U. Smith. 1999. Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM. FASEB J. 13:2173-2178.
-
(1999)
FASEB J.
, vol.13
, pp. 2173-2178
-
-
Carvalho, E.1
Jansson, P.A.2
Axelsen, M.3
Eriksson, J.W.4
Huang, X.5
Groop, L.6
Rondinone, C.7
Sjostrom, L.8
Smith, U.9
-
8
-
-
0029608743
-
Structural and functional analysis of pp70S6k
-
Cheatham, L., M. Monfar, M. M. Chou, and J. Blenis. 1995. Structural and functional analysis of pp70S6k. Proc. Natl. Acad. Sci. USA 92:11696-11700.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 11696-11700
-
-
Cheatham, L.1
Monfar, M.2
Chou, M.M.3
Blenis, J.4
-
9
-
-
0034635408
-
Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance
-
Clark, S. F., J. C. Molero, and D. E. James. 2000. Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance. J. Biol. Chem. 275:3819-3826.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 3819-3826
-
-
Clark, S.F.1
Molero, J.C.2
James, D.E.3
-
10
-
-
0033595120
-
Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes
-
Cline, G. W., K. F. Petersen, M. Krssak, J. Shen, R. S. Hundal, Z. Trajanoski, S. Inzucchi, A. Dresner, D. L. Rothman, and G. I. Shulman. 1999. Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. N. Engl. J. Med. 341:240-246.
-
(1999)
N. Engl. J. Med.
, vol.341
, pp. 240-246
-
-
Cline, G.W.1
Petersen, K.F.2
Krssak, M.3
Shen, J.4
Hundal, R.S.5
Trajanoski, Z.6
Inzucchi, S.7
Dresner, A.8
Rothman, D.L.9
Shulman, G.I.10
-
11
-
-
3042818799
-
Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
-
Corradetti, M. N., K. Inoki, N. Bardeesy, R. A. DePinho, and K. L. Guan. 2004. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 18:1533-1538.
-
(2004)
Genes Dev.
, vol.18
, pp. 1533-1538
-
-
Corradetti, M.N.1
Inoki, K.2
Bardeesy, N.3
Depinho, R.A.4
Guan, K.L.5
-
12
-
-
0029828590
-
The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases
-
Dennis, P. B., N. Pullen, S. C. Kozma, and G. Thomas. 1996. The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases. Mol. Cell. Biol. 16:6242-6251.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 6242-6251
-
-
Dennis, P.B.1
Pullen, N.2
Kozma, S.C.3
Thomas, G.4
-
13
-
-
0034988819
-
Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells
-
Esposito, D. L., Y. Li, A. Cama, and M. J. Quon. 2001. Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells. Endocrinology 142:2833-2840.
-
(2001)
Endocrinology
, vol.142
, pp. 2833-2840
-
-
Esposito, D.L.1
Li, Y.2
Cama, A.3
Quon, M.J.4
-
14
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Kara, K., Y. Maruki, X. Long, K. Yoshino, N. Oshiro, S. Hidayat, C. Tokunaga, J. Avruch, and K. Yonezawa. 2002. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110:177-189.
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Kara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
Tokunaga, C.7
Avruch, J.8
Yonezawa, K.9
-
15
-
-
3342958797
-
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
-
Harrington, L. S., G. M. Findlay, A. Gray, T. Tolkacheva, S. Wigfield, H. Rebholz, J. Barnett, N. R. Leslie, S. Cheng, P. R. Shepherd, I. Gout, C. P. Downes, and R. F. Lamb. 2004. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J. Cell Biol. 166:213-223.
-
(2004)
J. Cell Biol.
, vol.166
, pp. 213-223
-
-
Harrington, L.S.1
Findlay, G.M.2
Gray, A.3
Tolkacheva, T.4
Wigfield, S.5
Rebholz, H.6
Barnett, J.7
Leslie, N.R.8
Cheng, S.9
Shepherd, P.R.10
Gout, I.11
Downes, C.P.12
Lamb, R.F.13
-
16
-
-
0034816272
-
Frap-dependent serine phosphorylation of IRS-1 inhibits IRS-1 tyrosine phosphorylation
-
Hartman, M. E., M. Villela-Bach, J. Chen, and G. G. Freund. 2001. Frap-dependent serine phosphorylation of IRS-1 inhibits IRS-1 tyrosine phosphorylation. Biochem. Biophys. Res. Commun. 280:776-781.
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.280
, pp. 776-781
-
-
Hartman, M.E.1
Villela-Bach, M.2
Chen, J.3
Freund, G.G.4
-
17
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay, N., and N. Sonenberg. 2004. Upstream and downstream of mTOR. Genes Dev. 18:1926-1945.
-
(2004)
Genes Dev.
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
18
-
-
0036300508
-
Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity
-
Huang, C., R. Somwar, N. Patel, W. Niu, D. Torok, and A, Klip. 2002. Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity. Diabetes 51:2090-2098.
-
(2002)
Diabetes
, vol.51
, pp. 2090-2098
-
-
Huang, C.1
Somwar, R.2
Patel, N.3
Niu, W.4
Torok, D.5
Klip, A.6
-
19
-
-
0036095269
-
Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: Inhibition by the AMP-activated protein kinase activation
-
Ido, Y., D. Carling, and N. Ruderman. 2002. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes 51:159-167.
-
(2002)
Diabetes
, vol.51
, pp. 159-167
-
-
Ido, Y.1
Carling, D.2
Ruderman, N.3
-
20
-
-
0043127125
-
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
Inoki, K., Y. Li, T. Xu, and K. L. Guan. 2003. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17:1829-1834.
-
(2003)
Genes Dev.
, vol.17
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.L.4
-
21
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki, K., Y. Li, T. Zhu, J. Wu, and K. L. Guan. 2002. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4:648-657.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
22
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki, K., T. Zhu, and K. L. Guan. 2003. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115:577-590.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
23
-
-
0032496150
-
Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2
-
Inoue, G., B. Cheatham, R. Emkey, and C. R. Kahn. 1998. Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2. J. Biol. Chem. 273:11548-11555.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 11548-11555
-
-
Inoue, G.1
Cheatham, B.2
Emkey, R.3
Kahn, C.R.4
-
24
-
-
0033607531
-
Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
-
Isotani, S., K. Hara, C. Tokunaga, H. Inoue, J. Avruch, and K. Yonezawa. 1999. Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro. J. Biol. Chem. 274:34493-34498.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 34493-34498
-
-
Isotani, S.1
Hara, K.2
Tokunaga, C.3
Inoue, H.4
Avruch, J.5
Yonezawa, K.6
-
25
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
Jacinto, E., R. Loewith, A. Schmidt, S. Lin, M. A. Ruegg, A. Hall, and M. N. Hall. 2004. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6:1122-1128.
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Ruegg, M.A.5
Hall, A.6
Hall, M.N.7
-
26
-
-
0942268725
-
Rosiglitazone, an agonist of peroxisome-proliferator-activated receptor gamma (PPARgamma), decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo
-
Jiang, G., Q. Dallas-Yang, S. Biswas, Z. Li, and B. B. Zhang. 2004. Rosiglitazone, an agonist of peroxisome-proliferator-activated receptor gamma (PPARgamma), decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo. Biochem. J. 377:339-346.
-
(2004)
Biochem. J.
, vol.377
, pp. 339-346
-
-
Jiang, G.1
Dallas-Yang, Q.2
Biswas, S.3
Li, Z.4
Zhang, B.B.5
-
27
-
-
0037178786
-
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim, D. H., D. D. Sarbassov, S. M. Ali, J. E. King, R. R. Latek, H. Erdjument-Bromage, P. Tempst, and D. M. Sabatini. 2002. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110:163-175.
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
28
-
-
0034946949
-
Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4
-
Kim, J. K., A. Zisman, J. J. Fillmore, O. D. Peroni, K. Kotani, P. Perret, H. Zong, J. Dong, C. R. Kahn, B. B. Kahn, and G. I. Shulman. 2001. Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4. J. Clin. Investig. 108:153-160.
-
(2001)
J. Clin. Investig.
, vol.108
, pp. 153-160
-
-
Kim, J.K.1
Zisman, A.2
Fillmore, J.J.3
Peroni, O.D.4
Kotani, K.5
Perret, P.6
Zong, H.7
Dong, J.8
Kahn, C.R.9
Kahn, B.B.10
Shulman, G.I.11
-
29
-
-
0033515459
-
Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway
-
Li, J., K. DeFea, and R. A. Roth. 1999. Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway. J. Biol. Chem. 274:9351-9356.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 9351-9356
-
-
Li, J.1
DeFea, K.2
Roth, R.A.3
-
30
-
-
4444276510
-
Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity
-
Li, Y., K. Inoki, and K. L. Guan. 2004. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. Mol. Cell. Biol. 24:7965-7975.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 7965-7975
-
-
Li, Y.1
Inoki, K.2
Guan, K.L.3
-
31
-
-
0023924773
-
Impaired glucose tolerance as a disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians
-
Lillioja, S., D. M. Mott, B. V. Howard, P. H. Bennett, H. Yki-Jarvinen, D. Freymond, B. L. Nyomba, F. Zurlo, B. Swinburn, and C. Bogardus. 1988. Impaired glucose tolerance as a disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians. N. Engl. J. Med. 318:1217-1225.
-
(1988)
N. Engl. J. Med.
, vol.318
, pp. 1217-1225
-
-
Lillioja, S.1
Mott, D.M.2
Howard, B.V.3
Bennett, P.H.4
Yki-Jarvinen, H.5
Freymond, D.6
Nyomba, B.L.7
Zurlo, F.8
Swinburn, B.9
Bogardus, C.10
-
32
-
-
12144287284
-
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
-
Lizcano, J. M., O. Goransson, R. Toth, M. Deak, N. A. Morrice, J. Boudeau, S. A. Hawley, L. Udd, T. P. Makela, D. G. Hardie, and D. R. Alessi. 2004. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J. 23:833-843.
-
(2004)
EMBO J.
, vol.23
, pp. 833-843
-
-
Lizcano, J.M.1
Goransson, O.2
Toth, R.3
Deak, M.4
Morrice, N.A.5
Boudeau, J.6
Hawley, S.A.7
Udd, L.8
Makela, T.P.9
Hardie, D.G.10
Alessi, D.R.11
-
33
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewith, R., E. Jacinto, S. Wullschleger, A. Lorberg, J. L. Crespo, D. Bonenfant, W. Oppliger, P. Jenoe, and M. N. Hall. 2002. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 10:457-468.
-
(2002)
Mol. Cell
, vol.10
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
34
-
-
18044381192
-
Rheb binds and regulates the mTOR kinase
-
Long, X., Y. Lin, S. Ortiz-Vega, K. Yonezawa, and J. Avruch. 2005. Rheb binds and regulates the mTOR kinase. Curr. Biol. 15:702-713.
-
(2005)
Curr. Biol.
, vol.15
, pp. 702-713
-
-
Long, X.1
Lin, Y.2
Ortiz-Vega, S.3
Yonezawa, K.4
Avruch, J.5
-
35
-
-
21244456553
-
Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency
-
Long, X., S. Ortiz-Vega, Y. Lin, and J. Avruch. 2005. Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J. Biol. Chem. 280:23433-23436.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 23433-23436
-
-
Long, X.1
Ortiz-Vega, S.2
Lin, Y.3
Avruch, J.4
-
36
-
-
0030848939
-
Dual requirement for a newly identified phosphorylation site in p70s6k
-
Moser, B. A., P. B. Dennis, N. Pullen, R. B. Pearson, N. A. Williamson, R. E. Wettenhall, S. C. Kozma, and G. Thomas. 1997. Dual requirement for a newly identified phosphorylation site in p70s6k. Mol. Cell. Biol. 17:5648-5655.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 5648-5655
-
-
Moser, B.A.1
Dennis, P.B.2
Pullen, N.3
Pearson, R.B.4
Williamson, N.A.5
Wettenhall, R.E.6
Kozma, S.C.7
Thomas, G.8
-
37
-
-
0036299982
-
Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes
-
Musi, N., M. F. Hirshman, J. Nygren, M. Svanfeldt, P. Bavenholm, O. Rooyackers, G. Zhou, J. M. Williamson, O. Ljunqvist, S. Efendic, D. E. Moller, A. Thorell, and L. J. Goodyear. 2002. Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. Diabetes 51:2074-2081.
-
(2002)
Diabetes
, vol.51
, pp. 2074-2081
-
-
Musi, N.1
Hirshman, M.F.2
Nygren, J.3
Svanfeldt, M.4
Bavenholm, P.5
Rooyackers, O.6
Zhou, G.7
Williamson, J.M.8
Ljunqvist, O.9
Efendic, S.10
Moller, D.E.11
Thorell, A.12
Goodyear, L.J.13
-
38
-
-
8944240840
-
YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites
-
Myers, M. G., Jr., Y. Zhang, G. A. Aldaz, T. Grammer, E. M. Glasheen, L. Yenush, L. M. Wang, X. J. Sun, J. Blenis, J. H. Pierce, and M. F. White. 1996. YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites. Mol. Cell. Biol. 16:4147-4155.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 4147-4155
-
-
Myers Jr., M.G.1
Zhang, Y.2
Aldaz, G.A.3
Grammer, T.4
Glasheen, E.M.5
Yenush, L.6
Wang, L.M.7
Sun, X.J.8
Blenis, J.9
Pierce, J.H.10
White, M.F.11
-
39
-
-
0032544917
-
Characterization of the phosphoproteins and protein kinase activity in mTOR immunoprecipitates
-
Nishiuma, T., K. Hara, Y. Tsujishita, K. Kaneko, K. Shii, and K. Yonezawa. 1998. Characterization of the phosphoproteins and protein kinase activity in mTOR immunoprecipitates. Biochem. Biophys. Res. Commun. 252:440-444.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.252
, pp. 440-444
-
-
Nishiuma, T.1
Hara, K.2
Tsujishita, Y.3
Kaneko, K.4
Shii, K.5
Yonezawa, K.6
-
40
-
-
0037507252
-
The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
-
Nojima, H., C. Tokunaga, S. Eguchi, N. Oshiro, S. Hidayat, K. Yoshino, K. Hara, N. Tanaka, J. Avruch, and K. Yonezawa. 2003. The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J. Biol. Chem. 278:15461-15464.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 15461-15464
-
-
Nojima, H.1
Tokunaga, C.2
Eguchi, S.3
Oshiro, N.4
Hidayat, S.5
Yoshino, K.6
Hara, K.7
Tanaka, N.8
Avruch, J.9
Yonezawa, K.10
-
41
-
-
1942487890
-
Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function
-
Oshiro, N., K. Yoshino, S. Hidayat, C. Tokunaga, K. Hara, S. Eguchi, J. Avruch, and K. Yonezawa. 2004. Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. Genes Cells 9:359-366.
-
(2004)
Genes Cells
, vol.9
, pp. 359-366
-
-
Oshiro, N.1
Yoshino, K.2
Hidayat, S.3
Tokunaga, C.4
Hara, K.5
Eguchi, S.6
Avruch, J.7
Yonezawa, K.8
-
42
-
-
0035836770
-
A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
-
Ozes, O. N., H. Akca, L. D. Mayo, J. A. Gustin, T. Maehama, J. E. Dixon, and D. B. Donner. 2001. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc. Natl. Acad. Sci. USA 98:4640-4645.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 4640-4645
-
-
Ozes, O.N.1
Akca, H.2
Mayo, L.D.3
Gustin, J.A.4
Maehama, T.5
Dixon, J.E.6
Donner, D.B.7
-
43
-
-
0001437616
-
Bidirectional modulation of insulin action by amino acids
-
Patti, M. E., E. Brambilla, L. Luzi, E. J. Landaker, and C. R. Kahn. 1998. Bidirectional modulation of insulin action by amino acids. J. Clin. Investig. 101:1519-1529.
-
(1998)
J. Clin. Investig.
, vol.101
, pp. 1519-1529
-
-
Patti, M.E.1
Brambilla, E.2
Luzi, L.3
Landaker, E.J.4
Kahn, C.R.5
-
44
-
-
0038521284
-
Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells
-
Pirola, L., S. Bonnafous, A. M. Johnston, C. Chaussade, F. Portis, and E. Van Obberghen. 2003. Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells. J. Biol. Chem. 278:15641-15651.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 15641-15651
-
-
Pirola, L.1
Bonnafous, S.2
Johnston, A.M.3
Chaussade, C.4
Portis, F.5
Van Obberghen, E.6
-
45
-
-
0003146514
-
Diabetes mellitus
-
E. Braunwald, S. A. Fauci, L. D. Karsper, L. S. Hauser, L. D. Longo, and J. L. Jameson (ed.). McGraw-Hill Book Co., New York, N.Y.
-
Powers, A. C. 2001. Diabetes mellitus, p. 2109-2137. In E. Braunwald, S. A. Fauci, L. D. Karsper, L. S. Hauser, L. D. Longo, and J. L. Jameson (ed.), Harrison's principles of internal medicine, 15th ed. McGraw-Hill Book Co., New York, N.Y.
-
(2001)
Harrison's Principles of Internal Medicine, 15th Ed.
, pp. 2109-2137
-
-
Powers, A.C.1
-
46
-
-
0032578998
-
Phosphorylation and activation of p70s6k by PDK1
-
Pullen, N., P. B. Dennis, M. Andjelkovic, A. Dufner, S. C. Kozma, B. A. Hemmings, and G. Thomas. 1998. Phosphorylation and activation of p70s6k by PDK1. Science 279:707-710.
-
(1998)
Science
, vol.279
, pp. 707-710
-
-
Pullen, N.1
Dennis, P.B.2
Andjelkovic, M.3
Dufner, A.4
Kozma, S.C.5
Hemmings, B.A.6
Thomas, G.7
-
47
-
-
4644303065
-
SKAR is a specific target of S6 kinase 1 in cell growth control
-
Richardson, C. J., M. Broenstrup, D. C. Fingar, K. Julich, B. A. Ballif, S. Gygi, and J. Blenis. 2004. SKAR is a specific target of S6 kinase 1 in cell growth control. Curr. Biol. 14:1540-1549.
-
(2004)
Curr. Biol.
, vol.14
, pp. 1540-1549
-
-
Richardson, C.J.1
Broenstrup, M.2
Fingar, D.C.3
Julich, K.4
Ballif, B.A.5
Gygi, S.6
Blenis, J.7
-
48
-
-
0030890580
-
Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus
-
Rondinone, C. M., L. M. Wang, P. Lonnroth, C. Wesslau, J. H. Pierce, and U. Smith. 1997. Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Proc. Natl. Acad. Sci. USA 94:4171-4175.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 4171-4175
-
-
Rondinone, C.M.1
Wang, L.M.2
Lonnroth, P.3
Wesslau, C.4
Pierce, J.H.5
Smith, U.6
-
49
-
-
0037205409
-
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site
-
Saitoh, M., N. Pullen, P. Brennan, D. Cantrell, P. B. Dennis, and G. Thomas. 2002. Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site. J. Biol. Chem. 277:20104-20112.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 20104-20112
-
-
Saitoh, M.1
Pullen, N.2
Brennan, P.3
Cantrell, D.4
Dennis, P.B.5
Thomas, G.6
-
50
-
-
20044370885
-
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
-
Sakamoto, K., A. McCarthy, D. Smith, K. A. Green, D. Grahame Hardie, A. Ashworth, and D. R. Alessi. 2005. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J. 24:1810-1820.
-
(2005)
EMBO J.
, vol.24
, pp. 1810-1820
-
-
Sakamoto, K.1
McCarthy, A.2
Smith, D.3
Green, K.A.4
Grahame Hardie, D.5
Ashworth, A.6
Alessi, D.R.7
-
51
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov, D. D., D. A. Guertin, S. M. Ali, and D. M. Sabatini. 2005. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307:1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
52
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov, D. D., S. M. Ali, D. H. Kim, D. A. Guertin, R. R. Latek, H. Erdjument-Bromage, P. Tempst, and D. M. Sabatini. 2004. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14:1296-1302.
-
(2004)
Curr. Biol.
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
53
-
-
0038643484
-
Rheb promotes cell growth as a component of the insulin/TOR signalling network
-
Saucedo, L. J., X. Gao, D. A. Chiarelli, L. Li, D. Pan, and B. A. Edgar. 2003. Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat. Cell Biol. 5:566-571.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 566-571
-
-
Saucedo, L.J.1
Gao, X.2
Chiarelli, D.A.3
Li, L.4
Pan, D.5
Edgar, B.A.6
-
54
-
-
0037117409
-
Identification of a conserved motif required for mTOR signaling
-
Schalm, S. S., and J. Blenis. 2002. Identification of a conserved motif required for mTOR signaling. Curr. Biol. 12:632-639.
-
(2002)
Curr. Biol.
, vol.12
, pp. 632-639
-
-
Schalm, S.S.1
Blenis, J.2
-
55
-
-
0037718389
-
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
-
Schalm, S. S., D. C. Fingar, D. M. Sabatini, and J. Blenis. 2003. TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Curr. Biol. 13:797-806.
-
(2003)
Curr. Biol.
, vol.13
, pp. 797-806
-
-
Schalm, S.S.1
Fingar, D.C.2
Sabatini, D.M.3
Blenis, J.4
-
56
-
-
0028872684
-
Determination of absolute amounts of GDP and GTP bound to Ras in mammalian cells: Comparison of parental and Ras-overproducing NIH 3T3 fibroblasts
-
Scheele, J. S., J. M. Rhee, and G. R. Boss. 1995. Determination of absolute amounts of GDP and GTP bound to Ras in mammalian cells: comparison of parental and Ras-overproducing NIH 3T3 fibroblasts. Proc. Natl. Acad. Sci. USA 92:1097-1100.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 1097-1100
-
-
Scheele, J.S.1
Rhee, J.M.2
Boss, G.R.3
-
57
-
-
4544343980
-
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS 1/2 depletion, insulin resistance, and cell survival deficiencies
-
Shah, O. J., Z. Wang, and T. Hunter. 2004. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS 1/2 depletion, insulin resistance, and cell survival deficiencies. Curr. Biol. 14:1650-1656.
-
(2004)
Curr. Biol.
, vol.14
, pp. 1650-1656
-
-
Shah, O.J.1
Wang, Z.2
Hunter, T.3
-
58
-
-
3142594193
-
The LKB1 tumor suppressor negatively regulates mTOR signaling
-
Shaw, R. J., N. Bardeesy, B. D. Manning, L. Lopez, M. Kosmatka, R. A. DePinho, and L. C. Cantley. 2004. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 6:91-99.
-
(2004)
Cancer Cell
, vol.6
, pp. 91-99
-
-
Shaw, R.J.1
Bardeesy, N.2
Manning, B.D.3
Lopez, L.4
Kosmatka, M.5
Depinho, R.A.6
Cantley, L.C.7
-
59
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
Shaw, R. J., M. Kosmatka, N. Bardeesy, R. L. Hurley, L. A. Witters, R. A. DePinho, and L. C. Cantley. 2004. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl. Acad. Sci. USA 101:3329-3335.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
DePinho, R.A.6
Cantley, L.C.7
-
60
-
-
0033927667
-
Cellular mechanisms of insulin resistance
-
Shulman, G. I. 2000. Cellular mechanisms of insulin resistance. J. Clin. Investig. 106:171-176.
-
(2000)
J. Clin. Investig.
, vol.106
, pp. 171-176
-
-
Shulman, G.I.1
-
61
-
-
0025098765
-
Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy
-
Shulman, G. I., D. L. Rothman, T. Jue, P. Stein, R. A. DeFronzo, and R. G. Shulman. 1990. Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N. Engl. J. Med. 322:223-228.
-
(1990)
N. Engl. J. Med.
, vol.322
, pp. 223-228
-
-
Shulman, G.I.1
Rothman, D.L.2
Jue, T.3
Stein, P.4
DeFronzo, R.A.5
Shulman, R.G.6
-
62
-
-
2442544855
-
In vitro phosphorylation of insulin receptor substrate 1 by protein kinase C-zeta: Functional analysis and identification of novel phosphorylation sites
-
Sommerfeld, M. R., S. Metzger, M. Stosik, N. Tennagels, and J. Eckel. 2004. In vitro phosphorylation of insulin receptor substrate 1 by protein kinase C-zeta: functional analysis and identification of novel phosphorylation sites. Biochemistry 43:5888-5901.
-
(2004)
Biochemistry
, vol.43
, pp. 5888-5901
-
-
Sommerfeld, M.R.1
Metzger, S.2
Stosik, M.3
Tennagels, N.4
Eckel, J.5
-
63
-
-
0029133235
-
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus
-
Stumvoll, M., N. Nurjhan, G. Perriello, G. Dailey, and J. E. Gerich. 1995. Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N. Engl. J. Med. 333:550-554.
-
(1995)
N. Engl. J. Med.
, vol.333
, pp. 550-554
-
-
Stumvoll, M.1
Nurjhan, N.2
Perriello, G.3
Dailey, G.4
Gerich, J.E.5
-
64
-
-
0034751858
-
Serine phosphorylation of insulin receptor substrate-1: A novel target for the reversal of insulin resistance
-
Sykiotis, G. P., and A. G. Papavassiliou. 2001. Serine phosphorylation of insulin receptor substrate-1: a novel target for the reversal of insulin resistance. Mol. Endocrinol. 15:1864-1869.
-
(2001)
Mol. Endocrinol.
, vol.15
, pp. 1864-1869
-
-
Sykiotis, G.P.1
Papavassiliou, A.G.2
-
65
-
-
14244252683
-
Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes
-
Tremblay, F., A. Gagnon, A. Veilleux, A. Sorisky, and A. Marette. 2005. Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes. Endocrinology 146:1328-1337.
-
(2005)
Endocrinology
, vol.146
, pp. 1328-1337
-
-
Tremblay, F.1
Gagnon, A.2
Veilleux, A.3
Sorisky, A.4
Marette, A.5
-
66
-
-
0035851205
-
Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
-
Tremblay, F., and A. Marette. 2001. Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J. Biol. Chem. 276:38052-38060.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38052-38060
-
-
Tremblay, F.1
Marette, A.2
-
67
-
-
4544220704
-
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
-
Um, S. H., F. Frigerio, M. Watanabe, F. Picard, M. Joaquin, M. Sticker, S. Fumagalli, P. R. Allegrini, S. C. Kozma, J. Auwerx, and G. Thomas. 2004. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431:200-205.
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.H.1
Frigerio, F.2
Watanabe, M.3
Picard, F.4
Joaquin, M.5
Sticker, M.6
Fumagalli, S.7
Allegrini, P.R.8
Kozma, S.C.9
Auwerx, J.10
Thomas, G.11
-
68
-
-
0037251455
-
The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity
-
Viollet, B., F. Andreelli, S. B. Jorgensen, C. Perrin, A. Geloen, D. Flamez, J. Mu, C. Lenzner, O. Baud, M. Bennoun, E. Gomas, G. Nicolas, J. F. Wojtaszewski, A. Kahn, D. Carting, F. C. Schuit, M. J. Birnbaum, E. A. Richter, R. Burcelin, and S. Vaulont. 2003. The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. J. Clin. Investig. 111:91-98.
-
(2003)
J. Clin. Investig.
, vol.111
, pp. 91-98
-
-
Viollet, B.1
Andreelli, F.2
Jorgensen, S.B.3
Perrin, C.4
Geloen, A.5
Flamez, D.6
Mu, J.7
Lenzner, C.8
Baud, O.9
Bennoun, M.10
Gomas, E.11
Nicolas, G.12
Wojtaszewski, J.F.13
Kahn, A.14
Carting, D.15
Schuit, F.C.16
Birnbaum, M.J.17
Richter, E.A.18
Burcelin, R.19
Vaulont, S.20
more..
-
69
-
-
0028999052
-
Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation
-
Weng, Q. P., K. Andrabi, A. Klippel, M. T. Kozlowski, L. T. Williams, and J. Avruch. 1995. Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation. Proc. Natl. Acad. Sci. USA 92:5744-5748.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 5744-5748
-
-
Weng, Q.P.1
Andrabi, K.2
Klippel, A.3
Kozlowski, M.T.4
Williams, L.T.5
Avruch, J.6
-
70
-
-
0028939115
-
Multiple independent inputs are required for activation of the p70 S6 kinase
-
Weng, Q. P., K. Andrabi, M. T. Kozlowski, J. R. Grove, and J. Avruch. 1995. Multiple independent inputs are required for activation of the p70 S6 kinase. Mol. Cell. Biol. 15:2333-2340.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 2333-2340
-
-
Weng, Q.P.1
Andrabi, K.2
Kozlowski, M.T.3
Grove, J.R.4
Avruch, J.5
-
71
-
-
0032568921
-
Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies
-
Weng, Q. P., M. Kozlowski, C. Belham, A. Zhang, M. J. Comb, and J. Avruch. 1998. Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies. J. Biol. Chem. 273:16621-16629.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 16621-16629
-
-
Weng, Q.P.1
Kozlowski, M.2
Belham, C.3
Zhang, A.4
Comb, M.J.5
Avruch, J.6
-
72
-
-
4143050204
-
Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302
-
Werner, E. D., J. Lee, L. Hansen, M. Yuan, and S. E. Shoelson. 2004. Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302. J. Biol. Chem. 279:35298-35305.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 35298-35305
-
-
Werner, E.D.1
Lee, J.2
Hansen, L.3
Yuan, M.4
Shoelson, S.E.5
-
73
-
-
0031470652
-
The structural basis for 14-3-3:phosphopeptide binding specificity
-
Yaffe, M. B., K. Rittinger, S. Volinia, P. R. Caron, A. Aitken, H. Leffers, S. J. Gamblin, S. J. Smerdon, and L. C. Cantley. 1997. The structural basis for 14-3-3:phosphopeptide binding specificity. Cell 91:961-971.
-
(1997)
Cell
, vol.91
, pp. 961-971
-
-
Yaffe, M.B.1
Rittinger, K.2
Volinia, S.3
Caron, P.R.4
Aitken, A.5
Leffers, H.6
Gamblin, S.J.7
Smerdon, S.J.8
Cantley, L.C.9
-
74
-
-
0036636173
-
LKB1-a master tumour suppressor of the small intestine and beyond
-
Yoo, L. I., D. C. Chung, and J. Yuan. 2002. LKB1-a master tumour suppressor of the small intestine and beyond. Nat. Rev. Cancer 2:529-535.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 529-535
-
-
Yoo, L.I.1
Chung, D.C.2
Yuan, J.3
-
75
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
Zhou, G., R. Myers, Y. Li, Y. Chen, X. Shen, J. Fenyk-Melody, M. Wu, J. Ventre, T. Doebber, N. Fujii, N. Musi, M. F. Hirshman, L. J. Goodyear, and D. E. Moller. 2001. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Investig. 108:1167-1174.
-
(2001)
J. Clin. Investig.
, vol.108
, pp. 1167-1174
-
-
Zhou, G.1
Myers, R.2
Li, Y.3
Chen, Y.4
Shen, X.5
Fenyk-Melody, J.6
Wu, M.7
Ventre, J.8
Doebber, T.9
Fujii, N.10
Musi, N.11
Hirshman, M.F.12
Goodyear, L.J.13
Moller, D.E.14
|