S6K1-/-/S6K2-/- Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

Molecular and Cellular Biology

Volumn 24, Issue 8, 2004, Pages 3112-3124

  Pende, Mario ^a,c   Um, Sung Hee ^a   Mieulet, Virginie ^c   Sticker, Melanie ^a   Goss, Valerie L ^d   Mestan, Jurgen ^b   Mueller, Matthias ^b   Fumagalli, Stefano ^a   Kozma, Sara C ^a   Thomas, George ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c INSERM   (France)

^d CELL SIGNALING TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; HORMONE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGENIC AGENT; RAPAMYCIN; S6 KINASE; SERINE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; CELL CYCLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; EMBRYO; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; GENOTYPE; MOUSE; NEWBORN; NONHUMAN; NUCLEOLUS; NUTRIENT; PRIORITY JOURNAL; RNA TRANSLATION; SIGNAL TRANSDUCTION; TERMINAL OLIGOPYRIMIDINE TRACT;

ANIMALS; ANIMALS, NEWBORN; CELL CYCLE; EMBRYO; ENZYME ACTIVATION; FEMALE; FETAL VIABILITY; GENOTYPE; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIUM; PHENOTYPE; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; RNA 5' TERMINAL OLIGOPYRIMIDINE SEQUENCE; SIROLIMUS;

ANIMALIA; BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 11144356304     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.8.3112-3124.2004     Document Type: Article

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