메뉴 건너뛰기




Volumn 21, Issue 5, 2010, Pages 811-818

mTOR complex-2 activates ENaC by phosphorylating SGK1

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ALDOSTERONE; AMILORIDE; EPITHELIAL SODIUM CHANNEL; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SHORT HAIRPIN RNA; SODIUM ION;

EID: 77952565472     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2009111168     Document Type: Article
Times cited : (96)

References (39)
  • 1
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN: TOR signaling in growth and metabolism. Cell 124: 471-484, 2006
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 2
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA, Sabatini DM: Defining the role of mTOR in cancer. Cancer Cell 12: 9-22, 2007
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 3
    • 59749091850 scopus 로고    scopus 로고
    • A complex interplay between Akt, TSC2 and the two mTOR complexes
    • Huang J, Manning BD: A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem Soc Trans 37: 217-222, 2009
    • (2009) Biochem Soc Trans , vol.37 , pp. 217-222
    • Huang, J.1    Manning, B.D.2
  • 7
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM: Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 14: 1296-1302, 2004
    • (2004) Curr Biol , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 8
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • Fingar DC, Blenis J: Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23: 3151-3171, 2004
    • (2004) Oncogene , vol.23 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 9
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N, Sonenberg N: Upstream and downstream of mTOR. Genes Dev 18: 1926-1945, 2004
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 11
    • 0027311858 scopus 로고
    • Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
    • Kunz J, Henriquez R, Schneider U, Deuter-Reinhard M, Movva NR, Hall MN: Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell 73: 585-596, 1993
    • (1993) Cell , vol.73 , pp. 585-596
    • Kunz, J.1    Henriquez, R.2    Schneider, U.3    Deuter-Reinhard, M.4    Movva, N.R.5    Hall, M.N.6
  • 12
    • 0029983604 scopus 로고    scopus 로고
    • Cyclosporine, FK-506, rapamycin, and other immunomodulators
    • Yocum DE: Cyclosporine, FK-506, rapamycin, and other immunomodulators. Rheum Dis Clin North Am 22: 133-154, 1996
    • (1996) Rheum Dis Clin North Am , vol.22 , pp. 133-154
    • Yocum, D.E.1
  • 14
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101, 2005
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 15
    • 33749500123 scopus 로고    scopus 로고
    • (Patho)physiological significance of the serum- and glucocorticoid- inducible kinase isoforms
    • Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V: (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol Rev 86: 1151-1178, 2006
    • (2006) Physiol Rev , vol.86 , pp. 1151-1178
    • Lang, F.1    Bohmer, C.2    Palmada, M.3    Seebohm, G.4    Strutz-Seebohm, N.5    Vallon, V.6
  • 19
    • 0037016772 scopus 로고    scopus 로고
    • Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel
    • Snyder PM, Olson DR, Thomas BC: Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel. J Biol Chem 277: 5-8, 2002
    • (2002) J Biol Chem , vol.277 , pp. 5-8
    • Snyder, P.M.1    Olson, D.R.2    Thomas, B.C.3
  • 20
    • 0033151832 scopus 로고    scopus 로고
    • Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway
    • Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA: Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J 18: 3024-3033, 1999
    • (1999) EMBO J , vol.18 , pp. 3024-3033
    • Park, J.1    Leong, M.L.2    Buse, P.3    Maiyar, A.C.4    Firestone, G.L.5    Hemmings, B.A.6
  • 21
    • 0027534990 scopus 로고
    • Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum
    • Webster MK, Goya L, Ge Y, Maiyar AC, Firestone GL: Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol Cell Biol 13: 2031-2040, 1993
    • (1993) Mol Cell Biol , vol.13 , pp. 2031-2040
    • Webster, M.K.1    Goya, L.2    Ge, Y.3    Maiyar, A.C.4    Firestone, G.L.5
  • 22
    • 33749391922 scopus 로고    scopus 로고
    • Disinhibitory pathways for control of sodium transport: Regulation of ENaC by SGK1 and GILZ
    • Bhalla V, Soundararajan R, Pao AC, Li H, Pearce D: Disinhibitory pathways for control of sodium transport: Regulation of ENaC by SGK1 and GILZ. Am J Physiol Renal Physiol 291: F714-F721, 2006
    • (2006) Am J Physiol Renal Physiol , vol.291
    • Bhalla, V.1    Soundararajan, R.2    Pao, A.C.3    Li, H.4    Pearce, D.5
  • 23
    • 65949103405 scopus 로고    scopus 로고
    • Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1
    • Jones KT, Greer ER, Pearce D, Ashrafi K: Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1. PLoS Biol 7: e60, 2009
    • (2009) PLoS Biol , vol.7
    • Jones, K.T.1    Greer, E.R.2    Pearce, D.3    Ashrafi, K.4
  • 25
    • 61449244533 scopus 로고    scopus 로고
    • Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
    • Soukas AA, Kane EA, Carr CE, Melo JA, Ruvkun G: Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev 23: 496-511, 2009
    • (2009) Genes Dev , vol.23 , pp. 496-511
    • Soukas, A.A.1    Kane, E.A.2    Carr, C.E.3    Melo, J.A.4    Ruvkun, G.5
  • 27
    • 58649092475 scopus 로고    scopus 로고
    • mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
    • Garcia-Martinez JM, Alessi DR: mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J 416: 375-385, 2008
    • (2008) Biochem J , vol.416 , pp. 375-385
    • Garcia-Martinez, J.M.1    Alessi, D.R.2
  • 29
    • 54449095043 scopus 로고    scopus 로고
    • Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport
    • Wang J, Knight ZA, Fiedler D, Williams O, Shokat KM, Pearce D: Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport. Am J Physiol Renal Physiol 295: F843-F850, 2008
    • (2008) Am J Physiol Renal Physiol , vol.295
    • Wang, J.1    Knight, Z.A.2    Fiedler, D.3    Williams, O.4    Shokat, K.M.5    Pearce, D.6
  • 32
    • 33646060747 scopus 로고    scopus 로고
    • Sgk kinases and their role in epithelial transport
    • Loffing J, Flores SY, Staub O: Sgk kinases and their role in epithelial transport. Annu Rev Physiol 68: 461-490, 2006
    • (2006) Annu Rev Physiol , vol.68 , pp. 461-490
    • Loffing, J.1    Flores, S.Y.2    Staub, O.3
  • 33
    • 0033546341 scopus 로고    scopus 로고
    • Sgk is an aldosterone-induced kinase in the renal collecting duct: Effects on epithelial Na+ channels
    • Naray-Fejes-Toth A, Canessa C, Cleaveland ES, Aldrich G, Fejes-Toth G: Sgk is an aldosterone-induced kinase in the renal collecting duct: Effects on epithelial Na+ channels. J Biol Chem 274: 16973-16978, 1999
    • (1999) J Biol Chem , vol.274 , pp. 16973-16978
    • Naray-Fejes-Toth, A.1    Canessa, C.2    Cleaveland, E.S.3    Aldrich, G.4    Fejes-Toth, G.5
  • 35
    • 0035135841 scopus 로고    scopus 로고
    • Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
    • Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME: Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol 21: 952-965, 2001
    • (2001) Mol Cell Biol , vol.21 , pp. 952-965
    • Brunet, A.1    Park, J.2    Tran, H.3    Hu, L.S.4    Hemmings, B.A.5    Greenberg, M.E.6
  • 36
    • 0035907309 scopus 로고    scopus 로고
    • Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1
    • Mikosz CA, Brickley DR, Sharkey MS, Moran TW, Conzen SD: Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1. J Biol Chem 276: 16649-16654, 2001
    • (2001) J Biol Chem , vol.276 , pp. 16649-16654
    • Mikosz, C.A.1    Brickley, D.R.2    Sharkey, M.S.3    Moran, T.W.4    Conzen, S.D.5
  • 37
    • 0035882103 scopus 로고    scopus 로고
    • The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB
    • Biondi RM, Kieloch A, Currie RA, Deak M, Alessi DR: The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. EMBO J 20: 4380-4390, 2001
    • (2001) EMBO J , vol.20 , pp. 4380-4390
    • Biondi, R.M.1    Kieloch, A.2    Currie, R.A.3    Deak, M.4    Alessi, D.R.5
  • 38
    • 66049127140 scopus 로고    scopus 로고
    • Epithelial sodium channel regulated by differential composition of a signaling complex
    • Soundararajan R, Melters D, Shih IC, Wang J, Pearce D: Epithelial sodium channel regulated by differential composition of a signaling complex. Proc Natl Acad Sci U S A 106: 7804-7809, 2009
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 7804-7809
    • Soundararajan, R.1    Melters, D.2    Shih, I.C.3    Wang, J.4    Pearce, D.5
  • 39
    • 0036720843 scopus 로고    scopus 로고
    • Concerted action of ENaC, Nedd4-2, and Sgk1 in transepithelial Na(+) transport
    • Kamynina E, Staub O: Concerted action of ENaC, Nedd4-2, and Sgk1 in transepithelial Na(+) transport. Am J Physiol Renal Physiol 283: F377-F387, 2002
    • (2002) Am J Physiol Renal Physiol , vol.283
    • Kamynina, E.1    Staub, O.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.