-
1
-
-
0028360374
-
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
-
Brown E.J., Albers M.W., Shin T.B., Ichikawa K., Keith C.T., Lane W.S., Schreiber S.L. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature. 369:1994;756-758.
-
(1994)
Nature
, vol.369
, pp. 756-758
-
-
Brown, E.J.1
Albers, M.W.2
Shin, T.B.3
Ichikawa, K.4
Keith, C.T.5
Lane, W.S.6
Schreiber, S.L.7
-
2
-
-
0030881836
-
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
-
Brunn G.J., Hudson C.C., Sekulic A., Williams J.M., Hosoi H., Houghton P.J., Lawrence J.C. Jr., Abraham R.T. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science. 277:1997;99-101.
-
(1997)
Science
, vol.277
, pp. 99-101
-
-
Brunn, G.J.1
Hudson, C.C.2
Sekulic, A.3
Williams, J.M.4
Hosoi, H.5
Houghton, P.J.6
Lawrence J.C., Jr.7
Abraham, R.T.8
-
3
-
-
0032539664
-
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
-
Burnett P.E., Barrow R.K., Cohen N.A., Snyder S.H., Sabatini D.M. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc. Natl. Acad. Sci. USA. 95:1998;1432-1437.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 1432-1437
-
-
Burnett, P.E.1
Barrow, R.K.2
Cohen, N.A.3
Snyder, S.H.4
Sabatini, D.M.5
-
4
-
-
0029055145
-
Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue
-
Chen J., Zheng X.F., Brown E.J., Schreiber S.L. Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proc. Natl. Acad. Sci. USA. 92:1995;4947-4951.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 4947-4951
-
-
Chen, J.1
Zheng, X.F.2
Brown, E.J.3
Schreiber, S.L.4
-
5
-
-
0033593316
-
Size control in animal development
-
Conlon I., Raff M. Size control in animal development. Cell. 96:1999;235-244.
-
(1999)
Cell
, vol.96
, pp. 235-244
-
-
Conlon, I.1
Raff, M.2
-
6
-
-
0027770784
-
Identification and characterization of the tuberous sclerosis gene on chromosome 16. The European Chromosome 16 Tuberous Sclerosis Consortium
-
Consortium, T.E.C.T.S. (1993). Identification and characterization of the tuberous sclerosis gene on chromosome 16. The European Chromosome 16 Tuberous Sclerosis Consortium. Cell 75, 1305-1315.
-
(1993)
Cell
, vol.75
, pp. 1305-1315
-
-
Consortium, T.E.C.T.S.1
-
7
-
-
0035798097
-
Mammalian TOR: A homeostatic ATP sensor
-
Dennis P.B., Jaeschke A., Saitoh M., Fowler B., Kozma S.C., Thomas G. Mammalian TOR. a homeostatic ATP sensor Science. 294:2001;1102-1105.
-
(2001)
Science
, vol.294
, pp. 1102-1105
-
-
Dennis, P.B.1
Jaeschke, A.2
Saitoh, M.3
Fowler, B.4
Kozma, S.C.5
Thomas, G.6
-
9
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 411:2001;494-498.
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
10
-
-
0028566645
-
High-sensitivity sequencing of large proteins: Partial structure of the rapamycin-FKBP12 target
-
Erdjument-Bromage H., Lui M., Sabatini D.M., Snyder S.H., Tempst P. High-sensitivity sequencing of large proteins. partial structure of the rapamycin-FKBP12 target Protein Sci. 3:1994;2435-2446.
-
(1994)
Protein Sci.
, vol.3
, pp. 2435-2446
-
-
Erdjument-Bromage, H.1
Lui, M.2
Sabatini, D.M.3
Snyder, S.H.4
Tempst, P.5
-
11
-
-
0037097863
-
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
-
Fingar D.C., Salama S., Tsou C., Harlow E., Blenis J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 16:2002;1472-1487.
-
(2002)
Genes Dev.
, vol.16
, pp. 1472-1487
-
-
Fingar, D.C.1
Salama, S.2
Tsou, C.3
Harlow, E.4
Blenis, J.5
-
12
-
-
0034676457
-
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
-
Fraser A.G., Kamath R.S., Zipperlen P., Martinez-Campos M., Sohrmann M., Ahringer J. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature. 408:2000;325-330.
-
(2000)
Nature
, vol.408
, pp. 325-330
-
-
Fraser, A.G.1
Kamath, R.S.2
Zipperlen, P.3
Martinez-Campos, M.4
Sohrmann, M.5
Ahringer, J.6
-
13
-
-
0035312747
-
Regulation of translation initiation by FRAP/mTOR
-
Gingras A.C., Raught B., Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 15:2001;807-826.
-
(2001)
Genes Dev.
, vol.15
, pp. 807-826
-
-
Gingras, A.C.1
Raught, B.2
Sonenberg, N.3
-
15
-
-
0037163033
-
Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)
-
Goncharova E.A., Goncharov D.A., Eszterhas A., Hunter D.S., Glassberg M.K., Yeung R.S., Walker C.L., Noonan D., Kwiatkowski D.J., Chou M.M. Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). J. Biol. Chem. 277:2002;30958-30967.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 30958-30967
-
-
Goncharova, E.A.1
Goncharov, D.A.2
Eszterhas, A.3
Hunter, D.S.4
Glassberg, M.K.5
Yeung, R.S.6
Walker, C.L.7
Noonan, D.8
Kwiatkowski, D.J.9
Chou, M.M.10
-
16
-
-
0032486268
-
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
-
Hara K., Yonezawa K., Weng Q.P., Kozlowski M.T., Belham C., Avruch J. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J. Biol. Chem. 273:1998;14484-14494.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14484-14494
-
-
Hara, K.1
Yonezawa, K.2
Weng, Q.P.3
Kozlowski, M.T.4
Belham, C.5
Avruch, J.6
-
17
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Hara K., Maruki Y., Long X., Yoshino K., Oshiro N., Hidayat S., Tokunaga C., Avruch J., Yonezawa K. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. 110:2002;177-189.
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
Tokunaga, C.7
Avruch, J.8
Yonezawa, K.9
-
18
-
-
0033607531
-
Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
-
Isotani S., Hara K., Tokunaga C., Inoue H., Avruch J., Yonezawa K. Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro. J. Biol. Chem. 274:1999;34493-34498.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 34493-34498
-
-
Isotani, S.1
Hara, K.2
Tokunaga, C.3
Inoue, H.4
Avruch, J.5
Yonezawa, K.6
-
19
-
-
0036007420
-
Control of growth and organ size in Drosophila
-
Johnston L.A., Gallant P. Control of growth and organ size in Drosophila. Bioessays. 24:2002;54-64.
-
(2002)
Bioessays
, vol.24
, pp. 54-64
-
-
Johnston, L.A.1
Gallant, P.2
-
20
-
-
0028800996
-
PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints
-
Keith C.T., Schreiber S.L. PIK-related kinases. DNA repair, recombination, and cell cycle checkpoints Science. 270:1995;50-51.
-
(1995)
Science
, vol.270
, pp. 50-51
-
-
Keith, C.T.1
Schreiber, S.L.2
-
21
-
-
0030928485
-
A wat1 mutant of fission yeast is defective in cell morphology
-
Kemp J.T., Balasubramanian M.K., Gould K.L. A wat1 mutant of fission yeast is defective in cell morphology. Mol. Gen. Genet. 254:1997;127-138.
-
(1997)
Mol. Gen. Genet.
, vol.254
, pp. 127-138
-
-
Kemp, J.T.1
Balasubramanian, M.K.2
Gould, K.L.3
-
22
-
-
0037178786
-
MTOR interacts with raptor to form a nutrient-sensitive complet that signals to the cell growth machinery
-
Kim D.-H., Sarbassov D.D., Ali S.M., King J.E., Latek R.R., Erdjument-Bromage H., Tempst P., Sabatini D.M. mTOR interacts with raptor to form a nutrient-sensitive complet that signals to the cell growth machinery. Cell. 110:2002;163-175.
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.-H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
23
-
-
0036007421
-
Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K
-
Kozma S.C., Thomas G. Regulation of cell size in growth, development and human disease. PI3K, PKB and S6K Bioessays. 24:2002;65-71.
-
(2002)
Bioessays
, vol.24
, pp. 65-71
-
-
Kozma, S.C.1
Thomas, G.2
-
24
-
-
0036501277
-
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
-
Kwiatkowski D.J., Zhang H., Bandura J.L., Heiberger K.M., Glogauer M., el-Hashemite N., Onda H. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum. Mol. Genet. 11:2002;525-534.
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 525-534
-
-
Kwiatkowski, D.J.1
Zhang, H.2
Bandura, J.L.3
Heiberger, K.M.4
Glogauer, M.5
El-Hashemite, N.6
Onda, H.7
-
25
-
-
0037126596
-
RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p
-
Liu Z., Sekito T., Epstein C.B., Butow R.A. RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p. EMBO J. 20:2001;7209-7219.
-
(2001)
EMBO J.
, vol.20
, pp. 7209-7219
-
-
Liu, Z.1
Sekito, T.2
Epstein, C.B.3
Butow, R.A.4
-
26
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewith R., Jacinto E., Wullschleger S., Lorberg A., Crespo J.L., Bonenfant D., Oppliger W., Jenoe P., Hall M.N. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell. 10:2002;457-468.
-
(2002)
Mol. Cell
, vol.10
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
27
-
-
0034050449
-
WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A
-
Moreno C.S., Park S., Nelson K., Ashby D., Hubalek F., Lane W.S., Pallas D.C. WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. J. Biol. Chem. 275:2000;5257-5263.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 5257-5263
-
-
Moreno, C.S.1
Park, S.2
Nelson, K.3
Ashby, D.4
Hubalek, F.5
Lane, W.S.6
Pallas, D.C.7
-
28
-
-
0035969559
-
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
-
Nash P., Tang X., Orlicky S., Chen Q., Gertler F.B., Mendenhall M.D., Sicheri F., Pawson T., Tyers M. Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature. 414:2001;514-521.
-
(2001)
Nature
, vol.414
, pp. 514-521
-
-
Nash, P.1
Tang, X.2
Orlicky, S.3
Chen, Q.4
Gertler, F.B.5
Mendenhall, M.D.6
Sicheri, F.7
Pawson, T.8
Tyers, M.9
-
29
-
-
0028076764
-
The ancient regulatory-protein family of WD-repeat proteins
-
Neer E.J., Schmidt C.J., Nambudripad R., Smith T.F. The ancient regulatory-protein family of WD-repeat proteins. Nature. 371:1994;297-300.
-
(1994)
Nature
, vol.371
, pp. 297-300
-
-
Neer, E.J.1
Schmidt, C.J.2
Nambudripad, R.3
Smith, T.F.4
-
30
-
-
0034845927
-
Conserved Wat1/Pop3 WD-repeat protein of fission yeast secures genome stability through microtubule integrity and may be involved in mRNA maturation
-
Ochotorena I.L., Hirata D., Kominami K., Potashkin J., Sahin F., Wentz-Hunter K., Gould K.L., Sato K., Yoshida Y., Vardy L., Toda T. Conserved Wat1/Pop3 WD-repeat protein of fission yeast secures genome stability through microtubule integrity and may be involved in mRNA maturation. J. Cell Sci. 114:2001;2911-2920.
-
(2001)
J. Cell Sci.
, vol.114
, pp. 2911-2920
-
-
Ochotorena, I.L.1
Hirata, D.2
Kominami, K.3
Potashkin, J.4
Sahin, F.5
Wentz-Hunter, K.6
Gould, K.L.7
Sato, K.8
Yoshida, Y.9
Vardy, L.10
Toda, T.11
-
31
-
-
0033551234
-
Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein
-
Peterson R.T., Desai B.N., Hardwick J.S., Schreiber S.L. Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein. Proc. Natl. Acad. Sci. USA. 96:1999;4438-4442.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 4438-4442
-
-
Peterson, R.T.1
Desai, B.N.2
Hardwick, J.S.3
Schreiber, S.L.4
-
32
-
-
0030809956
-
Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8
-
Roberg K.J., Bickel S., Rowley N., Kaiser C.A. Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8. Genetics. 147:1997;1569-1584.
-
(1997)
Genetics
, vol.147
, pp. 1569-1584
-
-
Roberg, K.J.1
Bickel, S.2
Rowley, N.3
Kaiser, C.A.4
-
34
-
-
0028239893
-
RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast tors
-
Sabatini D.M., Erdjument-Bromage H., Lui M., Tempst P., Snyder S.H. RAFT1. a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast tors Cell. 78:1994;35-43.
-
(1994)
Cell
, vol.78
, pp. 35-43
-
-
Sabatini, D.M.1
Erdjument-Bromage, H.2
Lui, M.3
Tempst, P.4
Snyder, S.H.5
-
35
-
-
0028950217
-
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
-
Sabers C.J., Martin M.M., Brunn G.J., Williams J.M., Dumont F.J., Wiederrecht G., Abraham R.T. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J. Biol. Chem. 270:1995;815-822.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 815-822
-
-
Sabers, C.J.1
Martin, M.M.2
Brunn, G.J.3
Williams, J.M.4
Dumont, F.J.5
Wiederrecht, G.6
Abraham, R.T.7
-
36
-
-
0027136282
-
Comparative protein modelling by satisfaction of spatial restraints
-
Sali A., Blundell T.L. Comparative protein modelling by satisfaction of spatial restraints. J. Mol. Biol. 234:1993;779-815.
-
(1993)
J. Mol. Biol.
, vol.234
, pp. 779-815
-
-
Sali, A.1
Blundell, T.L.2
-
38
-
-
0034644525
-
TOR, a central controller of cell growth
-
Schmelzle T., Hall M.N. TOR, a central controller of cell growth. Cell. 103:2000;253-262.
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.N.2
-
39
-
-
0032560521
-
Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway
-
Scott P.H., Brunn G.J., Kohn A.D., Roth R.A., Lawrence J.C. Jr. Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. Proc. Natl. Acad. Sci. USA. 95:1998;7772-7777.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 7772-7777
-
-
Scott, P.H.1
Brunn, G.J.2
Kohn, A.D.3
Roth, R.A.4
Lawrence J.C., Jr.5
-
40
-
-
0034234924
-
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
-
Sekulic A., Hudson C.C., Homme J.L., Yin P., Otterness D.M., Karnitz L.M., Abraham R.T. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 60:2000;3504-3513.
-
(2000)
Cancer Res.
, vol.60
, pp. 3504-3513
-
-
Sekulic, A.1
Hudson, C.C.2
Homme, J.L.3
Yin, P.4
Otterness, D.M.5
Karnitz, L.M.6
Abraham, R.T.7
-
43
-
-
0031574072
-
The CLUSTAL_X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools
-
Thompson J.D., Gibson T.J., Plewniak F., Jeanmougin F., Higgins D.G. The CLUSTAL_X windows interface. flexible strategies for multiple sequence alignment aided by quality analysis tools Nucleic Acids Res. 25:1997;4876-4882.
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 4876-4882
-
-
Thompson, J.D.1
Gibson, T.J.2
Plewniak, F.3
Jeanmougin, F.4
Higgins, D.G.5
-
44
-
-
0030879277
-
Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34
-
van Slegtenhorst M., de Hoogt R., Hermans C., Nellist M., Janssen B., Verhoef S., Lindhout D., van den Ouweland A., Halley D., Young J.et al. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science. 277:1997;805-808.
-
(1997)
Science
, vol.277
, pp. 805-808
-
-
Van Slegtenhorst, M.1
De Hoogt, R.2
Hermans, C.3
Nellist, M.4
Janssen, B.5
Verhoef, S.6
Lindhout, D.7
Van den Ouweland, A.8
Halley, D.9
Young, J.10
-
45
-
-
0034764605
-
PI 3-kinase, mTOR, protein synthesis and cancer
-
Vogt P.K. PI 3-kinase, mTOR, protein synthesis and cancer. Trends Mol. Med. 7:2001;482-484.
-
(2001)
Trends Mol. Med.
, vol.7
, pp. 482-484
-
-
Vogt, P.K.1
-
46
-
-
0035313699
-
Phosphoserine/threonine-binding domains
-
Yaffe M.B., Elia A.E. Phosphoserine/threonine-binding domains. Curr. Opin. Cell Biol. 13:2001;131-138.
-
(2001)
Curr. Opin. Cell Biol.
, vol.13
, pp. 131-138
-
-
Yaffe, M.B.1
Elia, A.E.2
|