Signaling through cAMP and cAMP-dependent protein kinase: Diverse strategies for drug design

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1784, Issue 1, 2008, Pages 16-26

  Taylor, Susan S ^a   Kim, Choel ^a   Cheng, Cecilia Y ^a   Brown, Simon H J ^a   Wu, Jian ^a   Kannan, Natarajan ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

A Kinase Anchoring Proteins (AKAPs); Allostery; Dynamic; Holoenzyme; Kinase inhibitor; PKA; PKI; RI ; RII ; Signaling

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; CYCLIC NUCLEOTIDE; HOLOENZYME;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; DIMERIZATION; DRUG DESIGN; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SUBUNIT; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; CATALYTIC DOMAIN; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUG DESIGN; HOLOENZYMES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTEIN KINASE INHIBITORS; PROTEIN SUBUNITS; SIGNAL TRANSDUCTION;

EID: 38149061122     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2007.10.002     Document Type: Article

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