Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

Journal of Biological Chemistry

Volumn 277, Issue 42, 2002, Pages 39858-39866

  Basso, Andrea D ^a,b   Solit, David B ^b   Chiosis, Gabriela ^b   Giri, Banabihari ^c   Tsichlis, Philip ^c   Rosen, Neal ^a,b  

^a Weill Cornell Medical Center   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DEGRADATION; ENZYME INHIBITION; PROTEINS;

STEROID RECEPTORS;

BIOCHEMISTRY;

2 MORPHOLINO 8 PHENYLCHROMONE; ADENOSINE TRIPHOSPHATE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 37; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN DEPENDENT KINASE 4; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEASOME; PROTEIN INHIBITOR; PROTEIN KINASE B; PROTEIN KINASE C; RADICICOL; RAF PROTEIN; STEROID RECEPTOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CANCER CELL CULTURE; CELL CYCLE G1 PHASE; COMPLEX FORMATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG PROTEIN BINDING; HALF LIFE TIME; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL CYCLE PROTEINS; CHAPERONINS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYSTEINE ENDOPEPTIDASES; DOWN-REGULATION; DROSOPHILA PROTEINS; FEMALE; HSP90 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOBLOTTING; MICE; MICE, INBRED BALB C; MICROSCOPY, FLUORESCENCE; MOLECULAR CHAPERONES; MULTIENZYME COMPLEXES; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0037131187     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206322200     Document Type: Article

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