The protein kinase complement of the human genome

Science

Volumn 298, Issue 5600, 2002, Pages 1912-1934

  Manning, G ^a   Whyte, D B ^a   Martinez, R ^a   Hunter, T ^b   Sudarsanam, S ^a,c  

^a SUGEN INC   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA SEQUENCES; GENES; PHYSIOLOGY; TUMORS;

PHOSPHORYLATION;

ENZYMES;

COMPLEMENTARY DNA; CYCLIN DEPENDENT KINASE; EPIDERMAL GROWTH FACTOR; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; PROTEIN KINASE; PROTEIN TYROSINE KINASE; RNA;

GENOME; PROTEIN;

AMINO ACID SEQUENCE; AMPLICON; ANGIOGENESIS; APOPTOSIS; CALCIUM SIGNALING; CANCER; CATALYSIS; CHROMOSOME MAP; DNA SEQUENCE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME REGULATION; EXPRESSED SEQUENCE TAG; GENE LOCUS; GENOMICS; HEMATOPOIESIS; HUMAN; HUMAN GENOME; NEUROBIOLOGY; NONHUMAN; PHYLOGENY; PREDICTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PSEUDOGENE; REVIEW; SEQUENCE ANALYSIS; SEQUENCE DATABASE; SPECIES DIFFERENCE;

ANIMALS; CATALYSIS; CHROMOSOME MAPPING; COMPUTATIONAL BIOLOGY; DATABASES, GENETIC; GENES; GENOME, HUMAN; HUMANS; NEOPLASMS; PHYLOGENY; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; PSEUDOGENES; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION;

JANUS;

EID: 0037032835     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1075762     Document Type: Review

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39. We wish to thank the dozens of kinase researchers at SUGEN for their contributions to understanding the kinome at many levels. We particularly thank G. Plowman who guided the initial stages of the project, S. Caenepeel for extensive sequence analysis of kinases, and G. Charydczak for the computational support that made the genome mining possible. The SUGEN sequencing group provided cDNA confirmation of most predicted sequences. T.H. is a Frank and Else Schilling American Cancer Society Research Professor and serves on the Scientific Advisory Board of SUGEN.