A phospho-proteomic screen identifies novel S6K1 and mTORC1 substrates revealing additional complexity in the signaling network regulating cell growth

Cellular Signalling

Volumn 23, Issue 8, 2011, Pages 1338-1347

  Jastrzebski, Katarzyna ^a   Hannan, Katherine M ^a   House, Colin M ^a   Hung, Sandy S C ^a   Pearson, Richard B ^a,b,c   Hannan, Ross D ^a,b,c  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MONASH UNIVERSITY   (Australia)

Author keywords

Chaperonin; MTOR; Phospho proteomics; S6K1 signaling

Indexed keywords

CHAPERONIN; CHAPERONIN CONTAINING TCP1; CHAPERONIN CONTAINING TCP1 BETA; GLUCOSE REGULATED PROTEIN; GLUCOSE REGULATED PROTEIN 75; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEASOME; PROTEIN ANXA4; PROTEIN P85; PROTEIN PGK1; PROTEIN PSMA6; PROTEIN S6K1; RECEPTOR FOR ACTIVATED C KINASE 1; SERINE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE REGULATION; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; SIGNAL TRANSDUCTION; TRANSPORT VESICLE;

AMINO ACID SEQUENCE; ANIMALS; ANNEXIN A4; CELL GROWTH PROCESSES; CELL LINE; CHAPERONIN CONTAINING TCP-1; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NEUROPEPTIDES; PHOSPHOGLYCERATE KINASE; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEINS; PROTEOMICS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 79955847641     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2011.03.016     Document Type: Article

References (66)

1. Sengupta S., Peterson T.R., Sabatini D.M. Mol. Cell 2010, 40:310-322.
2. Jacinto E., Loewith R., Schmidt A., Lin S., Ruegg M.A., Hall A., Hall M.N. Nat. Cell Biol. 2004, 6:1122-1128.
3. Sarbassov D.D., Ali S.M., Kim D.H., Guertin D.A., Latek R.R., Erdjument-Bromage H., Tempst P., Sabatini D.M. Curr. Biol. 2004, 14:1296-1302.
4. Sarbassov D.D., Guertin D.A., Ali S.M., Sabatini D.M. Science 2005, 307:1098-1101.
5. Guertin D.A., Stevens D.M., Thoreen C.C., Burds A.A., Kalaany N.Y., Moffat J., Brown M., Fitzgerald K.J., Sabatini D.M. Dev. Cell 2006, 11:859-871.
6. Jacinto E., Facchinetti V., Liu D., Soto N., Wei S., Jung S.Y., Huang Q., Qin J., Su B. Cell 2006, 127:125-137.
7. Garcia-Martinez J.M., Alessi D.R. Biochem. J. 2008, 416:375-385.
8. Jastrzebski K., Hannan K.M., Tchoubrieva E.B., Hannan R.D., Pearson R.B. Growth Factors 2007, 25:209-226.
9. Ma X.M., Blenis J. Nat. Rev. Mol. Cell Biol. 2009, 10:307-318.
10. Sonenberg N., Hinnebusch A.G. Cell 2009, 136:731-745.
11. Dorrello N.V., Peschiaroli A., Guardavaccaro D., Colburn N.H., Sherman N.E., Pagano M. Science 2006, 314:467-471.
12. Ferrari S., Bandi H.R., Hofsteenge J., Bussian B.M., Thomas G. J. Biol. Chem. 1991, 266:22770-22775.
13. Krieg J., Hofsteenge J., Thomas G. J. Biol. Chem. 1988, 263:11473-11477.
14. Raught B., Peiretti F., Gingras A.C., Livingstone M., Shahbazian D., Mayeur G.L., Polakiewicz R.D., Sonenberg N., Hershey J.W. EMBO J. 2004, 23:1761-1769.
15. Wang X., Li W., Williams M., Terada N., Alessi D.R., Proud C.G. EMBO J. 2001, 20:4370-4379.
16. Richardson C.J., Broenstrup M., Fingar D.C., Julich K., Ballif B.A., Gygi S., Blenis J. Curr. Biol. 2004, 14:1540-1549.
17. Fang J., Meng Q., Vogt P.K., Zhang R., Jiang B.H. J. Cell. Physiol. 2006, 209:261-265.
18. Harada H., Andersen J.S., Mann M., Terada N., Korsmeyer S.J. Proc. Natl Acad. Sci. U.S.A. 2001, 98:9666-9670.
19. Harrington L.S., Findlay G.M., Gray A., Tolkacheva T., Wigfield S., Rebholz H., Barnett J., Leslie N.R., Cheng S., Shepherd P.R., Gout I., Downes C.P., Lamb R.F. J. Cell Biol. 2004, 166:213-223.
20. Shah O.J., Hunter T. Mol. Cell. Biol. 2006, 26:6425-6434.
21. Dibble C.C., Asara J.M., Manning B.D. Mol. Cell. Biol. 2009, 29:5657-5670.
22. Treins C., Warne P.H., Magnuson M.A., Pende M., Downward J. Oncogene 2010, 29:1003-1016.
23. Julien L.A., Carriere A., Moreau J., Roux P.P. Mol. Cell. Biol. 2010, 30:908-921.
24. Holz M.K., Blenis J. J. Biol. Chem. 2005, 280:26089-26093.
25. Hannan K.M., Brandenburger Y., Jenkins A., Sharkey K., Cavanaugh A., Rothblum L., Moss T., Poortinga G., McArthur G.A., Pearson R.B., Hannan R.D. Mol. Cell. Biol. 2003, 23:8862-8877.
26. Pearson R.B., Dennis P.B., Han J.W., Williamson N.A., Kozma S.C., Wettenhall R.E., Thomas G. EMBO J. 1995, 14:5279-5287.
27. Hannan K.M., Thomas G., Pearson R.B. Biochem. J. 2003, 370:469-477.
28. Conus N.M., Hannan K.M., Cristiano B.E., Hemmings B.A., Pearson R.B. J. Biol. Chem. 2002, 277:38021-38028.
29. Mitchelhill K.I., Michell B.J., House C.M., Stapleton D., Dyck J., Gamble J., Ullrich C., Witters L.A., Kemp B.E. J. Biol. Chem. 1997, 272:24475-24479.
30. Conus N.M., Hemmings B.A., Pearson R.B. J. Biol. Chem. 1998, 273:4776-4782.
31. Llorca O., Martin-Benito J., Grantham J., Ritco-Vonsovici M., Willison K.R., Carrascosa J.L., Valpuesta J.M. EMBO J. 2001, 20:4065-4075.
32. Flotow H., Thomas G. J. Biol. Chem. 1992, 267:3074-3078.
33. Zhang H., Zha X., Tan Y., Hornbeck P.V., Mastrangelo A.J., Alessi D.R., Polakiewicz R.D., Comb M.J. J. Biol. Chem. 2002, 277:39379-39387.
34. Park J., Leong M.L., Buse P., Maiyar A.C., Firestone G.L., Hemmings B.A. EMBO J. 1999, 18:3024-3033.
35. Kobayashi T., Deak M., Morrice N., Cohen P. Biochem. J. 1999, 344(Pt 1):189-197.
36. Alessi D.R., Caudwell F.B., Andjelkovic M., Hemmings B.A., Cohen P. FEBS Lett. 1996, 399:333-338.
37. Coffer P.J., Woodgett J.R. Biochem. Biophys. Res. Commun. 1994, 198:780-786.
38. Reinhard C., Fernandez A., Lamb N.J., Thomas G. EMBO J. 1994, 13:1557-1565.
39. Andersen J.S., Lam Y.W., Leung A.K., Ong S.E., Lyon C.E., Lamond A.I., Mann M. Nature 2005, 433:77-83.
40. Brackley K.I., Grantham J. Cell Stress Chaperones 2009, 14:23-31.
41. Ditzel L., Lowe J., Stock D., Stetter K.O., Huber H., Huber R., Steinbacher S. Cell 1998, 93:125-138.
42. Munoz I.G., Yebenes H., Zhou M., Mesa P., Serna M., Park A.Y., Bragado-Nilsson E., Beloso A., de Carcer G., Malumbres M., Robinson C.V., Valpuesta J.M., Montoya G. Nat. Struct. Mol. Biol. 2011, 18:14-19.
43. Gomez-Puertas P., Martin-Benito J., Carrascosa J.L., Willison K.R., Valpuesta J.M. J. Mol. Recognit. 2004, 17:85-94.
44. Grantham J., Brackley K.I., Willison K.R. Exp. Cell Res. 2006, 312:2309-2324.
45. McLaughlin J.N., Thulin C.D., Hart S.J., Resing K.A., Ahn N.G., Willardson B.M. Proc. Natl Acad. Sci. U.S.A. 2002, 99:7962-7967.
46. Sanij E., Hannan R.D. Epigenetics 2009, 4:374-382.
47. Bachmann R.A., Kim J.H., Wu A.L., Park I.H., Chen J. J. Biol. Chem. 2006, 281:7357-7363.
48. Tsang C.K., Liu H., Zheng X.F. Cell Cycle 2010, 9:953-957.
49. Abe Y., Yoon S.O., Kubota K., Mendoza M.C., Gygi S.P., Blenis J. J. Biol. Chem. 2009, 284:14939-14948.
50. Roobol A., Carden M.J. Eur. J. Cell Biol. 1999, 78:21-32.
51. Deocaris C.C., Kaul S.C., Wadhwa R. Protein Pept. Lett. 2009, 16:517-529.
52. Beutler E. Br. J. Haematol. 2007, 136:3-11.
53. Nilsson J., Sengupta J., Frank J., Nissen P. EMBO Rep. 2004, 5:1137-1141.
54. Sengupta J., Nilsson J., Gursky R., Spahn C.M., Nissen P., Frank J. Nat. Struct. Mol. Biol. 2004, 11:957-962.
55. Loreni F., Iadevaia V., Tino E., Caldarola S., Amaldi F. FEBS Lett. 2005, 579:5517-5520.
56. Ceci M., Gaviraghi C., Gorrini C., Sala L.A., Offenhauser N., Marchisio P.C., Biffo S. Nature 2003, 426:579-584.
57. Yam A.Y., Xia Y., Lin H.T., Burlingame A., Gerstein M., Frydman J. Nat. Struct. Mol. Biol. 2008, 15:1255-1262.
58. Wang J.L., Gray R.M., Haudek K.C., Patterson R.J. Biochim. Biophys. Acta 2004, 1673:75-93.
59. Gerke V., Creutz C.E., Moss S.E. Nat. Rev. Mol. Cell Biol. 2005, 6:449-461.
60. Barwise J.L., Walker J.H. J. Cell Sci. 1996, 109(Pt 1):247-255.
61. Murata S., Yashiroda H., Tanaka K. Nat. Rev. Mol. Cell Biol. 2009, 10:104-115.
62. Smith D.M., Chang S.C., Park S., Finley D., Cheng Y., Goldberg A.L. Mol. Cell 2007, 27:731-744.
63. Gillette T.G., Kumar B., Thompson D., Slaughter C.A., DeMartino G.N. J. Biol. Chem. 2008, 283:31813-31822.
64. Rabl J., Smith D.M., Yu Y., Chang S.C., Goldberg A.L., Cheng Y. Mol. Cell 2008, 30:360-368.
65. van der Heijden M.S., Bernards R. Clin. Cancer Res. 2010, 16:3094-3099.
66. Giordano A. Curr Opin Drug Discov Devel. 2010, 13:159-168.