-
1
-
-
1542777034
-
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD
-
Baas A.F., Kuipers J., van der Wel N.N., Batlle E., Koerten H.K., Peters P.J., Clevers H.C. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell. 116:2004;457-466
-
(2004)
Cell
, vol.116
, pp. 457-466
-
-
Baas, A.F.1
Kuipers, J.2
Van Der Wel, N.N.3
Batlle, E.4
Koerten, H.K.5
Peters, P.J.6
Clevers, H.C.7
-
2
-
-
0037068461
-
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
-
Bardeesy N., Sinha M., Hezel A.F., Signoretti S., Hathaway N.A., Sharpless N.E., Loda M., Carrasco D.R., DePinho R.A. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature. 419:2002;162-167
-
(2002)
Nature
, vol.419
, pp. 162-167
-
-
Bardeesy, N.1
Sinha, M.2
Hezel, A.F.3
Signoretti, S.4
Hathaway, N.A.5
Sharpless, N.E.6
Loda, M.7
Carrasco, D.R.8
Depinho, R.A.9
-
3
-
-
0037524354
-
LKB1, a protein kinase regulating cell proliferation and polarity
-
Boudeau J., Sapkota G., Alessi D.R. LKB1, a protein kinase regulating cell proliferation and polarity. FEBS Lett. 546:2003;159-165
-
(2003)
FEBS Lett.
, vol.546
, pp. 159-165
-
-
Boudeau, J.1
Sapkota, G.2
Alessi, D.R.3
-
4
-
-
0041920901
-
TSC2 regulates VEGF through mTOR-dependent and -independent pathways
-
Brugarolas J.B., Vazquez F., Reddy A., Sellers W.R., Kaelin W.G. Jr. TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell. 4:2003;147-158
-
(2003)
Cancer Cell
, vol.4
, pp. 147-158
-
-
Brugarolas, J.B.1
Vazquez, F.2
Reddy, A.3
Sellers, W.R.4
Kaelin Jr., W.G.5
-
5
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
-
Cantley L.C., Neel B.G. New insights into tumor suppression. PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway Proc. Natl. Acad. Sci. USA. 96:1999;4240-4245
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
6
-
-
2542590883
-
Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene
-
Carretero J., Medina P.P., Pio R., Montuenga L.M., Sanchez-Cespedes M. Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene. Oncogene. 13:2004;4037-4040
-
(2004)
Oncogene
, vol.13
, pp. 4037-4040
-
-
Carretero, J.1
Medina, P.P.2
Pio, R.3
Montuenga, L.M.4
Sanchez-Cespedes, M.5
-
7
-
-
1942469564
-
Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status
-
Cheng S.W., Fryer L.G., Carling D., Shepherd P.R. Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status. J. Biol. Chem. 279:2004;15719-15722
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 15719-15722
-
-
Cheng, S.W.1
Fryer, L.G.2
Carling, D.3
Shepherd, P.R.4
-
8
-
-
0032567252
-
Functional domains of the α1 catalytic subunit of the AMP-activated protein kinase
-
Crute B.E., Seefeld K., Gamble J., Kemp B.E., Witters L.A. Functional domains of the α1 catalytic subunit of the AMP-activated protein kinase. J. Biol. Chem. 273:1998;35347-35354
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 35347-35354
-
-
Crute, B.E.1
Seefeld, K.2
Gamble, J.3
Kemp, B.E.4
Witters, L.A.5
-
9
-
-
0035798097
-
Mammalian TOR: A homeostatic ATP sensor
-
Dennis P.B., Jaeshke A., Saitoh M., Fowler B., Kozma S.C., Thomas G. Mammalian TOR. A homeostatic ATP sensor Science. 294:2001;1102-1105
-
(2001)
Science
, vol.294
, pp. 1102-1105
-
-
Dennis, P.B.1
Jaeshke, A.2
Saitoh, M.3
Fowler, B.4
Kozma, S.C.5
Thomas, G.6
-
10
-
-
0023840093
-
Colonic hamartomas in tuberous sclerosis
-
Devroede G., Lemieux B., Masse S., Lamarche J., Herman P.S. Colonic hamartomas in tuberous sclerosis. Gastroenterology. 94:1988;182-188
-
(1988)
Gastroenterology
, vol.94
, pp. 182-188
-
-
Devroede, G.1
Lemieux, B.2
Masse, S.3
Lamarche, J.4
Herman, P.S.5
-
11
-
-
0033601224
-
Insulin-like growth factor (IGF)-I regulates IGF-binding protein-5 gene expression through the phosphatidylinositol 3-kinase, protein kinase B/Akt, and p70 S6 kinase signaling pathway
-
Duan C., Liimatta M.B., Bottum O.L. Insulin-like growth factor (IGF)-I regulates IGF-binding protein-5 gene expression through the phosphatidylinositol 3-kinase, protein kinase B/Akt, and p70 S6 kinase signaling pathway. J. Biol. Chem. 274:1999;37147-37153
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 37147-37153
-
-
Duan, C.1
Liimatta, M.B.2
Bottum, O.L.3
-
12
-
-
0141705466
-
Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin
-
El-Hashemite N., Walker V., Zhang H., Kwiatkowski D.J. Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin. Cancer Res. 63:2003;5173-5177
-
(2003)
Cancer Res.
, vol.63
, pp. 5173-5177
-
-
El-Hashemite, N.1
Walker, V.2
Zhang, H.3
Kwiatkowski, D.J.4
-
13
-
-
0035142924
-
Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome
-
Entius M.M., Keller J.J., Westerman A.M., van Rees B.P., van Velthuysen M.L., de Goeij A.F., Wilson J.H., Giardiello F.M., Offerhaus G.J. Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome. J. Clin. Pathol. 54:2001;126-131
-
(2001)
J. Clin. Pathol.
, vol.54
, pp. 126-131
-
-
Entius, M.M.1
Keller, J.J.2
Westerman, A.M.3
Van Rees, B.P.4
Van Velthuysen, M.L.5
De Goeij, A.F.6
Wilson, J.H.7
Giardiello, F.M.8
Offerhaus, G.J.9
-
14
-
-
2342545519
-
Target of rapamycin (TOR) An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
-
Fingar D.C., Blenis J. Target of rapamycin (TOR). An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression Oncogene. 23:2004;3151-3171
-
(2004)
Oncogene
, vol.23
, pp. 3151-3171
-
-
Fingar, D.C.1
Blenis, J.2
-
15
-
-
0037097863
-
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
-
Fingar D.C., Salama S., Tsou C., Harlow E., Blenis J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 16:2002;1472-1487
-
(2002)
Genes Dev.
, vol.16
, pp. 1472-1487
-
-
Fingar, D.C.1
Salama, S.2
Tsou, C.3
Harlow, E.4
Blenis, J.5
-
16
-
-
0038433304
-
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
-
Garami A., Zwartkruis F.J.T., Nobukuni T., Joaquin M., Roccio M., Stocker H., Kozma S.C., Hafen E., Bos J.L., Thomas G. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol. Cell. 11:2003;1457-1466
-
(2003)
Mol. Cell
, vol.11
, pp. 1457-1466
-
-
Garami, A.1
Zwartkruis, F.J.T.2
Nobukuni, T.3
Joaquin, M.4
Roccio, M.5
Stocker, H.6
Kozma, S.C.7
Hafen, E.8
Bos, J.L.9
Thomas, G.10
-
17
-
-
0003669987
-
-
(New York: Oxford University Press).
-
Gomez, M.R., Sampson, J.R., and Whittemore, V.H. (1999). Tuberous Sclerosis, 3rd ed. (New York: Oxford University Press).
-
(1999)
Tuberous Sclerosis, 3rd Ed.
-
-
Gomez, M.R.1
Sampson, J.R.2
Whittemore, V.H.3
-
18
-
-
0038199737
-
Management of cellular energy by the AMP-activated protein kinase system
-
Hardie D.G., Scott J.W., Pan D.A., Hudson E.R. Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett. 546:2003;113-120
-
(2003)
FEBS Lett.
, vol.546
, pp. 113-120
-
-
Hardie, D.G.1
Scott, J.W.2
Pan, D.A.3
Hudson, E.R.4
-
20
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade
-
Hawley S.A., Boudeau J., Reid J.L., Mustard K.J., Udd L., Makela T.P., Alessi D.R., Hardie D.G. Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2:2003;28
-
(2003)
J. Biol.
, vol.2
, pp. 28
-
-
Hawley, S.A.1
Boudeau, J.2
Reid, J.L.3
Mustard, K.J.4
Udd, L.5
Makela, T.P.6
Alessi, D.R.7
Hardie, D.G.8
-
21
-
-
0031012344
-
Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis
-
Hemminki A., Tomlinson I., Markie D., Jarvinen H., Sistonen P., Bjorkqvist A.M., Knuutila S., Salovaara R., Bodmer W., Shibata D., et al. Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. Nat. Genet. 15:1997;87-90
-
(1997)
Nat. Genet.
, vol.15
, pp. 87-90
-
-
Hemminki, A.1
Tomlinson, I.2
Markie, D.3
Jarvinen, H.4
Sistonen, P.5
Bjorkqvist, A.M.6
Knuutila, S.7
Salovaara, R.8
Bodmer, W.9
Shibata, D.10
-
22
-
-
0038094504
-
Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)
-
Huang S., Shu L., Dilling M.B., Easton J., Harwood F.C., Ichijo H., Houghton P.J. Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1). Mol. Cell. 11:2003;1491-1501
-
(2003)
Mol. Cell
, vol.11
, pp. 1491-1501
-
-
Huang, S.1
Shu, L.2
Dilling, M.B.3
Easton, J.4
Harwood, F.C.5
Ichijo, H.6
Houghton, P.J.7
-
23
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki K., Li Y., Zhu T., Wu J., Guan K.L. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4:2002;648-657
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
24
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki K., Zhu T., Guan K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell. 115:2003;577-590
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
25
-
-
0037173013
-
Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis
-
Jishage K., Nezu J., Kawase Y., Iwata T., Watanabe M., Miyoshi A., Ose A., Habu K., Kake T., Kamada N., et al. Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis. Proc. Natl. Acad. Sci. USA. 99:2002;8903-8908
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 8903-8908
-
-
Jishage, K.1
Nezu, J.2
Kawase, Y.3
Iwata, T.4
Watanabe, M.5
Miyoshi, A.6
Ose, A.7
Habu, K.8
Kake, T.9
Kamada, N.10
-
26
-
-
0037191045
-
Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent
-
Jaeschke A., Hartkamp J., Saitoh M., Roworth W., Nobukuni T., Hodges A., Sampson J., Thomas G., Lamb R. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent. J. Cell Biol. 159:2002;217-224
-
(2002)
J. Cell Biol.
, vol.159
, pp. 217-224
-
-
Jaeschke, A.1
Hartkamp, J.2
Saitoh, M.3
Roworth, W.4
Nobukuni, T.5
Hodges, A.6
Sampson, J.7
Thomas, G.8
Lamb, R.9
-
27
-
-
0345832116
-
Knockout of the α2 but not α1 5′-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside but not contraction-induced glucose uptake in skeletal muscle
-
Jorgensen S.B., Viollet B., Andreelli F., Frosig C., Birk J.B., Schjerling P., Vaulont S., Richter E.A., Wojtaszewski J.F. Knockout of the α2 but not α1 5′-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside but not contraction-induced glucose uptake in skeletal muscle. J. Biol. Chem. 279:2004;1070-1079
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 1070-1079
-
-
Jorgensen, S.B.1
Viollet, B.2
Andreelli, F.3
Frosig, C.4
Birk, J.B.5
Schjerling, P.6
Vaulont, S.7
Richter, E.A.8
Wojtaszewski, J.F.9
-
28
-
-
0037323971
-
AMP-activated protein kinase, super metabolic regulator
-
Kemp B.E., Stapleton D., Campbell D.J., Chen Z.P., Murthy S., Walter M., Gupta A., Adams J.J., Katsis F., van Denderen B., et al. AMP-activated protein kinase, super metabolic regulator. Biochem. Soc. Trans. 31:2003;162-168
-
(2003)
Biochem. Soc. Trans.
, vol.31
, pp. 162-168
-
-
Kemp, B.E.1
Stapleton, D.2
Campbell, D.J.3
Chen, Z.P.4
Murthy, S.5
Walter, M.6
Gupta, A.7
Adams, J.J.8
Katsis, F.9
Van Denderen, B.10
-
29
-
-
0037108682
-
Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
-
Kenerson H.L., Aicher L.D., True L.D., Yeung R.S. Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Cancer Res. 62:2002;5645-5650
-
(2002)
Cancer Res.
, vol.62
, pp. 5645-5650
-
-
Kenerson, H.L.1
Aicher, L.D.2
True, L.D.3
Yeung, R.S.4
-
30
-
-
0037276069
-
A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway
-
Kimura N., Tokunaga C., Dalal S., Richardson C., Yoshino K., Hara K., Kemp B.E., Witters L.A., Mimura O., Yonezawa K. A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway. Genes Cells. 8:2003;65-79
-
(2003)
Genes Cells
, vol.8
, pp. 65-79
-
-
Kimura, N.1
Tokunaga, C.2
Dalal, S.3
Richardson, C.4
Yoshino, K.5
Hara, K.6
Kemp, B.E.7
Witters, L.A.8
Mimura, O.9
Yonezawa, K.10
-
31
-
-
0036501277
-
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in TSC1 null cells
-
Kwiatkowski D.J., Zhang H., Bandura J.L., Heiberger K.M., Glogauer M., el-Hashemite N., Onda H. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in TSC1 null cells. Hum. Mol. Genet. 11:2002;525-534
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 525-534
-
-
Kwiatkowski, D.J.1
Zhang, H.2
Bandura, J.L.3
Heiberger, K.M.4
Glogauer, M.5
El-Hashemite, N.6
Onda, H.7
-
32
-
-
0242268407
-
MTor is required for hypertrophy of Pten-deficient neuronal soma in vivo
-
Kwon C.H., Zhu X., Zhang J., Baker S.J. mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo. Proc. Natl. Acad. Sci. USA. 100:2003;12923-12928
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 12923-12928
-
-
Kwon, C.H.1
Zhu, X.2
Zhang, J.3
Baker, S.J.4
-
33
-
-
12144287284
-
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
-
Lizcano J.M., Goransson O., Toth R., Deak M., Morrice N.A., Boudeau J., Hawley S.A., Udd L., Makela T.P., Hardie D.G., Alessi D.R. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J. 23:2004;833-843
-
(2004)
EMBO J.
, vol.23
, pp. 833-843
-
-
Lizcano, J.M.1
Goransson, O.2
Toth, R.3
Deak, M.4
Morrice, N.A.5
Boudeau, J.6
Hawley, S.A.7
Udd, L.8
Makela, T.P.9
Hardie, D.G.10
Alessi, D.R.11
-
34
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewith R., Jacinto E., Wullschleger S., Lorberg A., Crespo J.L., Bonenfant D., Oppliger W., Jenoe P., Hall M.N. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell. 10:2002;457-468
-
(2002)
Mol. Cell
, vol.10
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
35
-
-
0038540963
-
United at last: The tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling
-
Manning B.D., Cantley L.C. United at last. The tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling Biochem. Soc. Trans. 31:2003;573-578
-
(2003)
Biochem. Soc. Trans.
, vol.31
, pp. 573-578
-
-
Manning, B.D.1
Cantley, L.C.2
-
36
-
-
0036342294
-
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway
-
Manning B.D., Tee A.R., Logsdon M.N., Blenis J., Cantley L.C. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway. Mol. Cell. 10:2002;151-162
-
(2002)
Mol. Cell
, vol.10
, pp. 151-162
-
-
Manning, B.D.1
Tee, A.R.2
Logsdon, M.N.3
Blenis, J.4
Cantley, L.C.5
-
37
-
-
0037461735
-
A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity
-
Martin S.G., St Johnston D. A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. Nature. 421:2003;379-384
-
(2003)
Nature
, vol.421
, pp. 379-384
-
-
Martin, S.G.1
St Johnston, D.2
-
38
-
-
0037089467
-
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice
-
Miyoshi H., Nakau M., Ishikawa T.O., Seldin M.F., Oshima M., Taketo M.M. Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer Res. 62:2002;2261-2266
-
(2002)
Cancer Res.
, vol.62
, pp. 2261-2266
-
-
Miyoshi, H.1
Nakau, M.2
Ishikawa, T.O.3
Seldin, M.F.4
Oshima, M.5
Taketo, M.M.6
-
39
-
-
17944377486
-
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
-
Neshat M.S., Mellinghoff I.K., Tran C., Stiles B., Thomas G., Petersen R., Frost P., Gibbons J.J., Wu H., Sawyers C.L. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc. Natl. Acad. Sci. USA. 98:2001;10314-10319
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 10314-10319
-
-
Neshat, M.S.1
Mellinghoff, I.K.2
Tran, C.3
Stiles, B.4
Thomas, G.5
Petersen, R.6
Frost, P.7
Gibbons, J.J.8
Wu, H.9
Sawyers, C.L.10
-
40
-
-
0036943576
-
TSC2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway
-
Onda H., Crino P.B., Zhang H., Murphey R.D., Rastelli L., Gould-Rothberg B.E., Kwiatkowski D.J. TSC2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway. Mol. Cell. Neurosci. 21:2002;561-574
-
(2002)
Mol. Cell. Neurosci.
, vol.21
, pp. 561-574
-
-
Onda, H.1
Crino, P.B.2
Zhang, H.3
Murphey, R.D.4
Rastelli, L.5
Gould-Rothberg, B.E.6
Kwiatkowski, D.J.7
-
42
-
-
17944368972
-
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in PTEN+/- mice
-
Podsypanina K., Lee R.T., Politis C., Hennessy I., Crane A., Puc J., Neshat M., Wang H., Yang L., Gibbons J., et al. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in PTEN+/- mice. Proc. Natl. Acad. Sci. USA. 98:2001;10320-10325
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 10320-10325
-
-
Podsypanina, K.1
Lee, R.T.2
Politis, C.3
Hennessy, I.4
Crane, A.5
Puc, J.6
Neshat, M.7
Wang, H.8
Yang, L.9
Gibbons, J.10
-
43
-
-
0242361561
-
Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes
-
Rajasekhar V.K., Viale A., Socci N.D., Wiedmann M., Hu X., Holland E.C. Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes. Mol. Cell. 12:2003;889-901
-
(2003)
Mol. Cell
, vol.12
, pp. 889-901
-
-
Rajasekhar, V.K.1
Viale, A.2
Socci, N.D.3
Wiedmann, M.4
Hu, X.5
Holland, E.C.6
-
44
-
-
0033514509
-
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
-
Ramaswamy S., Nakamura N., Vazquez F., Batt D.B., Perera S., Roberts T.M., Sellers W.R. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc. Natl. Acad. Sci. USA. 96:1999;2110-2115
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 2110-2115
-
-
Ramaswamy, S.1
Nakamura, N.2
Vazquez, F.3
Batt, D.B.4
Perera, S.5
Roberts, T.M.6
Sellers, W.R.7
-
45
-
-
0037125996
-
Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis
-
Rossi D.J., Ylikorkala A., Korsisaari N., Salovaara R., Luukko K., Launonen V., Henkemeyer M., Ristimaki A., Aaltonen L.A., Makela T.P. Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis. Proc. Natl. Acad. Sci. USA. 99:2002;12327-12332
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 12327-12332
-
-
Rossi, D.J.1
Ylikorkala, A.2
Korsisaari, N.3
Salovaara, R.4
Luukko, K.5
Launonen, V.6
Henkemeyer, M.7
Ristimaki, A.8
Aaltonen, L.A.9
Makela, T.P.10
-
46
-
-
17144474893
-
Activity of LKB1 and AMPK-related kinases in skeletal muscle: Effects of contraction, phenformin and AICAR
-
Published online April 6, 2004.
-
Sakamoto, K., Goransson, O., Hardie, D.G., and Alessi, D.R. (2004). Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin and AICAR. Am. J. Physiol. Endocrinol. Metab. Published online April 6, 2004.
-
(2004)
Am. J. Physiol. Endocrinol. Metab.
-
-
Sakamoto, K.1
Goransson, O.2
Hardie, D.G.3
Alessi, D.R.4
-
47
-
-
0036645286
-
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung
-
Sanchez-Cespedes M., Parrella P., Esteller M., Nomoto S., Trink B., Engles J.M., Westra W.H., Herman J.G., Sidransky D. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res. 62:2002;3659-3662
-
(2002)
Cancer Res.
, vol.62
, pp. 3659-3662
-
-
Sanchez-Cespedes, M.1
Parrella, P.2
Esteller, M.3
Nomoto, S.4
Trink, B.5
Engles, J.M.6
Westra, W.H.7
Herman, J.G.8
Sidransky, D.9
-
48
-
-
85047691317
-
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations
-
Scott J.W., Hawley S.A., Green K.A., Anis M., Stewart G., Scullion G.A., Norman D.G., Hardie D.G. CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. J. Clin. Invest. 113:2004;274-284
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 274-284
-
-
Scott, J.W.1
Hawley, S.A.2
Green, K.A.3
Anis, M.4
Stewart, G.5
Scullion, G.A.6
Norman, D.G.7
Hardie, D.G.8
-
49
-
-
0141923009
-
Integration of growth factor and nutrient signaling: Implications for cancer biology
-
Shamji A.F., Nghiem P., Schreiber S.L. Integration of growth factor and nutrient signaling. Implications for cancer biology Mol. Cell. 12:2003;271-280
-
(2003)
Mol. Cell
, vol.12
, pp. 271-280
-
-
Shamji, A.F.1
Nghiem, P.2
Schreiber, S.L.3
-
50
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
Shaw R.J., Kosmatka M., Bardeesy N., Hurley R.L., Witters L.A., DePinho R.A., Cantley L.C. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl. Acad. Sci. USA. 101:2004;3329-3335
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
Depinho, R.A.6
Cantley, L.C.7
-
51
-
-
0036735346
-
Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779
-
Shi Y., Gera J., Hu L., Hsu J., Bookstein R., Li W., Lichtenstein A. Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779. Cancer Res. 62:2002;5027-5034
-
(2002)
Cancer Res.
, vol.62
, pp. 5027-5034
-
-
Shi, Y.1
Gera, J.2
Hu, L.3
Hsu, J.4
Bookstein, R.5
Li, W.6
Lichtenstein, A.7
-
52
-
-
0032475861
-
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
-
Stambolic V., Suzuki A., delaPompa J.L., Brothers G.M., Mirtsos C., Sasaki T., Ruland J., Penninger J.M., Sioderovski D.P., Mak T.W. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell. 95:1998;29-39
-
(1998)
Cell
, vol.95
, pp. 29-39
-
-
Stambolic, V.1
Suzuki, A.2
Delapompa, J.L.3
Brothers, G.M.4
Mirtsos, C.5
Sasaki, T.6
Ruland, J.7
Penninger, J.M.8
Sioderovski, D.P.9
Mak, T.W.10
-
53
-
-
0034141355
-
The regulation of AMP-activated protein kinase by phosphorylation
-
Stein S.C., Woods A., Jones N.A., Davison M.D., Carling D. The regulation of AMP-activated protein kinase by phosphorylation. Biochem. J. 345:2000;437-443
-
(2000)
Biochem. J.
, vol.345
, pp. 437-443
-
-
Stein, S.C.1
Woods, A.2
Jones, N.A.3
Davison, M.D.4
Carling, D.5
-
54
-
-
13044305289
-
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5-triphosphate and Akt/protein kinase B signaling pathway
-
Sun H., Lesche R., Li D., Liliental J., Zhang H., Gao J., Gavrilova N., Mueller B., Liu X., Wu H. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3, 4, 5-triphosphate and Akt/protein kinase B signaling pathway. Proc. Natl. Acad. Sci. USA. 96:1999;6199-6204
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 6199-6204
-
-
Sun, H.1
Lesche, R.2
Li, D.3
Liliental, J.4
Zhang, H.5
Gao, J.6
Gavrilova, N.7
Mueller, B.8
Liu, X.9
Wu, H.10
-
55
-
-
0033529838
-
Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest
-
Tiainen M., Ylikorkala A., Makela T.P. Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. Proc. Natl. Acad. Sci. USA. 96:1999;9248-9251
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 9248-9251
-
-
Tiainen, M.1
Ylikorkala, A.2
Makela, T.P.3
-
56
-
-
0037251455
-
The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity
-
Viollet B., Andreelli F., Jorgensen S.B., Perrin C., Geloen A., Flamez D., Mu J., Lenzner C., Baud O., Bennoun M., et al. The AMP-activated protein kinase .2 catalytic subunit controls whole-body insulin sensitivity. J. Clin. Invest. 111:2003;91-98
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 91-98
-
-
Viollet, B.1
Andreelli, F.2
Jorgensen, S.B.3
Perrin, C.4
Geloen, A.5
Flamez, D.6
Mu, J.7
Lenzner, C.8
Baud, O.9
Bennoun, M.10
-
57
-
-
0032893658
-
Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence
-
Wang Z.J., Ellis I., Zauber P., Iwama T., Marchese C., Talbot I., Xue W.H., Yan Z.Y., Tomlinson I. Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence. J. Pathol. 188:1999;9-13
-
(1999)
J. Pathol.
, vol.188
, pp. 9-13
-
-
Wang, Z.J.1
Ellis, I.2
Zauber, P.3
Iwama, T.4
Marchese, C.5
Talbot, I.6
Xue, W.H.7
Yan, Z.Y.8
Tomlinson, I.9
-
58
-
-
0034090975
-
The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry
-
Watts J.L., Morton D.G., Bestman J., Kemphues K.J. The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. Development. 127:2000;1467-1475
-
(2000)
Development
, vol.127
, pp. 1467-1475
-
-
Watts, J.L.1
Morton, D.G.2
Bestman, J.3
Kemphues, K.J.4
-
59
-
-
10744230065
-
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
-
Woods A., Johnstone S.R., Dickerson K., Leiper F.C., Fryer L.G., Neumann D., Schlattner U., Wallimann T., Carlson M., Carling D. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr. Biol. 13:2003;2004-2008
-
(2003)
Curr. Biol.
, vol.13
, pp. 2004-2008
-
-
Woods, A.1
Johnstone, S.R.2
Dickerson, K.3
Leiper, F.C.4
Fryer, L.G.5
Neumann, D.6
Schlattner, U.7
Wallimann, T.8
Carlson, M.9
Carling, D.10
-
60
-
-
0035903028
-
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
-
Ylikorkala A., Rossi D.J., Korsisaari N., Luukko K., Alitalo K., Henkemeyer M., Makela T.P. Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science. 293:2001;1323-1326
-
(2001)
Science
, vol.293
, pp. 1323-1326
-
-
Ylikorkala, A.1
Rossi, D.J.2
Korsisaari, N.3
Luukko, K.4
Alitalo, K.5
Henkemeyer, M.6
Makela, T.P.7
-
61
-
-
0347988005
-
Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR
-
Zhang H., Cicchetti G., Onda H., Koon H.B., Asrican K., Bajraszewski N., Vazquez F., Carpenter C.L., Kwiatkowski D.J. Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. J. Clin. Invest. 112:2003;1223-1233
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1223-1233
-
-
Zhang, H.1
Cicchetti, G.2
Onda, H.3
Koon, H.B.4
Asrican, K.5
Bajraszewski, N.6
Vazquez, F.7
Carpenter, C.L.8
Kwiatkowski, D.J.9
|