Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Nature

Volumn 431, Issue 7005, 2004, Pages 200-205

  Um, Sung Hee ^a   Frigerio, Francesca ^a   Watanabe, Mitsuhiro ^b   Picard, Frédéric ^b,d   Joaquin, Manel ^a   Sticker, Melanie ^a   Fumagalli, Stefano ^a   Allegrini, Peter R ^c   Kozma, Sara C ^a,e   Auwerx, Johan ^b   Thomas, George ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^b INSTITUT CLINIQUE DE LA SOURIS   (France)

^c NOVARTIS PHARMA AG   (Switzerland)

^d LAVAL UNIVERSITY   (Canada)

^e UNIVERSITY OF CINCINNATI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; GENES; GLUCOSE; LIVING SYSTEMS STUDIES; NUTRITION; PROTEINS;

FASTING; OBESITY; RAPAMYCIN; SIGNALLING MECHANISMS;

INSULIN;

FATTY ACID; GLUCOSE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; S6 KINASE;

MEDICINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID OXIDATION; GENETIC MODEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; MALE; MOUSE; NONHUMAN; OBESITY; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WILD TYPE;

ADIPOCYTES; AGING; ANIMALS; BLOOD GLUCOSE; DIETARY FATS; ENZYME ACTIVATION; FASTING; FATTY ACIDS, NONESTERIFIED; GENE DELETION; INSULIN; INSULIN RESISTANCE; LIPOLYSIS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OBESITY; OXIDATION-REDUCTION; PHOSPHOPROTEINS; PHOSPHORYLATION; RECEPTOR, INSULIN; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA, MESSENGER; SIGNAL TRANSDUCTION;

ANIMALIA; MAMMALIA;

EID: 4544220704     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02866     Document Type: Article

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