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Volumn 10, Issue 3, 2002, Pages 457-468

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; PROTEIN; PROTEIN AVO 1; PROTEIN AVO 2; PROTEIN AVO 3; PROTEIN CONTROLLER OF GROWTH 1; PROTEIN TARGET OF RAPAMYCIN 1; PROTEIN TARGET OF RAPAMYCIN 2; PROTEIN TARGET OF RAPAMYCIN COMPLEX 1; RAPAMYCIN; UNCLASSIFIED DRUG;

EID: 0036753494     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(02)00636-6     Document Type: Article
Times cited : (1578)

References (56)
  • 1
    • 0032802378 scopus 로고    scopus 로고
    • Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast
    • Alarcon C.M., Heitman J., Cardenas M.E. Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast. Mol. Biol. Cell. 10:1999;2531-2546
    • (1999) Mol. Biol. Cell , vol.10 , pp. 2531-2546
    • Alarcon, C.M.1    Heitman, J.2    Cardenas, M.E.3
  • 2
    • 0029392854 scopus 로고
    • HEAT repeats in the Huntington's disease protein
    • Andrade M.A., Bork P. HEAT repeats in the Huntington's disease protein. Nat. Genet. 11:1995;115-116
    • (1995) Nat. Genet , vol.11 , pp. 115-116
    • Andrade, M.A.1    Bork, P.2
  • 4
    • 0033540030 scopus 로고    scopus 로고
    • The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
    • Beck T., Hall M.N. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature. 402:1999;689-692
    • (1999) Nature , vol.402 , pp. 689-692
    • Beck, T.1    Hall, M.N.2
  • 5
    • 0033588918 scopus 로고    scopus 로고
    • Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast
    • Beck T., Schmidt A., Hall M.N. Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast. J. Cell Biol. 146:1999;1227-1238
    • (1999) J. Cell Biol , vol.146 , pp. 1227-1238
    • Beck, T.1    Schmidt, A.2    Hall, M.N.3
  • 6
    • 0032515061 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Δ mutant
    • Beeler T., Bacikova D., Gable K., Hopkins L., Johnson C., Slife H., Dunn T. The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Δ mutant. J. Biol. Chem. 273:1998;30688-30694
    • (1998) J. Biol. Chem , vol.273 , pp. 30688-30694
    • Beeler, T.1    Bacikova, D.2    Gable, K.3    Hopkins, L.4    Johnson, C.5    Slife, H.6    Dunn, T.7
  • 7
    • 0028024386 scopus 로고
    • The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast
    • Benedetti H., Raths S., Crausaz F., Riezman H. The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast. Mol. Biol. Cell. 5:1994;1023-1037
    • (1994) Mol. Biol. Cell , vol.5 , pp. 1023-1037
    • Benedetti, H.1    Raths, S.2    Crausaz, F.3    Riezman, H.4
  • 9
    • 0033573016 scopus 로고    scopus 로고
    • The TOR signaling cascade regulates gene expression in response to nutrients
    • Cardenas M.E., Cutler N.S., Lorenz M.C., Di Como C.J., Heitman J. The TOR signaling cascade regulates gene expression in response to nutrients. Genes Dev. 13:1999;3271-3279
    • (1999) Genes Dev , vol.13 , pp. 3271-3279
    • Cardenas, M.E.1    Cutler, N.S.2    Lorenz, M.C.3    Di Como, C.J.4    Heitman, J.5
  • 10
    • 0030722988 scopus 로고    scopus 로고
    • A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium
    • Chen M.Y., Long Y., Devreotes P.N. A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium. Genes Dev. 11:1997;3218-3231
    • (1997) Genes Dev , vol.11 , pp. 3218-3231
    • Chen, M.Y.1    Long, Y.2    Devreotes, P.N.3
  • 11
    • 0035064356 scopus 로고    scopus 로고
    • Screening from a subtracted embryonic chick hindbrain cDNA library: Identification of genes expressed during hindbrain, midbrain and cranial neural crest development
    • Christiansen J.H., Coles E.G., Robinson V., Pasini A., Wilkinson D.G. Screening from a subtracted embryonic chick hindbrain cDNA library. identification of genes expressed during hindbrain, midbrain and cranial neural crest development Mech. Dev. 102:2001;119-133
    • (2001) Mech. Dev , vol.102 , pp. 119-133
    • Christiansen, J.H.1    Coles, E.G.2    Robinson, V.3    Pasini, A.4    Wilkinson, D.G.5
  • 13
    • 0000593120 scopus 로고
    • Preparation of yeast RNA
    • F.M. Ausubel, R. Brent, R.E. Kinston, D.D. Moore, J.G. Seidman, J.A. Smith, & K. Struhl. New York: John Wiley & Sons
    • Collart M.A., Oliviero S. Preparation of yeast RNA. Ausubel F.M., Brent R., Kinston R.E., Moore D.D., Seidman J.G., Smith J.A., Struhl K. Current Protocols in Molecular Biology. 1993;John Wiley & Sons, New York. 13.12.1-13.12.5.pp
    • (1993) Current Protocols in Molecular Biology , pp. 13121-13125
    • Collart, M.A.1    Oliviero, S.2
  • 14
    • 0037076314 scopus 로고    scopus 로고
    • The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine
    • Crespo J.L., Powers T., Fowler B., Hall M.N. The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Proc. Natl. Acad. Sci. USA. 99:2002;6784-6789
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 6784-6789
    • Crespo, J.L.1    Powers, T.2    Fowler, B.3    Hall, M.N.4
  • 15
    • 0032999830 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): Balancing the opposing forces of protein synthesis and degradation
    • Dennis P.B., Fumagalli S., Thomas G. Target of rapamycin (TOR). balancing the opposing forces of protein synthesis and degradation Curr. Opin. Genet. Dev. 9:1999;49-54
    • (1999) Curr. Opin. Genet. Dev , vol.9 , pp. 49-54
    • Dennis, P.B.1    Fumagalli, S.2    Thomas, G.3
  • 16
    • 0029808294 scopus 로고    scopus 로고
    • Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases
    • Di Como C.J., Arndt K.T. Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases. Genes Dev. 10:1996;1904-1916
    • (1996) Genes Dev , vol.10 , pp. 1904-1916
    • Di Como, C.J.1    Arndt, K.T.2
  • 17
    • 0035312747 scopus 로고    scopus 로고
    • Regulation of translation initiation by FRAP/mTOR
    • Gingras A.C., Raught B., Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 15:2001;807-826
    • (2001) Genes Dev , vol.15 , pp. 807-826
    • Gingras, A.C.1    Raught, B.2    Sonenberg, N.3
  • 18
    • 0033150672 scopus 로고    scopus 로고
    • Topological characteristics of helical repeat proteins
    • Groves M.R., Barford D. Topological characteristics of helical repeat proteins. Curr. Opin. Struct. Biol. 9:1999;383-389
    • (1999) Curr. Opin. Struct. Biol , vol.9 , pp. 383-389
    • Groves, M.R.1    Barford, D.2
  • 20
    • 0033592983 scopus 로고    scopus 로고
    • Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins
    • Hardwick J.S., Kuruvilla F.G., Tong J.K., Shamji A.F., Schreiber S.L. Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins. Proc. Natl. Acad. Sci. USA. 96:1999;14866-14870
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 14866-14870
    • Hardwick, J.S.1    Kuruvilla, F.G.2    Tong, J.K.3    Shamji, A.F.4    Schreiber, S.L.5
  • 21
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • Heitman J., Movva N.R., Hall M.N. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science. 253:1991;905-909. a
    • (1991) Science , vol.253 , pp. 905-909
    • Heitman, J.1    Movva, N.R.2    Hall, M.N.3
  • 22
    • 0026012156 scopus 로고
    • FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae
    • Heitman J., Movva N.R., Hiestand P.C., Hall M.N. FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA. 88:1991;1948-1952. b
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 1948-1952
    • Heitman, J.1    Movva, N.R.2    Hiestand, P.C.3    Hall, M.N.4
  • 23
    • 0028137771 scopus 로고
    • TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast
    • Helliwell S.B., Wagner P., Kunz J., Deuter-Reinhard M., Henriquez R., Hall M.N. TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Mol. Biol. Cell. 5:1994;105-118
    • (1994) Mol. Biol. Cell , vol.5 , pp. 105-118
    • Helliwell, S.B.1    Wagner, P.2    Kunz, J.3    Deuter-Reinhard, M.4    Henriquez, R.5    Hall, M.N.6
  • 24
    • 0031882240 scopus 로고    scopus 로고
    • TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae
    • Helliwell S.B., Howald I., Barbet N., Hall M.N. TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae. Genetics. 148:1998;99-112. a
    • (1998) Genetics , vol.148 , pp. 99-112
    • Helliwell, S.B.1    Howald, I.2    Barbet, N.3    Hall, M.N.4
  • 25
    • 0032488042 scopus 로고    scopus 로고
    • The Rho1 effector Pkc1, but not Bni1, mediates signalling from Tor2 to the actin cytoskeleton
    • Helliwell S.B., Schmidt A., Ohya Y., Hall M.N. The Rho1 effector Pkc1, but not Bni1, mediates signalling from Tor2 to the actin cytoskeleton. Curr. Biol. 8:1998;1211-1214. b
    • (1998) Curr. Biol , vol.8 , pp. 1211-1214
    • Helliwell, S.B.1    Schmidt, A.2    Ohya, Y.3    Hall, M.N.4
  • 27
    • 0035930339 scopus 로고    scopus 로고
    • TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway
    • Jacinto E., Guo B., Arndt K.T., Schmelzle T., Hall M.N. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway. Mol. Cell. 8:2001;1017-1026
    • (2001) Mol. Cell , vol.8 , pp. 1017-1026
    • Jacinto, E.1    Guo, B.2    Arndt, K.T.3    Schmelzle, T.4    Hall, M.N.5
  • 28
    • 0033577745 scopus 로고    scopus 로고
    • Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast
    • Jiang Y., Broach J.R. Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast. EMBO J. 18:1999;2782-2792
    • (1999) EMBO J , vol.18 , pp. 2782-2792
    • Jiang, Y.1    Broach, J.R.2
  • 29
    • 0035006616 scopus 로고    scopus 로고
    • Fission yeast tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature
    • Kawai M., Nakashima A., Ueno M., Ushimaru T., Aiba K., Doi H., Uritani M. Fission yeast tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature. Curr. Genet. 39:2001;166-174
    • (2001) Curr. Genet , vol.39 , pp. 166-174
    • Kawai, M.1    Nakashima, A.2    Ueno, M.3    Ushimaru, T.4    Aiba, K.5    Doi, H.6    Uritani, M.7
  • 30
    • 0030928485 scopus 로고    scopus 로고
    • A wat1 mutant of fission yeast is defective in cell morphology
    • Kemp J.T., Balasubramanian M.K., Gould K.L. A wat1 mutant of fission yeast is defective in cell morphology. Mol. Gen. Genet. 254:1997;127-138
    • (1997) Mol. Gen. Genet , vol.254 , pp. 127-138
    • Kemp, J.T.1    Balasubramanian, M.K.2    Gould, K.L.3
  • 32
    • 0034645038 scopus 로고    scopus 로고
    • Mechanism of metabolic control: Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors
    • Komeili A., Wedaman K.P., O'Shea E.K., Powers T. Mechanism of metabolic control. target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors J. Cell Biol. 151:2000;863-878
    • (2000) J. Cell Biol , vol.151 , pp. 863-878
    • Komeili, A.1    Wedaman, K.P.2    O'Shea, E.K.3    Powers, T.4
  • 33
    • 0027311858 scopus 로고
    • Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
    • Kunz J., Henriquez R., Schneider U., Deuter-Reinhard M., Movva N.R., Hall M.N. Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell. 73:1993;585-596
    • (1993) Cell , vol.73 , pp. 585-596
    • Kunz, J.1    Henriquez, R.2    Schneider, U.3    Deuter-Reinhard, M.4    Movva, N.R.5    Hall, M.N.6
  • 34
    • 0034711280 scopus 로고    scopus 로고
    • HEAT repeats mediate plasma membrane localization of Tor2p in yeast
    • Kunz J., Schneider U., Howald I., Schmidt A., Hall M.N. HEAT repeats mediate plasma membrane localization of Tor2p in yeast. J. Biol. Chem. 275:2000;37011-37020
    • (2000) J. Biol. Chem , vol.275 , pp. 37011-37020
    • Kunz, J.1    Schneider, U.2    Howald, I.3    Schmidt, A.4    Hall, M.N.5
  • 35
    • 0032849043 scopus 로고    scopus 로고
    • A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium
    • Lee S., Parent C.A., Insall R., Firtel R.A. A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium. Mol. Biol. Cell. 10:1999;2829-2845
    • (1999) Mol. Biol. Cell , vol.10 , pp. 2829-2845
    • Lee, S.1    Parent, C.A.2    Insall, R.3    Firtel, R.A.4
  • 36
    • 0037126596 scopus 로고    scopus 로고
    • RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p
    • Liu Z., Sekito T., Epstein C.B., Butow R.A. RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p. EMBO J. 20:2001;7209-7219
    • (2001) EMBO J , vol.20 , pp. 7209-7219
    • Liu, Z.1    Sekito, T.2    Epstein, C.B.3    Butow, R.A.4
  • 37
    • 0031820288 scopus 로고    scopus 로고
    • Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
    • Longtine M.S., McKenzie A. III, Demarini D.J., Shah N.G., Wach A., Brachat A., Philippsen P., Pringle J.R. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast. 14:1998;953-961
    • (1998) Yeast , vol.14 , pp. 953-961
    • Longtine, M.S.1    McKenzie, A.2    Demarini, D.J.3    Shah, N.G.4    Wach, A.5    Brachat, A.6    Philippsen, P.7    Pringle, J.R.8
  • 38
    • 0028825698 scopus 로고
    • TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin
    • Lorenz M.C., Heitman J. TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin. J. Biol. Chem. 270:1995;27531-27537
    • (1995) J. Biol. Chem , vol.270 , pp. 27531-27537
    • Lorenz, M.C.1    Heitman, J.2
  • 42
    • 0030809956 scopus 로고    scopus 로고
    • Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8
    • Roberg K.J., Bickel S., Rowley N., Kaiser C.A. Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8. Genetics. 147:1997;1569-1584
    • (1997) Genetics , vol.147 , pp. 1569-1584
    • Roberg, K.J.1    Bickel, S.2    Rowley, N.3    Kaiser, C.A.4
  • 43
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle T., Hall M.N. TOR, a central controller of cell growth. Cell. 103:2000;253-262
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 44
    • 0036174159 scopus 로고    scopus 로고
    • Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast
    • Schmelzle T., Helliwell S.B., Hall M.N. Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast. Mol. Cell. Biol. 22:2002;1329-1339
    • (2002) Mol. Cell. Biol , vol.22 , pp. 1329-1339
    • Schmelzle, T.1    Helliwell, S.B.2    Hall, M.N.3
  • 45
    • 0030479340 scopus 로고    scopus 로고
    • TOR2 is required for organization of the actin cytoskeleton in yeast
    • Schmidt A., Kunz J., Hall M.N. TOR2 is required for organization of the actin cytoskeleton in yeast. Proc. Natl. Acad. Sci. USA. 93:1996;13780-13785
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13780-13785
    • Schmidt, A.1    Kunz, J.2    Hall, M.N.3
  • 46
    • 0030906569 scopus 로고    scopus 로고
    • The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2
    • Schmidt A., Bickle M., Beck T., Hall M.N. The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell. 88:1997;531-542
    • (1997) Cell , vol.88 , pp. 531-542
    • Schmidt, A.1    Bickle, M.2    Beck, T.3    Hall, M.N.4
  • 47
    • 0032403058 scopus 로고    scopus 로고
    • The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease
    • Schmidt A., Beck T., Koller A., Kunz J., Hall M.N. The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease. EMBO J. 17:1998;6924-6931
    • (1998) EMBO J , vol.17 , pp. 6924-6931
    • Schmidt, A.1    Beck, T.2    Koller, A.3    Kunz, J.4    Hall, M.N.5
  • 48
    • 0026030568 scopus 로고
    • Chemistry and biology of the immunophilins and their immunosuppressive ligands
    • Schreiber S.L. Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science. 251:1991;283-287
    • (1991) Science , vol.251 , pp. 283-287
    • Schreiber, S.L.1
  • 49
    • 0025978949 scopus 로고
    • Getting started with yeast
    • Sherman F. Getting started with yeast. Methods Enzymol. 194:1991;3-21
    • (1991) Methods Enzymol , vol.194 , pp. 3-21
    • Sherman, F.1
  • 50
    • 0029927505 scopus 로고    scopus 로고
    • Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels
    • Shevchenko A., Wilm M., Vorm O., Mann M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal. Chem. 68:1996;850-858
    • (1996) Anal. Chem , vol.68 , pp. 850-858
    • Shevchenko, A.1    Wilm, M.2    Vorm, O.3    Mann, M.4
  • 51
    • 0033983556 scopus 로고    scopus 로고
    • Novel WD-repeat protein Mip1p facilitates function of the meiotic regulator Mei2p in fission yeast
    • Shinozaki-Yabana S., Watanabe Y., Yamamoto M. Novel WD-repeat protein Mip1p facilitates function of the meiotic regulator Mei2p in fission yeast. Mol. Cell. Biol. 20:2000;1234-1242
    • (2000) Mol. Cell. Biol , vol.20 , pp. 1234-1242
    • Shinozaki-Yabana, S.1    Watanabe, Y.2    Yamamoto, M.3
  • 53
    • 0035831446 scopus 로고    scopus 로고
    • The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine
    • Weisman R., Choder M. The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine. J. Biol. Chem. 276:2001;7027-7032
    • (2001) J. Biol. Chem , vol.276 , pp. 7027-7032
    • Weisman, R.1    Choder, M.2
  • 55
    • 0035072833 scopus 로고    scopus 로고
    • A motif-based profile scanning approach for genome-wide prediction of signaling pathways
    • Yaffe M.B., Leparc G.G., Lai J., Obata T., Volinia S., Cantley L.C. A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nat. Biotechnol. 19:2001;348-353
    • (2001) Nat. Biotechnol , vol.19 , pp. 348-353
    • Yaffe, M.B.1    Leparc, G.G.2    Lai, J.3    Obata, T.4    Volinia, S.5    Cantley, L.C.6
  • 56
    • 0029071264 scopus 로고
    • TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin
    • Zheng X.F., Florentino D., Chen J., Crabtree G.R., Schreiber S.L. TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell. 82:1995;121-130
    • (1995) Cell , vol.82 , pp. 121-130
    • Zheng, X.F.1    Florentino, D.2    Chen, J.3    Crabtree, G.R.4    Schreiber, S.L.5


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