Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

Molecular Cell

Volumn 29, Issue 5, 2008, Pages 541-551

  Ozcan, Umut ^a   Ozcan, Lale ^a   Yilmaz, Erkan ^a   Düvel, Katrin ^a   Sahin, Mustafa ^b   Manning, Brendan D ^a   Hotamisligil, Gökhan S ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

CELLCYCLE; PROTEINS; SIGNALING

Indexed keywords

CHAPERONE; INSULIN; INSULIN RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; TUBERIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; GENE LOSS; HUMAN; HUMAN CELL; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; TUMOR SUPPRESSOR GENE; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE; CHILD, PRESCHOOL; EIF-2 KINASE; ENDOPLASMIC RETICULUM; GENES, TUMOR SUPPRESSOR; HUMANS; INSULIN; INSULIN RESISTANCE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASMS; NEURONS; OXIDATIVE STRESS; PHENYLBUTYRATES; SIGNAL TRANSDUCTION; SIROLIMUS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

MAMMALIA;

EID: 40649104735     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2007.12.023     Document Type: Article

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