-
1
-
-
0031919552
-
Insulin signal transduction through protein kinase cascades
-
Avruch, J. Insulin signal transduction through protein kinase cascades. Mol. Cell Biochem. 182, 31-48 (1998).
-
(1998)
Mol. Cell Biochem.
, vol.182
, pp. 31-48
-
-
Avruch, J.1
-
2
-
-
0025343230
-
Signal transduction by receptors with tyrosine kinase activity
-
Ullrich, A. & Schlessinger, J. Signal transduction by receptors with tyrosine kinase activity. Cell 61, 203-212 (1990).
-
(1990)
Cell
, vol.61
, pp. 203-212
-
-
Ullrich, A.1
Schlessinger, J.2
-
3
-
-
0033525870
-
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
-
Elchebly, M. et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283, 1544-1548 (1999).
-
(1999)
Science
, vol.283
, pp. 1544-1548
-
-
Elchebly, M.1
-
4
-
-
2942628012
-
Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms
-
Ueki, K., Kondo, T. & Kahn, C. R. Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol. Cell Biol. 24, 5434-5446 (2004).
-
(2004)
Mol. Cell Biol.
, vol.24
, pp. 5434-5446
-
-
Ueki, K.1
Kondo, T.2
Kahn, C.R.3
-
5
-
-
0035930605
-
SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-α in the adipose tissue of obese mice
-
Emanuelli, B. et al. SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-α in the adipose tissue of obese mice. J. Biol. Chem. 276, 47944-47949 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47944-47949
-
-
Emanuelli, B.1
-
6
-
-
0030657907
-
Reduced insulin receptor signaling in the obese spontaneously hypertensive Koletsky rat
-
Friedman, J. E. et al. Reduced insulin receptor signaling in the obese spontaneously hypertensive Koletsky rat. Am. J. Physiol. 273, E1014-E1023 (1997).
-
(1997)
Am. J. Physiol.
, vol.273
-
-
Friedman, J.E.1
-
7
-
-
0025813375
-
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
-
Sun, X. J. et al. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352, 73-77 (1991).
-
(1991)
Nature
, vol.352
, pp. 73-77
-
-
Sun, X.J.1
-
8
-
-
0029148591
-
Role of IRS-2 in insulin and cytokine signalling
-
Sun, X. J. et al. Role of IRS-2 in insulin and cytokine signalling. Nature 377, 173-177 (1995).
-
(1995)
Nature
, vol.377
, pp. 173-177
-
-
Sun, X.J.1
-
9
-
-
0030995946
-
The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family
-
Lavan, B. E., Lane, W. S. & Lienhard, G. E. The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family. J. Biol. Chem. 272, 11439-11443 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 11439-11443
-
-
Lavan, B.E.1
Lane, W.S.2
Lienhard, G.E.3
-
10
-
-
0032562592
-
Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells
-
Fantin, V. R. et al. Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells. J. Biol. Chem. 273, 10726-10732 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 10726-10732
-
-
Fantin, V.R.1
-
11
-
-
0037816152
-
Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5
-
Cai, D., Dhe-Paganon, S., Melendez, P. A., Lee, J. & Shoelson, S. E. Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. J. Biol. Chem. 278, 25323-25330 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 25323-25330
-
-
Cai, D.1
Dhe-Paganon, S.2
Melendez, P.A.3
Lee, J.4
Shoelson, S.E.5
-
12
-
-
0034609569
-
Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase in vitro
-
Lehr, S. et al. Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase in vitro. Biochemistry 39, 10898-10907 (2000).
-
(2000)
Biochemistry
, vol.39
, pp. 10898-10907
-
-
Lehr, S.1
-
13
-
-
0034648794
-
CAP defines a second signalling pathway required for insulin-stimulated glucose transport
-
Baumann, C. A. et al. CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature 407, 202-207 (2000).
-
(2000)
Nature
, vol.407
, pp. 202-207
-
-
Baumann, C.A.1
-
14
-
-
0028912999
-
Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain
-
Gustafson, T. A., He, W., Craparo, A., Schaub, C. D. & O'Neill, T. J. Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol. Cell Biol. 15, 2500-2508 (1995).
-
(1995)
Mol. Cell Biol.
, vol.15
, pp. 2500-2508
-
-
Gustafson, T.A.1
He, W.2
Craparo, A.3
Schaub, C.D.4
O'Neill, T.J.5
-
15
-
-
0042570843
-
Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
-
Virkamaki, A., Ueki, K. & Kahn, C. R. Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J. Clin. Invest. 103, 931-943 (1999).
-
(1999)
J. Clin. Invest.
, vol.103
, pp. 931-943
-
-
Virkamaki, A.1
Ueki, K.2
Kahn, C.R.3
-
16
-
-
15644368839
-
The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling
-
Myers, M. G. Jr et al. The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling. J. Biol. Chem. 273, 26908-26914 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 26908-26914
-
-
Myers Jr., M.G.1
-
18
-
-
0029038910
-
Association of insulin receptor substrate 1 with simian virus 40 large T antigen
-
Fei, Z. L., D'Ambrosio, C., Li, S., Surmacz, E. & Baserga, R. Association of insulin receptor substrate 1 with simian virus 40 large T antigen. Mol. Cell Biol. 15, 4232-4239 (1995).
-
(1995)
Mol. Cell Biol.
, vol.15
, pp. 4232-4239
-
-
Fei, Z.L.1
D'Ambrosio, C.2
Li, S.3
Surmacz, E.4
Baserga, R.5
-
19
-
-
33244481462
-
Ser/Thr phosphorylation of IRS proteins: A molecular basis for insulin resistance
-
Zick, Y. Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance. Sci. STKE 2005, PE4 (2005).
-
(2005)
Sci. STKE
, vol.2005
-
-
Zick, Y.1
-
20
-
-
0038321436
-
Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes
-
Bouzakri, K. et al. Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes. Diabetes 52, 1319-1325 (2003).
-
(2003)
Diabetes
, vol.52
, pp. 1319-1325
-
-
Bouzakri, K.1
-
21
-
-
3342958797
-
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
-
Harrington, L. S. et al. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J. Cell Biol. 166, 213-223 (2004).
-
(2004)
J. Cell Biol.
, vol.166
, pp. 213-223
-
-
Harrington, L.S.1
-
22
-
-
0029665179
-
Activation of cJun NH2-terminal kinase/stress-activated protein kinase by insulin
-
Miller, B. S. et al. Activation of cJun NH2-terminal kinase/stress- activated protein kinase by insulin. Biochemistry 35, 8769-8775 (1996).
-
(1996)
Biochemistry
, vol.35
, pp. 8769-8775
-
-
Miller, B.S.1
-
23
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
-
Cai, D. et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB. Nature Med. 11, 183-190 (2005).
-
(2005)
Nature Med.
, vol.11
, pp. 183-190
-
-
Cai, D.1
-
24
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi, J. et al. A central role for JNK in obesity and insulin resistance. Nature 420, 333-336 (2002).
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
-
25
-
-
0034708832
-
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
-
Aguirre, V., Uchida, T., Yenush, L., Davis, R. & White, M. F. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J. Biol. Chem. 275, 9047-9054 (2000). An important paper that established the connection between Ser307 phosphorylation, JNK and insulin resistance.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 9047-9054
-
-
Aguirre, V.1
Uchida, T.2
Yenush, L.3
Davis, R.4
White, M.F.5
-
26
-
-
0030995955
-
14-3-3 (ε) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner
-
Craparo, A., Freund, R. & Gustafson, T. A. 14-3-3 (ε) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner. J. Biol. Chem. 272, 11663-11669 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 11663-11669
-
-
Craparo, A.1
Freund, R.2
Gustafson, T.A.3
-
27
-
-
18844411108
-
Deletion of Gabi in the liver leads to enhanced glucose tolerance and improved hepatic insulin action
-
Bard-Chapeau, E. A. et al. Deletion of Gabi in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nature Med. 11, 567-571 (2005).
-
(2005)
Nature Med.
, vol.11
, pp. 567-571
-
-
Bard-Chapeau, E.A.1
-
28
-
-
0344035946
-
Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway
-
Hirashima, Y. et al. Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway. J. Endocrinol. 179, 253-266 (2003).
-
(2003)
J. Endocrinol.
, vol.179
, pp. 253-266
-
-
Hirashima, Y.1
-
29
-
-
0036830636
-
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
-
Rui, L., Yuan, M., Frantz, D., Shoelson, S. & White, M. F. SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J. Biol. Chem. 277, 42394-42398 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 42394-42398
-
-
Rui, L.1
Yuan, M.2
Frantz, D.3
Shoelson, S.4
White, M.F.5
-
30
-
-
0033636780
-
Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
-
Shimomura, I. et al. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol. Cell 6, 77-86 (2000).
-
(2000)
Mol. Cell
, vol.6
, pp. 77-86
-
-
Shimomura, I.1
-
31
-
-
0034810894
-
Defects of the insulin receptor substrate (IRS) system in human metabolic disorders
-
Sesti, G. et al. Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. FASEB J. 15, 2099-2111 (2001).
-
(2001)
FASEB J.
, vol.15
, pp. 2099-2111
-
-
Sesti, G.1
-
32
-
-
0028032895
-
Alternative pathway of insulin signaling in targeted disruption of the IRS-1 gene
-
Araki, E. et al. Alternative pathway of insulin signaling in targeted disruption of the IRS-1 gene. Nature 372, 186-190 (1994).
-
(1994)
Nature
, vol.372
, pp. 186-190
-
-
Araki, E.1
-
33
-
-
9644260562
-
Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus
-
Kubota, N. et al. Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus. J. Clin. Invest. 114, 917-927 (2004).
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 917-927
-
-
Kubota, N.1
-
34
-
-
0032567937
-
Disruption of IRS-2 causes type 2 diabetes in mice
-
Withers, D. J. et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391, 900-904 (1998).
-
(1998)
Nature
, vol.391
, pp. 900-904
-
-
Withers, D.J.1
-
35
-
-
20444417035
-
Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin
-
Tseng, Y. H. et al. Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nature Cell Biol. 7, 601-611 (2005).
-
(2005)
Nature Cell Biol.
, vol.7
, pp. 601-611
-
-
Tseng, Y.H.1
-
36
-
-
0035099508
-
Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation
-
Miki, H. et al. Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation. Mol. Cell Biol. 21, 2521-2532 (2001).
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 2521-2532
-
-
Miki, H.1
-
37
-
-
21444460644
-
Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in I6 myotubes
-
Huang, C., Thirone, A. C., Huang, X. & Klip, A. Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in I6 myotubes. J. Biol. Chem. 280, 19426-19435 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 19426-19435
-
-
Huang, C.1
Thirone, A.C.2
Huang, X.3
Klip, A.4
-
38
-
-
14644426519
-
Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism
-
Taniguchi, C. M., Ueki, K. & Kahn, R. Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism. J. Clin. Invest 115, 718-727 (2005).
-
(2005)
J. Clin. Invest
, vol.115
, pp. 718-727
-
-
Taniguchi, C.M.1
Ueki, K.2
Kahn, R.3
-
39
-
-
0000772655
-
The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action
-
Sun, X. J. et al. The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action. Mol. Endocrinol. 11, 251-262 (1997).
-
(1997)
Mol. Endocrinol.
, vol.11
, pp. 251-262
-
-
Sun, X.J.1
-
40
-
-
10644251864
-
Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes
-
Miura, A. et al. Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes. Biochemistry 43, 15503-15509 (2004).
-
(2004)
Biochemistry
, vol.43
, pp. 15503-15509
-
-
Miura, A.1
-
41
-
-
0034750801
-
Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling
-
Tsuruzoe, K., Emkey, R., Kriauciunas, K. M., Ueki, K. & Kahn, C. R. Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling. Mol. Cell Biol. 21, 26-38 (2001).
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 26-38
-
-
Tsuruzoe, K.1
Emkey, R.2
Kriauciunas, K.M.3
Ueki, K.4
Kahn, C.R.5
-
42
-
-
0032496150
-
Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2
-
Inoue, G., Cheatham, B., Emkey, R. & Kahn, C. R. Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2. J. Biol. Chem. 273, 11548-11555 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 11548-11555
-
-
Inoue, G.1
Cheatham, B.2
Emkey, R.3
Kahn, C.R.4
-
43
-
-
0030911521
-
Insulin receptor substrate (IRS)-2 is dephosphorylated more rapidly than IRS-1 via its association with phosphatidylinositol 3-kinase in skeletal muscle cells
-
Ogihara, T. et al. Insulin receptor substrate (IRS)-2 is dephosphorylated more rapidly than IRS-1 via its association with phosphatidylinositol 3-kinase in skeletal muscle cells. J. Biol. Chem. 272, 12868-12873 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 12868-12873
-
-
Ogihara, T.1
-
44
-
-
0029866195
-
Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786
-
Sawka-Verhelle, D., Tartare-Deckert, S., White, M. F. & Van Obberghen, E. Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786. J. Biol. Chem. 271, 5980-5983 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 5980-5983
-
-
Sawka-Verhelle, D.1
Tartare-Deckert, S.2
White, M.F.3
Van Obberghen, E.4
-
45
-
-
0026489451
-
IRS-1 activates phosphatidylinositol 3′-kinase by associating with src homology 2 domains of p85
-
Myers, M. G. Jr et al. IRS-1 activates phosphatidylinositol 3′-kinase by associating with src homology 2 domains of p85. Proc. Natl Acad. Sci. USA 89, 10350-10354 (1992).
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 10350-10354
-
-
Myers Jr., M.G.1
-
46
-
-
0028308412
-
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation
-
Cheatham, B. et al. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol. Cell Biol. 14, 4902-4911 (1994).
-
(1994)
Mol. Cell Biol.
, vol.14
, pp. 4902-4911
-
-
Cheatham, B.1
-
47
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylatesand activates protein kinase Bα
-
Alessi, D. R. et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylatesand activates protein kinase Bα. Curr. Biol. 7, 261-269 (1997). Describes the discovery of PDK1.
-
(1997)
Curr. Biol.
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
-
48
-
-
0032566691
-
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
-
Le Good, J. A. et al. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 281, 2042-2045 (1998).
-
(1998)
Science
, vol.281
, pp. 2042-2045
-
-
Le Good, J.A.1
-
49
-
-
13844312400
-
Phosphorylation and regulation of Akt/ PKB by the rictor-mTOR complex
-
Sarbassov, D. D., Guertin, D. A., Ali, S. M. & Sabatini, D. M. Phosphorylation and regulation of Akt/ PKB by the rictor-mTOR complex. Science 307, 1098-1101 (2005).
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
50
-
-
0032904432
-
PTEN: A tumour suppressor that functions as a phospholipid phosphatase
-
Maehama, T. & Dixon, J. E. PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol. 9, 125-128 (1999).
-
(1999)
Trends Cell Biol.
, vol.9
, pp. 125-128
-
-
Maehama, T.1
Dixon, J.E.2
-
51
-
-
19944430614
-
Muscle-specific Pten deletion protects against insulin resistance and diabetes
-
Wijesekara, N. et al. Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol. Cell Biol. 25, 1135-1145 (2005).
-
(2005)
Mol. Cell Biol.
, vol.25
, pp. 1135-1145
-
-
Wijesekara, N.1
-
52
-
-
20444487358
-
PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes
-
Tang, X., Powelka, A. M., Soriano, N. A., Czech, M. P. & Guilherme, A. PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes. J. Biol. Chem. 280, 22523-22529 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 22523-22529
-
-
Tang, X.1
Powelka, A.M.2
Soriano, N.A.3
Czech, M.P.4
Guilherme, A.5
-
53
-
-
20044364159
-
Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity
-
Sleeman, M. W. et al. Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity. Nature Med. 11, 199-205 (2005).
-
(2005)
Nature Med.
, vol.11
, pp. 199-205
-
-
Sleeman, M.W.1
-
54
-
-
0032143284
-
Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling
-
Shepherd, P. R., Withers, D. J. & Siddle, K. Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem. J. 333, 471-490 (1998).
-
(1998)
Biochem. J.
, vol.333
, pp. 471-490
-
-
Shepherd, P.R.1
Withers, D.J.2
Siddle, K.3
-
55
-
-
0031887249
-
Regulation of the p85/p110 phosphatidylinositol 3′-kinase: Stabilization and inhibition of the p110α catalytic subunit by the p85 regulatory subunit
-
Yu, J. et al. Regulation of the p85/p110 phosphatidylinositol 3′-kinase: stabilization and inhibition of the p110α catalytic subunit by the p85 regulatory subunit. Mol. Cell Biol. 18, 1379-1387 (1998). Helped to define the molecular and functional relationships between the regulatory and catalytic subunitsof PI3K.
-
(1998)
Mol. Cell Biol.
, vol.18
, pp. 1379-1387
-
-
Yu, J.1
-
56
-
-
0034625182
-
p110β is up-regulated during differentiation of 3T3-L1 cells and contributes to the highly insulin-responsive glucose transport activity
-
Asano, T. et al. p110β is up-regulated during differentiation of 3T3-L1 cells and contributes to the highly insulin-responsive glucose transport activity. J. Biol. Chem. 275, 17671-17676 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 17671-17676
-
-
Asano, T.1
-
57
-
-
0027967958
-
Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase
-
Tanti, J. F., Gremeaux, T., Van Obberghen, E. & Le Marchand-Brustel, Y. Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase. Biochem. J. 304, 17-21 (1994).
-
(1994)
Biochem. J.
, vol.304
, pp. 17-21
-
-
Tanti, J.F.1
Gremeaux, T.2
Van Obberghen, E.3
Le Marchand-Brustel, Y.4
-
58
-
-
0028023002
-
Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling
-
Tanti, J. F., Gremeaux, T., van Obberghen, E. & Le Marchand-Brustel, Y. Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling. J. Biol. Chem. 269, 6051-6057 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 6051-6057
-
-
Tanti, J.F.1
Gremeaux, T.2
Van Obberghen, E.3
Le Marchand-Brustel, Y.4
-
59
-
-
0029913340
-
Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain
-
Antonetti, D. A., Algenstaedt, P. & Kahn, C. R. Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain. Mol. Cell Biol. 16, 2195-2203 (1996).
-
(1996)
Mol. Cell Biol.
, vol.16
, pp. 2195-2203
-
-
Antonetti, D.A.1
Algenstaedt, P.2
Kahn, C.R.3
-
60
-
-
0037039317
-
Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase
-
Ueki, K. et al. Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase. Proc. Natl Acad. Sci. USA 99, 419-424 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 419-424
-
-
Ueki, K.1
-
61
-
-
0032909703
-
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 α subunit of phosphoinositide 3-kinase
-
Terauchi, Y. et al. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 α subunit of phosphoinositide 3-kinase. Nature Genet. 21, 230-235 (1999). The first description of the paradoxical negative regulation of insulin signalling by the regulatory subunit p85α.
-
(1999)
Nature Genet.
, vol.21
, pp. 230-235
-
-
Terauchi, Y.1
-
62
-
-
0347624591
-
p50α/p55α phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity
-
Chen, D. et al. p50α/p55α phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity. Mol. Cell Biol. 24, 320-329 (2004).
-
(2004)
Mol. Cell Biol.
, vol.24
, pp. 320-329
-
-
Chen, D.1
-
63
-
-
0033757592
-
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 α
-
Fruman, D. A. et al. Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 α. Nature Genet. 26, 379-382 (2000).
-
(2000)
Nature Genet.
, vol.26
, pp. 379-382
-
-
Fruman, D.A.1
-
64
-
-
0036142957
-
Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
-
Mauvais-Jarvis, F. et al. Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. J. Clin. Invest. 109, 141-149 (2002).
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 141-149
-
-
Mauvais-Jarvis, F.1
-
65
-
-
1442348156
-
Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle
-
Barbour, L. A. et al. Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle. Endocrinology 145, 1144-1150 (2004). Shows that the physiologic upregulation of p85α in vivo induces insulin resistance.
-
(2004)
Endocrinology
, vol.145
, pp. 1144-1150
-
-
Barbour, L.A.1
-
66
-
-
23644448924
-
Increased p85/55/50 expression and decreased phosphatidylinositol 3-kinase activity in insulin-resistant human skeletal muscle
-
Bandyopadhyay, G. K., Yu, J. G., Ofrecio, J. & Olefsky, J. M. Increased p85/55/50 expression and decreased phosphatidylinositol 3-kinase activity in insulin-resistant human skeletal muscle. Diabetes 54, 2351-2359 (2005).
-
(2005)
Diabetes
, vol.54
, pp. 2351-2359
-
-
Bandyopadhyay, G.K.1
Yu, J.G.2
Ofrecio, J.3
Olefsky, J.M.4
-
67
-
-
0033780412
-
Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85α regulatory subunit
-
Ueki, K., Algenstaedt, P., Mauvais-Jarvis, F. & Kahn, C. R. Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85α regulatory subunit. Mol. Cell Biol. 20, 8035-8046 (2000).
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 8035-8046
-
-
Ueki, K.1
Algenstaedt, P.2
Mauvais-Jarvis, F.3
Kahn, C.R.4
-
68
-
-
23744456586
-
The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
-
Luo, J., Field, S. J., Lee, J. Y., Engelman, J. A. & Cantley, L. C. The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. J. Cell Biol. 170, 455-464 (2005).
-
(2005)
J. Cell Biol.
, vol.170
, pp. 455-464
-
-
Luo, J.1
Field, S.J.2
Lee, J.Y.3
Engelman, J.A.4
Cantley, L.C.5
-
69
-
-
0346220260
-
Positive and negative roles of p85 α and p85 β regulatory subunits of phosphoinositide 3-kinase in insulin signaling
-
Ueki, K. et al. Positive and negative roles of p85 α and p85 β regulatory subunits of phosphoinositide 3-kinase in insulin signaling. J. Biol. Chem. 278, 48453-48466 (2003). The first published connection between the p85α regulatory subunit and JNK activation.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 48453-48466
-
-
Ueki, K.1
-
71
-
-
0035555195
-
Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells
-
Fang, D. & Liu, Y. C. Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells. Nature Immunol. 2, 870-875 (2001).
-
(2001)
Nature Immunol.
, vol.2
, pp. 870-875
-
-
Fang, D.1
Liu, Y.C.2
-
72
-
-
0028338545
-
Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85
-
Zheng, Y., Bagrodia, S. & Cerione, R. A. Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85. J. Biol. Chem. 269, 18727-18730 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 18727-18730
-
-
Zheng, Y.1
Bagrodia, S.2
Cerione, R.A.3
-
73
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
Cross, D. A., Alessi, D. R., Cohen, P., Andjelkovich, M. & Hemmings, B. A. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378, 785-789 (1995).
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
74
-
-
0035477020
-
GSK3 takes centre stage more than 20 years after its discovery
-
Frame, S. & Cohen, P. GSK3 takes centre stage more than 20 years after its discovery. Biochem. J. 359, 1-16 (2001).
-
(2001)
Biochem. J.
, vol.359
, pp. 1-16
-
-
Frame, S.1
Cohen, P.2
-
75
-
-
0037677096
-
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation
-
Sano, H. et al. Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. J. Biol. Chem. 278, 14599-14602 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 14599-14602
-
-
Sano, H.1
-
77
-
-
0037418528
-
The many forks in FOXO's road
-
Tran, H., Brunet, A., Griffith, E. C. & Greenberg, M. E. The many forks in FOXO's road. Sci. STKE 2003, RE5 (2003).
-
(2003)
Sci. STKE
, vol.2003
-
-
Tran, H.1
Brunet, A.2
Griffith, E.C.3
Greenberg, M.E.4
-
78
-
-
0038187621
-
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1α interaction
-
Puigserver, P. et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1α interaction. Nature 423, 550-555 (2003).
-
(2003)
Nature
, vol.423
, pp. 550-555
-
-
Puigserver, P.1
-
79
-
-
0037237279
-
The forkhead transcription factor Foxo1 regulates adipocyte differentiation
-
Nakae, J. et al. The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev. Cell 4, 119-129 (2003).
-
(2003)
Dev. Cell
, vol.4
, pp. 119-129
-
-
Nakae, J.1
-
80
-
-
11144244418
-
Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes
-
Wolfrum, C., Asilmaz, E., Luca, E., Friedman, J. M. & Stoffel, M. Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes. Nature 432, 1027-1032 (2004).
-
(2004)
Nature
, vol.432
, pp. 1027-1032
-
-
Wolfrum, C.1
Asilmaz, E.2
Luca, E.3
Friedman, J.M.4
Stoffel, M.5
-
81
-
-
2342565881
-
Advances in protein kinase B signalling: AKTion on multiple fronts
-
Brazil, D. P., Yang, Z. Z. & Hemmings, B. A. Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem. Sci. 29, 233-242 (2004).
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 233-242
-
-
Brazil, D.P.1
Yang, Z.Z.2
Hemmings, B.A.3
-
82
-
-
15944406764
-
PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
-
Gao, T., Furnari, F. & Newton, A. C. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol. Cell 18, 13-24 (2005).
-
(2005)
Mol. Cell
, vol.18
, pp. 13-24
-
-
Gao, T.1
Furnari, F.2
Newton, A.C.3
-
83
-
-
0038242819
-
TRB3: A tribbles homolog that inhibits Akt/PKB activation by insulin in liver
-
Du, K., Herzig, S., Kulkami, R. N. & Montminy, M. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300, 1574-1577 (2003).
-
(2003)
Science
, vol.300
, pp. 1574-1577
-
-
Du, K.1
Herzig, S.2
Kulkami, R.N.3
Montminy, M.4
-
84
-
-
2442701392
-
PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3
-
Koo, S. H. et al. PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3. Nature Med. 10, 530-534 (2004).
-
(2004)
Nature Med.
, vol.10
, pp. 530-534
-
-
Koo, S.H.1
-
85
-
-
0035448879
-
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene
-
Chen, W. S. et al. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 15, 2203-2208 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 2203-2208
-
-
Chen, W.S.1
-
86
-
-
0035914388
-
Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
-
Cho, H., Thorvaldsen, J. L., Chu, Q., Feng, F. & Birnbaum, M. J. Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J. Biol. Chem. 276, 38349-38352 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38349-38352
-
-
Cho, H.1
Thorvaldsen, J.L.2
Chu, Q.3
Feng, F.4
Birnbaum, M.J.5
-
87
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ)
-
Cho, H. et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ). Science 292, 1728-1731 (2001).
-
(2001)
Science
, vol.292
, pp. 1728-1731
-
-
Cho, H.1
-
88
-
-
2542528670
-
A family with severe insulin resistance and diabetes due to a mutation in AKT2
-
George, S. et al. A family with severe insulin resistance and diabetes due to a mutation in AKT2. Science 304, 1325-1328 (2004).
-
(2004)
Science
, vol.304
, pp. 1325-1328
-
-
George, S.1
-
89
-
-
23144449547
-
Essential role of protein kinase B γ (PKB γ/Akt3) in postnatal brain development but not in glucose homeostasis
-
Tschopp, O. et al. Essential role of protein kinase B γ (PKB γ/Akt3) in postnatal brain development but not in glucose homeostasis. Development 132, 2943-2954 (2005).
-
(2005)
Development
, vol.132
, pp. 2943-2954
-
-
Tschopp, O.1
-
90
-
-
0032881288
-
AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation
-
Chan, T. O., Rittenhouse, S. E. & Tsichlis, P. N. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide- dependent phosphorylation. Annu. Rev. Biochem. 68, 965-1014 (1999).
-
(1999)
Annu. Rev. Biochem.
, vol.68
, pp. 965-1014
-
-
Chan, T.O.1
Rittenhouse, S.E.2
Tsichlis, P.N.3
-
91
-
-
1542781732
-
Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B
-
Bae, S. S., Cho, H., Mu, J. & Birnbaum, M. J. Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B. J. Biol. Chem. 278, 49530-49536 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 49530-49536
-
-
Bae, S.S.1
Cho, H.2
Mu, J.3
Birnbaum, M.J.4
-
92
-
-
0037934650
-
Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing
-
Jiang, Z. Y. et al. Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc. Natl Acad. Sci. USA 100, 7569-7574 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 7569-7574
-
-
Jiang, Z.Y.1
-
93
-
-
0032571257
-
Insulin increases the association of Akt-2 with Glut4-containing vesicles
-
Calera, M. R. et al. Insulin increases the association of Akt-2 with Glut4-containing vesicles. J. Biol. Chem. 273, 7201-7204 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 7201-7204
-
-
Calera, M.R.1
-
94
-
-
15444374951
-
Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles
-
Yamada, E. et al. Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles. J. Cell Biol. 168, 921-928 (2005).
-
(2005)
J. Cell Biol.
, vol.168
, pp. 921-928
-
-
Yamada, E.1
-
95
-
-
0033214101
-
Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3
-
Masure, S. et al. Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3. Eur. J. Biochem. 265, 353-360 (1999).
-
(1999)
Eur. J. Biochem.
, vol.265
, pp. 353-360
-
-
Masure, S.1
-
96
-
-
0035830320
-
Insulin and PIP3 activate PKC-ζ by mechanisms that are both dependent and independent of phosphorylation of activation loop (T410) and autophosphorylation (T560) sites
-
Standaert, M. L., Bandyopadhyay, G., Kanoh, Y., Sajan, M. P. & Farese, R. V. Insulin and PIP3 activate PKC-ζ by mechanisms that are both dependent and independent of phosphorylation of activation loop (T410) and autophosphorylation (T560) sites. Biochemistry 40, 249-255 (2001).
-
(2001)
Biochemistry
, vol.40
, pp. 249-255
-
-
Standaert, M.L.1
Bandyopadhyay, G.2
Kanoh, Y.3
Sajan, M.P.4
Farese, R.V.5
-
97
-
-
0036288402
-
Function and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant states
-
Farese, R. V. Function and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant states. Am. J. Physiol. Endocrinol. Metab. 283, E1-E11 (2002).
-
(2002)
Am. J. Physiol. Endocrinol. Metab.
, vol.283
-
-
Farese, R.V.1
-
98
-
-
18044382930
-
Atypical protein kinase C in insulin action and insulin resistance
-
Farese, R. V., Sajan, M. P. & Standaert, M. L. Atypical protein kinase C in insulin action and insulin resistance. Biochem. Soc. Trans. 33, 350-353 (2005).
-
(2005)
Biochem. Soc. Trans.
, vol.33
, pp. 350-353
-
-
Farese, R.V.1
Sajan, M.P.2
Standaert, M.L.3
-
99
-
-
0036709020
-
Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling
-
Pouyssegur, J., Volmat, V. & Lenormand, P. Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling. Biochem. Pharmacol. 64, 755-763 (2002).
-
(2002)
Biochem. Pharmacol.
, vol.64
, pp. 755-763
-
-
Pouyssegur, J.1
Volmat, V.2
Lenormand, P.3
-
100
-
-
17144458301
-
Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice
-
Pages, G. et al. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science 286, 1374-1377 (1999).
-
(1999)
Science
, vol.286
, pp. 1374-1377
-
-
Pages, G.1
-
101
-
-
19944433322
-
The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis
-
Bost, F. et al. The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. Diabetes 54, 402-411 (2005).
-
(2005)
Diabetes
, vol.54
, pp. 402-411
-
-
Bost, F.1
-
102
-
-
22144479017
-
Ras plasma membrane signalling platforms
-
Hancock, J. F. & Parton, R. G. Ras plasma membrane signalling platforms. Biochem. J. 389, 1-11 (2005).
-
(2005)
Biochem. J.
, vol.389
, pp. 1-11
-
-
Hancock, J.F.1
Parton, R.G.2
-
103
-
-
0028074316
-
Phosphatidylinositol-3-OH kinase as a direct target of Ras
-
Rodriguez-Viciana, P. et al. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370, 527-532 (1994).
-
(1994)
Nature
, vol.370
, pp. 527-532
-
-
Rodriguez-Viciana, P.1
-
104
-
-
8444238236
-
The RAF proteins take centre stage
-
Wellbrock, C., Karasarides, M. & Marais, R. The RAF proteins take centre stage. Nature Rev. Mol. Cell Biol. 5, 875-885 (2004).
-
(2004)
Nature Rev. Mol. Cell Biol.
, vol.5
, pp. 875-885
-
-
Wellbrock, C.1
Karasarides, M.2
Marais, R.3
-
105
-
-
0034597710
-
Small GTPase Rac1: Structure, localization, and expression of the human gene
-
Matos, P. et al. Small GTPase Rac1: structure, localization, and expression of the human gene. Biochem. Biophys. Res. Commun. 277, 741-751 (2000).
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.277
, pp. 741-751
-
-
Matos, P.1
-
106
-
-
0030588593
-
Genomic organization and chromosomal location of murine Cdc42
-
Marks, P. W. & Kwiatkowski, D. J. Genomic organization and chromosomal location of murine Cdc42. Genomics 38, 13-18 (1996).
-
(1996)
Genomics
, vol.38
, pp. 13-18
-
-
Marks, P.W.1
Kwiatkowski, D.J.2
-
107
-
-
0029410624
-
The GTP-binding protein Rac does not couple PI3-kinase to insulin-stimulated glucose transport in adipocytes
-
Marcusohn, J., Isakoff, S. J., Rose, E., Symons, M. & Skolnik, E. Y. The GTP-binding protein Rac does not couple PI3-kinase to insulin-stimulated glucose transport in adipocytes. Curr. Biol. 5, 1296-1302 (1995).
-
(1995)
Curr. Biol.
, vol.5
, pp. 1296-1302
-
-
Marcusohn, J.1
Isakoff, S.J.2
Rose, E.3
Symons, M.4
Skolnik, E.Y.5
-
108
-
-
0038190982
-
Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes
-
Usui, I., Imamura, T., Huang, J., Satoh, H. & Olefeky, J. M. Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes. J. Biol. Chem. 278, 13765-13774 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 13765-13774
-
-
Usui, I.1
Imamura, T.2
Huang, J.3
Satoh, H.4
Olefeky, J.M.5
-
109
-
-
0032054723
-
Signal transduction by the c-Jun N-terminal kinase (JNK) - From inflammation to development
-
Ip, Y. T. & Davis, R. J. Signal transduction by the c-Jun N-terminal kinase (JNK) - from inflammation to development. Curr. Opin. Cell Biol. 10, 205-219 (1998).
-
(1998)
Curr. Opin. Cell Biol.
, vol.10
, pp. 205-219
-
-
Ip, Y.T.1
Davis, R.J.2
-
110
-
-
19644367000
-
Activation and signaling of the p38 MAP kinase pathway
-
Zarubin, T. & Han, J. Activation and signaling of the p38 MAP kinase pathway. Cell Res. 15, 11-18 (2005).
-
(2005)
Cell Res.
, vol.15
, pp. 11-18
-
-
Zarubin, T.1
Han, J.2
-
111
-
-
0036968480
-
Activation of the glucose transporter GLUT4 by insulin
-
Furtado, L. M., Somwar, R., Sweeney, G., Niu, W. & Klip, A. Activation of the glucose transporter GLUT4 by insulin. Biochem. Cell Biol. 80, 569-578 (2002).
-
(2002)
Biochem. Cell Biol.
, vol.80
, pp. 569-578
-
-
Furtado, L.M.1
Somwar, R.2
Sweeney, G.3
Niu, W.4
Klip, A.5
-
112
-
-
0037341276
-
Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: Potential role of p38 in the downregulation of GLUT4 expression
-
Carlson, C. J., Koterski, S., Sciotti, R. J., Poccard, G. B. & Rondinone, C. M. Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression. Diabetes 52, 634-641 (2003).
-
(2003)
Diabetes
, vol.52
, pp. 634-641
-
-
Carlson, C.J.1
Koterski, S.2
Sciotti, R.J.3
Poccard, G.B.4
Rondinone, C.M.5
-
113
-
-
0038521292
-
TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport
-
Chiang, S. H. et al. TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. EMBO J. 22, 2679-2691 (2003).
-
(2003)
EMBO J.
, vol.22
, pp. 2679-2691
-
-
Chiang, S.H.1
-
114
-
-
0035316576
-
Cbl: Many adaptations to regulate protein tyrosine kinases
-
Thien, C. B. & Langdon, W. Y. Cbl: many adaptations to regulate protein tyrosine kinases. Nature Rev. Mol. Cell Biol. 2, 294-307 (2001).
-
(2001)
Nature Rev. Mol. Cell Biol.
, vol.2
, pp. 294-307
-
-
Thien, C.B.1
Langdon, W.Y.2
-
115
-
-
85047692840
-
c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action
-
Molero, J. C. et al. c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action. J. Clin. Invest. 114, 1326-1333 (2004).
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 1326-1333
-
-
Molero, J.C.1
-
116
-
-
8744305112
-
Analysis of insulin signalling by RNAi-based gene silencing
-
Zhou, Q. L. et al. Analysis of insulin signalling by RNAi-based gene silencing. Biochem. Soc. Trans. 32, 817-821 (2004).
-
(2004)
Biochem. Soc. Trans.
, vol.32
, pp. 817-821
-
-
Zhou, Q.L.1
-
117
-
-
24944560377
-
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells
-
Stegmeier, F., Hu, G., Rickles, R. J., Hannon, G. J. & Elledge, S. J. A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc. Natl Acad. Sci. USA 102, 13212-13217 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 13212-13217
-
-
Stegmeier, F.1
Hu, G.2
Rickles, R.J.3
Hannon, G.J.4
Elledge, S.J.5
-
118
-
-
0037948173
-
Generation of Ski-knockdown mice by expressing a long double-strand RNA from an RNA polymerase II promoter
-
Shinagawa, T. & Ishii, S. Generation of Ski-knockdown mice by expressing a long double-strand RNA from an RNA polymerase II promoter. Genes Dev. 17, 1340-1345 (2003).
-
(2003)
Genes Dev.
, vol.17
, pp. 1340-1345
-
-
Shinagawa, T.1
Ishii, S.2
-
119
-
-
23744479962
-
Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice
-
Ding, S. et al. Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Cell 122, 473-483 (2005).
-
(2005)
Cell
, vol.122
, pp. 473-483
-
-
Ding, S.1
-
120
-
-
0025342410
-
Insulin receptor structure and function in normal and pathological conditions
-
Becker, A. B. & Roth, R. A. Insulin receptor structure and function in normal and pathological conditions. Annu. Rev. Med. 41, 99-115 (1990).
-
(1990)
Annu. Rev. Med.
, vol.41
, pp. 99-115
-
-
Becker, A.B.1
Roth, R.A.2
-
121
-
-
0023253912
-
Separate domains of the insulin receptor contain sites of autophosphorylation and tyrosine kinase activity
-
Goren, H. J., White, M. F. & Kahn, C. R. Separate domains of the insulin receptor contain sites of autophosphorylation and tyrosine kinase activity. Biochemistry 26, 2374-2382 (1987).
-
(1987)
Biochemistry
, vol.26
, pp. 2374-2382
-
-
Goren, H.J.1
White, M.F.2
Kahn, C.R.3
-
122
-
-
0028319209
-
Tissue-specific expression of two alternatively spliced isoforms of the human insulin receptor protein
-
Sesti, G. et al. Tissue-specific expression of two alternatively spliced isoforms of the human insulin receptor protein. Acta Diabetol. 31, 59-65 (1994).
-
(1994)
Acta Diabetol.
, vol.31
, pp. 59-65
-
-
Sesti, G.1
-
123
-
-
0025941580
-
Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells
-
Yamaguchi, Y. et al. Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells. Endocrinology 129, 2058-2066 (1991).
-
(1991)
Endocrinology
, vol.129
, pp. 2058-2066
-
-
Yamaguchi, Y.1
-
124
-
-
0035265835
-
Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic β cells
-
Leibiger, B. et al. Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic β cells. Mol. Cell 7, 559-570 (2001).
-
(2001)
Mol. Cell
, vol.7
, pp. 559-570
-
-
Leibiger, B.1
-
125
-
-
0033555859
-
Emergent properties of networks of biological signaling pathways
-
Bhalla, U. S. & Iyengar, R. Emergent properties of networks of biological signaling pathways. Science 283, 381-387 (1999).
-
(1999)
Science
, vol.283
, pp. 381-387
-
-
Bhalla, U.S.1
Iyengar, R.2
|