PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2

Current Biology

Volumn 9, Issue 8, 1999, Pages 393-404

  Balendran, Anudharan ^a   Casamayor, Antonio ^a   Deak, Maria ^c   Paterson, Andrew ^c   Gaffney, Piers ^b   Currie, Richard ^a   Downes, C Peter ^a   Alessi, Dario R ^c  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; SACCHAROMYCES CEREVISIAE; TRIXIS;

EID: 0033594480     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(99)80186-9     Document Type: Article

References (44)

1. 1. Vanhaesbroeck B, Leevers SJ, Panayotoy G, Waterfield MD: Phosphoinositide-3 kinases: a conserved family of signal transducers. Trends Biochem Sci 1997, 22:267-272.
2. 2. Shepherd PR, Withers DJ, Siddle K: Phosphoinositide 3-kinase: the key switch in insulin signalling. Biochem J 1988, 333:471-479.
3. 3. Alessi DR, Downes CP: The role of PI 3-kinase in insulin action. Biochim Biophys Acta 1998, 1436:151-164.
4. 4. Woscholski R, Parker PJ: Inositol lipid 5-phosphatases - traffic signals and signal traffic. Trends Biochem Sci 1997, 22:427-431.
5. 5. Myers MP, Pass I, Batty IH, VanderKaay J, Stolarov JP, Hemmings BA, et al.: The lipid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc Natl Acad Sci USA 1998, 95:13513-13518.
6. 6. Maehama T, Dixon JE: The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998, 273:13375-13378
7. 7. Kohn AD, Kovacina KS, Roth RA: Insulin stimulates the kinase activity of Rac-pk, a pleckstrin-homology domain-containing Ser/Thr kinase. EMBO J 1995, 14:4288-4295.
8. 8. Cross DAE, Alessi DR, Cohen P, Andjelkovic M, Hemmings BA: Inhibition of glycogen-synthase kinase-3 by insulin is mediated by protein kinase B. Nature 1995, 378:785-789.
9. 9. Deprez J, Vertommen D, Alessi DR, Hue L, Rider MH: Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase-B and other protein kinases of the insulin signalling cascades. J Biol Chem 1997, 272:17269-17275.
10. 10. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Hu LS, Anderson J, et al.: Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 1999, 96:857-868.
11. 11. Liao JF, Barthel A, Nakatani K, Roth RA: Activation of protein kinase B/Akt is sufficient to repress the glucocorticoid and cAMP induction of phosphoenolpyruvate carboxykinase gene. J Biol Chem 1998, 273:27320-27324.
12. 12. Welsh GI, Miller CM, Loughlin AJ, Price NT, Proud CG: Regulation of eukaryotic initiation factor elF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin. FEBS Lett 1998, 421:125-130.
13. 13. Alessi DR, Cohen P: Mechanism of activation and function of protein kinase B. Curr Opin Genet Dev 1998, 8:55-62.
14. 14. Alessi DR, Andjelkovic M, Caudwell FB, Cron P, Morrice N, Cohen P, Hemmings B: Mechanism of activation of protein kinase B by insulin and IGF1. EMBO J 1996, 15:6541-6551.
15. s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. EMBO J 1995, 14:5278-5287.
16. 16. Mellor H, Parker PJ: The extended protein kinase C superfamily. Biochem J 1998, 32:281-292.
17. 17. Kobayashi T, Cohen P: Activation of SGK by PDK1. Biochem J 1999, 337:319-328.
18. 18. Casamayor A, Torrance PD, Kobayashi T, Thorner J, Alessi DR: Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol 1999, 9:186-197.
19. 19. Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PRJ, Reese CB, Cohen P: Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr Biol 1997, 7:261-269.
20. 20. Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, et al.: 3-phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr Biol 1997, 7:776-789.
21. 21. Stokoe D, Stephens LR, Copeland T, Gaffney PRJ, Reese CB, Painter GF: Dual role of phosphatidyinositiol-3,4,5-trisphosphate in the activation of protein kinase B. Science 1997, 277:567-570.
22. 22. Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, et al.: Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science 1998, 279:710-714.
23. 23. LeGood JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ: Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 1998, 281:2042-2045.
24. 24. Chou MM, Hou WM, Johnson J, Graham LK, Lee MH, Chen CS, et al.: Regulation of protein kinase C zeta by PI 3-kinase and PDK1. Curr Biol 1998, 8:1069-1077.
25. 25. Dutil EM, Toker A, Newton AC: Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1). Curr Biol 1988, 8:1366-1375.
26. 26. Alessi DR, Kozlowski MT, Weng QP, Morrice N, Avruch J: 3-phosphoinositide dependent protein kinase 1 (PDK1) phosphorylates and activates the p70S6 kinase in vivo and in vitro. Curr Biol 1998, 8:69-81.
27. 27. Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G: Phosphorylation and activation of p70(s6k) by PDK1. Science 1998, 279:707-710.
28. 28. Cheng XD, Ma YL, Moore M, Hemmings BA, Taylor SS: Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase. Proc Natl Acad Sci USA 1998, 95:9849-9854.
29. 29. Palmer RH, Ridden J, Parker PJ: Cloning and expression patterns of 2 members of a novel protein-kinase C-related kinase family. Eur J Biochem 1995, 227:344-351.
30. 30. Vincent S, Settleman J: The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization. Mol Cell Biol 1997, 17:2247-2256.
31. 31. Currie RA, Walker KS, Gray A, Deak M, Casamayor A, Downes CP, et al.: The role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localisation of 3-phosphoinositide-dependent protein kinase-1. Biochem J 1999, 337: 575-583.
32. 32. Bornancin F, Parker PJ: Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase C alpha. Curr Biol 1996, 6:1114-1123.
33. 33. Amano M, Mukai H, Ono Y, Chihara K, Matsui T, Hamajima Y, et al.: Identification of a putative target for Rho as the Serine-threonine kinase N. Science 1996, 271:648-650.
34. 34. Vincent S, Settleman J: The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization. Mol Cell Biol 1997, 17:2247-2256.
35. 35. Cryns VL, Byun Y, Rana A, Mellor H, Lustig KD, Ghanem L, et al.: Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis - Identification by a novel, small pool expression cloning strategy. J Biol Chem 1997, 272:29449-29453.
36. 36. Yu W, Liu J, Morrice NA, Wettenhall REH: Isolation and characterisation of a structural homologue of human PRK2 from rat liver. J Biol Chem 1997, 272:10030-10034.
37. 2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein activated protein kinase-2. Biochem J 1998, 336:241-246.
38. 38. Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S: Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci USA 1998, 95:11211-11216.
39. 39. Burnett PE, Barrow RK, Cohen NA, Snyder SH, Sabatini DM: RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc Natl Acad Sci USA 1998, 95:1432-1437.
40. 40. Andjelkovic M, Alessi DR, Meier R, Fernandez A, Lamb NJC, Frech M et al. : Role of translocation in the activation and function of protein kinase B. J Biol Chem 1997, 272:31515-31524.
41. 41. Walker KS, Deak M, Paterson A, Hudson K, Cohen P, Alessi DR: Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha. Biochem J 1998, 331:299-308.
42. 42. Deak M, Clifton AD, Lucocq JM, Alessi DR: Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J 1998,17:4426-4441.
43. 3] and its stereoisomers. Bioorg Med Chem Lett 1997, 7:3171-3176.
44. 44. Alessi DR, Caudwell FB, Andjelkovic M, Hemmings BA, Cohen P: Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70s6 kinase. FEBS Lett 1996, 399:333-338.