Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

Developmental Cell

Volumn 11, Issue 6, 2006, Pages 859-871

  Guertin, David A ^a,c   Stevens, Deanna M ^a   Thoreen, Carson C ^a   Burds, Aurora A ^b   Kalaany, Nada Y ^a   Moffat, Jason ^a,c   Brown, Michael ^b   Fitzgerald, Kevin J ^d   Sabatini, David M ^a,b,c  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d BRISTOL MYERS SQUIBB   (United States)

Author keywords

DEVBIO; SIGNALING

Indexed keywords

INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; PROTEIN KINASE C ALPHA; PROTEIN S6K1; PROTEIN SUBUNIT; REGULATOR PROTEIN; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; EMBRYO DEVELOPMENT; HYDROPHOBICITY; IN VIVO STUDY; MOUSE; NONHUMAN; NULL CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; CYTOSKELETON; EMBRYO; FETAL DEVELOPMENT; FETAL VIABILITY; FORKHEAD TRANSCRIPTION FACTORS; GENE TARGETING; GLYCOGEN SYNTHASE KINASE 3; INSULIN; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE C-ALPHA; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

RAPTORES;

EID: 33751348056     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.devcel.2006.10.007     Document Type: Article

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