Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

FEBS Letters

Volumn 399, Issue 3, 1996, Pages 333-338

  Alessi, Dario R ^a   Caudwell, F Barry ^a   Andjelkovic, Mirjana ^b   Hemmings, Brian A ^b   Cohen, Philip ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

Akt or RAC kinase; Insulin; Kinase specificity; Kinase substrate; PI 3 kinase; Protein kinase B; S6 kinase

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE; PROTEIN KINASE P60;

AMINO ACID SEQUENCE; ARTICLE; COMPARATIVE STUDY; CONSENSUS SEQUENCE; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

AMINO ACID SEQUENCE; HISTONES; HUMANS; INFANT, NEWBORN; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SUBSTRATE SPECIFICITY;

EID: 0030590875     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(96)01370-1     Document Type: Article

References (23)

1. [1] Coffer, P.J. and Woodgett, J.R. (1991) Eur. J. Biochem. 201, 475-481.
2. [2] Jones, P.F., Jakubowicz, T., Pitossi, F.J., Maurer, F. and Hemmings, B.A. (1991) Proc. Natl. Acad. Sci. USA 88, 4171-4175.
3. [3] Belacossa, A., Testa, J.R., Staal, S.P. and Tsichlis, P.N. (1991) Science 254, 244-247.
4. [4] Staal, S.P., Hartley, J.W. and Rowe, W.P. (1977) Proc. Nat. Acad. Sci. USA 74, 3065-3070.
5. [5] Jones, P.F., Jakubowicz, T. and Hemmings, B.A. (1991) Cell Regul. 2, 1001-1009.
6. [6] Konishi, H., Kuroda, S., Tanaka, M., Matsuzaki, H., Ono, Y., Kameyama, K., Haga, T. and Kikkawa (1995) Biochem. Biophys. Res. Commun. 216, 526-534.
7. [7] Cheng, J.Q., Ruggeri, B., Klein, W.M., Sonoda, G., Altomare, D.A., Watson, D.K., Testa, J.R. (1996) Proc. Natl. Acad. Sci. USA 93, 3636-3641.
8. [8] Kohn, A.D., Kovacina, K.S. and Roth, R.A. (1995) EMBO J. 14, 4288-4295.
9. [9] Cross, D.A.E., Alessi, D.R., Cohen, P. Andjelkovic, M. and Hemmings, B.A. (1995) Nature 378, 785-789.
10. [10] Alessi, D.R., Andjelkovic, M., Caudwell, F.B., Cron, P., Morrice, N. Cohen, P. and Hemmings, B. (1996) EMBO J. 15, 6541-6552.
11. [11] Franke, T.F., Yang, S.I., Chan, T.O., Datta, K., Kazlauskas, A., Morrison, D.K., Kaplan, D.R. and Tsichlis, P.N. (1995) Cell 81, 727-736.
12. [12] Burgering, B.M.T. and Coffer, P.J. (1995) Nature 376, 599-602.
13. [13] Welsh, G.I., Foulstone, E.J., Young, S.J., Tavare, J.M. and Proud, C.G. (1994) Biochem. J. 303, 15-20.
14. [14] Carpenter, C.L. and Cantley, L.C. (1996) Curr. Opin. Cell Biol. 8, 253-158.
15. [15] Sutherland, C., Campbell, D.G. and Cohen, P. (1993) Eur. J. Biochem. 212, 581-588.
16. [16] Leighton, I.A., Dalby, K.N., Caudwell, F.B., Cohen, P.T.W. and Cohen, P. (1995) FEBS Lett. 375, 289-293.
17. [17] Alessi, D.R., Cohen, P., Leevers, S., Cowley, S. and Marshall, C.J. (1995) Methods Enzymol. 255, 279-290.
18. [18] Bradford, M.M. (1976) Anal. Biochem. 72, 248-254.
19. [19] Pinna, L.A. and Ruzzene, M. (1996) Biochem. Biophys. Acta 1314, 191-225.
20. [20] Sutherland, C., Leighton, I.A. and Cohen, P. (1993) Biochem. J. 296, 15-19.
21. [21] Eldar-Finkelman, H., Seger, R., Vandenheede, J.R. and Krebs, E.G. (1995) J. Biol. Chem. 270, 987-990.
22. [22] Saito, Y., Vandenheede, J.R. and Cohen, P. (1994) Biochem. J. 296, 15-19.
23. [23] Stokoe, D., Campbell, D.G., Nakielny, S., Leevers, S.J., Marshall, C. and Cohen, P. (1992) EMBO J. 11, 3985-3999.