mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action

Journal of Biological Chemistry

Volumn 285, Issue 11, 2010, Pages 7866-7879

  Soliman, Ghada A ^a   Acosta Jaquez, Hugo A ^a   Dunlop, Elaine A ^b   Ekim, Bilgen ^a   Maj, Nicole E ^a   Tee, Andrew R ^b   Fingar, Diane C ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYST ACTIVITY; CELL PROLIFERATION; CELL SIGNALING; INSULIN; MAMMALS;

AUTOPHOSPHORYLATION; CELLULAR ENERGY; COMPLEX 1; CYCLING CELLS; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); MECHANISM OF ACTION; MULTI-PROTEIN COMPLEX; PHOSPHATIDYLINOSITOL;

ANTIBIOTICS;

INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; RAPAMYCIN; SERINE; ANTIBODY; ANTINEOPLASTIC ANTIBIOTIC; CRTC2 PROTEIN, HUMAN; MTORC1 PROTEIN, HUMAN; MTORC1 PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CATALYSIS; CELL STRAIN 3T3; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOLYSIS; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CYTOLOGY; FIBROBLAST; IMMUNOLOGY; KIDNEY; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; RABBIT;

MAMMALIA;

3T3-L1 CELLS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIBODIES; CATALYSIS; CELL LINE, TRANSFORMED; FIBROBLASTS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY; MICE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RABBITS; SERINE; SIGNAL TRANSDUCTION; SIROLIMUS; TRANSCRIPTION FACTORS;

EID: 77950900079     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.096222     Document Type: Article

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