-
1
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Hará K, Marukl Y, Long X, et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 2002;110:177-189
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hará, K.1
Marukl, Y.2
Long, X.3
-
2
-
-
0037178786
-
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim. DH, Sarbassov DD, All SM, et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002;110:163-175.
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.H.1
Sarbassov, D.D.2
All, S.M.3
-
3
-
-
0037623417
-
GfSL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive Interaction between raptor and mTOR
-
Kim DH, Sarbassov DD, Ali SM, et al. GfSL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive Interaction between raptor and mTOR. MoI Cell 2003;11:895-904.
-
(2003)
Mol Cell
, vol.11
, pp. 895-904
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
-
4
-
-
33847397874
-
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
-
Haar EY Lee SI, Bandhakavi S, Griffin TJ, Kim DH. InsuUn signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol 2007;9:316-323.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 316-323
-
-
Haar, E.V.1
Lee, S.I.2
Bandhakavi, S.3
Griffin, T.J.4
Kim, D.H.5
-
5
-
-
12344262762
-
mTOR, translational control and human disease
-
Tee AR, Blenls J. mTOR, translational control and human disease. Semin CeU Dev Biol 2005;16:29-37.
-
(2005)
Semin Cell Dev Biol
, vol.16
, pp. 29-37
-
-
Tee, A.R.1
Blenls, J.2
-
6
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regu-lates the cytoskeleton
-
Sarbassov DD, All SM, Kim DH, et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regu-lates the cytoskeleton. Curr Biol 2004;14:1.296-302.
-
(2004)
Curr Biol
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
All, S.M.2
Kim, D.H.3
-
7
-
-
33748471980
-
mSinl is necessary for Akt/PKB phosphorylation, and its iso-forms define three distinct mTORC2s
-
Frias MA, Thoreen CC, Jaffe JD, et al. inSinl is necessary for Akt/PKB phosphorylation, and its iso-forms define three distinct mTORC2s. Curr Biol 2006:16: 1865-1870.
-
(2006)
Curr Biol
, vol.16
, pp. 1865-1870
-
-
Frias, M.A.1
Thoreen, C.C.2
Jaffe, J.D.3
-
8
-
-
33749076673
-
SINl/MIPl maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
-
Jacinto E, Facchinetti V, Liu. D, et al. SINl/MIPl. maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 2006;127:125-37.
-
(2006)
Cell
, vol.127
, pp. 125-137
-
-
Jacinto, E.1
Facchinetti, V.2
Liu, D.3
-
9
-
-
33751079895
-
Identification of Sinl as an essential TORC2 component required for complex formation and kinase activity
-
Yang Q, Inoki K, Ikenoue T, Guan KL. Identification of Sinl as an essential TORC2 component required for complex formation and kinase activity. Genes Dev 2006; 20:2820-2832.
-
(2006)
Genes Dev
, vol.20
, pp. 2820-2832
-
-
Yang, Q.1
Inoki, K.2
Ikenoue, T.3
Guan, K.L.4
-
10
-
-
34347210090
-
Identification of Protor as a novel Rictor-binding component of mTOR complex-2
-
Pearce LR, Huang X, Boudeau J, et al. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem. J 2007;405:513-522.
-
(2007)
Biochem. J
, vol.405
, pp. 513-522
-
-
Pearce, L.R.1
Huang, X.2
Boudeau, J.3
-
11
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov DD, Ali SM, Sengupta S, et al. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 2006;22:159-168.
-
(2006)
Mol Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
-
12
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, All SM, Sabatlni DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005;307:1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatlni, D.M.4
-
13
-
-
4644359805
-
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase
-
Feng J, Park J, Cron P1 Hess D, Hemmings BA. Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J Biol Chem. 2004;279:41189-41196.
-
(2004)
J Biol Chem
, vol.279
, pp. 41189-41196
-
-
Feng, J.1
Park, J.2
Cron, P.3
Hess, D.4
Hemmings, B.A.5
-
14
-
-
20044390541
-
Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM
-
Viniegra JG, Martinez N, Modirassari P, et al. Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM. J Biol Chem 2005; 280:4029-4036.
-
(2005)
J Biol Chem
, vol.280
, pp. 4029-4036
-
-
Viniegra, J.G.1
Martinez, N.2
Modirassari, P.3
-
15
-
-
42949165854
-
PKBa/ Aktl acts downstream of DNA-PK in the DNA double-strand break response and promotes survival
-
Bozulic L, Surucu B, Hynx D, Hemmings BA. PKBa/ Aktl acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. MoI. Cell 2008;30:203-213.
-
(2008)
Mol Cell
, vol.30
, pp. 203-213
-
-
Bozulic, L.1
Surucu, B.2
Hynx, D.3
Hemmings, B.A.4
-
16
-
-
33748950810
-
Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability
-
Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA. MultialleUc disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell 2006;11:583-589.
-
(2006)
Dev Cell
, vol.11
, pp. 583-589
-
-
Shiota, C.1
Woo, J.T.2
Lindner, J.3
Shelton, K.D.4
Magnuson, M.A.5
-
17
-
-
33751348056
-
Ablation in mice of the mTORC components raptor, rictor, or mLSTS reveals that mTORC2 is required for signaling to Akt-FOXO and PKCa, but not S6K1
-
Guertin DA, Stevens DM, Thoreen CC, et al. Ablation in mice of the m'i'ORC components raptor, rictor, or mLSTS reveals that mTORC2 is required for signaling to Akt-FOXO and PKCa, but not S6K1. Dev CeU 2006;11:859-871.
-
(2006)
Dev Cell
, vol.11
, pp. 859-871
-
-
Guertin, D.A.1
Stevens, D.M.2
Thoreen, C.C.3
-
18
-
-
1942469564
-
Thr244* is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status
-
Cheng SW Fryer LG, Carling D, Shepherd PR. Thr244* is a novel mammalian, target of rapamycin. (mTOR) phosphorylation site regulated by nutrient status. J Biol Chem 2004;279:15719-15722.
-
(2004)
J Biol Chem
, vol.279
, pp. 15719-15722
-
-
Cheng, S.W.1
Fryer, L.G.2
Carling, D.3
Shepherd, P.R.4
-
19
-
-
21844468767
-
Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase
-
Chiang GG, Abraham RT. Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J Biol Chem. 2005;280: 25485-25490.
-
(2005)
J Biol Chem
, vol.280
, pp. 25485-25490
-
-
Chiang, G.G.1
Abraham, R.T.2
-
20
-
-
22544455676
-
Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
-
HoIz MK, Blenis J. Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J Biol Chem 2005:280: 26089-26093.
-
(2005)
J Biol Chem
, vol.280
, pp. 26089-2609
-
-
Holz, M.K.1
Blenis, J.2
-
21
-
-
0034629365
-
FKBP12-rapamycin-associated protein (FRAP) auto-phosphorylates at serine 2481 under translationally repressive conditions
-
Peterson RT, Beal PA, Comb MJ, Schreiber SL. FKBP12-rapamycin-associated protein (FRAP) auto-phosphorylates at serine 2481 under translationally repressive conditions. J Biol Chem 2000;275:7416-7423.
-
(2000)
J Biol Chem
, vol.275
, pp. 7416-7423
-
-
Peterson, R.T.1
Beal, P.A.2
Comb, M.J.3
Schreiber, S.L.4
-
22
-
-
0034234924
-
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
-
Sekulic A, Hudson. CC, Homme JL, et al. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res 2000;60:3504-3513.
-
(2000)
Cancer Res
, vol.60
, pp. 3504-3513
-
-
Sekulic, A.1
Hudson, C.C.2
Homme, J.L.3
-
23
-
-
3342958797
-
The TSC.1-2 tumor suppressor controls insulln-PI3K signal-ing via regulation of 1RS proteins
-
Harrington LS, Findlay GM, Gray A, et al. The TSC.1-2 tumor suppressor controls insulln-PI3K signal-ing via regulation of 1RS proteins. J Cell Biol 2004:166: 213-223.
-
(2004)
J Cell Biol
, vol.166
, pp. 213-223
-
-
Harrington, L.S.1
Findlay, G.M.2
Gray, A.3
-
24
-
-
4544343980
-
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRSl/2 depletion, insulin resistance, and cell survival deficiencies
-
Shah OJ, Wang Z, Hunter T. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRSl/2 depletion, insulin resistance, and cell survival deficien-cies. Curr Biol 2004;14:1650-1656.
-
(2004)
Curr Biol
, vol.14
, pp. 1650-1656
-
-
Shah, O.J.1
Wang, Z.2
Hunter, T.3
-
25
-
-
32944457518
-
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
O'Reilly KE, RoJo F, She QB, et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006;66:1500-1508.
-
(2006)
Cancer Res
, vol.66
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.B.3
-
26
-
-
54749095517
-
Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/ rlctor-independent Akt activation
-
Wang X, Yue P, Kim YA, et al. Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/ rlctor-independent Akt activation. Cancer Res 2008;68: 7409-18.
-
(2008)
Cancer Res
, vol.68
, pp. 7409-7418
-
-
Wang, X.1
Yue, P.2
Kim, Y.A.3
-
27
-
-
27744569843
-
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
-
Holz MK, BaIlIf BA, Gygi SP, Blenls J. mTOR and S6.K. 1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 2005:123:569-580.
-
(2005)
Cell
, vol.123
, pp. 569-580
-
-
Holz, M.K.1
Ballif, B.A.2
Gygi, S.P.3
Blenls, J.4
-
28
-
-
33846590132
-
The hallmark of AGC kinase functional divergence is Its C-terminal tail, a cis-actlng regulatory module
-
Kannan N, Haste N, Taylor SS, Neuwald AF. The hallmark of AGC kinase functional divergence is Its C--terminal tail, a ds-actlng regulatory module. Proc Natl Acad Sei U S A 2007;104:1272-1277
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 1272-1277
-
-
Kannan, N.1
Haste, N.2
Taylor, S.S.3
Neuwald, A.F.4
|