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Volumn 5, Issue 6, 2003, Pages 566-571

Rheb promotes cell growth as a component of the insulin/TOR signalling network

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; MESSENGER RNA; RAS PROTEIN; RHEB PROTEIN; UNCLASSIFIED DRUG;

EID: 0038643484     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb996     Document Type: Article
Times cited : (551)

References (30)
  • 1
    • 0032909884 scopus 로고    scopus 로고
    • The gene search system. A method for efficient detection and rapid molecular identification of genes in Drosophila melanogaster
    • Toba, G. et al. The gene search system. A method for efficient detection and rapid molecular identification of genes in Drosophila melanogaster. Genetics 151, 725-737 (1999).
    • (1999) Genetics , vol.151 , pp. 725-737
    • Toba, G.1
  • 2
    • 0030584086 scopus 로고    scopus 로고
    • Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye
    • Freeman, M. Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87, 651-660 (1996).
    • (1996) Cell , vol.87 , pp. 651-660
    • Freeman, M.1
  • 3
    • 0028237671 scopus 로고
    • rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein
    • Yamagata, K. et al. rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein. J. Biol. Chem. 269, 16333-16339 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 16333-16339
    • Yamagata, K.1
  • 4
    • 0029560416 scopus 로고
    • A novel approach for expression cloning of small GTPases: Identification, tissue distribution and chromosome mapping of the human homolog of rheb
    • Gromov, P. S., Madsen, P., Tomerup, N. & Celis, J. E. A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb. FEBS Lett. 377, 221-226 (1995).
    • (1995) FEBS Lett. , vol.377 , pp. 221-226
    • Gromov, P.S.1    Madsen, P.2    Tomerup, N.3    Celis, J.E.4
  • 5
    • 0031040449 scopus 로고    scopus 로고
    • Induction of Drosophila eye development by decapentaplegic
    • Pignoni, F. & Zipursky, S. L. Induction of Drosophila eye development by decapentaplegic. Development 124, 271-278 (1997).
    • (1997) Development , vol.124 , pp. 271-278
    • Pignoni, F.1    Zipursky, S.L.2
  • 6
    • 0032568795 scopus 로고    scopus 로고
    • Coordination of growth and cell division in the Drosophila wing
    • Neufeld, T. P., de la Cruz, A. F., Johnston, L. A. & Edgar, B. A. Coordination of growth and cell division in the Drosophila wing. Cell 93, 1183-1193 (1998).
    • (1998) Cell , vol.93 , pp. 1183-1193
    • Neufeld, T.P.1    de la Cruz, A.F.2    Johnston, L.A.3    Edgar, B.A.4
  • 8
    • 0036484062 scopus 로고    scopus 로고
    • Drosophila's Insulin/PI3-Kinase pathway coordinates cellular metabolism with nutritional conditions
    • Britton, J. S., Lockwood, W. K., Li, L., Cohen, S. M. & Edgar, B. A. Drosophila's Insulin/PI3-Kinase pathway coordinates cellular metabolism with nutritional conditions. Dev. Cell 2, 239-249 (2002).
    • (2002) Dev. Cell , vol.2 , pp. 239-249
    • Britton, J.S.1    Lockwood, W.K.2    Li, L.3    Cohen, S.M.4    Edgar, B.A.5
  • 9
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki, K., Li, Y., Zhu, T., Wu, J. & Guan, K. L. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nature Cell Biol. 4, 648-657 (2002).
    • (2002) Nature Cell Biol. , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 10
    • 0036714127 scopus 로고    scopus 로고
    • Akt regulates growth by directly phosphorylating Tsc2
    • Potter, C. J., Pedraza, L. G. & Xu, T. Akt regulates growth by directly phosphorylating Tsc2. Nature Cell Biol. 4, 658-665 (2002).
    • (2002) Nature Cell Biol. , vol.4 , pp. 658-665
    • Potter, C.J.1    Pedraza, L.G.2    Xu, T.3
  • 11
    • 0036342294 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
    • Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J. & Cantley, L. C. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol. Cell 10, 151-162 (2002).
    • (2002) Mol. Cell , vol.10 , pp. 151-162
    • Manning, B.D.1    Tee, A.R.2    Logsdon, M.N.3    Blenis, J.4    Cantley, L.C.5
  • 12
    • 0035805162 scopus 로고    scopus 로고
    • Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size
    • Potter, C. J., Huang, H. & Xu, T. Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell 105, 357-368 (2001).
    • (2001) Cell , vol.105 , pp. 357-368
    • Potter, C.J.1    Huang, H.2    Xu, T.3
  • 13
    • 0034982971 scopus 로고    scopus 로고
    • TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
    • Gao, X. & Pan, D. TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev. 15, 1383-1392 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 1383-1392
    • Gao, X.1    Pan, D.2
  • 14
    • 0036712905 scopus 로고    scopus 로고
    • Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
    • Gao, X. et al. Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nature Cell Biol. 4, 699-704 (2002).
    • (2002) Nature Cell Biol. , vol.4 , pp. 699-704
    • Gao, X.1
  • 15
    • 0034312315 scopus 로고    scopus 로고
    • Regulation of cellular growth by the Drosophila target of rapamycin dTOR
    • Zhang, H., Stallock, J. P., Ng, J. C., Reinhard, C. & Neufeld, T. P. Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev. 14, 2712-2724 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 2712-2724
    • Zhang, H.1    Stallock, J.P.2    Ng, J.C.3    Reinhard, C.4    Neufeld, T.P.5
  • 16
    • 0033103536 scopus 로고    scopus 로고
    • Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis
    • Lee, T. & Luo, L. Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron 22, 451-461 (1999).
    • (1999) Neuron , vol.22 , pp. 451-461
    • Lee, T.1    Luo, L.2
  • 17
    • 0034312279 scopus 로고    scopus 로고
    • Genetic and biochemical characterization of dTOR, the Drosophila homolog of mammalian TOR
    • Oldham, S., Montagne, J., Radimerski, T., Thomas, G. & Hafen, E. Genetic and biochemical characterization of dTOR, the Drosophila homolog of mammalian TOR. Genes Dev. 14, 2689-2694 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 2689-2694
    • Oldham, S.1    Montagne, J.2    Radimerski, T.3    Thomas, G.4    Hafen, E.5
  • 18
    • 0032843917 scopus 로고    scopus 로고
    • Drosophila S6 kinase: A regulator of cell size
    • Montagne, J. et al. Drosophila S6 kinase: a regulator of cell size. Science 285, 2126-2129(1999).
    • (1999) Science , vol.285 , pp. 2126-2129
    • Montagne, J.1
  • 19
    • 0036119219 scopus 로고    scopus 로고
    • dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1
    • Radimerski, T. et al. dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. Nature Cell Biol. 4, 251-255 (2002).
    • (2002) Nature Cell Biol. , vol.4 , pp. 251-255
    • Radimerski, T.1
  • 20
    • 0036343149 scopus 로고    scopus 로고
    • Expression of the Aspergillus fumigatus rheb homologue, rhbA, is induced by nitrogen starvation
    • Panepinto, J. C., Oliver, B. G., Amlung, T. W., Askew, D. S. & Rhodes, J. C. Expression of the Aspergillus fumigatus rheb homologue, rhbA, is induced by nitrogen starvation. Fungal Genet. Biol. 36, 207-214 (2002).
    • (2002) Fungal Genet. Biol. , vol.36 , pp. 207-214
    • Panepinto, J.C.1    Oliver, B.G.2    Amlung, T.W.3    Askew, D.S.4    Rhodes, J.C.5
  • 21
    • 0036715018 scopus 로고    scopus 로고
    • Interactions between Ras1, dMyc, and PI3K in the developing Drosophila wing
    • Prober, D. A. & Edgar, B. A. Interactions between Ras1, dMyc, and PI3K in the developing Drosophila wing. Genes Dev. 16, 2286-2299 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 2286-2299
    • Prober, D.A.1    Edgar, B.A.2
  • 22
    • 0026679892 scopus 로고
    • Raf functions downstream of Ras1 in the Sevenless signal transduction pathway
    • Dickson, B., Sprenger, F., Morrison, D. & Hafen, E. Raf functions downstream of Ras1 in the Sevenless signal transduction pathway. Nature 360, 600-603 (1992).
    • (1992) Nature , vol.360 , pp. 600-603
    • Dickson, B.1    Sprenger, F.2    Morrison, D.3    Hafen, E.4
  • 23
    • 0031039427 scopus 로고    scopus 로고
    • Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals
    • Yee, W. M. & Worley, P. F. Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals. Mol. Cell Biol. 17, 921-933 (1997).
    • (1997) Mol. Cell Biol. , vol.17 , pp. 921-933
    • Yee, W.M.1    Worley, P.F.2
  • 24
    • 0030888163 scopus 로고    scopus 로고
    • The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation
    • Clark, G. J. et al. The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation. J. Biol. Chem. 272, 10608-10615 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 10608-10615
    • Clark, G.J.1
  • 25
    • 0030828764 scopus 로고    scopus 로고
    • The GAP-related domain of tuberin, the product of the TSC2 gene, is a target for missense mutations in tuberous sclerosis
    • Maheshwar, M. M. et al. The GAP-related domain of tuberin, the product of the TSC2 gene, is a target for missense mutations in tuberous sclerosis. Hum. Mol. Genet. 6, 1991-1996 (1997).
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 1991-1996
    • Maheshwar, M.M.1
  • 26
    • 0034646618 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake
    • Urano, J., Tabancay, A. P., Yang, W. & Tamanoi, F. The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake. J. Biol. Chem. 275, 11198-11206 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 11198-11206
    • Urano, J.1    Tabancay, A.P.2    Yang, W.3    Tamanoi, F.4
  • 27
    • 0034051278 scopus 로고    scopus 로고
    • Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation
    • Mach, K. E., Furge, K. A. & Albright, C. F. Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation. Genetics 155, 611-622 (2000).
    • (2000) Genetics , vol.155 , pp. 611-622
    • Mach, K.E.1    Furge, K.A.2    Albright, C.F.3
  • 28
    • 0023832435 scopus 로고
    • A stable genomic source of P element transposase in Drosophila melanogaster
    • Robertson, H. M. et al. A stable genomic source of P element transposase in Drosophila melanogaster. Genetics 118, 461-470 (1988).
    • (1988) Genetics , vol.118 , pp. 461-470
    • Robertson, H.M.1
  • 29
    • 0028211876 scopus 로고
    • Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis
    • Brand, A. H. & Perrimon, N. Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis. Genes Dev. 8, 629-639 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 629-639
    • Brand, A.H.1    Perrimon, N.2
  • 30
    • 0034657764 scopus 로고    scopus 로고
    • Drosophila PTEN regulates cell growth and proliferation through PI3K- dependent and -independent pathways
    • Gao, X., Neufeld, T. P. & Pan, D. Drosophila PTEN regulates cell growth and proliferation through PI3K- dependent and -independent pathways. Dev. Biol. 221, 404-418 (2000).
    • (2000) Dev. Biol. , vol.221 , pp. 404-418
    • Gao, X.1    Neufeld, T.P.2    Pan, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.