-
1
-
-
33645294370
-
3,3′-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5
-
Abdelrahim M, Newman K, Vanderlaag K, Samudio I, Safe S. 2006. 3,3′-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5. Carcinogenesis 27: 717-728.
-
(2006)
Carcinogenesis
, vol.27
, pp. 717-728
-
-
Abdelrahim, M.1
Newman, K.2
Vanderlaag, K.3
Samudio, I.4
Safe, S.5
-
2
-
-
84887621906
-
Paneth cells as a site of origin for intestinal inflammation
-
Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Bock J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, et al. 2013. Paneth cells as a site of origin for intestinal inflammation. Nature 503: 272-276.
-
(2013)
Nature
, vol.503
, pp. 272-276
-
-
Adolph, T.E.1
Tomczak, M.F.2
Niederreiter, L.3
Ko, H.J.4
Bock, J.5
Martinez-Naves, E.6
Glickman, J.N.7
Tschurtschenthaler, M.8
Hartwig, J.9
Hosomi, S.10
-
3
-
-
84938513689
-
Trib3 is elevated in Parkinson’s disease and mediates death in Parkinson’s disease models
-
Aime P, Sun X, Zareen N, Rao A, Berman Z, Volpicelli-Daley L, Bernd P, Crary JF, Levy OA, Greene LA. 2015. Trib3 is elevated in Parkinson’s disease and mediates death in Parkinson’s disease models. J Neurosci 35: 10731-10749.
-
(2015)
J Neurosci
, vol.35
, pp. 10731-10749
-
-
Aime, P.1
Sun, X.2
Zareen, N.3
Rao, A.4
Berman, Z.5
Volpicelli-Daley, L.6
Bernd, P.7
Crary, J.F.8
Levy, O.A.9
Greene, L.A.10
-
4
-
-
79952283168
-
Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response
-
Ali MM, Bagratuni T, Davenport EL, Nowak PR, Silva-Santisteban MC, Hardcastle A, McAndrews C, Rowlands MG, Morgan GJ, Aherne W, et al. 2011. Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response. EMBO J 30: 894-905.
-
(2011)
EMBO J
, vol.30
, pp. 894-905
-
-
Ali, M.M.1
Bagratuni, T.2
Davenport, E.L.3
Nowak, P.R.4
Silva-Santisteban, M.C.5
Hardcastle, A.6
McAndrews, C.7
Rowlands, M.G.8
Morgan, G.J.9
Aherne, W.10
-
5
-
-
77952093535
-
Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic β cell dysfunction and apoptosis
-
Allagnat F, Christulia F, Ortis F, Pirot P, Lortz S, Lenzen S, Eizirik DL, Cardozo AK. 2010. Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic β cell dysfunction and apoptosis. Diabetologia 53: 1120-1130.
-
(2010)
Diabetologia
, vol.53
, pp. 1120-1130
-
-
Allagnat, F.1
Christulia, F.2
Ortis, F.3
Pirot, P.4
Lortz, S.5
Lenzen, S.6
Eizirik, D.L.7
Cardozo, A.K.8
-
6
-
-
84870988528
-
C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells
-
Allagnat F, Fukaya M, Nogueira TC, Delaroche D,Welsh N, Marselli L, Marchetti P, Haefliger JA, Eizirik DL, Cardozo AK. 2012. C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells. Cell Death Differ 19: 1836-1846.
-
(2012)
Cell Death Differ
, vol.19
, pp. 1836-1846
-
-
Allagnat, F.1
Fukaya, M.2
Nogueira, T.C.3
Delaroche, D.4
Welsh, N.5
Marselli, L.6
Marchetti, P.7
Haefliger, J.A.8
Eizirik, D.L.9
Cardozo, A.K.10
-
7
-
-
0037205462
-
The roles of ATF3 in liver dysfunction and the regulation of phosphoenolpyruvate carboxykinase gene expression
-
Allen-Jennings AE, Hartman MG, Kociba GJ, Hai T. 2002. The roles of ATF3 in liver dysfunction and the regulation of phosphoenolpyruvate carboxykinase gene expression. J Biol Chem 277: 20020-20025.
-
(2002)
J Biol Chem
, vol.277
, pp. 20020-20025
-
-
Allen-Jennings, A.E.1
Hartman, M.G.2
Kociba, G.J.3
Hai, T.4
-
8
-
-
1442307970
-
Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells
-
Ameri K, Lewis CE, Raida M, Sowter H, Hai T, Harris AL. 2004. Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells. Blood 103: 1876-1882.
-
(2004)
Blood
, vol.103
, pp. 1876-1882
-
-
Ameri, K.1
Lewis, C.E.2
Raida, M.3
Sowter, H.4
Hai, T.5
Harris, A.L.6
-
9
-
-
0037779439
-
Regulated expression of ATF5 is required for the progression of neural progenitor cells to neurons
-
Angelastro JM, Ignatova TN, Kukekov VG, Steindler DA, Stengren GB, Mendelsohn C, Greene LA. 2003. Regulated expression of ATF5 is required for the progression of neural progenitor cells to neurons. J Neurosci 23: 4590-4600.
-
(2003)
J Neurosci
, vol.23
, pp. 4590-4600
-
-
Angelastro, J.M.1
Ignatova, T.N.2
Kukekov, V.G.3
Steindler, D.A.4
Stengren, G.B.5
Mendelsohn, C.6
Greene, L.A.7
-
10
-
-
17644367544
-
Downregulation of activating transcription factor 5 is required for differentiation of neural progenitor cells into astrocytes
-
Angelastro JM, Mason JL, Ignatova TN, Kukekov VG, Stengren GB, Goldman JE, Greene LA. 2005. Downregulation of activating transcription factor 5 is required for differentiation of neural progenitor cells into astrocytes. J Neurosci 25: 3889-3899.
-
(2005)
J Neurosci
, vol.25
, pp. 3889-3899
-
-
Angelastro, J.M.1
Mason, J.L.2
Ignatova, T.N.3
Kukekov, V.G.4
Stengren, G.B.5
Goldman, J.E.6
Greene, L.A.7
-
11
-
-
84938987663
-
Mutation of ATF6 causes autosomal recessive achromatopsia
-
Ansar M, Santos-Cortez RL, Saqib MA, Zulfiqar F, Lee K, Ashraf NM, Ullah E, Wang X, Sajid S, Khan FS, et al. 2015. Mutation of ATF6 causes autosomal recessive achromatopsia. Hum Genet 134: 941-950.
-
(2015)
Hum Genet
, vol.134
, pp. 941-950
-
-
Ansar, M.1
Santos-Cortez, R.L.2
Saqib, M.A.3
Zulfiqar, F.4
Lee, K.5
Ashraf, N.M.6
Ullah, E.7
Wang, X.8
Sajid, S.9
Khan, F.S.10
-
12
-
-
29344457845
-
Transformation-associated gene regulation by ATF6α during hepatocarcinogenesis
-
Arai M, Kondoh N, Imazeki N, Hada A, Hatsuse K, Kimura F, Matsubara O, Mori K, Wakatsuki T, Yamamoto M. 2006. Transformation-associated gene regulation by ATF6α during hepatocarcinogenesis. FEBS Lett 580: 184-190.
-
(2006)
FEBS Lett
, vol.580
, pp. 184-190
-
-
Arai, M.1
Kondoh, N.2
Imazeki, N.3
Hada, A.4
Hatsuse, K.5
Kimura, F.6
Matsubara, O.7
Mori, K.8
Wakatsuki, T.9
Yamamoto, M.10
-
13
-
-
84875235453
-
Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity
-
Atkins C, Liu Q, Minthorn E, Zhang SY, Figueroa DJ, Moss K, Stanley TB, Sanders B, Goetz A, Gaul N, et al. 2013. Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res 73: 1993-2002.
-
(2013)
Cancer Res
, vol.73
, pp. 1993-2002
-
-
Atkins, C.1
Liu, Q.2
Minthorn, E.3
Zhang, S.Y.4
Figueroa, D.J.5
Moss, K.6
Stanley, T.B.7
Sanders, B.8
Goetz, A.9
Gaul, N.10
-
14
-
-
67649450485
-
Translation attenuation through eIF2α phosphorylation prevents oxidative stress and maintains the differentiated state in β cells
-
Back SH, Scheuner D, Han J, Song B, Ribick M, Wang J, Gildersleeve RD, Pennathur S, Kaufman RJ. 2009. Translation attenuation through eIF2α phosphorylation prevents oxidative stress and maintains the differentiated state in β cells. Cell Metab 10: 13-26.
-
(2009)
Cell Metab
, vol.10
, pp. 13-26
-
-
Back, S.H.1
Scheuner, D.2
Han, J.3
Song, B.4
Ribick, M.5
Wang, J.6
Gildersleeve, R.D.7
Pennathur, S.8
Kaufman, R.J.9
-
15
-
-
77955486614
-
XBP1s levels are implicated in the biology and outcome of myeloma mediating different clinical outcomes to thalidomide-based treatments
-
Bagratuni T,Wu P, Gonzalez de Castro D, Davenport EL, Dickens NJ, Walker BA, Boyd K, Johnson DC, Gregory W, Morgan GJ, et al. 2010. XBP1s levels are implicated in the biology and outcome of myeloma mediating different clinical outcomes to thalidomide-based treatments. Blood 116: 250-253.
-
(2010)
Blood
, vol.116
, pp. 250-253
-
-
Bagratuni, T.1
Wu, P.2
Gonzalez De Castro, D.3
Davenport, E.L.4
Dickens, N.J.5
Walker, B.A.6
Boyd, K.7
Johnson, D.C.8
Gregory, W.9
Morgan, G.J.10
-
16
-
-
84903774348
-
Novel bioinformatics method for identification of genome-wide non-canonical spliced regions using RNA-seq data
-
Bai Y, Hassler J, Ziyar A, Li P, Wright Z, Menon R, Omenn GS, Cavalcoli JD, Kaufman RJ, Sartor MA. 2014. Novel bioinformatics method for identification of genome-wide non-canonical spliced regions using RNA-seq data. PLoS One 9: e100864.
-
(2014)
PLoS One
, vol.9
, pp. 100864
-
-
Bai, Y.1
Hassler, J.2
Ziyar, A.3
Li, P.4
Wright, Z.5
Menon, R.6
Omenn, G.S.7
Cavalcoli, J.D.8
Kaufman, R.J.9
Sartor, M.A.10
-
17
-
-
84907343347
-
Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions
-
Baleriola J, Walker CA, Jean YY, Crary JF, Troy CM, Nagy PL, Hengst U. 2014. Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions. Cell 158: 1159-1172.
-
(2014)
Cell
, vol.158
, pp. 1159-1172
-
-
Baleriola, J.1
Walker, C.A.2
Jean, Y.Y.3
Crary, J.F.4
Troy, C.M.5
Nagy, P.L.6
Hengst, U.7
-
18
-
-
84884660617
-
Gene expression regulation by upstream open reading frames and human disease
-
Barbosa C, Peixeiro I, Romao L. 2013. Gene expression regulation by upstream open reading frames and human disease. PLoS Genet 9: e1003529.
-
(2013)
PLoS Genet
, vol.9
, pp. 1003529
-
-
Barbosa, C.1
Peixeiro, I.2
Romao, L.3
-
19
-
-
0029130373
-
Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153)
-
Batchvarova N, Wang XZ, Ron D. 1995. Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153). EMBO J 14: 4654-4661.
-
(1995)
EMBO J
, vol.14
, pp. 4654-4661
-
-
Batchvarova, N.1
Wang, X.Z.2
Ron, D.3
-
20
-
-
33751159209
-
Intracellular signaling by the unfolded protein response
-
Bernales S, Papa FR, Walter P. 2006. Intracellular signaling by the unfolded protein response. Annu Rev Cell Dev Biol 22: 487-508.
-
(2006)
Annu Rev Cell Dev Biol
, vol.22
, pp. 487-508
-
-
Bernales, S.1
Papa, F.R.2
Walter, P.3
-
21
-
-
0033782015
-
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
-
Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D. 2000. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol 2: 326-332.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 326-332
-
-
Bertolotti, A.1
Zhang, Y.2
Hendershot, L.M.3
Harding, H.P.4
Ron, D.5
-
22
-
-
84937790383
-
The transcription factor XBP1 is selectively required for eosinophil differentiation
-
Bettigole SE, Lis R, Adoro S, Lee AH, Spencer LA, Weller PF, Glimcher LH. 2015. The transcription factor XBP1 is selectively required for eosinophil differentiation. Nat Immunol 16: 829-837.
-
(2015)
Nat Immunol
, vol.16
, pp. 829-837
-
-
Bettigole, S.E.1
Lis, R.2
Adoro, S.3
Lee, A.H.4
Spencer, L.A.5
Weller, P.F.6
Glimcher, L.H.7
-
23
-
-
27144458505
-
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
-
Bi M, Naczki C, Koritzinsky M, Fels D, Blais J, Hu N, Harding H, Novoa I, Varia M, Raleigh J, et al. 2005. ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J 24: 3470-3481.
-
(2005)
EMBO J
, vol.24
, pp. 3470-3481
-
-
Bi, M.1
Naczki, C.2
Koritzinsky, M.3
Fels, D.4
Blais, J.5
Hu, N.6
Harding, H.7
Novoa, I.8
Varia, M.9
Raleigh, J.10
-
24
-
-
84897550127
-
ATF3 is a novel regulator of mouse neutrophil migration
-
Boespflug ND, Kumar S, McAlees JW, Phelan JD, Grimes HL, Hoebe K, Hai T, Filippi MD, Karp CL. 2014. ATF3 is a novel regulator of mouse neutrophil migration. Blood 123: 2084-2093.
-
(2014)
Blood
, vol.123
, pp. 2084-2093
-
-
Boespflug, N.D.1
Kumar, S.2
McAlees, J.W.3
Phelan, J.D.4
Grimes, H.L.5
Hoebe, K.6
Hai, T.7
Filippi, M.D.8
Karp, C.L.9
-
25
-
-
0037814982
-
Gene modulation by the cyclooxygenase inhibitor, sulindac sulfide, in human colorectal carcinoma cells: Possible link to apoptosis
-
Bottone FG Jr, Martinez JM, Collins JB, Afshari CA, Eling TE. 2003. Gene modulation by the cyclooxygenase inhibitor, sulindac sulfide, in human colorectal carcinoma cells: possible link to apoptosis. J Biol Chem 278: 25790-25801.
-
(2003)
J Biol Chem
, vol.278
, pp. 25790-25801
-
-
Bottone, F.G.1
Martinez, J.M.2
Collins, J.B.3
Afshari, C.A.4
Eling, T.E.5
-
26
-
-
79954417075
-
Parkin is transcriptionally regulated by ATF4: Evidence for an interconnection between mitochondrial stress and ER stress
-
Bouman L, Schlierf A, Lutz AK, Shan J, Deinlein A, Kast J, Galehdar Z, Palmisano V, Patenge N, Berg D, et al. 2011. Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ 18: 769-782.
-
(2011)
Cell Death Differ
, vol.18
, pp. 769-782
-
-
Bouman, L.1
Schlierf, A.2
Lutz, A.K.3
Shan, J.4
Deinlein, A.5
Kast, J.6
Galehdar, Z.7
Palmisano, V.8
Patenge, N.9
Berg, D.10
-
27
-
-
0037011917
-
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
-
Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D. 2002. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415: 92-96.
-
(2002)
Nature
, vol.415
, pp. 92-96
-
-
Calfon, M.1
Zeng, H.2
Urano, F.3
Till, J.H.4
Hubbard, S.R.5
Harding, H.P.6
Clark, S.G.7
Ron, D.8
-
28
-
-
77955286526
-
Activating transcription factor 4 regulates osteoclast differentiation in mice
-
Cao H, Yu S, Yao Z, Galson DL, Jiang Y, Zhang X, Fan J, Lu B, Guan Y, Luo M, et al. 2010. Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest 120: 2755-2766.
-
(2010)
J Clin Invest
, vol.120
, pp. 2755-2766
-
-
Cao, H.1
Yu, S.2
Yao, Z.3
Galson, D.L.4
Jiang, Y.5
Zhang, X.6
Fan, J.7
Lu, B.8
Guan, Y.9
Luo, M.10
-
29
-
-
34047136169
-
The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis
-
Carrasco DR, Sukhdeo K, Protopopova M, Sinha R, Enos M, Carrasco DE, Zheng M, Mani M, Henderson J, Pinkus GS, et al. 2007. The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer Cell 11: 349-360.
-
(2007)
Cancer Cell
, vol.11
, pp. 349-360
-
-
Carrasco, D.R.1
Sukhdeo, K.2
Protopopova, M.3
Sinha, R.4
Enos, M.5
Carrasco, D.E.6
Zheng, M.7
Mani, M.8
Henderson, J.9
Pinkus, G.S.10
-
30
-
-
79956036398
-
The ER stress factor XBP1s prevents amyloid-β neurotoxicity
-
Casas-Tinto S, Zhang Y, Sanchez-Garcia J, Gomez-Velazquez M, Rincon-Limas DE, Fernandez-Funez P. 2011. The ER stress factor XBP1s prevents amyloid-β neurotoxicity. Hum Mol Genet 20: 2144-2160.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 2144-2160
-
-
Casas-Tinto, S.1
Zhang, Y.2
Sanchez-Garcia, J.3
Gomez-Velazquez, M.4
Rincon-Limas, D.E.5
Fernandez-Funez, P.6
-
31
-
-
84855310090
-
Activating transcription factor 4 (ATF4) is upregulated by human herpesvirus 8 infection, increases virus replication and promotes proangiogenic properties
-
Caselli E, Benedetti S, Grigolato J, Caruso A, Di Luca D. 2012. Activating transcription factor 4 (ATF4) is upregulated by human herpesvirus 8 infection, increases virus replication and promotes proangiogenic properties. Arch Virol 157: 63-74.
-
(2012)
Arch Virol
, vol.157
, pp. 63-74
-
-
Caselli, E.1
Benedetti, S.2
Grigolato, J.3
Caruso, A.4
Di Luca, D.5
-
32
-
-
0037066741
-
The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi
-
Chen X, Shen J, Prywes R. 2002. The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi. J Biol Chem 277: 13045-13052.
-
(2002)
J Biol Chem
, vol.277
, pp. 13045-13052
-
-
Chen, X.1
Shen, J.2
Prywes, R.3
-
33
-
-
84866135183
-
Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes
-
Chen Y, Wang JJ, Li J, Hosoya KI, Ratan R, Townes T, Zhang SX. 2012. Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes. Diabetologia 55: 2533-2545.
-
(2012)
Diabetologia
, vol.55
, pp. 2533-2545
-
-
Chen, Y.1
Wang, J.J.2
Li, J.3
Hosoya, K.I.4
Ratan, R.5
Townes, T.6
Zhang, S.X.7
-
34
-
-
84897541350
-
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
-
Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y, et al. 2014. XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. Nature 508: 103-107.
-
(2014)
Nature
, vol.508
, pp. 103-107
-
-
Chen, X.1
Iliopoulos, D.2
Zhang, Q.3
Tang, Q.4
Greenblatt, M.B.5
Hatziapostolou, M.6
Lim, E.7
Tam, W.L.8
Ni, M.9
Chen, Y.10
-
35
-
-
85009344484
-
Achromatopsia mutations target sequential steps of ATF6 activation
-
Chiang WC, Chan P,Wissinger B, Vincent A, Skorczyk-Werner A, Krawczynski MR, Kaufman RJ, Tsang SH, Heon E, Kohl S, et al. 2017. Achromatopsia mutations target sequential steps of ATF6 activation. Proc Natl Acad Sci 114: 400-405.
-
(2017)
Proc Natl Acad Sci
, vol.114
, pp. 400-405
-
-
Chiang, W.C.1
Chan, P.2
Wissinger, B.3
Vincent, A.4
Skorczyk-Werner, A.5
Krawczynski, M.R.6
Kaufman, R.J.7
Tsang, S.H.8
Heon, E.9
Kohl, S.10
-
36
-
-
84923871028
-
α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson’s disease
-
Credle JJ, Forcelli PA, Delannoy M, Oaks AW, Permaul E, Berry DL, Duka V,Wills J, Sidhu A. 2015. α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson’s disease. Neurobiol Dis 76: 112-125.
-
(2015)
Neurobiol Dis
, vol.76
, pp. 112-125
-
-
Credle, J.J.1
Forcelli, P.A.2
Delannoy, M.3
Oaks, A.W.4
Permaul, E.5
Berry, D.L.6
Duka, V.7
Wills, J.8
Sidhu, A.9
-
37
-
-
84859587957
-
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule
-
Cross BC, Bond PJ, Sadowski PG, Jha BK, Zak J, Goodman JM, Silverman RH, Neubert TA, Baxendale IR, Ron D, et al. 2012. The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc Natl Acad Sci 109: E869-E878.
-
(2012)
Proc Natl Acad Sci
, vol.109
, pp. E869-E878
-
-
Cross, B.C.1
Bond, P.J.2
Sadowski, P.G.3
Jha, B.K.4
Zak, J.5
Goodman, J.M.6
Silverman, R.H.7
Neubert, T.A.8
Baxendale, I.R.9
Ron, D.10
-
38
-
-
84931569761
-
ER stress sensor XBP1 controls anti-tumor immunity by disrupting dendritic cell homeostasis
-
Cubillos-Ruiz JR, Silberman PC, Rutkowski MR, Chopra S, Perales-Puchalt A, Song M, Zhang S, Bettigole SE, Gupta D, Holcomb K, et al. 2015. ER stress sensor XBP1 controls anti-tumor immunity by disrupting dendritic cell homeostasis. Cell 161: 1527-1538.
-
(2015)
Cell
, vol.161
, pp. 1527-1538
-
-
Cubillos-Ruiz, J.R.1
Silberman, P.C.2
Rutkowski, M.R.3
Chopra, S.4
Perales-Puchalt, A.5
Song, M.6
Zhang, S.7
Bettigole, S.E.8
Gupta, D.9
Holcomb, K.10
-
39
-
-
57649171080
-
Regulation of interleukin-8 gene at a distinct site of its promoter by CCAAT enhancer-binding protein homologous protein in prostaglandin E2-treated human T cells
-
Cucinotta M, Visalli M, Aguennouz M, Valenti A, Loddo S, Altucci L, Teti D. 2008. Regulation of interleukin-8 gene at a distinct site of its promoter by CCAAT enhancer-binding protein homologous protein in prostaglandin E2-treated human T cells. J Biol Chem 283: 29760-29769.
-
(2008)
J Biol Chem
, vol.283
, pp. 29760-29769
-
-
Cucinotta, M.1
Visalli, M.2
Aguennouz, M.3
Valenti, A.4
Loddo, S.5
Altucci, L.6
Teti, D.7
-
40
-
-
84927941385
-
The stress-responsive geneATF3 regulates the histone acetyltransferase Tip60
-
Cui H, Guo M, Xu D, Ding ZC, Zhou G, Ding HF, Zhang J, Tang Y, Yan C. 2015. The stress-responsive geneATF3 regulates the histone acetyltransferase Tip60. Nat Commun 6: 6752.
-
(2015)
Nat Commun
, vol.6
, pp. 6752
-
-
Cui, H.1
Guo, M.2
Xu, D.3
Ding, Z.C.4
Zhou, G.5
Ding, H.F.6
Zhang, J.7
Tang, Y.8
Yan, C.9
-
41
-
-
84876407251
-
The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma
-
Dalton LE, Clarke HJ, Knight J, Lawson MH,Wason J, Lomas DA, Howat WJ, Rintoul RC, Rassl DM, Marciniak SJ. 2013. The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma. Br J Cancer 108: 1340-1347.
-
(2013)
Br J Cancer
, vol.108
, pp. 1340-1347
-
-
Dalton, L.E.1
Clarke, H.J.2
Knight, J.3
Lawson, M.H.4
Wason, J.5
Lomas, D.A.6
Howat, W.J.7
Rintoul, R.C.8
Rassl, D.M.9
Marciniak, S.J.10
-
42
-
-
43949090166
-
Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrinetreated breast cancer
-
Davies MP, Barraclough DL, Stewart C, Joyce KA, Eccles RM, Barraclough R, Rudland PS, Sibson DR. 2008. Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrinetreated breast cancer. Int J Cancer 123: 85-88.
-
(2008)
Int J Cancer
, vol.123
, pp. 85-88
-
-
Davies, M.P.1
Barraclough, D.L.2
Stewart, C.3
Joyce, K.A.4
Eccles, R.M.5
Barraclough, R.6
Rudland, P.S.7
Sibson, D.R.8
-
43
-
-
84892737895
-
Highdensity lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3
-
De Nardo D, Labzin LI, Kono H, Seki R, Schmidt SV, Beyer M, Xu D, Zimmer S, Lahrmann C, Schildberg FA, et al. 2014. Highdensity lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nat Immunol 15: 152-160.
-
(2014)
Nat Immunol
, vol.15
, pp. 152-160
-
-
De Nardo, D.1
Labzin, L.I.2
Kono, H.3
Seki, R.4
Schmidt, S.V.5
Beyer, M.6
Xu, D.7
Zimmer, S.8
Lahrmann, C.9
Schildberg, F.A.10
-
44
-
-
0037031145
-
Activation of GCN2 in UV-irradiated cells inhibits translation
-
Deng J, Harding HP, Raught B, Gingras AC, Berlanga JJ, Scheuner D, Kaufman RJ, Ron D, Sonenberg N. 2002. Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol 12: 1279-1286.
-
(2002)
Curr Biol
, vol.12
, pp. 1279-1286
-
-
Deng, J.1
Harding, H.P.2
Raught, B.3
Gingras, A.C.4
Berlanga, J.J.5
Scheuner, D.6
Kaufman, R.J.7
Ron, D.8
Sonenberg, N.9
-
45
-
-
8644282751
-
Translational repression mediates activation of nuclear factor κB by phosphorylated translation initiation factor 2
-
Deng J, Lu PD, Zhang Y, Scheuner D, Kaufman RJ, Sonenberg N, Harding HP, Ron D. 2004. Translational repression mediates activation of nuclear factor κB by phosphorylated translation initiation factor 2. Mol Cell Biol 24: 10161-10168.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 10161-10168
-
-
Deng, J.1
Lu, P.D.2
Zhang, Y.3
Scheuner, D.4
Kaufman, R.J.5
Sonenberg, N.6
Harding, H.P.7
Ron, D.8
-
46
-
-
84936817064
-
ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis
-
Dey S, Sayers CM, Verginadis II, Lehman SL, Cheng Y, Cerniglia GJ, Tuttle SW, Feldman MD, Zhang PJ, Fuchs SY, et al. 2015. ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis. J Clin Invest 125: 2592-2608.
-
(2015)
J Clin Invest
, vol.125
, pp. 2592-2608
-
-
Dey, S.1
Sayers, C.M.2
Verginadis, I.I.3
Lehman, S.L.4
Cheng, Y.5
Cerniglia, G.J.6
Tuttle, S.W.7
Feldman, M.D.8
Zhang, P.J.9
Fuchs, S.Y.10
-
47
-
-
84892393658
-
The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis
-
DeZwaan-McCabe D, Riordan JD, Arensdorf AM, Icardi MS, Dupuy AJ, Rutkowski DT. 2013. The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis. PLoS Genet 9: e1003937.
-
(2013)
PLoS Genet
, vol.9
, pp. 1003937
-
-
DeZwaan-McCabe, D.1
Riordan, J.D.2
Arensdorf, A.M.3
Icardi, M.S.4
Dupuy, A.J.5
Rutkowski, D.T.6
-
48
-
-
79953203956
-
BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner
-
Dluzen D, Li G, Tacelosky D, Moreau M, Liu DX. 2011. BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner. J Biol Chem 286: 7705-7713.
-
(2011)
J Biol Chem
, vol.286
, pp. 7705-7713
-
-
Dluzen, D.1
Li, G.2
Tacelosky, D.3
Moreau, M.4
Liu, D.X.5
-
49
-
-
84939152599
-
Transcription factor ATF4 induces NLRP1 inflammasome expression during endoplasmic reticulum stress
-
D’Osualdo A, Anania VG, Yu K, Lill JR, Kaufman RJ, Matsuzawa S, Reed JC. 2015. Transcription factor ATF4 induces NLRP1 inflammasome expression during endoplasmic reticulum stress. PLoS One 10: e0130635.
-
(2015)
PLoS One
, vol.10
, pp. 130635
-
-
D’Osualdo, A.1
Anania, V.G.2
Yu, K.3
Lill, J.R.4
Kaufman, R.J.5
Matsuzawa, S.6
Reed, J.C.7
-
50
-
-
67449113506
-
Suppression of NF-κB by cyclosporin a and tacrolimus (FK506) via induction of the C/EBP family: Implication for unfolded protein response
-
Du S, Hiramatsu N, Hayakawa K, Kasai A, Okamura M, Huang T, Yao J, Takeda M, Araki I, Sawada N, et al. 2009. Suppression of NF-κB by cyclosporin a and tacrolimus (FK506) via induction of the C/EBP family: implication for unfolded protein response. J Immunol 182: 7201-7211.
-
(2009)
J Immunol
, vol.182
, pp. 7201-7211
-
-
Du, S.1
Hiramatsu, N.2
Hayakawa, K.3
Kasai, A.4
Okamura, M.5
Huang, T.6
Yao, J.7
Takeda, M.8
Araki, I.9
Sawada, N.10
-
51
-
-
84905392984
-
Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib
-
Edagawa M, Kawauchi J, Hirata M, Goshima H, Inoue M, Okamoto T, Murakami A, Maehara Y, Kitajima S. 2014. Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib. J Biol Chem 289: 21544-21561.
-
(2014)
J Biol Chem
, vol.289
, pp. 21544-21561
-
-
Edagawa, M.1
Kawauchi, J.2
Hirata, M.3
Goshima, H.4
Inoue, M.5
Okamoto, T.6
Murakami, A.7
Maehara, Y.8
Kitajima, S.9
-
52
-
-
33646491144
-
C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation
-
Endo M, Mori M, Akira S, Gotoh T. 2006. C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation. J Immunol 176: 6245-6253.
-
(2006)
J Immunol
, vol.176
, pp. 6245-6253
-
-
Endo, M.1
Mori, M.2
Akira, S.3
Gotoh, T.4
-
53
-
-
84890076252
-
Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes
-
Engin F, Yermalovich A, Nguyen T, Hummasti S, Fu W, Eizirik DL, Mathis D, Hotamisligil GS. 2013. Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes. Sci Transl Med 5: 211ra156.
-
(2013)
Sci Transl Med
, vol.5
, pp. 156
-
-
Engin, F.1
Yermalovich, A.2
Nguyen, T.3
Hummasti, S.4
Fu, W.5
Eizirik, D.L.6
Mathis, D.7
Hotamisligil, G.S.8
-
54
-
-
72949096111
-
Fibroblast growth factor 2 positively regulates expression of activating transcription factor 4 in osteoblasts
-
Fei Y, Xiao L, Hurley MM. 2010. Fibroblast growth factor 2 positively regulates expression of activating transcription factor 4 in osteoblasts. Biochem Biophys Res Commun 391: 335-339.
-
(2010)
Biochem Biophys Res Commun
, vol.391
, pp. 335-339
-
-
Fei, Y.1
Xiao, L.2
Hurley, M.M.3
-
55
-
-
84904053401
-
Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress
-
Feng YX, Sokol ES, Del Vecchio CA, Sanduja S, Claessen JH, Proia TA, Jin DX, Reinhardt F, Ploegh HL, Wang Q, et al. 2014. Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress. Cancer Discov 4: 702-715.
-
(2014)
Cancer Discov
, vol.4
, pp. 702-715
-
-
Feng, Y.X.1
Sokol, E.S.2
Del Vecchio, C.A.3
Sanduja, S.4
Claessen, J.H.5
Proia, T.A.6
Jin, D.X.7
Reinhardt, F.8
Ploegh, H.L.9
Wang, Q.10
-
56
-
-
84938197286
-
Selective small molecule activator of the apoptotic arm of the UPR
-
National Center for Biotechnology Information, Bethesda, MD
-
Flaherty DP, Golden JE, Liu C, Hedrick M, Gosalia P, Li Y, Milewski M, Sugarman E, Suyama E, Nguyen K, et al. 2010. Selective small molecule activator of the apoptotic arm of the UPR. In Probe reports from the NIH Molecular Libraries Program. National Center for Biotechnology Information, Bethesda, MD. https://www.ncbi.nlm.nih.gov/books/NBK133431.
-
(2010)
Probe reports from the NIH Molecular Libraries Program
-
-
Flaherty, D.P.1
Golden, J.E.2
Liu, C.3
Hedrick, M.4
Gosalia, P.5
Li, Y.6
Milewski, M.7
Sugarman, E.8
Suyama, E.9
Nguyen, K.10
-
57
-
-
84918587731
-
Discovery of sulfonamidebenzamides as selective apoptotic CHOP pathway activators of the unfolded protein response
-
Flaherty DP, Miller JR, Garshott DM, Hedrick M, Gosalia P, Li Y, Milewski M, Sugarman E, Vasile S, Salaniwal S, et al. 2014. Discovery of sulfonamidebenzamides as selective apoptotic CHOP pathway activators of the unfolded protein response. ACS Med Chem Lett 5: 1278-1283.
-
(2014)
ACS Med Chem Lett
, vol.5
, pp. 1278-1283
-
-
Flaherty, D.P.1
Miller, J.R.2
Garshott, D.M.3
Hedrick, M.4
Gosalia, P.5
Li, Y.6
Milewski, M.7
Sugarman, E.8
Vasile, S.9
Salaniwal, S.10
-
58
-
-
84877836210
-
In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis
-
Gargiulo G, Cesaroni M, Serresi M, de Vries N, Hulsman D, Bruggeman SW, Lancini C, van Lohuizen M. 2013. In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis. Cancer Cell 23: 660-676.
-
(2013)
Cancer Cell
, vol.23
, pp. 660-676
-
-
Gargiulo, G.1
Cesaroni, M.2
Serresi, M.3
de Vries, N.4
Hulsman, D.5
Bruggeman, S.W.6
Lancini, C.7
van Lohuizen, M.8
-
59
-
-
33646547951
-
Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4
-
Gilchrist M, Thorsson V, Li B, Rust AG, Korb M, Roach JC, Kennedy K, Hai T, Bolouri H, Aderem A. 2006. Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4. Nature 441: 173-178.
-
(2006)
Nature
, vol.441
, pp. 173-178
-
-
Gilchrist, M.1
Thorsson, V.2
Li, B.3
Rust, A.G.4
Korb, M.5
Roach, J.C.6
Kennedy, K.7
Hai, T.8
Bolouri, H.9
Aderem, A.10
-
60
-
-
84901062946
-
Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD
-
Gonzalez-Rodriguez A, Mayoral R, Agra N, Valdecantos MP, Pardo V, Miquilena-Colina ME, Vargas-Castrillon J, Lo Iacono O, Corazzari M, Fimia GM, et al. 2014. Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. Cell Death Dis 5: e1179.
-
(2014)
Cell Death Dis
, vol.5
, pp. 1179
-
-
Gonzalez-Rodriguez, A.1
Mayoral, R.2
Agra, N.3
Valdecantos, M.P.4
Pardo, V.5
Miquilena-Colina, M.E.6
Vargas-Castrillon, J.7
Lo Iacono, O.8
Corazzari, M.9
Fimia, G.M.10
-
61
-
-
78049271424
-
Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression
-
Goodall JC, Wu C, Zhang Y, McNeill L, Ellis L, Saudek V, Gaston JS. 2010. Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression. Proc Natl Acad Sci 107: 17698-17703.
-
(2010)
Proc Natl Acad Sci
, vol.107
, pp. 17698-17703
-
-
Goodall, J.C.1
Wu, C.2
Zhang, Y.3
McNeill, L.4
Ellis, L.5
Saudek, V.6
Gaston, J.S.7
-
62
-
-
84923172388
-
IL-4 abrogates T(H)17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells
-
Guenova E, Skabytska Y, Hoetzenecker W, Weindl G, Sauer K, Tham M, Kim KW, Park JH, Seo JH, Ignatova D, et al. 2015. IL-4 abrogates T(H)17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells. Proc Natl Acad Sci 112: 2163-2168.
-
(2015)
Proc Natl Acad Sci
, vol.112
, pp. 2163-2168
-
-
Guenova, E.1
Skabytska, Y.2
Hoetzenecker, W.3
Weindl, G.4
Sauer, K.5
Tham, M.6
Kim, K.W.7
Park, J.H.8
Seo, J.H.9
Ignatova, D.10
-
63
-
-
84907820400
-
Endoplasmic reticulum chaperones and oxidoreductases: Critical regulators of tumor cell survival and immunorecognition
-
Gutierrez T, Simmen T. 2014. Endoplasmic reticulum chaperones and oxidoreductases: critical regulators of tumor cell survival and immunorecognition. Front Oncol 4: 291.
-
(2014)
Front Oncol
, vol.4
, pp. 291
-
-
Gutierrez, T.1
Simmen, T.2
-
64
-
-
17944362905
-
Heme-regulated eIF2α kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency
-
Han AP, Yu C, Lu L, Fujiwara Y, Browne C, Chin G, Fleming M, Leboulch P, Orkin SH, Chen JJ. 2001. Heme-regulated eIF2α kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. EMBO J 20: 6909-6918.
-
(2001)
EMBO J
, vol.20
, pp. 6909-6918
-
-
Han, A.P.1
Yu, C.2
Lu, L.3
Fujiwara, Y.4
Browne, C.5
Chin, G.6
Fleming, M.7
Leboulch, P.8
Orkin, S.H.9
Chen, J.J.10
-
65
-
-
68049110633
-
IRE1α kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates
-
Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR. 2009. IRE1α kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell 138: 562-575.
-
(2009)
Cell
, vol.138
, pp. 562-575
-
-
Han, D.1
Lerner, A.G.2
Vande Walle, L.3
Upton, J.P.4
Xu, W.5
Hagen, A.6
Backes, B.J.7
Oakes, S.A.8
Papa, F.R.9
-
66
-
-
84877578475
-
ER-stressinduced transcriptional regulation increases protein synthesis leading to cell death
-
Han J, Back SH, Hur J, Lin YH, Gildersleeve R, Shan J, Yuan CL, Krokowski D, Wang S, Hatzoglou M, et al. 2013a. ER-stressinduced transcriptional regulation increases protein synthesis leading to cell death. Nat Cell Biol 15: 481-490.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 481-490
-
-
Han, J.1
Back, S.H.2
Hur, J.3
Lin, Y.H.4
Gildersleeve, R.5
Shan, J.6
Yuan, C.L.7
Krokowski, D.8
Wang, S.9
Hatzoglou, M.10
-
67
-
-
84876485565
-
ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice
-
Han J, Murthy R,Wood B, Song B,Wang S, Sun B, Malhi H, Kaufman RJ. 2013b. ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice. Diabetologia 56: 911-924.
-
(2013)
Diabetologia
, vol.56
, pp. 911-924
-
-
Han, J.1
Murthy, R.2
Wood, B.3
Song, B.4
Wang, S.5
Sun, B.6
Malhi, H.7
Kaufman, R.J.8
-
68
-
-
84940557532
-
Antioxidants complement the requirement for protein chaperone function to maintain β-cell function and glucose homeostasis
-
Han J, Song B, Kim J, Kodali VK, Pottekat A, Wang M, Hassler J, Wang S, Pennathur S, Back SH, et al. 2015. Antioxidants complement the requirement for protein chaperone function to maintain β-cell function and glucose homeostasis. Diabetes 64: 2892-2904.
-
(2015)
Diabetes
, vol.64
, pp. 2892-2904
-
-
Han, J.1
Song, B.2
Kim, J.3
Kodali, V.K.4
Pottekat, A.5
Wang, M.6
Hassler, J.7
Wang, S.8
Pennathur, S.9
Back, S.H.10
-
69
-
-
0036729656
-
Mouse Atf5: Molecular cloning of two novel mRNAs, genomic organization, and odorant sensory neuron localization
-
Hansen MB, Mitchelmore C, Kjaerulff KM, Rasmussen TE, Pedersen KM, Jensen NA. 2002. Mouse Atf5: molecular cloning of two novel mRNAs, genomic organization, and odorant sensory neuron localization. Genomics 80: 344-350.
-
(2002)
Genomics
, vol.80
, pp. 344-350
-
-
Hansen, M.B.1
Mitchelmore, C.2
Kjaerulff, K.M.3
Rasmussen, T.E.4
Pedersen, K.M.5
Jensen, N.A.6
-
70
-
-
0033590451
-
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
-
Harding HP, Zhang Y, Ron D. 1999. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397: 271-274.
-
(1999)
Nature
, vol.397
, pp. 271-274
-
-
Harding, H.P.1
Zhang, Y.2
Ron, D.3
-
71
-
-
0033634654
-
Regulated translation initiation controls stress-induced gene expression in mammalian cells
-
Harding HP, Novoa I, Zhang Y, Zeng H,Wek R, Schapira M, Ron D. 2000. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 6: 1099-1108.
-
(2000)
Mol Cell
, vol.6
, pp. 1099-1108
-
-
Harding, H.P.1
Novoa, I.2
Zhang, Y.3
Zeng, H.4
Wek, R.5
Schapira, M.6
Ron, D.7
-
72
-
-
84868135034
-
ATF6α promotes astroglial activation and neuronal survival in a chronic mouse model of Parkinson’s disease
-
Hashida K, Kitao Y, Sudo H, Awa Y, Maeda S, Mori K, Takahashi R, Iinuma M, Hori O. 2012. ATF6α promotes astroglial activation and neuronal survival in a chronic mouse model of Parkinson’s disease. PLoS One 7: e47950.
-
(2012)
PLoS One
, vol.7
, pp. 47950
-
-
Hashida, K.1
Kitao, Y.2
Sudo, H.3
Awa, Y.4
Maeda, S.5
Mori, K.6
Takahashi, R.7
Iinuma, M.8
Hori, O.9
-
73
-
-
84946083953
-
The IRE1α/XBP1s pathway is essential for the glucose response and protection of β cells
-
Hassler JR, Scheuner DL,Wang S, Han J, Kodali VK, Li P, Nguyen J, George JS, Davis C, Wu SP, et al. 2015. The IRE1α/XBP1s pathway is essential for the glucose response and protection of β cells. PLoS Biol 13: e1002277.
-
(2015)
PLoS Biol
, vol.13
, pp. 1002277
-
-
Hassler, J.R.1
Scheuner, D.L.2
Wang, S.3
Han, J.4
Kodali, V.K.5
Li, P.6
Nguyen, J.7
George, J.S.8
Davis, C.9
Wu, S.P.10
-
74
-
-
0345269274
-
C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform
-
Hattori T, Ohoka N, Hayashi H, Onozaki K. 2003. C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform. FEBS Lett 541: 33-39.
-
(2003)
FEBS Lett
, vol.541
, pp. 33-39
-
-
Hattori, T.1
Ohoka, N.2
Hayashi, H.3
Onozaki, K.4
-
75
-
-
60549085835
-
Acquisition of anergy to proinflammatory cytokines in nonimmune cells through endoplasmic reticulum stress response: A mechanism for subsidence of inflammation
-
Hayakawa K, Hiramatsu N, Okamura M, Yamazaki H, Nakajima S, Yao J, Paton AW, Paton JC, Kitamura M. 2009. Acquisition of anergy to proinflammatory cytokines in nonimmune cells through endoplasmic reticulum stress response: a mechanism for subsidence of inflammation. J Immunol 182: 1182-1191.
-
(2009)
J Immunol
, vol.182
, pp. 1182-1191
-
-
Hayakawa, K.1
Hiramatsu, N.2
Okamura, M.3
Yamazaki, H.4
Nakajima, S.5
Yao, J.6
Paton, A.W.7
Paton, J.C.8
Kitamura, M.9
-
76
-
-
0032693671
-
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
-
Haze K, Yoshida H, Yanagi H, Yura T, Mori K. 1999. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell 10: 3787-3799.
-
(1999)
Mol Biol Cell
, vol.10
, pp. 3787-3799
-
-
Haze, K.1
Yoshida, H.2
Yanagi, H.3
Yura, T.4
Mori, K.5
-
77
-
-
0035877643
-
Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation
-
He CH, Gong P, Hu B, Stewart D, Choi ME, Choi AM, Alam J. 2001. Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation. J Biol Chem 276: 20858-20865.
-
(2001)
J Biol Chem
, vol.276
, pp. 20858-20865
-
-
He, C.H.1
Gong, P.2
Hu, B.3
Stewart, D.4
Choi, M.E.5
Choi, A.M.6
Alam, J.7
-
78
-
-
0034213391
-
Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor
-
Hettmann T, Barton K, Leiden JM. 2000. Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor. Dev Biol 222: 110-123.
-
(2000)
Dev Biol
, vol.222
, pp. 110-123
-
-
Hettmann, T.1
Barton, K.2
Leiden, J.M.3
-
79
-
-
85026485015
-
ER stress and the unfolded protein response in neurodegeneration
-
Hetz C, Saxena S. 2017. ER stress and the unfolded protein response in neurodegeneration. Nat Rev Neurol 13: 477-491.
-
(2017)
Nat Rev Neurol
, vol.13
, pp. 477-491
-
-
Hetz, C.1
Saxena, S.2
-
80
-
-
70349627027
-
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
-
Hetz C, Thielen P, Matus S, Nassif M, Court F, Kiffin R, Martinez G, Cuervo AM, Brown RH, Glimcher LH. 2009. XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev 23: 2294-2306.
-
(2009)
Genes Dev
, vol.23
, pp. 2294-2306
-
-
Hetz, C.1
Thielen, P.2
Matus, S.3
Nassif, M.4
Court, F.5
Kiffin, R.6
Martinez, G.7
Cuervo, A.M.8
Brown, R.H.9
Glimcher, L.H.10
-
81
-
-
84975072542
-
Translational control by 5′-untranslated regions of eukaryotic mRNAs
-
Hinnebusch AG, Ivanov IP, Sonenberg N. 2016. Translational control by 5′-untranslated regions of eukaryotic mRNAs. Science 352: 1413-1416.
-
(2016)
Science
, vol.352
, pp. 1413-1416
-
-
Hinnebusch, A.G.1
Ivanov, I.P.2
Sonenberg, N.3
-
82
-
-
84855548457
-
ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression
-
Hoetzenecker W, Echtenacher B, Guenova E, Hoetzenecker K, Woelbing F, Bruck J, Teske A, Valtcheva N, Fuchs K, Kneilling M, et al. 2012. ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression. Nat Med 18: 128-134.
-
(2012)
Nat Med
, vol.18
, pp. 128-134
-
-
Hoetzenecker, W.1
Echtenacher, B.2
Guenova, E.3
Hoetzenecker, K.4
Woelbing, F.5
Bruck, J.6
Teske, A.7
Valtcheva, N.8
Fuchs, K.9
Kneilling, M.10
-
83
-
-
17644407706
-
Microarray expression profiling identifies early signaling transcripts associated with 6-OHDA-induced dopaminergic cell death
-
Holtz WA, Turetzky JM, O’Malley KL. 2005. Microarray expression profiling identifies early signaling transcripts associated with 6-OHDA-induced dopaminergic cell death. Antioxid Redox Signal 7: 639-648.
-
(2005)
Antioxid Redox Signal
, vol.7
, pp. 639-648
-
-
Holtz, W.A.1
Turetzky, J.M.2
O’Malley, K.L.3
-
84
-
-
84863399030
-
Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors
-
Horiguchi M, Koyanagi S, Okamoto A, Suzuki SO, Matsunaga N, Ohdo S. 2012. Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors. Cancer Res 72: 395-401.
-
(2012)
Cancer Res
, vol.72
, pp. 395-401
-
-
Horiguchi, M.1
Koyanagi, S.2
Okamoto, A.3
Suzuki, S.O.4
Matsunaga, N.5
Ohdo, S.6
-
85
-
-
77950343252
-
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
-
Hotamisligil GS. 2010. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140: 900-917.
-
(2010)
Cell
, vol.140
, pp. 900-917
-
-
Hotamisligil, G.S.1
-
86
-
-
84901594244
-
Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish
-
Howarth DL, Lindtner C, Vacaru AM, Sachidanandam R, Tsedensodnom O, Vasilkova T, Buettner C, Sadler KC. 2014. Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish. PLoS Genet 10: e1004335.
-
(2014)
PLoS Genet
, vol.10
, pp. 1004335
-
-
Howarth, D.L.1
Lindtner, C.2
Vacaru, A.M.3
Sachidanandam, R.4
Tsedensodnom, O.5
Vasilkova, T.6
Buettner, C.7
Sadler, K.C.8
-
87
-
-
33645815074
-
Autocrine tumor necrosis factor α links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expression
-
Hu P, Han Z, Couvillon AD, Kaufman RJ, Exton JH. 2006. Autocrine tumor necrosis factor α links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expression. Mol Cell Biol 26: 3071-3084.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 3071-3084
-
-
Hu, P.1
Han, Z.2
Couvillon, A.D.3
Kaufman, R.J.4
Exton, J.H.5
-
88
-
-
84862969851
-
Activation of ATF4 mediates unwanted Mcl-1 accumulation by proteasome inhibition
-
Hu J, Dang N, Menu E, De Bruyne E, Xu D, Van Camp B, Van Valckenborgh E, Vanderkerken K. 2012. Activation of ATF4 mediates unwanted Mcl-1 accumulation by proteasome inhibition. Blood 119: 826-837.
-
(2012)
Blood
, vol.119
, pp. 826-837
-
-
Hu, J.1
Dang, N.2
Menu, E.3
De Bruyne, E.4
Xu, D.5
Van Camp, B.6
Van Valckenborgh, E.7
Vanderkerken, K.8
-
89
-
-
84928346009
-
ATF4 is a novel regulator of MCP-1 in microvascular endothelial cells
-
Huang H, Jing G,Wang JJ, Sheibani N, Zhang SX. 2015. ATF4 is a novel regulator of MCP-1 in microvascular endothelial cells. J Inflamm 12: 31.
-
(2015)
J Inflamm
, vol.12
, pp. 31
-
-
Huang, H.1
Jing, G.2
Wang, J.J.3
Sheibani, N.4
Zhang, S.X.5
-
90
-
-
84875811673
-
p58(IPK)-mediated attenuation of the proapoptotic PERK-CHOP pathway allows malignant progression upon low glucose
-
Huber AL, Lebeau J, Guillaumot P, Petrilli V, Malek M, Chilloux J, Fauvet F, Payen L, Kfoury A, Renno T, et al. 2013. p58(IPK)-mediated attenuation of the proapoptotic PERK-CHOP pathway allows malignant progression upon low glucose. Mol Cell 49: 1049-1059.
-
(2013)
Mol Cell
, vol.49
, pp. 1049-1059
-
-
Huber, A.L.1
Lebeau, J.2
Guillaumot, P.3
Petrilli, V.4
Malek, M.5
Chilloux, J.6
Fauvet, F.7
Payen, L.8
Kfoury, A.9
Renno, T.10
-
91
-
-
84961213893
-
C/EBPγ is a critical regulator of cellular stress response networks through heterodimerization with ATF4
-
Huggins CJ, Mayekar MK, Martin N, Saylor KL, Gonit M, Jailwala P, Kasoji M, Haines DC, Quinones OA, Johnson PF. 2015. C/EBPγ is a critical regulator of cellular stress response networks through heterodimerization with ATF4. Mol Cell Biol 36: 693-713.
-
(2015)
Mol Cell Biol
, vol.36
, pp. 693-713
-
-
Huggins, C.J.1
Mayekar, M.K.2
Martin, N.3
Saylor, K.L.4
Gonit, M.5
Jailwala, P.6
Kasoji, M.7
Haines, D.C.8
Quinones, O.A.9
Johnson, P.F.10
-
92
-
-
33749234216
-
Drugs, their targets and the nature and number of drug targets
-
Imming P, Sinning C, Meyer A. 2006. Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov 5: 821-834.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 821-834
-
-
Imming, P.1
Sinning, C.2
Meyer, A.3
-
93
-
-
84959142802
-
ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies
-
Ishizawa J, Kojima K, Chachad D, Ruvolo P, Ruvolo V, Jacamo RO, Borthakur G, Mu H, Zeng Z, Tabe Y, et al. 2016. ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies. Sci Signal 9: ra17.
-
(2016)
Sci Signal
, vol.9
, pp. 17
-
-
Ishizawa, J.1
Kojima, K.2
Chachad, D.3
Ruvolo, P.4
Ruvolo, V.5
Jacamo, R.O.6
Borthakur, G.7
Mu, H.8
Zeng, Z.9
Tabe, Y.10
-
94
-
-
0037385313
-
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
-
Iwakoshi NN, Lee AH, Vallabhajosyula P, Otipoby KL, Rajewsky K, Glimcher LH. 2003. Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol 4: 321-329.
-
(2003)
Nat Immunol
, vol.4
, pp. 321-329
-
-
Iwakoshi, N.N.1
Lee, A.H.2
Vallabhajosyula, P.3
Otipoby, K.L.4
Rajewsky, K.5
Glimcher, L.H.6
-
95
-
-
34948897411
-
The transcription factor XBP-1 is essential for the development and survival of dendritic cells
-
Iwakoshi NN, Pypaert M, Glimcher LH. 2007. The transcription factor XBP-1 is essential for the development and survival of dendritic cells. J Exp Med 204: 2267-2275.
-
(2007)
J Exp Med
, vol.204
, pp. 2267-2275
-
-
Iwakoshi, N.N.1
Pypaert, M.2
Glimcher, L.H.3
-
96
-
-
84891815469
-
Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages
-
Iwasaki Y, Suganami T, Hachiya R, Shirakawa I, Kim-Saijo M, Tanaka M, Hamaguchi M, Takai-Igarashi T, Nakai M, Miyamoto Y, et al. 2014. Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages. Diabetes 63: 152-161.
-
(2014)
Diabetes
, vol.63
, pp. 152-161
-
-
Iwasaki, Y.1
Suganami, T.2
Hachiya, R.3
Shirakawa, I.4
Kim-Saijo, M.5
Tanaka, M.6
Hamaguchi, M.7
Takai-Igarashi, T.8
Nakai, M.9
Miyamoto, Y.10
-
98
-
-
33644783632
-
Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3), which promotes viability of Hodgkin/Reed-Sternberg cells
-
Janz M, Hummel M, Truss M,Wollert-Wulf B, Mathas S, Johrens K, Hagemeier C, Bommert K, Stein H, Dorken B, et al. 2006. Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3), which promotes viability of Hodgkin/Reed-Sternberg cells. Blood 107: 2536-2539.
-
(2006)
Blood
, vol.107
, pp. 2536-2539
-
-
Janz, M.1
Hummel, M.2
Truss, M.3
Wollert-Wulf, B.4
Mathas, S.5
Johrens, K.6
Hagemeier, C.7
Bommert, K.8
Stein, H.9
Dorken, B.10
-
99
-
-
24144472287
-
Role of CHOPin hepatic apoptosis in the murine model of intragastric ethanol feeding
-
Ji C, Mehrian-Shai R, Chan C, Hsu YH, Kaplowitz N. 2005. Role of CHOPin hepatic apoptosis in the murine model of intragastric ethanol feeding. Alcohol Clin Exp Res 29: 1496-1503.
-
(2005)
Alcohol Clin Exp Res
, vol.29
, pp. 1496-1503
-
-
Ji, C.1
Mehrian-Shai, R.2
Chan, C.3
Hsu, Y.H.4
Kaplowitz, N.5
-
100
-
-
0043133837
-
Phosphorylation of the α subunit of eukaryotic initiation factor 2 is required for activation of NF-κB in response to diverse cellular stresses
-
Jiang HY, Wek SA, McGrath BC, Scheuner D, Kaufman RJ, Cavener DR, Wek RC. 2003. Phosphorylation of the α subunit of eukaryotic initiation factor 2 is required for activation of NF-κB in response to diverse cellular stresses. Mol Cell Biol 23: 5651-5663.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 5651-5663
-
-
Jiang, H.Y.1
Wek, S.A.2
McGrath, B.C.3
Scheuner, D.4
Kaufman, R.J.5
Cavener, D.R.6
Wek, R.C.7
-
101
-
-
50249086073
-
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
-
Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EE, Higgins DE, Schreiber S, Glimcher LH, et al. 2008. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134: 743-756.
-
(2008)
Cell
, vol.134
, pp. 743-756
-
-
Kaser, A.1
Lee, A.H.2
Franke, A.3
Glickman, J.N.4
Zeissig, S.5
Tilg, H.6
Nieuwenhuis, E.E.7
Higgins, D.E.8
Schreiber, S.9
Glimcher, L.H.10
-
102
-
-
0033562966
-
Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls
-
Kaufman RJ. 1999. Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev 13: 1211-1233.
-
(1999)
Genes Dev
, vol.13
, pp. 1211-1233
-
-
Kaufman, R.J.1
-
103
-
-
0036853914
-
Orchestrating the unfolded protein response in health and disease
-
Kaufman RJ. 2002. Orchestrating the unfolded protein response in health and disease. J Clin Invest 110: 1389-1398.
-
(2002)
J Clin Invest
, vol.110
, pp. 1389-1398
-
-
Kaufman, R.J.1
-
104
-
-
1542316306
-
Regulation of mRNA translation by protein folding in the endoplasmic reticulum
-
Kaufman RJ. 2004. Regulation of mRNA translation by protein folding in the endoplasmic reticulum. Trends Biochem Sci 29: 152-158.
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 152-158
-
-
Kaufman, R.J.1
-
105
-
-
33751331444
-
Activating transcription factor 3 (ATF3) represses the expression of CCL4 in murine macrophages
-
Khuu CH, Barrozo RM, Hai T, Weinstein SL. 2007. Activating transcription factor 3 (ATF3) represses the expression of CCL4 in murine macrophages. Mol Immunol 44: 1598-1605.
-
(2007)
Mol Immunol
, vol.44
, pp. 1598-1605
-
-
Khuu, C.H.1
Barrozo, R.M.2
Hai, T.3
Weinstein, S.L.4
-
106
-
-
84940789708
-
Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma
-
Kikuchi S, Suzuki R, Ohguchi H, Yoshida Y, Lu D, Cottini F, Jakubikova J, Bianchi G, Harada T, Gorgun G, et al. 2015. Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma. Leukemia 29: 1918-1927.
-
(2015)
Leukemia
, vol.29
, pp. 1918-1927
-
-
Kikuchi, S.1
Suzuki, R.2
Ohguchi, H.3
Yoshida, Y.4
Lu, D.5
Cottini, F.6
Jakubikova, J.7
Bianchi, G.8
Harada, T.9
Gorgun, G.10
-
107
-
-
72049124015
-
ATF4-dependent transcription mediates signaling of amino acid limitation
-
Kilberg MS, Shan J, Su N. 2009. ATF4-dependent transcription mediates signaling of amino acid limitation. Trends Endocrinol Metab 20: 436-443.
-
(2009)
Trends Endocrinol Metab
, vol.20
, pp. 436-443
-
-
Kilberg, M.S.1
Shan, J.2
Su, N.3
-
108
-
-
33745293067
-
NFATc4 and ATF3 negatively regulate adiponectin gene expression in 3T3-L1 adipocytes
-
Kim HB, Kong M, Kim TM, Suh YH, Kim WH, Lim JH, Song JH, Jung MH. 2006. NFATc4 and ATF3 negatively regulate adiponectin gene expression in 3T3-L1 adipocytes. Diabetes 55: 1342-1352.
-
(2006)
Diabetes
, vol.55
, pp. 1342-1352
-
-
Kim, H.B.1
Kong, M.2
Kim, T.M.3
Suh, Y.H.4
Kim, W.H.5
Lim, J.H.6
Song, J.H.7
Jung, M.H.8
-
109
-
-
84862518603
-
Expression of ER stress and autophagy-related molecules in human non-small cell lung cancer and premalignant lesions
-
Kim KM, Yu TK, Chu HH, Park HS, Jang KY, Moon WS, Kang MJ, Lee DG, Kim MH, Lee JH, et al. 2012. Expression of ER stress and autophagy-related molecules in human non-small cell lung cancer and premalignant lesions. Int J Cancer 131: E362-E370.
-
(2012)
Int J Cancer
, vol.131
, pp. E362-E370
-
-
Kim, K.M.1
Yu, T.K.2
Chu, H.H.3
Park, H.S.4
Jang, K.Y.5
Moon, W.S.6
Kang, M.J.7
Lee, D.G.8
Kim, M.H.9
Lee, J.H.10
-
110
-
-
84872057896
-
Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
-
Kim KH, Jeong YT, Oh H, Kim SH, Cho JM, Kim YN, Kim SS, Kim DH, Hur KY, Kim HK, et al. 2013. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med 19: 83-92.
-
(2013)
Nat Med
, vol.19
, pp. 83-92
-
-
Kim, K.H.1
Jeong, Y.T.2
Oh, H.3
Kim, S.H.4
Cho, J.M.5
Kim, Y.N.6
Kim, S.S.7
Kim, D.H.8
Hur, K.Y.9
Kim, H.K.10
-
111
-
-
84858611085
-
FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis
-
Kode A, Mosialou I, Silva BC, Joshi S, Ferron M, Rached MT, Kousteni S. 2012. FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis. J Biol Chem 287: 8757-8768.
-
(2012)
J Biol Chem
, vol.287
, pp. 8757-8768
-
-
Kode, A.1
Mosialou, I.2
Silva, B.C.3
Joshi, S.4
Ferron, M.5
Rached, M.T.6
Kousteni, S.7
-
112
-
-
84933277514
-
Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia
-
Kohl S, Zobor D, Chiang W-C,Weisschuh N, Staller J, Menendez IG, Chang S, Beck SC, Garrido MG, Sothilingam V, et al. 2015. Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia. Nat Genet 47: 757-765.
-
(2015)
Nat Genet
, vol.47
, pp. 757-765
-
-
Kohl, S.1
Zobor, D.2
Chiang, W.-C.3
Weisschuh, N.4
Staller, J.5
Menendez, I.G.6
Chang, S.7
Beck, S.C.8
Garrido, M.G.9
Sothilingam, V.10
-
113
-
-
13944263299
-
OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes
-
Kondo S, Murakami T, Tatsumi K, Ogata M, Kanemoto S, Otori K, Iseki K, Wanaka A, Imaizumi K. 2005. OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes. Nat Cell Biol 7: 186-194.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 186-194
-
-
Kondo, S.1
Murakami, T.2
Tatsumi, K.3
Ogata, M.4
Kanemoto, S.5
Otori, K.6
Iseki, K.7
Wanaka, A.8
Imaizumi, K.9
-
114
-
-
33847188475
-
BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer
-
Kondo S, Saito A, Hino S, Murakami T, Ogata M, Kanemoto S, Nara S, Yamashita A, Yoshinaga K, Hara H, et al. 2007. BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer. Mol Cell Biol 27: 1716-1729.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 1716-1729
-
-
Kondo, S.1
Saito, A.2
Hino, S.3
Murakami, T.4
Ogata, M.5
Kanemoto, S.6
Nara, S.7
Yamashita, A.8
Yoshinaga, K.9
Hara, H.10
-
115
-
-
84915814883
-
The RtcB RNA ligase is an essential component of the metazoan unfolded protein response
-
Kosmaczewski SG, Edwards TJ, Han SM, Eckwahl MJ, Meyer BI, Peach S, Hesselberth JR, Wolin SL, Hammarlund M. 2014. The RtcB RNA ligase is an essential component of the metazoan unfolded protein response. EMBO Rep 15: 1278-1285.
-
(2014)
EMBO Rep
, vol.15
, pp. 1278-1285
-
-
Kosmaczewski, S.G.1
Edwards, T.J.2
Han, S.M.3
Eckwahl, M.J.4
Meyer, B.I.5
Peach, S.6
Hesselberth, J.R.7
Wolin, S.L.8
Hammarlund, M.9
-
116
-
-
0026342613
-
An analysis of vertebrate mRNA sequences: Intimations of translational control
-
Kozak M. 1991. An analysis of vertebrate mRNA sequences: intimations of translational control. J Cell Biol 115: 887-903.
-
(1991)
J Cell Biol
, vol.115
, pp. 887-903
-
-
Kozak, M.1
-
117
-
-
84898009679
-
Evidence for eIF2α phosphorylationindependent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications
-
Krishnamoorthy J, Rajesh K, Mirzajani F, Kesoglidou P, Papadakis AI, Koromilas AE. 2014. Evidence for eIF2α phosphorylationindependent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications. Cell Cycle 13: 801-806.
-
(2014)
Cell Cycle
, vol.13
, pp. 801-806
-
-
Krishnamoorthy, J.1
Rajesh, K.2
Mirzajani, F.3
Kesoglidou, P.4
Papadakis, A.I.5
Koromilas, A.E.6
-
118
-
-
84911929992
-
Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK
-
Krysov S, Steele AJ, Coelho V, Linley A, Sanchez Hidalgo M, Carter M, Potter KN, Kennedy B, Duncombe AS, Ashton-Key M, et al. 2014. Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK. Blood 124: 3101-3109.
-
(2014)
Blood
, vol.124
, pp. 3101-3109
-
-
Krysov, S.1
Steele, A.J.2
Coelho, V.3
Linley, A.4
Sanchez Hidalgo, M.5
Carter, M.6
Potter, K.N.7
Kennedy, B.8
Duncombe, A.S.9
Ashton-Key, M.10
-
119
-
-
84945157580
-
ATF3 is a key regulator of macrophage IFN responses
-
Labzin LI, Schmidt SV, Masters SL, Beyer M, Krebs W, Klee K, Stahl R, Lutjohann D, Schultze JL, Latz E, et al. 2015. ATF3 is a key regulator of macrophage IFN responses. J Immunol 195: 4446-4455.
-
(2015)
J Immunol
, vol.195
, pp. 4446-4455
-
-
Labzin, L.I.1
Schmidt, S.V.2
Masters, S.L.3
Beyer, M.4
Krebs, W.5
Klee, K.6
Stahl, R.7
Lutjohann, D.8
Schultze, J.L.9
Latz, E.10
-
121
-
-
45849137877
-
Regulation of hepatic lipogenesis by the transcription factor XBP1
-
Lee AH, Scapa EF, Cohen DE, Glimcher LH. 2008. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320: 1492-1496.
-
(2008)
Science
, vol.320
, pp. 1492-1496
-
-
Lee, A.H.1
Scapa, E.F.2
Cohen, D.E.3
Glimcher, L.H.4
-
122
-
-
65449141379
-
An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2α phosphorylation
-
Lee YY, Cevallos RC, Jan E. 2009. An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2α phosphorylation. J Biol Chem 284: 6661-6673.
-
(2009)
J Biol Chem
, vol.284
, pp. 6661-6673
-
-
Lee, Y.Y.1
Cevallos, R.C.2
Jan, E.3
-
123
-
-
77953485026
-
Induction of the unfolded protein response and cell death pathway in Alzheimer’s disease, but not in aged Tg2576 mice
-
Lee JH,Won SM, Suh J, Son SJ, Moon GJ, Park UJ,Gwag BJ. 2010a. Induction of the unfolded protein response and cell death pathway in Alzheimer’s disease, but not in aged Tg2576 mice. Exp Mol Med 42: 386-394.
-
(2010)
Exp Mol Med
, vol.42
, pp. 386-394
-
-
Lee, J.H.1
Won, S.M.2
Suh, J.3
Son, S.J.4
Moon, G.J.5
Park, U.J.6
Gwag, B.J.7
-
124
-
-
77950285163
-
Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH
-
Lee MW, Chanda D, Yang J, Oh H, Kim SS, Yoon YS, Hong S, Park KG, Lee IK, Choi CS, et al. 2010b. Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH. Cell Metab 11: 331-339.
-
(2010)
Cell Metab
, vol.11
, pp. 331-339
-
-
Lee, M.W.1
Chanda, D.2
Yang, J.3
Oh, H.4
Kim, S.S.5
Yoon, Y.S.6
Hong, S.7
Park, K.G.8
Lee, I.K.9
Choi, C.S.10
-
125
-
-
79957773163
-
Dual and opposing roles of the unfolded protein response regulated by IRE1α and XBP1 in proinsulin processing and insulin secretion
-
Lee AH, Heidtman K, Hotamisligil GS, Glimcher LH. 2011a. Dual and opposing roles of the unfolded protein response regulated by IRE1α and XBP1 in proinsulin processing and insulin secretion. Proc Natl Acad Sci 108: 8885-8890.
-
(2011)
Proc Natl Acad Sci
, vol.108
, pp. 8885-8890
-
-
Lee, A.H.1
Heidtman, K.2
Hotamisligil, G.S.3
Glimcher, L.H.4
-
126
-
-
79960110157
-
The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism
-
Lee JH, Giannikopoulos P, Duncan SA, Wang J, Johansen CT, Brown JD, Plutzky J, Hegele RA, Glimcher LH, Lee AH. 2011b. The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism. Nat Med 17: 812-815.
-
(2011)
Nat Med
, vol.17
, pp. 812-815
-
-
Lee, J.H.1
Giannikopoulos, P.2
Duncan, S.A.3
Wang, J.4
Johansen, C.T.5
Brown, J.D.6
Plutzky, J.7
Hegele, R.A.8
Glimcher, L.H.9
Lee, A.H.10
-
127
-
-
40949116757
-
The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic β-cell apoptosis
-
Li D, Yin X, Zmuda EJ, Wolford CC, Dong X, White MF, Hai T. 2008. The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic β-cell apoptosis. Diabetes 57: 635-644.
-
(2008)
Diabetes
, vol.57
, pp. 635-644
-
-
Li, D.1
Yin, X.2
Zmuda, E.J.3
Wolford, C.C.4
Dong, X.5
White, M.F.6
Hai, T.7
-
128
-
-
78650105442
-
NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis
-
Li G, Scull C, Ozcan L, Tabas I. 2010. NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis. J Cell Biol 191: 1113-1125.
-
(2010)
J Cell Biol
, vol.191
, pp. 1113-1125
-
-
Li, G.1
Scull, C.2
Ozcan, L.3
Tabas, I.4
-
129
-
-
80051686720
-
ATF4 deficiency protects mice from high-carbohydrate-dietinduced liver steatosis
-
Li H, Meng Q, Xiao F, Chen S, Du Y, Yu J, Wang C, Guo F. 2011. ATF4 deficiency protects mice from high-carbohydrate-dietinduced liver steatosis. Biochem J 438: 283-289.
-
(2011)
Biochem J
, vol.438
, pp. 283-289
-
-
Li, H.1
Meng, Q.2
Xiao, F.3
Chen, S.4
Du, Y.5
Yu, J.6
Wang, C.7
Guo, F.8
-
130
-
-
84908570844
-
XBP1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of breast cancer cells
-
Li H, Chen X, Gao Y, Wu J, Zeng F, Song F. 2015. XBP1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of breast cancer cells. Cell Signal 27: 82-89.
-
(2015)
Cell Signal
, vol.27
, pp. 82-89
-
-
Li, H.1
Chen, X.2
Gao, Y.3
Wu, J.4
Zeng, F.5
Song, F.6
-
131
-
-
33750350899
-
Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element
-
Liang G, Audas TE, Li Y, Cockram GP, Dean JD, Martyn AC, Kokame K, Lu R. 2006a. Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. Mol Cell Biol 26: 7999-8010.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 7999-8010
-
-
Liang, G.1
Audas, T.E.2
Li, Y.3
Cockram, G.P.4
Dean, J.D.5
Martyn, A.C.6
Kokame, K.7
Lu, R.8
-
132
-
-
30044438461
-
PERK (eIF2α kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis
-
Liang SH, Zhang W, McGrath BC, Zhang P, Cavener DR. 2006b. PERK (eIF2α kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis. Biochem J 393: 201-209.
-
(2006)
Biochem J
, vol.393
, pp. 201-209
-
-
Liang, S.H.1
Zhang, W.2
McGrath, B.C.3
Zhang, P.4
Cavener, D.R.5
-
133
-
-
84981294965
-
Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames
-
Liang XH, Shen W, Sun H, Migawa MT, Vickers TA, Crooke ST. 2016. Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames. Nat Biotechnol 34: 875-880.
-
(2016)
Nat Biotechnol
, vol.34
, pp. 875-880
-
-
Liang, X.H.1
Shen, W.2
Sun, H.3
Migawa, M.T.4
Vickers, T.A.5
Crooke, S.T.6
-
134
-
-
48549103399
-
CAAT/enhancer binding protein homologous protein-dependent death receptor 5 induction is a major component of SHetA2-induced apoptosis in lung cancer cells
-
Lin YD, Chen S, Yue P, ZouW, Benbrook DM, Liu S, Le TC, Berlin KD, Khuri FR, Sun SY. 2008. CAAT/enhancer binding protein homologous protein-dependent death receptor 5 induction is a major component of SHetA2-induced apoptosis in lung cancer cells. Cancer Res 68: 5335-5344.
-
(2008)
Cancer Res
, vol.68
, pp. 5335-5344
-
-
Lin, Y.D.1
Chen, S.2
Yue, P.3
Zou, W.4
Benbrook, D.M.5
Liu, S.6
Le, T.C.7
Berlin, K.D.8
Khuri, F.R.9
Sun, S.Y.10
-
135
-
-
0024280877
-
Distinct cloned class II MHC DNA binding proteins recognize the X box transcription element
-
Liou HC, Boothby MR, Glimcher LH. 1988. Distinct cloned class II MHC DNA binding proteins recognize the X box transcription element. Science 242: 69-71.
-
(1988)
Science
, vol.242
, pp. 69-71
-
-
Liou, H.C.1
Boothby, M.R.2
Glimcher, L.H.3
-
136
-
-
84879790611
-
Over-expression of atf4 in Xenopus embryos interferes with neurogenesis and eye formation
-
Liu JT, Yang Y, Guo XG, Chen M, Ding HZ, Chen YL,Wang MR. 2011. Over-expression of atf4 in Xenopus embryos interferes with neurogenesis and eye formation. Dongwuxue Yanjiu 32: 485-491.
-
(2011)
Dongwuxue Yanjiu
, vol.32
, pp. 485-491
-
-
Liu, J.T.1
Yang, Y.2
Guo, X.G.3
Chen, M.4
Ding, H.Z.5
Chen, Y.L.6
Wang, M.R.7
-
137
-
-
5444264022
-
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response
-
Lu PD, Harding HP, Ron D. 2004. Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. J Cell Biol 167: 27-33.
-
(2004)
J Cell Biol
, vol.167
, pp. 27-33
-
-
Lu, P.D.1
Harding, H.P.2
Ron, D.3
-
138
-
-
84926106643
-
A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB
-
Lu Y, Liang FX,Wang X. 2014. A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB. Mol Cell 55: 758-770.
-
(2014)
Mol Cell
, vol.55
, pp. 758-770
-
-
Lu, Y.1
Liang, F.X.2
Wang, X.3
-
139
-
-
62949158170
-
Expression pattern of XBP1(S) in human B-cell lymphomas
-
Maestre L, Tooze R, Canamero M, Montes-Moreno S, Ramos R, Doody G, Boll M, Barrans S, Baena S, Piris MA, et al. 2009. Expression pattern of XBP1(S) in human B-cell lymphomas. Haematologica 94: 419-422.
-
(2009)
Haematologica
, vol.94
, pp. 419-422
-
-
Maestre, L.1
Tooze, R.2
Canamero, M.3
Montes-Moreno, S.4
Ramos, R.5
Doody, G.6
Boll, M.7
Barrans, S.8
Baena, S.9
Piris, M.A.10
-
140
-
-
77954620620
-
Activation transcription factor-3 activation and the development of spinal cord degeneration in a rat model of amyotrophic lateral sclerosis
-
Malaspina A, Ngoh SF, Ward RE, Hall JC, Tai FW, Yip PK, Jones C, Jokic N, Averill SA, Michael-Titus AT, et al. 2010. Activation transcription factor-3 activation and the development of spinal cord degeneration in a rat model of amyotrophic lateral sclerosis. Neuroscience 169: 812-827.
-
(2010)
Neuroscience
, vol.169
, pp. 812-827
-
-
Malaspina, A.1
Ngoh, S.F.2
Ward, R.E.3
Hall, J.C.4
Tai, F.W.5
Yip, P.K.6
Jones, C.7
Jokic, N.8
Averill, S.A.9
Michael-Titus, A.T.10
-
141
-
-
84879568119
-
C/EBP homologous protein-induced macrophage apoptosis protects mice fromsteatohepatitis
-
Malhi H, Kropp EM, Clavo VF, Kobrossi CR, Han J, Mauer AS, Yong J, Kaufman RJ. 2013. C/EBP homologous protein-induced macrophage apoptosis protects mice fromsteatohepatitis. J Biol Chem 288: 18624-18642.
-
(2013)
J Biol Chem
, vol.288
, pp. 18624-18642
-
-
Malhi, H.1
Kropp, E.M.2
Clavo, V.F.3
Kobrossi, C.R.4
Han, J.5
Mauer, A.S.6
Yong, J.7
Kaufman, R.J.8
-
142
-
-
77951290227
-
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
-
Martinon F, Chen X, Lee AH, Glimcher LH. 2010. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol 11: 411-418.
-
(2010)
Nat Immunol
, vol.11
, pp. 411-418
-
-
Martinon, F.1
Chen, X.2
Lee, A.H.3
Glimcher, L.H.4
-
143
-
-
17644415702
-
ATF5 regulates the proliferation and differentiation of oligodendrocytes
-
Mason JL, Angelastro JM, Ignatova TN, Kukekov VG, Lin G, Greene LA, Goldman JE. 2005. ATF5 regulates the proliferation and differentiation of oligodendrocytes. Mol Cell Neurosci 29: 372-380.
-
(2005)
Mol Cell Neurosci
, vol.29
, pp. 372-380
-
-
Mason, J.L.1
Angelastro, J.M.2
Ignatova, T.N.3
Kukekov, V.G.4
Lin, G.5
Greene, L.A.6
Goldman, J.E.7
-
144
-
-
0036464604
-
Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice
-
Masuoka HC, Townes TM. 2002. Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. Blood 99: 736-745.
-
(2002)
Blood
, vol.99
, pp. 736-745
-
-
Masuoka, H.C.1
Townes, T.M.2
-
145
-
-
61849095684
-
JNK activity is essential for Atf4 expression and late-stage osteoblast differentiation
-
Matsuguchi T, Chiba N, Bandow K, Kakimoto K, Masuda A, Ohnishi T. 2009. JNK activity is essential for Atf4 expression and late-stage osteoblast differentiation. J Bone Miner Res 24: 398-410.
-
(2009)
J Bone Miner Res
, vol.24
, pp. 398-410
-
-
Matsuguchi, T.1
Chiba, N.2
Bandow, K.3
Kakimoto, K.4
Masuda, A.5
Ohnishi, T.6
-
146
-
-
34447120709
-
Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians
-
Meex SJR, van Greevenbroek MMJ, Ayoubi TA, Vlietinck R, van Vliet-Ostaptchouk JV, Hofker MH, Vermeulen VMM-J, Schalkwijk CG, Feskens EJM, Boer JMA, et al. 2007. Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians. J Clin Endocrinol Metab 92: 2720-2725.
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 2720-2725
-
-
Meex, S.J.R.1
van Greevenbroek, M.M.J.2
Ayoubi, T.A.3
Vlietinck, R.4
van Vliet-Ostaptchouk, J.V.5
Hofker, M.H.6
Vermeulen, V.M.M.-J.7
Schalkwijk, C.G.8
Feskens, E.J.M.9
Boer, J.M.A.10
-
147
-
-
84862501186
-
Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma
-
Mimura N, Fulciniti M, Gorgun G, Tai YT, Cirstea D, Santo L, Hu Y, Fabre C, Minami J, Ohguchi H, et al. 2012. Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma. Blood 119: 5772-5781.
-
(2012)
Blood
, vol.119
, pp. 5772-5781
-
-
Mimura, N.1
Fulciniti, M.2
Gorgun, G.3
Tai, Y.T.4
Cirstea, D.5
Santo, L.6
Hu, Y.7
Fabre, C.8
Minami, J.9
Ohguchi, H.10
-
148
-
-
33845311194
-
ATF4 regulates γ-secretase activity during amino acid imbalance
-
Mitsuda T, Hayakawa Y, Itoh M, Ohta K, Nakagawa T. 2007. ATF4 regulates γ-secretase activity during amino acid imbalance. Biochem Biophys Res Commun 352: 722-727.
-
(2007)
Biochem Biophys Res Commun
, vol.352
, pp. 722-727
-
-
Mitsuda, T.1
Hayakawa, Y.2
Itoh, M.3
Ohta, K.4
Nakagawa, T.5
-
149
-
-
84861450392
-
Sustained translational repression by eIF2α-P mediates prion neurodegeneration
-
Moreno JA, Radford H, Peretti D, Steinert JR, Verity N, Martin MG, Halliday M, Morgan J, Dinsdale D, Ortori CA, et al. 2012. Sustained translational repression by eIF2α-P mediates prion neurodegeneration. Nature 485: 507-511.
-
(2012)
Nature
, vol.485
, pp. 507-511
-
-
Moreno, J.A.1
Radford, H.2
Peretti, D.3
Steinert, J.R.4
Verity, N.5
Martin, M.G.6
Halliday, M.7
Morgan, J.8
Dinsdale, D.9
Ortori, C.A.10
-
150
-
-
84885463900
-
Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice
-
Moreno JA, Halliday M, Molloy C, Radford H, Verity N, Axten JM, Ortori CA, Willis AE, Fischer PM, Barrett DA, et al. 2013. Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice. Sci Transl Med 5: 206ra138.
-
(2013)
Sci Transl Med
, vol.5
, pp. 206
-
-
Moreno, J.A.1
Halliday, M.2
Molloy, C.3
Radford, H.4
Verity, N.5
Axten, J.M.6
Ortori, C.A.7
Willis, A.E.8
Fischer, P.M.9
Barrett, D.A.10
-
151
-
-
20944445990
-
Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway
-
Nagamori I, Yabuta N, Fujii T, Tanaka H, Yomogida K, Nishimune Y, Nojima H. 2005. Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway. Genes Cells 10: 575-594.
-
(2005)
Genes Cells
, vol.10
, pp. 575-594
-
-
Nagamori, I.1
Yabuta, N.2
Fujii, T.3
Tanaka, H.4
Yomogida, K.5
Nishimune, Y.6
Nojima, H.7
-
152
-
-
77955492781
-
Anti-inflammatory subtilase cytotoxin up-regulates A20 through the unfolded protein response
-
Nakajima S, Saito Y, Takahashi S, Hiramatsu N, Kato H, Johno H, Yao J, Paton AW, Paton JC, Kitamura M. 2010. Anti-inflammatory subtilase cytotoxin up-regulates A20 through the unfolded protein response. Biochem Biophys Res Commun 397: 176-180.
-
(2010)
Biochem Biophys Res Commun
, vol.397
, pp. 176-180
-
-
Nakajima, S.1
Saito, Y.2
Takahashi, S.3
Hiramatsu, N.4
Kato, H.5
Johno, H.6
Yao, J.7
Paton, A.W.8
Paton, J.C.9
Kitamura, M.10
-
153
-
-
84885437087
-
ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells
-
Niederreiter L, Fritz TM, Adolph TE, Krismer AM, Offner FA, Tschurtschenthaler M, Flak MB, Hosomi S, Tomczak MF, Kaneider NC, et al. 2013. ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells. J Exp Med 210: 2041-2056.
-
(2013)
J Exp Med
, vol.210
, pp. 2041-2056
-
-
Niederreiter, L.1
Fritz, T.M.2
Adolph, T.E.3
Krismer, A.M.4
Offner, F.A.5
Tschurtschenthaler, M.6
Flak, M.B.7
Hosomi, S.8
Tomczak, M.F.9
Kaneider, N.C.10
-
154
-
-
85016301922
-
Endoplasmic reticulum proteostasis in glioblastoma-From molecular mechanisms to therapeutic perspectives
-
Obacz J, Avril T, Le Reste PJ, Urra H, Quillien V, Hetz C, Chevet E. 2017. Endoplasmic reticulum proteostasis in glioblastoma-From molecular mechanisms to therapeutic perspectives. Sci Signal 10: eaal2323.
-
(2017)
Sci Signal
, vol.10
, pp. l2323
-
-
Obacz, J.1
Avril, T.2
Le Reste, P.J.3
Urra, H.4
Quillien, V.5
Hetz, C.6
Chevet, E.7
-
155
-
-
84898921541
-
Roles of eIF2α kinases in the pathogenesis of Alzheimer’s disease
-
Ohno M. 2014. Roles of eIF2α kinases in the pathogenesis of Alzheimer’s disease. Front Mol Neurosci 7: 22.
-
(2014)
Front Mol Neurosci
, vol.7
, pp. 22
-
-
Ohno, M.1
-
156
-
-
84864693470
-
Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome
-
Oslowski CM, Hara T, O’Sullivan-Murphy B, Kanekura K, Lu S, Hara M, Ishigaki S, Zhu LJ, Hayashi E, Hui ST, et al. 2012. Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab 16: 265-273.
-
(2012)
Cell Metab
, vol.16
, pp. 265-273
-
-
Oslowski, C.M.1
Hara, T.2
O’Sullivan-Murphy, B.3
Kanekura, K.4
Lu, S.5
Hara, M.6
Ishigaki, S.7
Zhu, L.J.8
Hayashi, E.9
Hui, S.T.10
-
157
-
-
0036175128
-
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
-
Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, Araki E, Mori M. 2002. Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest 109: 525-532.
-
(2002)
J Clin Invest
, vol.109
, pp. 525-532
-
-
Oyadomari, S.1
Koizumi, A.2
Takeda, K.3
Gotoh, T.4
Akira, S.5
Araki, E.6
Mori, M.7
-
158
-
-
0029001576
-
A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-κB
-
Pahl HL, Baeuerle PA. 1995. A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-κB. EMBO J 14: 2580-2588.
-
(1995)
EMBO J
, vol.14
, pp. 2580-2588
-
-
Pahl, H.L.1
Baeuerle, P.A.2
-
159
-
-
79953224498
-
Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation
-
Palam LR, Baird TD, Wek RC. 2011. Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation. J Biol Chem 286: 10939-10949.
-
(2011)
J Biol Chem
, vol.286
, pp. 10939-10949
-
-
Palam, L.R.1
Baird, T.D.2
Wek, R.C.3
-
160
-
-
79251589342
-
Identification of an Ire1α endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma
-
Papandreou I, Denko NC, Olson M, Van Melckebeke H, Lust S, Tam A, Solow-Cordero DE, Bouley DM, Offner F, Niwa M, et al. 2011. Identification of an Ire1α endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood 117: 1311-1314.
-
(2011)
Blood
, vol.117
, pp. 1311-1314
-
-
Papandreou, I.1
Denko, N.C.2
Olson, M.3
Van Melckebeke, H.4
Lust, S.5
Tam, A.6
Solow-Cordero, D.E.7
Bouley, D.M.8
Offner, F.9
Niwa, M.10
-
162
-
-
77950523710
-
The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation
-
Park SW, Zhou Y, Lee J, Lu A, Sun C, Chung J, Ueki K, Ozcan U. 2010b. The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation. Nat Med 16: 429-437.
-
(2010)
Nat Med
, vol.16
, pp. 429-437
-
-
Park, S.W.1
Zhou, Y.2
Lee, J.3
Lu, A.4
Sun, C.5
Chung, J.6
Ueki, K.7
Ozcan, U.8
-
163
-
-
33644603375
-
The expression of transcription factor activating transcription factor 3 in the human prostate and its regulation by androgen in prostate cancer
-
Pelzer AE, Bektic J, Haag P, Berger AP, Pycha A, Schafer G, Rogatsch H, Horninger W, Bartsch G, Klocker H. 2006. The expression of transcription factor activating transcription factor 3 in the human prostate and its regulation by androgen in prostate cancer. J Urol 175: 1517-1522.
-
(2006)
J Urol
, vol.175
, pp. 1517-1522
-
-
Pelzer, A.E.1
Bektic, J.2
Haag, P.3
Berger, A.P.4
Pycha, A.5
Schafer, G.6
Rogatsch, H.7
Horninger, W.8
Bartsch, G.9
Klocker, H.10
-
164
-
-
84871429513
-
Transcriptional upregulation of ULK1 by ATF4 contributes to cancer cell survival
-
Pike LR, Singleton DC, Buffa F, Abramczyk O, Phadwal K, Li JL, Simon AK, Murray JT, Harris AL. 2013. Transcriptional upregulation of ULK1 by ATF4 contributes to cancer cell survival. Biochem J 449: 389-400.
-
(2013)
Biochem J
, vol.449
, pp. 389-400
-
-
Pike, L.R.1
Singleton, D.C.2
Buffa, F.3
Abramczyk, O.4
Phadwal, K.5
Li, J.L.6
Simon, A.K.7
Murray, J.T.8
Harris, A.L.9
-
165
-
-
80054680024
-
Silencing GADD153/CHOP gene expression protects against Alzheimer’s disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus
-
Prasanthi JR, Larson T, Schommer J, Ghribi O. 2011. Silencing GADD153/CHOP gene expression protects against Alzheimer’s disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus. PLoS One 6: e26420.
-
(2011)
PLoS One
, vol.6
, pp. 26420
-
-
Prasanthi, J.R.1
Larson, T.2
Schommer, J.3
Ghribi, O.4
-
166
-
-
84869027086
-
ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation
-
Qing G, Li B, Vu A, Skuli N, Walton ZE, Liu X, Mayes PA, Wise DR, Thompson CB, Maris JM, et al. 2012. ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. Cancer Cell 22: 631-644.
-
(2012)
Cancer Cell
, vol.22
, pp. 631-644
-
-
Qing, G.1
Li, B.2
Vu, A.3
Skuli, N.4
Walton, Z.E.5
Liu, X.6
Mayes, P.A.7
Wise, D.R.8
Thompson, C.B.9
Maris, J.M.10
-
167
-
-
84884292103
-
Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis
-
Qiu Q, Zheng Z, Chang L, Zhao YS, Tan C, Dandekar A, Zhang Z, Lin Z, Gui M, Li X, et al. 2013. Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis. EMBO J 32: 2477-2490.
-
(2013)
EMBO J
, vol.32
, pp. 2477-2490
-
-
Qiu, Q.1
Zheng, Z.2
Chang, L.3
Zhao, Y.S.4
Tan, C.5
Dandekar, A.6
Zhang, Z.7
Lin, Z.8
Gui, M.9
Li, X.10
-
168
-
-
75149115329
-
FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts
-
Rached MT, Kode A, Xu L, Yoshikawa Y, Paik JH, Depinho RA, Kousteni S. 2010. FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts. Cell Metab 11: 147-160.
-
(2010)
Cell Metab
, vol.11
, pp. 147-160
-
-
Rached, M.T.1
Kode, A.2
Xu, L.3
Yoshikawa, Y.4
Paik, J.H.5
Depinho, R.A.6
Kousteni, S.7
-
169
-
-
0035913294
-
Plasma cell differentiation requires the transcription factor XBP-1
-
Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher LH. 2001. Plasma cell differentiation requires the transcription factor XBP-1. Nature 412: 300-307.
-
(2001)
Nature
, vol.412
, pp. 300-307
-
-
Reimold, A.M.1
Iwakoshi, N.N.2
Manis, J.3
Vallabhajosyula, P.4
Szomolanyi-Tsuda, E.5
Gravallese, E.M.6
Friend, D.7
Grusby, M.J.8
Alt, F.9
Glimcher, L.H.10
-
170
-
-
84866001506
-
Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing
-
Ri M, Tashiro E, Oikawa D, Shinjo S, Tokuda M, Yokouchi Y, Narita T, Masaki A, Ito A, Ding J, et al. 2012. Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood Cancer J 2: e79.
-
(2012)
Blood Cancer J
, vol.2
, pp. 79
-
-
Ri, M.1
Tashiro, E.2
Oikawa, D.3
Shinjo, S.4
Tokuda, M.5
Yokouchi, Y.6
Narita, T.7
Masaki, A.8
Ito, A.9
Ding, J.10
-
171
-
-
80055033307
-
Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis
-
Rinella ME, Siddiqui MS, Gardikiotes K, Gottstein J, Elias M, Green RM. 2011. Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis. Hepatology 54: 1600-1609.
-
(2011)
Hepatology
, vol.54
, pp. 1600-1609
-
-
Rinella, M.E.1
Siddiqui, M.S.2
Gardikiotes, K.3
Gottstein, J.4
Elias, M.5
Green, R.M.6
-
172
-
-
4344660747
-
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth
-
Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee A-H, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, et al. 2004. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res 64: 5943-5947.
-
(2004)
Cancer Res
, vol.64
, pp. 5943-5947
-
-
Romero-Ramirez, L.1
Cao, H.2
Nelson, D.3
Hammond, E.4
Lee, A.-H.5
Yoshida, H.6
Mori, K.7
Glimcher, L.H.8
Denko, N.C.9
Giaccia, A.J.10
-
173
-
-
75149147734
-
X box-binding protein 1 regulates angiogenesis in human pancreatic adenocarcinomas
-
Romero-Ramirez L, Cao H, Regalado MP, Kambham N, Siemann D, Kim JJ, Le QT, Koong AC. 2009. X box-binding protein 1 regulates angiogenesis in human pancreatic adenocarcinomas. Transl Oncol 2: 31-38.
-
(2009)
Transl Oncol
, vol.2
, pp. 31-38
-
-
Romero-Ramirez, L.1
Cao, H.2
Regalado, M.P.3
Kambham, N.4
Siemann, D.5
Kim, J.J.6
Le, Q.T.7
Koong, A.C.8
-
174
-
-
0036856008
-
Translational control in the endoplasmic reticulum stress response
-
Ron D. 2002. Translational control in the endoplasmic reticulum stress response. J Clin Invest 110: 1383-1388.
-
(2002)
J Clin Invest
, vol.110
, pp. 1383-1388
-
-
Ron, D.1
-
175
-
-
0026546365
-
CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription
-
Ron D, Habener JF. 1992. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev 6: 439-453.
-
(1992)
Genes Dev
, vol.6
, pp. 439-453
-
-
Ron, D.1
Habener, J.F.2
-
176
-
-
82155178703
-
ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia
-
Rousseau J, Gagne V, Labuda M, Beaubois C, Sinnett D, Laverdiere C, Moghrabi A, Sallan SE, Silverman LB, Neuberg D, et al. 2011. ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia. Blood 118: 5883-5890.
-
(2011)
Blood
, vol.118
, pp. 5883-5890
-
-
Rousseau, J.1
Gagne, V.2
Labuda, M.3
Beaubois, C.4
Sinnett, D.5
Laverdiere, C.6
Moghrabi, A.7
Sallan, S.E.8
Silverman, L.B.9
Neuberg, D.10
-
177
-
-
57049111040
-
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators
-
Rutkowski DT, Wu J, Back SH, Callaghan MU, Ferris SP, Iqbal J, Clark R, Miao H, Hassler JR, Fornek J, et al. 2008. UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell 15: 829-840.
-
(2008)
Dev Cell
, vol.15
, pp. 829-840
-
-
Rutkowski, D.T.1
Wu, J.2
Back, S.H.3
Callaghan, M.U.4
Ferris, S.P.5
Iqbal, J.6
Clark, R.7
Miao, H.8
Hassler, J.R.9
Fornek, J.10
-
178
-
-
84907360215
-
Structure and mechanism of action of the hydroxy-arylaldehyde class of IRE1 endoribonuclease inhibitors
-
Sanches M, Duffy NM, Talukdar M, Thevakumaran N, Chiovitti D, Canny MD, Lee K, Kurinov I, Uehling D, Al-awar R, et al. 2014. Structure and mechanism of action of the hydroxy-arylaldehyde class of IRE1 endoribonuclease inhibitors. Nat Commun 5: 4202.
-
(2014)
Nat Commun
, vol.5
, pp. 4202
-
-
Sanches, M.1
Duffy, N.M.2
Talukdar, M.3
Thevakumaran, N.4
Chiovitti, D.5
Canny, M.D.6
Lee, K.7
Kurinov, I.8
Uehling, D.9
Al-awar, R.10
-
179
-
-
84874343795
-
Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response
-
Sayers CM, Papandreou I, Guttmann DM, Maas NL, Diehl JA, Witze ES, Koong AC, Koumenis C. 2013. Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response. Mol Pharmacol 83: 594-604.
-
(2013)
Mol Pharmacol
, vol.83
, pp. 594-604
-
-
Sayers, C.M.1
Papandreou, I.2
Guttmann, D.M.3
Maas, N.L.4
Diehl, J.A.5
Witze, E.S.6
Koong, A.C.7
Koumenis, C.8
-
180
-
-
84891955443
-
CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model
-
Scaiewicz V, Nahmias A, Chung RT, Mueller T, Tirosh B, Shibolet O. 2013. CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model. PLoS One 8: e81065.
-
(2013)
PLoS One
, vol.8
, pp. 81065
-
-
Scaiewicz, V.1
Nahmias, A.2
Chung, R.T.3
Mueller, T.4
Tirosh, B.5
Shibolet, O.6
-
181
-
-
43549105167
-
The unfolded protein response: A pathway that links insulin demand with β-cell failure and diabetes
-
Scheuner D, Kaufman RJ. 2008. The unfolded protein response: a pathway that links insulin demand with β-cell failure and diabetes. Endocr Rev 29: 317-333.
-
(2008)
Endocr Rev
, vol.29
, pp. 317-333
-
-
Scheuner, D.1
Kaufman, R.J.2
-
182
-
-
48749105093
-
ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo
-
Schewe DM, Aguirre-Ghiso JA. 2008. ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo. Proc Natl Acad Sci 105: 10519-10524.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 10519-10524
-
-
Schewe, D.M.1
Aguirre-Ghiso, J.A.2
-
183
-
-
84873409612
-
Pharmacological targeting of endoplasmic reticulum stress signaling in cancer
-
Schonthal AH. 2013. Pharmacological targeting of endoplasmic reticulum stress signaling in cancer. Biochem Pharmacol 85: 653-666.
-
(2013)
Biochem Pharmacol
, vol.85
, pp. 653-666
-
-
Schonthal, A.H.1
-
184
-
-
22244446505
-
The mammalian unfolded protein response
-
Schroder M, Kaufman RJ. 2005. The mammalian unfolded protein response. Annu Rev Biochem 74: 739-789.
-
(2005)
Annu Rev Biochem
, vol.74
, pp. 739-789
-
-
Schroder, M.1
Kaufman, R.J.2
-
186
-
-
84893357959
-
ATF3 expression improves motor function in the ALS mouse model by promoting motor neuron survival and retaining muscle innervation
-
Seijffers R, Zhang J, Matthews JC, Chen A, Tamrazian E, Babaniyi O, Selig M, Hynynen M, Woolf CJ, Brown RH Jr. 2014. ATF3 expression improves motor function in the ALS mouse model by promoting motor neuron survival and retaining muscle innervation. Proc Natl Acad Sci 111: 1622-1627.
-
(2014)
Proc Natl Acad Sci
, vol.111
, pp. 1622-1627
-
-
Seijffers, R.1
Zhang, J.2
Matthews, J.C.3
Chen, A.4
Tamrazian, E.5
Babaniyi, O.6
Selig, M.7
Hynynen, M.8
Woolf, C.J.9
Brown, R.H.10
-
187
-
-
85016147149
-
Translation from unconventional 5′ start sites drives tumour initiation
-
Sendoel A, Dunn JG, Rodriguez EH, Naik S, Gomez NC, Hurwitz B, Levorse J, Dill BD, Schramek D, Molina H, et al. 2017. Translation from unconventional 5′ start sites drives tumour initiation. Nature 541: 494-499.
-
(2017)
Nature
, vol.541
, pp. 494-499
-
-
Sendoel, A.1
Dunn, J.G.2
Rodriguez, E.H.3
Naik, S.4
Gomez, N.C.5
Hurwitz, B.6
Levorse, J.7
Dill, B.D.8
Schramek, D.9
Molina, H.10
-
188
-
-
70350539531
-
Atf4 regulates obesity, glucose homeostasis, and energy expenditure
-
Seo J, Fortuno ES 3rd, Suh JM, Stenesen D, Tang W, Parks EJ, Adams CM, Townes T, Graff JM. 2009. Atf4 regulates obesity, glucose homeostasis, and energy expenditure. Diabetes 58: 2565-2573.
-
(2009)
Diabetes
, vol.58
, pp. 2565-2573
-
-
Seo, J.1
Fortuno, E.S.2
Suh, J.M.3
Stenesen, D.4
Tang, W.5
Parks, E.J.6
Adams, C.M.7
Townes, T.8
Graff, J.M.9
-
189
-
-
84908158825
-
Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling
-
Shao M, Shan B, Liu Y, Deng Y, Yan C,Wu Y, Mao T, Qiu Y, Zhou Y, Jiang S, et al. 2014. Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling. Nat Commun 5: 3528.
-
(2014)
Nat Commun
, vol.5
, pp. 3528
-
-
Shao, M.1
Shan, B.2
Liu, Y.3
Deng, Y.4
Yan, C.5
Wu, Y.6
Mao, T.7
Qiu, Y.8
Zhou, Y.9
Jiang, S.10
-
190
-
-
18244405070
-
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development
-
Shen X, Ellis RE, Lee K, Liu CY, Yang K, Solomon A, Yoshida H, Morimoto R, Kurnit DM, Mori K, et al. 2001. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 107: 893-903.
-
(2001)
Cell
, vol.107
, pp. 893-903
-
-
Shen, X.1
Ellis, R.E.2
Lee, K.3
Liu, C.Y.4
Yang, K.5
Solomon, A.6
Yoshida, H.7
Morimoto, R.8
Kurnit, D.M.9
Mori, K.10
-
191
-
-
0036069980
-
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals
-
Shen J, Chen X, Hendershot L, Prywes R. 2002. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev Cell 3: 99-111.
-
(2002)
Dev Cell
, vol.3
, pp. 99-111
-
-
Shen, J.1
Chen, X.2
Hendershot, L.3
Prywes, R.4
-
192
-
-
77953230937
-
A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications
-
Sheng Z, Li L, Zhu LJ, Smith TW, Demers A, Ross AH, Moser RP, Green MR. 2010. A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications. Nat Med 16: 671-677.
-
(2010)
Nat Med
, vol.16
, pp. 671-677
-
-
Sheng, Z.1
Li, L.2
Zhu, L.J.3
Smith, T.W.4
Demers, A.5
Ross, A.H.6
Moser, R.P.7
Green, M.R.8
-
193
-
-
22244472001
-
Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells
-
Shiraishi T, Yoshida T, Nakata S, Horinaka M, Wakada M, Mizutani Y, Miki T, Sakai T. 2005. Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells. Cancer Res 65: 6364-6370.
-
(2005)
Cancer Res
, vol.65
, pp. 6364-6370
-
-
Shiraishi, T.1
Yoshida, T.2
Nakata, S.3
Horinaka, M.4
Wakada, M.5
Mizutani, Y.6
Miki, T.7
Sakai, T.8
-
194
-
-
0038216621
-
Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: A possible involvement of the ER stress pathway in hepatocarcinogenesis
-
Shuda M, Kondoh N, Imazeki N, Tanaka K, Okada T, Mori K, Hada A, Arai M, Wakatsuki T, Matsubara O, et al. 2003. Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis. J Hepatol 38: 605-614.
-
(2003)
J Hepatol
, vol.38
, pp. 605-614
-
-
Shuda, M.1
Kondoh, N.2
Imazeki, N.3
Tanaka, K.4
Okada, T.5
Mori, K.6
Hada, A.7
Arai, M.8
Wakatsuki, T.9
Matsubara, O.10
-
195
-
-
0030954870
-
The transmembrane kinase Ire1p is a site-specific endonuclease that initiatesmRNAsplicing in the unfolded protein response
-
Sidrauski C,Walter P. 1997. The transmembrane kinase Ire1p is a site-specific endonuclease that initiatesmRNAsplicing in the unfolded protein response. Cell 90: 1031-1039.
-
(1997)
Cell
, vol.90
, pp. 1031-1039
-
-
Sidrauski, C.1
Walter, P.2
-
196
-
-
0030297538
-
tRNA ligase is required for regulated mRNA splicing in the unfolded protein response
-
Sidrauski C, Cox JS, Walter P. 1996. tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell 87: 405-413.
-
(1996)
Cell
, vol.87
, pp. 405-413
-
-
Sidrauski, C.1
Cox, J.S.2
Walter, P.3
-
197
-
-
28244466782
-
CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism
-
Silva RM, Ries V, Oo TF, Yarygina O, Jackson-Lewis V, Ryu EJ, Lu PD, Marciniak SJ, Ron D, Przedborski S, et al. 2005. CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. J Neurochem 95: 974-986.
-
(2005)
J Neurochem
, vol.95
, pp. 974-986
-
-
Silva, R.M.1
Ries, V.2
Oo, T.F.3
Yarygina, O.4
Jackson-Lewis, V.5
Ryu, E.J.6
Lu, P.D.7
Marciniak, S.J.8
Ron, D.9
Przedborski, S.10
-
198
-
-
55849096988
-
Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes
-
Song B, Scheuner D, Ron D, Pennathur S, Kaufman RJ. 2008. Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest 118: 3378-3389.
-
(2008)
J Clin Invest
, vol.118
, pp. 3378-3389
-
-
Song, B.1
Scheuner, D.2
Ron, D.3
Pennathur, S.4
Kaufman, R.J.5
-
199
-
-
0033962298
-
A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2α
-
Sood R, Porter AC, Olsen DA, Cavener DR, Wek RC. 2000. A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2α. Genetics 154: 787-801.
-
(2000)
Genetics
, vol.154
, pp. 787-801
-
-
Sood, R.1
Porter, A.C.2
Olsen, D.A.3
Cavener, D.R.4
Wek, R.C.5
-
200
-
-
78049480651
-
Stress signaling in the methionine-choline-deficient model of murine fatty liver disease
-
Soon RK Jr, Yan JS, Grenert JP, Maher JJ. 2010. Stress signaling in the methionine-choline-deficient model of murine fatty liver disease. Gastroenterology 139: 1730-1739.
-
(2010)
Gastroenterology
, vol.139
, pp. 1730-1739
-
-
Soon, R.K.1
Yan, J.S.2
Grenert, J.P.3
Maher, J.J.4
-
201
-
-
84975221855
-
Overexpression of CHOP in myelinating cells does not confer a significant phenotype under normal or metabolic stress conditions
-
Southwood CM, Fykkolodziej B, Maheras KJ, Garshott DM, Estill M, Fribley AM, Gow A. 2016. Overexpression of CHOP in myelinating cells does not confer a significant phenotype under normal or metabolic stress conditions. J Neurosci 36: 6803-6819.
-
(2016)
J Neurosci
, vol.36
, pp. 6803-6819
-
-
Southwood, C.M.1
Fykkolodziej, B.2
Maheras, K.J.3
Garshott, D.M.4
Estill, M.5
Fribley, A.M.6
Gow, A.7
-
202
-
-
84873287971
-
ATF4 protects against neuronal death in cellular Parkinson’s disease models by maintaining levels of parkin
-
Sun X, Liu J, Crary JF, Malagelada C, Sulzer D, Greene LA, Levy OA. 2013. ATF4 protects against neuronal death in cellular Parkinson’s disease models by maintaining levels of parkin. J Neurosci 33: 2398-2407.
-
(2013)
J Neurosci
, vol.33
, pp. 2398-2407
-
-
Sun, X.1
Liu, J.2
Crary, J.F.3
Malagelada, C.4
Sulzer, D.5
Greene, L.A.6
Levy, O.A.7
-
203
-
-
84860284366
-
Key role of ATF3 in p53-dependent DR5 induction upon DNA damage of human colon cancer cells
-
Taketani K, Kawauchi J, Tanaka-Okamoto M, Ishizaki H, Tanaka Y, Sakai T, Miyoshi J, Maehara Y, Kitajima S. 2012. Key role of ATF3 in p53-dependent DR5 induction upon DNA damage of human colon cancer cells. Oncogene 31: 2210-2221.
-
(2012)
Oncogene
, vol.31
, pp. 2210-2221
-
-
Taketani, K.1
Kawauchi, J.2
Tanaka-Okamoto, M.3
Ishizaki, H.4
Tanaka, Y.5
Sakai, T.6
Miyoshi, J.7
Maehara, Y.8
Kitajima, S.9
-
204
-
-
39149109306
-
CHOPdeficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury
-
Tamaki N, Hatano E, Taura K, Tada M, Kodama Y, Nitta T, Iwaisako K, Seo S, Nakajima A, Ikai I, et al. 2008. CHOPdeficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury. Am J Physiol Gastrointest Liver Physiol 294: G498-G505.
-
(2008)
Am J Physiol Gastrointest Liver Physiol
, vol.294
, pp. G498-G505
-
-
Tamaki, N.1
Hatano, E.2
Taura, K.3
Tada, M.4
Kodama, Y.5
Nitta, T.6
Iwaisako, K.7
Seo, S.8
Nakajima, A.9
Ikai, I.10
-
205
-
-
0033749370
-
Role of C/EBP homologous protein (CHOP-10) in the programmed activation of CCAAT/enhancer-binding protein-β during adipogenesis
-
Tang QQ, Lane MD. 2000. Role of C/EBP homologous protein (CHOP-10) in the programmed activation of CCAAT/enhancer-binding protein-β during adipogenesis. Proc Natl Acad Sci 97: 12446-12450.
-
(2000)
Proc Natl Acad Sci
, vol.97
, pp. 12446-12450
-
-
Tang, Q.Q.1
Lane, M.D.2
-
206
-
-
0030995509
-
Pre-mRNA splicing: The discovery of a new spliceosome doubles the challenge
-
Tarn WY, Steitz JA. 1997. Pre-mRNA splicing: the discovery of a new spliceosome doubles the challenge. Trends Biochem Sci 22: 132-137.
-
(1997)
Trends Biochem Sci
, vol.22
, pp. 132-137
-
-
Tarn, W.Y.1
Steitz, J.A.2
-
207
-
-
33644774734
-
Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians
-
Thameem F, Farook VS, Bogardus C, Prochazka M. 2006. Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians. Diabetes 55: 839-842.
-
(2006)
Diabetes
, vol.55
, pp. 839-842
-
-
Thameem, F.1
Farook, V.S.2
Bogardus, C.3
Prochazka, M.4
-
208
-
-
84908003234
-
The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors
-
Thevenot PT, Sierra RA, Raber PL, Al-Khami AA, Trillo-Tinoco J, Zarreii P, Ochoa AC, Cui Y, Del Valle L, Rodriguez PC. 2014. The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors. Immunity 41: 389-401.
-
(2014)
Immunity
, vol.41
, pp. 389-401
-
-
Thevenot, P.T.1
Sierra, R.A.2
Raber, P.L.3
Al-Khami, A.A.4
Trillo-Tinoco, J.5
Zarreii, P.6
Ochoa, A.C.7
Cui, Y.8
Del Valle, L.9
Rodriguez, P.C.10
-
209
-
-
0032525990
-
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
-
Tirasophon W, Welihinda AA, Kaufman RJ. 1998. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev 12: 1812-1824.
-
(1998)
Genes Dev
, vol.12
, pp. 1812-1824
-
-
Tirasophon, W.1
Welihinda, A.A.2
Kaufman, R.J.3
-
210
-
-
23944434028
-
XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells
-
Tirosh B, Iwakoshi NN, Glimcher LH, Ploegh HL. 2005. XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells. J Exp Med 202: 505-516.
-
(2005)
J Exp Med
, vol.202
, pp. 505-516
-
-
Tirosh, B.1
Iwakoshi, N.N.2
Glimcher, L.H.3
Ploegh, H.L.4
-
211
-
-
33646824929
-
Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response
-
Tirosh B, Iwakoshi NN, Glimcher LH, Ploegh HL. 2006. Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response. J Biol Chem 281: 5852-5860.
-
(2006)
J Biol Chem
, vol.281
, pp. 5852-5860
-
-
Tirosh, B.1
Iwakoshi, N.N.2
Glimcher, L.H.3
Ploegh, H.L.4
-
212
-
-
59449103777
-
CCAAT/enhancer-binding protein β promotes osteoblast differentiation by enhancing Runx2 activity with ATF4
-
Tominaga H, Maeda S, Hayashi M, Takeda S, Akira S, Komiya S, Nakamura T, Akiyama H, Imamura T. 2008. CCAAT/enhancer-binding protein β promotes osteoblast differentiation by enhancing Runx2 activity with ATF4. Mol Biol Cell 19: 5373-5386.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 5373-5386
-
-
Tominaga, H.1
Maeda, S.2
Hayashi, M.3
Takeda, S.4
Akira, S.5
Komiya, S.6
Nakamura, T.7
Akiyama, H.8
Imamura, T.9
-
213
-
-
84898909262
-
Attenuation of steatohepatitis, fibrosis, and carcinogenesis in mice fed a methionine-choline deficient diet by CCAAT/enhancer-binding protein homologous protein deficiency
-
Toriguchi K, Hatano E, Tanabe K, Takemoto K, Nakamura K, Koyama Y, Seo S, Taura K, Uemoto S. 2014. Attenuation of steatohepatitis, fibrosis, and carcinogenesis in mice fed a methionine-choline deficient diet by CCAAT/enhancer-binding protein homologous protein deficiency. J Gastroenterol Hepatol 29: 1109-1118.
-
(2014)
J Gastroenterol Hepatol
, vol.29
, pp. 1109-1118
-
-
Toriguchi, K.1
Hatano, E.2
Tanabe, K.3
Takemoto, K.4
Nakamura, K.5
Koyama, Y.6
Seo, S.7
Taura, K.8
Uemoto, S.9
-
214
-
-
84864278763
-
Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance
-
Usui M, Yamaguchi S, Tanji Y, Tominaga R, Ishigaki Y, Fukumoto M, Katagiri H, Mori K, Oka Y, Ishihara H. 2012. Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance. Metabolism 61: 1118-1128.
-
(2012)
Metabolism
, vol.61
, pp. 1118-1128
-
-
Usui, M.1
Yamaguchi, S.2
Tanji, Y.3
Tominaga, R.4
Ishigaki, Y.5
Fukumoto, M.6
Katagiri, H.7
Mori, K.8
Oka, Y.9
Ishihara, H.10
-
215
-
-
84882855544
-
CHOP is a critical regulator of acetaminophen-induced hepatotoxicity
-
Uzi D, Barda L, Scaiewicz V, Mills M, Mueller T, Gonzalez-Rodriguez A, Valverde AM, Iwawaki T, Nahmias Y, Xavier R, et al. 2013. CHOP is a critical regulator of acetaminophen-induced hepatotoxicity. J Hepatol 59: 495-503.
-
(2013)
J Hepatol
, vol.59
, pp. 495-503
-
-
Uzi, D.1
Barda, L.2
Scaiewicz, V.3
Mills, M.4
Mueller, T.5
Gonzalez-Rodriguez, A.6
Valverde, A.M.7
Iwawaki, T.8
Nahmias, Y.9
Xavier, R.10
-
216
-
-
84899844505
-
Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1
-
Valdes P, Mercado G, Vidal RL, Molina C, Parsons G, Court FA, Martinez A, Galleguillos D, Armentano D, Schneider BL, et al. 2014. Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1. Proc Natl Acad Sci 111: 6804-6809.
-
(2014)
Proc Natl Acad Sci
, vol.111
, pp. 6804-6809
-
-
Valdes, P.1
Mercado, G.2
Vidal, R.L.3
Molina, C.4
Parsons, G.5
Court, F.A.6
Martinez, A.7
Galleguillos, D.8
Armentano, D.9
Schneider, B.L.10
-
217
-
-
84902343044
-
The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress
-
van Galen P, Kreso A, Mbong N, Kent DG, Fitzmaurice T, Chambers JE, Xie S, Laurenti E, Hermans K, Eppert K, et al. 2014. The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress. Nature 510: 268-272.
-
(2014)
Nature
, vol.510
, pp. 268-272
-
-
van Galen, P.1
Kreso, A.2
Mbong, N.3
Kent, D.G.4
Fitzmaurice, T.5
Chambers, J.E.6
Xie, S.7
Laurenti, E.8
Hermans, K.9
Eppert, K.10
-
218
-
-
3843117589
-
Reinitiation involving upstream ORFs regulates ATF4 mRNAtranslation in mammalian cells
-
Vattem KM, Wek RC. 2004. Reinitiation involving upstream ORFs regulates ATF4 mRNAtranslation in mammalian cells. Proc Natl Acad Sci 101: 11269-11274.
-
(2004)
Proc Natl Acad Sci
, vol.101
, pp. 11269-11274
-
-
Vattem, K.M.1
Wek, R.C.2
-
219
-
-
84860471873
-
Targeting the UPR transcription factor XBP1 protects against Huntington’s disease through the regulation of FoxO1 and autophagy
-
Vidal RL, Figueroa A, Court FA, Thielen P, Molina C, Wirth C, Caballero B, Kiffin R, Segura-Aguilar J, Cuervo AM, et al. 2012. Targeting the UPR transcription factor XBP1 protects against Huntington’s disease through the regulation of FoxO1 and autophagy. Hum Mol Genet 21: 2245-2262.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 2245-2262
-
-
Vidal, R.L.1
Figueroa, A.2
Court, F.A.3
Thielen, P.4
Molina, C.5
Wirth, C.6
Caballero, B.7
Kiffin, R.8
Segura-Aguilar, J.9
Cuervo, A.M.10
-
220
-
-
79953319782
-
Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease
-
Volkmann K, Lucas JL, Vuga D,Wang X, Brumm D, Stiles C, Kriebel D, Der-Sarkissian A, Krishnan K, Schweitzer C, et al. 2011. Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease. J Biol Chem 286: 12743-12755.
-
(2011)
J Biol Chem
, vol.286
, pp. 12743-12755
-
-
Volkmann, K.1
Lucas, J.L.2
Vuga, D.3
Wang, X.4
Brumm, D.5
Stiles, C.6
Kriebel, D.7
Der-Sarkissian, A.8
Krishnan, K.9
Schweitzer, C.10
-
221
-
-
82255173966
-
The unfolded protein response: From stress pathway to homeostatic regulation
-
Walter P, Ron D. 2011. The unfolded protein response: from stress pathway to homeostatic regulation. Science 334: 1081-1086.
-
(2011)
Science
, vol.334
, pp. 1081-1086
-
-
Walter, P.1
Ron, D.2
-
222
-
-
84906712846
-
The impact of the endoplasmic reticulum protein-folding environment on cancer development
-
Wang M, Kaufman RJ. 2014. The impact of the endoplasmic reticulum protein-folding environment on cancer development. Nat Rev Cancer 14: 581-597.
-
(2014)
Nat Rev Cancer
, vol.14
, pp. 581-597
-
-
Wang, M.1
Kaufman, R.J.2
-
223
-
-
84955445779
-
Protein misfolding in the endoplasmic reticulum as a conduit to human disease
-
Wang M, Kaufman RJ. 2016. Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature 529: 326-335.
-
(2016)
Nature
, vol.529
, pp. 326-335
-
-
Wang, M.1
Kaufman, R.J.2
-
224
-
-
77951223217
-
Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6
-
Wang H, Mo P, Ren S, Yan C. 2010. Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6. J Biol Chem 285: 13201-13210.
-
(2010)
J Biol Chem
, vol.285
, pp. 13201-13210
-
-
Wang, H.1
Mo, P.2
Ren, S.3
Yan, C.4
-
225
-
-
84865129257
-
The stress response mediator ATF3 represses androgen signaling by binding the androgen receptor
-
Wang H, Jiang M, Cui H, Chen M, Buttyan R, Hayward SW, Hai T, Wang Z, Yan C. 2012a. The stress response mediator ATF3 represses androgen signaling by binding the androgen receptor. Mol Cell Biol 32: 3190-3202.
-
(2012)
Mol Cell Biol
, vol.32
, pp. 3190-3202
-
-
Wang, H.1
Jiang, M.2
Cui, H.3
Chen, M.4
Buttyan, R.5
Hayward, S.W.6
Hai, T.7
Wang, Z.8
Yan, C.9
-
226
-
-
84870357261
-
Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors
-
Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schurer SC, Oakes SA, Papa FR, Maly DJ. 2012b. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nat Chem Biol 8: 982-989.
-
(2012)
Nat Chem Biol
, vol.8
, pp. 982-989
-
-
Wang, L.1
Perera, B.G.2
Hari, S.B.3
Bhhatarai, B.4
Backes, B.J.5
Seeliger, M.A.6
Schurer, S.C.7
Oakes, S.A.8
Papa, F.R.9
Maly, D.J.10
-
227
-
-
84867063735
-
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis
-
Wang S, Chen Z, Lam V, Han J, Hassler J, Finck BN, Davidson NO, Kaufman RJ. 2012c. IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis. Cell Metab 16: 473-486.
-
(2012)
Cell Metab
, vol.16
, pp. 473-486
-
-
Wang, S.1
Chen, Z.2
Lam, V.3
Han, J.4
Hassler, J.5
Finck, B.N.6
Davidson, N.O.7
Kaufman, R.J.8
-
228
-
-
84868527256
-
Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons
-
Wang SZ, Ou J, Zhu LJ, Green MR. 2012d. Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons. Proc Natl Acad Sci 109: 18589-18594.
-
(2012)
Proc Natl Acad Sci
, vol.109
, pp. 18589-18594
-
-
Wang, S.Z.1
Ou, J.2
Zhu, L.J.3
Green, M.R.4
-
229
-
-
84872094361
-
miR-214 targets ATF4 to inhibit bone formation
-
Wang X, Guo B, Li Q, Peng J, Yang Z, Wang A, Li D, Hou Z, Lv K, Kan G, et al. 2013a. miR-214 targets ATF4 to inhibit bone formation. Nat Med 19: 93-100.
-
(2013)
Nat Med
, vol.19
, pp. 93-100
-
-
Wang, X.1
Guo, B.2
Li, Q.3
Peng, J.4
Yang, Z.5
Wang, A.6
Li, D.7
Hou, Z.8
Lv, K.9
Kan, G.10
-
230
-
-
84874484624
-
The role of CCAAT enhancer-binding protein homologous protein in human immunodeficiency virus protease-inhibitor-induced hepatic lipotoxicity in mice
-
Wang Y, Zhang L, Wu X, Gurley EC, Kennedy E, Hylemon PB, Pandak WM, Sanyal AJ, Zhou H. 2013b. The role of CCAAT enhancer-binding protein homologous protein in human immunodeficiency virus protease-inhibitor-induced hepatic lipotoxicity in mice. Hepatology 57: 1005-1016.
-
(2013)
Hepatology
, vol.57
, pp. 1005-1016
-
-
Wang, Y.1
Zhang, L.2
Wu, X.3
Gurley, E.C.4
Kennedy, E.5
Hylemon, P.B.6
Pandak, W.M.7
Sanyal, A.J.8
Zhou, H.9
-
231
-
-
84916208738
-
Endoplasmic reticulum stress mediates the anti-inflammatory effect of ethyl pyruvate in endothelial cells
-
Wang G, Liu K, Li Y, Yi W, Yang Y, Zhao D, Fan C, Yang H, Geng T, Xing J, et al. 2014. Endoplasmic reticulum stress mediates the anti-inflammatory effect of ethyl pyruvate in endothelial cells. PLoS One 9: e113983.
-
(2014)
PLoS One
, vol.9
, pp. 113983
-
-
Wang, G.1
Liu, K.2
Li, Y.3
Yi, W.4
Yang, Y.5
Zhao, D.6
Fan, C.7
Yang, H.8
Geng, T.9
Xing, J.10
-
232
-
-
84922810694
-
Identification of protein disulfide isomerase 1 as a key isomerase for disulfide bond formation in apolipoprotein B100
-
Wang S, Park S, Kodali VK, Han J, Yip T, Chen Z, Davidson NO, Kaufman RJ. 2015. Identification of protein disulfide isomerase 1 as a key isomerase for disulfide bond formation in apolipoprotein B100. Mol Biol Cell 26: 594-604.
-
(2015)
Mol Biol Cell
, vol.26
, pp. 594-604
-
-
Wang, S.1
Park, S.2
Kodali, V.K.3
Han, J.4
Yip, T.5
Chen, Z.6
Davidson, N.O.7
Kaufman, R.J.8
-
233
-
-
41449112857
-
Stress-induced translation of ATF5 mRNA is regulated by the 5′-untranslated region
-
Watatani Y, Ichikawa K, Nakanishi N, Fujimoto M, Takeda H, Kimura N, Hirose H, Takahashi S, Takahashi Y. 2008. Stress-induced translation of ATF5 mRNA is regulated by the 5′-untranslated region. J Biol Chem 283: 2543-2553.
-
(2008)
J Biol Chem
, vol.283
, pp. 2543-2553
-
-
Watatani, Y.1
Ichikawa, K.2
Nakanishi, N.3
Fujimoto, M.4
Takeda, H.5
Kimura, N.6
Hirose, H.7
Takahashi, S.8
Takahashi, Y.9
-
234
-
-
35748973890
-
Negative regulation of TLR-signaling pathways by activating transcription factor-3
-
Whitmore MM, Iparraguirre A, Kubelka L, Weninger W, Hai T, Williams BR. 2007. Negative regulation of TLR-signaling pathways by activating transcription factor-3. J Immunol 179: 3622-3630.
-
(2007)
J Immunol
, vol.179
, pp. 3622-3630
-
-
Whitmore, M.M.1
Iparraguirre, A.2
Kubelka, L.3
Weninger, W.4
Hai, T.5
Williams, B.R.6
-
235
-
-
0033230617
-
PKR; a sentinel kinase for cellular stress
-
Williams BR. 1999. PKR; a sentinel kinase for cellular stress. Oncogene 18: 6112-6120.
-
(1999)
Oncogene
, vol.18
, pp. 6112-6120
-
-
Williams, B.R.1
-
236
-
-
84930917503
-
CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis
-
Willy JA, Young SK, Stevens JL, Masuoka HC, Wek RC. 2015. CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis. Mol Biol Cell 26: 2190-2204.
-
(2015)
Mol Biol Cell
, vol.26
, pp. 2190-2204
-
-
Willy, J.A.1
Young, S.K.2
Stevens, J.L.3
Masuoka, H.C.4
Wek, R.C.5
-
237
-
-
77950537400
-
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response
-
Winnay JN, Boucher J, Mori MA, Ueki K, Kahn CR. 2010. A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nat Med 16: 438-445.
-
(2010)
Nat Med
, vol.16
, pp. 438-445
-
-
Winnay, J.N.1
Boucher, J.2
Mori, M.A.3
Ueki, K.4
Kahn, C.R.5
-
238
-
-
77950887221
-
Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1
-
Wiseman RL, Zhang Y, Lee KP, Harding HP, Haynes CM, Price J, Sicheri F, Ron D. 2010. Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol Cell 38: 291-304.
-
(2010)
Mol Cell
, vol.38
, pp. 291-304
-
-
Wiseman, R.L.1
Zhang, Y.2
Lee, K.P.3
Harding, H.P.4
Haynes, C.M.5
Price, J.6
Sicheri, F.7
Ron, D.8
-
239
-
-
34548189283
-
ATF6α optimizes longterm endoplasmic reticulum function to protect cells from chronic stress
-
Wu J, Rutkowski DT, Dubois M, Swathirajan J, Saunders T, Wang J, Song B, Yau GD, Kaufman RJ. 2007. ATF6α optimizes longterm endoplasmic reticulum function to protect cells from chronic stress. Dev Cell 13: 351-364.
-
(2007)
Dev Cell
, vol.13
, pp. 351-364
-
-
Wu, J.1
Rutkowski, D.T.2
Dubois, M.3
Swathirajan, J.4
Saunders, T.5
Wang, J.6
Song, B.7
Yau, G.D.8
Kaufman, R.J.9
-
240
-
-
77952716949
-
Opposing roles for calcineurin and ATF3 in squamous skin cancer
-
Wu X, Nguyen BC, Dziunycz P, Chang S, Brooks Y, Lefort K, Hofbauer GF, Dotto GP. 2010. Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature 465: 368-372.
-
(2010)
Nature
, vol.465
, pp. 368-372
-
-
Wu, X.1
Nguyen, B.C.2
Dziunycz, P.3
Chang, S.4
Brooks, Y.5
Lefort, K.6
Hofbauer, G.F.7
Dotto, G.P.8
-
241
-
-
84880134855
-
Inhibition of endoplasmic reticulum stress is involved in the neuroprotective effects of candesartan cilexitil in the rotenone rat model of Parkinson’s disease
-
Wu L, Tian YY, Shi JP, Xie W, Shi JQ, Lu J, Zhang YD. 2013. Inhibition of endoplasmic reticulum stress is involved in the neuroprotective effects of candesartan cilexitil in the rotenone rat model of Parkinson’s disease. Neurosci Lett 548: 50-55.
-
(2013)
Neurosci Lett
, vol.548
, pp. 50-55
-
-
Wu, L.1
Tian, Y.Y.2
Shi, J.P.3
Xie, W.4
Shi, J.Q.5
Lu, J.6
Zhang, Y.D.7
-
242
-
-
84899445472
-
A missense polymorphism in ATF6 gene is associated with susceptibility to hepatocellular carcinoma probably by altering ATF6 level
-
Wu X, Xin Z, Zhang W, Zheng S,Wu J, Chen K,Wang H, Zhu X, Li Z, Duan Z, et al. 2014. A missense polymorphism in ATF6 gene is associated with susceptibility to hepatocellular carcinoma probably by altering ATF6 level. Int J Cancer 135: 61-68.
-
(2014)
Int J Cancer
, vol.135
, pp. 61-68
-
-
Wu, X.1
Xin, Z.2
Zhang, W.3
Zheng, S.4
Wu, J.5
Chen, K.6
Wang, H.7
Zhu, X.8
Li, Z.9
Duan, Z.10
-
243
-
-
84883348454
-
ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice
-
Xiao G, Zhang T, Yu S, Lee S, Calabuig-Navarro V, Yamauchi J, Ringquist S, Dong HH. 2013. ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice. J Biol Chem 288: 25350-25361.
-
(2013)
J Biol Chem
, vol.288
, pp. 25350-25361
-
-
Xiao, G.1
Zhang, T.2
Yu, S.3
Lee, S.4
Calabuig-Navarro, V.5
Yamauchi, J.6
Ringquist, S.7
Dong, H.H.8
-
244
-
-
84907966643
-
ATF3 functions as a novel tumor suppressor with prognostic significance in esophageal squamous cell carcinoma
-
Xie JJ, Xie YM, Chen B, Pan F, Guo JC, Zhao Q, Shen JH, Wu ZY, Wu JY, Xu LY, et al. 2014. ATF3 functions as a novel tumor suppressor with prognostic significance in esophageal squamous cell carcinoma. Oncotarget 5: 8569-8582.
-
(2014)
Oncotarget
, vol.5
, pp. 8569-8582
-
-
Xie, J.J.1
Xie, Y.M.2
Chen, B.3
Pan, F.4
Guo, J.C.5
Zhao, Q.6
Shen, J.H.7
Wu, Z.Y.8
Wu, J.Y.9
Xu, L.Y.10
-
245
-
-
85027947620
-
The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells
-
Xu T, Yang L, Yan C,Wang X, Huang P, Zhao F, Zhao L, Zhang M, JiaW,Wang X, et al. 2014. The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells. Cell Res 24: 1137-1140.
-
(2014)
Cell Res
, vol.24
, pp. 1137-1140
-
-
Xu, T.1
Yang, L.2
Yan, C.3
Wang, X.4
Huang, P.5
Zhao, F.6
Zhao, L.7
Zhang, M.8
Jia, W.9
Wang, X.10
-
246
-
-
84923525246
-
Transcriptional activation of Fsp27 by the liver-enriched transcription factor CREBH promotes lipid droplet growth and hepatic steatosis
-
Xu X, Park JG, So JS, Lee AH. 2015. Transcriptional activation of Fsp27 by the liver-enriched transcription factor CREBH promotes lipid droplet growth and hepatic steatosis. Hepatology 61: 857-869.
-
(2015)
Hepatology
, vol.61
, pp. 857-869
-
-
Xu, X.1
Park, J.G.2
So, J.S.3
Lee, A.H.4
-
247
-
-
8544283103
-
CHOPis involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells
-
Yamaguchi H,Wang HG. 2004. CHOPis involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J Biol Chem 279: 45495-45502.
-
(2004)
J Biol Chem
, vol.279
, pp. 45495-45502
-
-
Yamaguchi, H.1
Wang, H.G.2
-
248
-
-
34548172495
-
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6α and XBP1
-
Yamamoto K, Sato T, Matsui T, Sato M, Okada T, Yoshida H, Harada A, Mori K. 2007. Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6α and XBP1. Dev Cell 13: 365-376.
-
(2007)
Dev Cell
, vol.13
, pp. 365-376
-
-
Yamamoto, K.1
Sato, T.2
Matsui, T.3
Sato, M.4
Okada, T.5
Yoshida, H.6
Harada, A.7
Mori, K.8
-
249
-
-
77956232915
-
Induction of liver steatosis and lipid droplet formation in ATF6α-knockout mice burdened with pharmacological endoplasmic reticulum stress
-
Yamamoto K, Takahara K, Oyadomari S, Okada T, Sato T, Harada A, Mori K. 2010. Induction of liver steatosis and lipid droplet formation in ATF6α-knockout mice burdened with pharmacological endoplasmic reticulum stress. Mol Biol Cell 21: 2975-2986.
-
(2010)
Mol Biol Cell
, vol.21
, pp. 2975-2986
-
-
Yamamoto, K.1
Takahara, K.2
Oyadomari, S.3
Okada, T.4
Sato, T.5
Harada, A.6
Mori, K.7
-
250
-
-
33745070550
-
Involvement of endoplasmic reticulum stress on the cell death induced by 6-hydroxydopamine in human neuroblastoma SH-SY5Y cells
-
Yamamuro A, Yoshioka Y, Ogita K, Maeda S. 2006. Involvement of endoplasmic reticulum stress on the cell death induced by 6-hydroxydopamine in human neuroblastoma SH-SY5Y cells. Neurochem Res 31: 657-664.
-
(2006)
Neurochem Res
, vol.31
, pp. 657-664
-
-
Yamamuro, A.1
Yoshioka, Y.2
Ogita, K.3
Maeda, S.4
-
251
-
-
69849109361
-
Activation of the Akt-NF-κB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response
-
Yamazaki H, Hiramatsu N, Hayakawa K, Tagawa Y, Okamura M, Ogata R, Huang T, Nakajima S, Yao J, Paton AW, et al. 2009. Activation of the Akt-NF-κB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response. J Immunol 183: 1480-1487.
-
(2009)
J Immunol
, vol.183
, pp. 1480-1487
-
-
Yamazaki, H.1
Hiramatsu, N.2
Hayakawa, K.3
Tagawa, Y.4
Okamura, M.5
Ogata, R.6
Huang, T.7
Nakajima, S.8
Yao, J.9
Paton, A.W.10
-
252
-
-
11144357428
-
ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology: Implication for Coffin-Lowry syndrome
-
Yang X, Matsuda K, Bialek P, Jacquot S, Masuoka HC, Schinke T, Li L, Brancorsini S, Sassone-Corsi P, Townes TM, et al. 2004. ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology: implication for Coffin-Lowry syndrome. Cell 117: 387-398.
-
(2004)
Cell
, vol.117
, pp. 387-398
-
-
Yang, X.1
Matsuda, K.2
Bialek, P.3
Jacquot, S.4
Masuoka, H.C.5
Schinke, T.6
Li, L.7
Brancorsini, S.8
Sassone-Corsi, P.9
Townes, T.M.10
-
253
-
-
0034515724
-
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
-
Ye J, Rawson RB, Komuro R, Chen X, Dave UP, Prywes R, Brown MS, Goldstein JL. 2000. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell 6: 1355-1364.
-
(2000)
Mol Cell
, vol.6
, pp. 1355-1364
-
-
Ye, J.1
Rawson, R.B.2
Komuro, R.3
Chen, X.4
Dave, U.P.5
Prywes, R.6
Brown, M.S.7
Goldstein, J.L.8
-
254
-
-
77953565102
-
The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
-
Ye J, Kumanova M, Hart LS, Sloane K, Zhang H, De Panis DN, Bobrovnikova-Marjon E, Diehl JA, Ron D, Koumenis C. 2010. The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J 29: 2082-2096.
-
(2010)
EMBO J
, vol.29
, pp. 2082-2096
-
-
Ye, J.1
Kumanova, M.2
Hart, L.S.3
Sloane, K.4
Zhang, H.5
De Panis, D.N.6
Bobrovnikova-Marjon, E.7
Diehl, J.A.8
Ron, D.9
Koumenis, C.10
-
255
-
-
41649111514
-
A potential dichotomous role of ATF3, an adaptive-response gene, in cancer development
-
Yin X, Dewille JW, Hai T. 2008. A potential dichotomous role of ATF3, an adaptive-response gene, in cancer development. Oncogene 27: 2118-2127.
-
(2008)
Oncogene
, vol.27
, pp. 2118-2127
-
-
Yin, X.1
Dewille, J.W.2
Hai, T.3
-
256
-
-
77957868981
-
ATF3, an adaptive-response gene, enhances TGFβ signaling and cancer-initiating cell features in breast cancer cells
-
Yin X, Wolford CC, Chang YS, McConoughey SJ, Ramsey SA, Aderem A, Hai T. 2010. ATF3, an adaptive-response gene, enhances TGFβ signaling and cancer-initiating cell features in breast cancer cells. J Cell Sci 123: 3558-3565.
-
(2010)
J Cell Sci
, vol.123
, pp. 3558-3565
-
-
Yin, X.1
Wolford, C.C.2
Chang, Y.S.3
McConoughey, S.J.4
Ramsey, S.A.5
Aderem, A.6
Hai, T.7
-
257
-
-
0035966269
-
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
-
Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. 2001. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107: 881-891.
-
(2001)
Cell
, vol.107
, pp. 881-891
-
-
Yoshida, H.1
Matsui, T.2
Yamamoto, A.3
Okada, T.4
Mori, K.5
-
258
-
-
32644432826
-
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response
-
Yoshida H, Oku M, Suzuki M, Mori K. 2006. pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response. J Cell Biol 172: 565-575.
-
(2006)
J Cell Biol
, vol.172
, pp. 565-575
-
-
Yoshida, H.1
Oku, M.2
Suzuki, M.3
Mori, K.4
-
259
-
-
70349226800
-
The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts
-
Yoshizawa T, Hinoi E, Jung DY, Kajimura D, Ferron M, Seo J, Graff JM, Kim JK, Karsenty G. 2009. The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. J Clin Invest 119: 2807-2817.
-
(2009)
J Clin Invest
, vol.119
, pp. 2807-2817
-
-
Yoshizawa, T.1
Hinoi, E.2
Jung, D.Y.3
Kajimura, D.4
Ferron, M.5
Seo, J.6
Graff, J.M.7
Kim, J.K.8
Karsenty, G.9
-
260
-
-
0042824071
-
Transcriptional regulation of the human transferrin gene by GADD153 in hepatoma cells
-
You KR, Liu MJ, Han XJ, Lee ZW, Kim DG. 2003. Transcriptional regulation of the human transferrin gene by GADD153 in hepatoma cells. Hepatology 38: 745-755.
-
(2003)
Hepatology
, vol.38
, pp. 745-755
-
-
You, K.R.1
Liu, M.J.2
Han, X.J.3
Lee, Z.W.4
Kim, D.G.5
-
261
-
-
84879074800
-
ATF3 suppresses metastasis of bladder cancer by regulating gelsolin-mediated remodeling of the actin cytoskeleton
-
Yuan X, Yu L, Li J, Xie G, Rong T, Zhang L, Chen J, Meng Q, Irving AT, Wang D, et al. 2013. ATF3 suppresses metastasis of bladder cancer by regulating gelsolin-mediated remodeling of the actin cytoskeleton. Cancer Res 73: 3625-3637.
-
(2013)
Cancer Res
, vol.73
, pp. 3625-3637
-
-
Yuan, X.1
Yu, L.2
Li, J.3
Xie, G.4
Rong, T.5
Zhang, L.6
Chen, J.7
Meng, Q.8
Irving, A.T.9
Wang, D.10
-
262
-
-
47949099916
-
From endoplasmic-reticulum stress to the inflammatory response
-
Zhang K, Kaufman RJ. 2008. From endoplasmic-reticulum stress to the inflammatory response. Nature 454: 455-462.
-
(2008)
Nature
, vol.454
, pp. 455-462
-
-
Zhang, K.1
Kaufman, R.J.2
-
263
-
-
14944371187
-
The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis
-
Zhang K,Wong HN, Song B, Miller CN, Scheuner D, Kaufman RJ. 2005. The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis. J Clin Invest 115: 268-281.
-
(2005)
J Clin Invest
, vol.115
, pp. 268-281
-
-
Zhang, K.1
Wong, H.N.2
Song, B.3
Miller, C.N.4
Scheuner, D.5
Kaufman, R.J.6
-
264
-
-
32044453080
-
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
-
Zhang K, Shen X, Wu J, Sakaki K, Saunders T, Rutkowski DT, Back SH, Kaufman RJ. 2006. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 124: 587-599.
-
(2006)
Cell
, vol.124
, pp. 587-599
-
-
Zhang, K.1
Shen, X.2
Wu, J.3
Sakaki, K.4
Saunders, T.5
Rutkowski, D.T.6
Back, S.H.7
Kaufman, R.J.8
-
265
-
-
79953794116
-
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis
-
Zhang K, Wang S, Malhotra J, Hassler JR, Back SH, Wang G, Chang L, Xu W, Miao H, Leonardi R, et al. 2011. The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis. EMBO J 30: 1357-1375.
-
(2011)
EMBO J
, vol.30
, pp. 1357-1375
-
-
Zhang, K.1
Wang, S.2
Malhotra, J.3
Hassler, J.R.4
Back, S.H.5
Wang, G.6
Chang, L.7
Xu, W.8
Miao, H.9
Leonardi, R.10
-
266
-
-
84862828272
-
Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice
-
Zhang C, Wang G, Zheng Z, Maddipati KR, Zhang X, Dyson G, Williams P, Duncan SA, Kaufman RJ, Zhang K. 2012. Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. Hepatology 55: 1070-1082.
-
(2012)
Hepatology
, vol.55
, pp. 1070-1082
-
-
Zhang, C.1
Wang, G.2
Zheng, Z.3
Maddipati, K.R.4
Zhang, X.5
Dyson, G.6
Williams, P.7
Duncan, S.A.8
Kaufman, R.J.9
Zhang, K.10
-
267
-
-
84883339670
-
Central activating transcription factor 4 (ATF4) regulates hepatic insulin resistance in mice via S6K1 signaling and the vagus nerve
-
Zhang Q, Yu J, Liu B, Lv Z, Xia T, Xiao F, Chen S, Guo F. 2013. Central activating transcription factor 4 (ATF4) regulates hepatic insulin resistance in mice via S6K1 signaling and the vagus nerve. Diabetes 62: 2230-2239.
-
(2013)
Diabetes
, vol.62
, pp. 2230-2239
-
-
Zhang, Q.1
Yu, J.2
Liu, B.3
Lv, Z.4
Xia, T.5
Xiao, F.6
Chen, S.7
Guo, F.8
-
268
-
-
84948759928
-
ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver
-
Zhao Y, Zhou J, Liu D, Dong F, Cheng H,Wang W, Pang Y,Wang Y, Mu X, Ni Y, et al. 2015. ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver. Blood 126: 2383-2391.
-
(2015)
Blood
, vol.126
, pp. 2383-2391
-
-
Zhao, Y.1
Zhou, J.2
Liu, D.3
Dong, F.4
Cheng, H.5
Wang, W.6
Pang, Y.7
Wang, Y.8
Mu, X.9
Ni, Y.10
-
269
-
-
41449095062
-
Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions
-
Zhou D, Palam LR, Jiang L, Narasimhan J, Staschke KA,Wek RC. 2008. Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions. J Biol Chem 283: 7064-7073.
-
(2008)
J Biol Chem
, vol.283
, pp. 7064-7073
-
-
Zhou, D.1
Palam, L.R.2
Jiang, L.3
Narasimhan, J.4
Staschke, K.A.5
Wek, R.C.6
-
270
-
-
79952381078
-
Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction
-
Zhou Y, Lee J, Reno CM, Sun C, Park SW, Chung J, Lee J, Fisher SJ, White MF, Biddinger SB, et al. 2011. Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med 17: 356-365.
-
(2011)
Nat Med
, vol.17
, pp. 356-365
-
-
Zhou, Y.1
Lee, J.2
Reno, C.M.3
Sun, C.4
Park, S.W.5
Chung, J.6
Lee, J.7
Fisher, S.J.8
White, M.F.9
Biddinger, S.B.10
-
271
-
-
84909999517
-
Activating transcription factor 4 mediates a multidrug resistance phenotype of esophageal squamous cell carcinoma cells through transactivation of STAT3 expression
-
Zhu H, Chen X, Chen B, Chen B, Fan J, Song W, Xie Z, Jiang D, Li Q, Zhou M, et al. 2014a. Activating transcription factor 4 mediates a multidrug resistance phenotype of esophageal squamous cell carcinoma cells through transactivation of STAT3 expression. Cancer Lett 354: 142-152.
-
(2014)
Cancer Lett
, vol.354
, pp. 142-152
-
-
Zhu, H.1
Chen, X.2
Chen, B.3
Chen, B.4
Fan, J.5
Song, W.6
Xie, Z.7
Jiang, D.8
Li, Q.9
Zhou, M.10
-
272
-
-
84905241767
-
Activating transcription factor 4 promotes esophageal squamous cell carcinoma invasion and metastasis in mice and is associated with poor prognosis in human patients
-
Zhu H, Chen X, Chen B, Chen B, Song W, Sun D, Zhao Y. 2014b. Activating transcription factor 4 promotes esophageal squamous cell carcinoma invasion and metastasis in mice and is associated with poor prognosis in human patients. PLoS One 9: e103882.
-
(2014)
PLoS One
, vol.9
, pp. 103882
-
-
Zhu, H.1
Chen, X.2
Chen, B.3
Chen, B.4
Song, W.5
Sun, D.6
Zhao, Y.7
-
273
-
-
77954825385
-
The roles of ATF3, an adaptive-response gene, in highfat-diet-induced diabetes and pancreatic β-cell dysfunction
-
Zmuda EJ, Qi L, Zhu MX, Mirmira RG, Montminy MR, Hai T. 2010. The roles of ATF3, an adaptive-response gene, in highfat-diet-induced diabetes and pancreatic β-cell dysfunction. Mol Endocrinol 24: 1423-1433.
-
(2010)
Mol Endocrinol
, vol.24
, pp. 1423-1433
-
-
Zmuda, E.J.1
Qi, L.2
Zhu, M.X.3
Mirmira, R.G.4
Montminy, M.R.5
Hai, T.6
-
274
-
-
84859577308
-
AAVmediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington’s disease
-
Zuleta A, Vidal RL, Armentano D, Parsons G, Hetz C. 2012. AAVmediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington’s disease. Biochem Biophys Res Commun 420: 558-563.
-
(2012)
Biochem Biophys Res Commun
, vol.420
, pp. 558-563
-
-
Zuleta, A.1
Vidal, R.L.2
Armentano, D.3
Parsons, G.4
Hetz, C.5
|