Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease

Journal of Biological Chemistry

Volumn 286, Issue 14, 2011, Pages 12743-12755

  Volkmann, Kori ^a   Lucas, Julie L ^a   Vuga, Danka ^a   Wang, Xiaoping ^a   Brumm, Duane ^a   Stiles, Caryn ^a   Kriebel, David ^a   Der Sarkissian, Ani ^a   Krishnan, Kris ^a   Schweitzer, Colleen ^a   Liu, Zheng ^a   Malyankar, Uriel M ^a   Chiovitti, David ^b   Canny, Marella ^b   Durocher, Dan ^b,c   Sicheri, Frank ^b,c   Patterson, John B ^a  

^a MannKind Corporation   (United States)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSOLIC; DOSE-DEPENDENT MANNER; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASE; HUMAN CELLS; HYDROLYZED PRODUCTS; IN-VIVO; KINETIC ANALYSIS; METHOXY; RNA SUBSTRATE; SALICYLALDEHYDE; SALICYLALDIMINES; SELECTIVE INHIBITORS; SITE-SPECIFIC; STEM-LOOP; THERAPEUTIC TARGETS; UNFOLDED PROTEIN RESPONSE; UP-REGULATION;

ALCOHOLS; ENZYMES; NUCLEIC ACIDS; RNA; SUGARS; SURFACE PLASMON RESONANCE; TRANSCRIPTION FACTORS;

ALDEHYDES;

3 ETHOXY 5,6 DIBROMOSALICYLALDEHYDE; MESSENGER RNA; PROTEIN IRE1; PROTEIN IRE1ALPHA; RIBONUCLEASE A; RIBONUCLEASE L; RIBONUCLEASE T1; SALICYLALDEHYDE; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENDOPLASMIC RETICULUM STRESS; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN HYDROLYSIS; PROTEIN TARGETING; TRANSCRIPTION REGULATION; UPREGULATION;

ALDEHYDES; ANIMALS; BLOTTING, WESTERN; CELL LINE; DNA-BINDING PROTEINS; ENDORIBONUCLEASES; ENZYME INHIBITORS; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE PROTEINS; MICE; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE; TRANSCRIPTION FACTORS;

EID: 79953319782     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.199737     Document Type: Article

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