Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress responses

Molecular Pharmacology

Volumn 83, Issue 3, 2013, Pages 594-604

  Sayers, Carly M ^a   Papandreou, Ioanna ^a   Guttmann, David M ^a   Maas, Nancy L ^b   Diehl, J Alan ^a   Witze, Eric S ^a   Koong, Albert C ^a   Koumenis, Constantinos ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ANTINEOPLASTIC AGENT; CHECKPOINT KINASE 2; E235; E235 1756; HISTONE H2AX; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL AGING; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRESS; CELL VIABILITY; CONCENTRATION RESPONSE; DNA DAMAGE; FIBROSARCOMA; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; INTEGRATED STRESS RESPONSE; INTRACELLULAR SIGNALING; MELANOMA CELL; MOLECULAR LIBRARY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; CELL AGING; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; FEMALE; FIBROSARCOMA; HUMANS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84874343795     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.081810     Document Type: Article

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