Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors

Nature Communications

Volumn 5, Issue , 2014, Pages

  Sanches, Mario ^a   Duffy, Nicole M ^a   Talukdar, Manisha ^a,b   Thevakumaran, Nero ^a,b   Chiovitti, David ^a   Canny, Marella D ^a   Lee, Kenneth ^a,b   Kurinov, Igor ^c   Uehling, David ^d   Al Awar, Rima ^d,e   Poda, Gennadiy ^d   Prakesch, Michael ^d   Wilson, Brian ^d   Tam, Victor ^f   Schweitzer, Colleen ^f   Toro, Andras ^f   Lucas, Julie L ^f   Vuga, Danka ^f   Lehmann, Lynn ^g   Durocher, Daniel ^a,b   Zeng, Qingping ^f   Patterson, John B ^f   Sicheri, Frank ^a,b   more..

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c ARGONNE NATIONAL LABORATORY   (United States)

^d ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

^f MannKind Corporation   (United States)

^g NanoTemper Technologies GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD59 ANTIGEN; HYDROXY ARY LALDEHYDE DERIVATIVE; MESSENGER RNA; MKC 3426; MKC 3437; MKC 3820; MKC 3946; MKC 3964; MKC 3987; MKC 4027; MKC 9989; OICR 464; OICR 573; PROTEIN IRE1; RIBONUCLEASE; RIBONUCLEASE INHIBITOR; SCHIFF BASE; UNCLASSIFIED DRUG; ALDEHYDE; BENZALDEHYDE DERIVATIVE; CD59 PROTEIN, HUMAN; COUMARIN DERIVATIVE; DNA BINDING PROTEIN; ENZYME INHIBITOR; ERN2 PROTEIN, MOUSE; MEMBRANE PROTEIN; MKC9989; MOLECULAR LIBRARY; MORPHOLINE DERIVATIVE; OICR464; OICR573; PROTEIN SERINE THREONINE KINASE; REGULATORY FACTOR X TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR;

ALDEHYDE; CELL ORGANELLE; ENZYME ACTIVITY; HOMEOSTASIS; INHIBITION; INHIBITOR;

ANIMAL CELL; ARTICLE; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INHIBITION; HYDROGEN BOND; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DNA MUTATIONAL ANALYSIS; DRUG EFFECTS; ENZYME ACTIVE SITE; GENETICS; HUMAN; METABOLISM; MOLECULAR LIBRARY; PATHOLOGY; PHARMACOLOGY; PLASMACYTOMA; PROTEIN CONFORMATION; TUMOR CELL LINE;

ALDEHYDES; ANTIGENS, CD59; BENZALDEHYDES; BINDING SITES; CATALYTIC DOMAIN; CELL LINE, TUMOR; COUMARINS; CRYSTALLOGRAPHY, X-RAY; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; ENZYME INHIBITORS; HUMANS; MEMBRANE PROTEINS; MOLECULAR STRUCTURE; MORPHOLINES; PLASMACYTOMA; PROTEIN CONFORMATION; PROTEIN-SERINE-THREONINE KINASES; REGULATORY FACTOR X TRANSCRIPTION FACTORS; RIBONUCLEASES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS;

EID: 84907360215     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms5202     Document Type: Article

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