The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response

Cell

Volumn 90, Issue 6, 1997, Pages 1031-1039

  Sidrauski, Carmela ^a   Walter, Peter ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDONUCLEASE; MESSENGER RNA; PHOSPHOTRANSFERASE;

ARTICLE; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; RNA SPLICING; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 0030954870     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80369-4     Document Type: Article

References (33)

1. Bork, P., and Sander, C. (1993). A hybrid protein kinase-RNase in an interferon-induced pathway? FEBS Lett. 334, 149-152.
2. Clark, M.W., and Abelson, J. (1987). The subnuclear localization of tRNA ligase in yeast. J. Cell Biol. 105, 1515-1526.
3. Cox, J.S., Shamu, C.E., and Walter, P. (1993).Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell 73, 1197-1206.
4. Cox, J.S., and Walter, P. (1996). A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 87, 391-404.
5. Dong, B., and Silverman, R.H. (1995). 2-5A-dependent RNase molecules dimerize during activation by 2-5A*. J. Biol. Chem. 270, 4133-4137.
6. Dong, B., Xu, L., Zhou, A., Hassel, B.A., Lee, X., Torrence, P.F., and Silverman, R.H. (1994). Intrinsic molecular activities of the interferon-induced 2-5A-dependent RNase. J. Biol. Chem. 269, 14153-14158.
7. Greer, C.L. (1986). Assembly of a tRNA splicing complex: evidence for concerted excision and joining steps in splicing in vitro. Mol. Cell. Biol. 6, 635-644.
8. Greer, C.L., Peebles, C.L., Gegenheimer, P., and Abelson, J. (1983). Mechanism of action of a yeast RNA ligase in tRNA splicing. Cell 32, 537-546.
9. Greer, C.L., Soll, D., and Willis, I. (1987). Substrate recognition and identification of splice sites by the tRNA-splicing endonuclease and ligase from Saccharomyces cerevisiae. Mol. Cell. Biol. 7, 76-84.
10. Hassel, B.A., Zhou, A., Sotomayor, C., Maran, A., and Silverman, R.H. (1993). A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon. EMBO J. 12, 3297-3304.
11. Kleman-Leyer, K., Ambruster, D.W., and Daniels, C.J. (1997). Properties of H. volcanii tRNA intron endonuclease reveal a relationship between the archaeal and eucaryal intron processing systems. Cell 89, 839-847.
12. Kohno, K., Normington, K., Sambrook, J., Gething, M.J., and Mori, K. (1993). The promoter region of the yeast KAR2(BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum. Mol. Cell. Biol. 13, 877-890.
13. Krause, D., Lesiak, K., Imiai, J., Sawai, H., Torrence, P.F., and Silverman, R.H. (1986). Activation of 2-5A-dependent RNase by analogs of 2-5A. J. Biol. Chem. 261, 6836-6839.
14. Lim, D., Ho, J.X., Keeling, K., Gilliland, G.L, Ji, X., Ruker, F., and Carter, D.C. (1994). Three-dimensional structure of Schistosoma japonicum glutathione-S-transferase fused with a six-amino acid conserved neutralizing epitope of gp41 from HIV. Prot. Sci. 3, 2233-2244.
15. Mattoccia, E., Baldi, I.M., Gandini-Attardi, D., Ciafre, S., and Tocchini-Valentini, G.P. (1988). Site-selection by the tRNA splicing endo-nuclease of Xenopus laevis. Cell 55, 731-738.
16. McMillan, D.R., Gething, M.-J., and Sambrook, J. (1994). The cellular response to unfolded proteins: intercompartmental signaling. Curr. Opin. Biotechnol. 5, 540-545.
17. Moore, M.J., Query, C.C., and Sharp, P.A. (1993). Splicing of precursors to mRNAs by the spliceosome. In the RNA World. R.F. Gesteland and J.F. Atkins, eds. (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press), pp. 303-357.
18. Mori, K., Kawahara, T., Yoshida, H., Yanagi, H., and Yura, T. (1996). Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway. Genes to Cells 1, 803-817.
19. +/CDC28-related kinase activity is required for signaling from the ER to the nucleus. Cell 74, 743-756.
20. Mori, K., Sant, A., Kohno, K., Normington, K., Gething, M.J., and Sambrook, J.F. (1992). A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2(BiP) gene by unfolded proteins. EMBO J. 11, 2583-2593.
21. Nikawa, J., Akiyoshi, M., Hirata, S., and Fukuda, T. (1996). Saccharomyces cerevisiae IRE2/HAC1 is involved in IRE1-mediated KAR2 expression. Nucleic Acids Res. 24, 4222-4226.
22. O'Connor, J.P., and Peebles, C.L. (1991). In vivo pre-tRNA processing in Saccharomyces cerevisiae. Mol. Cell. Biol. 11, 425-439.
23. Peebles, C.L., Gegenheimer, P., and Abelson, J. (1983). Precise excision of intervening sequences from precursor transfer RNA by a membrane associated endonuclease. Cell 32, 525-536.
24. Reyes, V.M., and Abelson, J. (1988). Substrate recognition and splice site determination in yeast tRNA splicing. Cell 55, 710-730.
25. Schwer, B., and Guthrie, C. (1991). PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome. Nature 349, 494-499.
26. Shamu, C.E., Cox, J.S., and Walter, P. (1994). The unfolded-protein-response pathway in yeast. Trends Cell Biol. 4, 56-60.
27. Shamu, C.E., and Walter, P. (1996). Oligomerization and phosphorylation of the Ire 1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J. 15, 3028-3039.
28. Sidrauski, C., Cox, J.S., and Walter, P. (1996). tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell 87, 405-413.
29. Stern, S., Moazed, D., and Noller, H.F. (1986). Structural analysis of RNA using chemical and enzymatic probing monitored by primer extension. Meth. Enzymol. 164, 481-489.
30. Sweet, D.J. (1993). A kinase that responds to stress. Curr. Biol. 3, 622-624.
31. Trotta, C.R., Miao, F., Arn, E.A., Stevens, S.W., Ho, C.K., Rauhut, R., and Abelson, J.N. (1997). The yeast tRNA splicing endonuclease: a tetrameric enzyme with two active site subunits homologous to the archaeal tRNA endonucleases. Cell 89, 849-858.
32. Welihinda, A.A., and Kaufman, R.J. (1996). The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-autophosphorylation of Ire 1p (Ern 1p) are required for kinase activation. J. Biol. Chem. 271, 18181-18187.
33. Zhou, A., Hassel, B.A., and Silverman, R.H. (1993). Expression cloning of 2-5A-dependent RNAse: a uniquely regulated mediator of interferon action. Cell 72, 753-765.