CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 294, Issue 2, 2008, Pages

  Tamaki, Nobuyuki ^a   Hatano, Etsuro ^a   Taura, Kojiro ^a,b   Tada, Masaharu ^a   Kodama, Yuzo ^b   Nitta, Takashi ^a   Iwaisako, Keiko ^a   Seo, Satoru ^a   Nakajima, Akio ^a   Ikai, Iwao ^a   Uemoto, Shinji ^a  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Apoptosis; Bile duct ligation; Endoplasmic reticulum stress; Necrosis; Transforming growth factor 1

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CASPASE 3; GLYCOCHENODEOXYCHOLIC ACID; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PROPIDIUM IODIDE; PROTEIN BAX; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; CELL DEATH; CELL ISOLATION; CHOLESTASIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; HISTOPATHOLOGY; KNOCKOUT MOUSE; LIVER CELL DAMAGE; LIVER FIBROSIS; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STRESS;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CASPASE 3; CCAAT-ENHANCER-BINDING PROTEINS; CELLS, CULTURED; CHOLAGOGUES AND CHOLERETICS; CHOLESTASIS; ENDOPLASMIC RETICULUM; GLYCOCHENODEOXYCHOLIC ACID; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; LIGATION; LIVER; LIVER CIRRHOSIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NECROSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 39149109306     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00482.2007     Document Type: Article

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