The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

EMBO Journal

Volumn 29, Issue 12, 2010, Pages 2082-2096

  Ye, Jiangbin ^a   Kumanova, Monika ^a   Hart, Lori S ^a   Sloane, Kelly ^a   Zhang, Haiyan ^a   De Panis, Diego N ^a   Bobrovnikova Marjon, Ekaterina ^b   Diehl, J Alan ^b   Ron, David ^c   Koumenis, Constantinos ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amino acid; Asparagine; ATF4; GCN2; Metabolismx

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ASPARAGINE; ASPARTATE AMMONIA LIGASE; PROTEIN GCN2; PROTEIN KINASE R; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CANCER INHIBITION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL; TUMOR GROWTH;

ACTIVATING TRANSCRIPTION FACTOR 4; AMINO ACIDS; ANIMALS; CELL PROLIFERATION; CELL SURVIVAL; CULTURE MEDIA; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; HUMANS; MICE; PROTEIN-SERINE-THREONINE KINASES;

EUKARYOTA;

EID: 77953565102     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2010.81     Document Type: Article

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