AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington's disease

Biochemical and Biophysical Research Communications

Volumn 420, Issue 3, 2012, Pages 558-563

  Zuleta, Amparo ^a,b   Vidal, Rene L ^a,e   Armentano, Donna ^c   Parsons, Geoffrey ^c   Hetz, Claudio ^a,b,d,e  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

^c GENZYME CORPORATION   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e Neurounion Biomedical Foundation   (Chile)

Author keywords

Endoplasmic reticulum stress; Gene therapy; Htt aggregation; Huntington's disease; Unfolded protein response; XBP1

Indexed keywords

HUNTINGTIN; HYBRID PROTEIN; PARVOVIRUS VECTOR; X BOX BINDING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INCLUSION; CONTROLLED STUDY; CORPUS STRIATUM; ENDOPLASMIC RETICULUM STRESS; GENE THERAPY; HISTOPATHOLOGY; HUNTINGTON CHOREA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

ANIMALS; CORPUS STRIATUM; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM STRESS; GENE THERAPY; GENETIC VECTORS; HUNTINGTON DISEASE; MALE; MICE; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS; TRANSDUCTION, GENETIC; UNFOLDED PROTEIN RESPONSE;

ANIMALIA; MUS;

EID: 84859577308     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.03.033     Document Type: Article

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