-
1
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups and the National Cancer Institute of Canada Clinical Trials Group
-
R. Stupp, W. P. Mason, M. J. van den Bent, M. Weller, B. Fisher, M. J. Taphoorn, K. Belanger, A. A. Brandes, C. Marosi, U. Bogdahn, J. Curschmann, R. C. Janzer, S. K. Ludwin, T. Gorlia, A. Allgeier, D. Lacombe, J. G. Cairncross, E. Eisenhauer, R. O. Mirimanoff; European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups and the National Cancer Institute of Canada Clinical Trials Group, Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 352, 987-996 (2005).
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 987-996
-
-
Stupp, R.1
Mason, W.P.2
Van Den-Bent, M.J.3
Weller, M.4
Fisher, B.5
Taphoorn, M.J.6
Belanger, K.7
Brandes, A.A.8
Marosi, C.9
Bogdahn, U.10
Curschmann, J.11
Janzer, R.C.12
Ludwin, S.K.13
Gorlia, T.14
Allgeier, A.15
Lacombe, D.16
Cairncross, J.G.17
Eisenhauer, E.18
Mirimanoff, R.O.19
-
2
-
-
84958544011
-
Long-term results of carmustine wafer implantation for newly diagnosed glioblastomas: A controlled propensity-matched analysis of a French multicenter cohort
-
J. Pallud, E. Audureau, G. Noel, R. Corns, E. Lechapt-Zalcman, J. Duntze, V. Pavlov, J. Guyotat, P. D. Hieu, P. J. Le Reste, T. Faillot, C.-F. Litre, N. Desse, A. Petit, E. Emery, J. Voirin, J. Peltier, F. Caire, J.-R. Vignes, J.-L. Barat, O. Langlois, E. Dezamis, E. Parraga, M. Zanello, E. Nader, M. Lefranc, L. Bauchet, B. Devaux, P. Menei, P. Metellus; Club de Neuro-Oncologie of the Société Française de Neurochirurgie, Long-term results of carmustine wafer implantation for newly diagnosed glioblastomas: A controlled propensity-matched analysis of a French multicenter cohort. Neuro Oncol. 17, 1609-1619 (2015).
-
(2015)
Neuro Oncol.
, vol.17
, pp. 1609-1619
-
-
Pallud, J.1
Audureau, E.2
Noel, G.3
Corns, R.4
Lechapt-Zalcman, E.5
Duntze, J.6
Pavlov, V.7
Guyotat, J.8
Hieu, P.D.9
Le Reste, P.J.10
Faillot, T.11
Litre, C.-F.12
Desse, N.13
Petit, A.14
Emery, E.15
Voirin, J.16
Peltier, J.17
Caire, F.18
Vignes, J.-R.19
Barat, J.-L.20
Langlois, O.21
Dezamis, E.22
Parraga, E.23
Zanello, M.24
Nader, E.25
Lefranc, M.26
Bauchet, L.27
Devaux, B.28
Menei, P.29
Metellus, P.30
more..
-
3
-
-
84881156635
-
Prospective evaluation of health-related quality of life in patients with glioblastoma multiforme treated on a phase II trial of hypofractionated IMRT with temozolomide
-
K. Reddy, L. E. Gaspar, B. D. Kavanagh, A. Waziri, D. M. Damek, D. Ney, K. O. Lillehei, C. Chen, Prospective evaluation of health-related quality of life in patients with glioblastoma multiforme treated on a phase II trial of hypofractionated IMRT with temozolomide. J. Neurooncol. 114, 111-116 (2013).
-
(2013)
J. Neurooncol.
, vol.114
, pp. 111-116
-
-
Reddy, K.1
Gaspar, L.E.2
Kavanagh, B.D.3
Waziri, A.4
Damek, D.M.5
Ney, D.6
Lillehei, K.O.7
Chen, C.8
-
4
-
-
84966687479
-
The 2016 world health organization classification of tumors of the central nervous system: A summary
-
D. N. Louis, A. Perry, G. Reifenberger, A. von Deimling, D. Figarella-Branger, W. K. Cavenee, H. Ohgaki, O. D. Wiestler, P. Kleihues, D. W. Ellison, The 2016 World Health Organization classification of tumors of the central nervous system: A summary. Acta Neuropathol. 131, 803-820 (2016).
-
(2016)
Acta Neuropathol.
, vol.131
, pp. 803-820
-
-
Louis, D.N.1
Perry, A.2
Reifenberger, G.3
Von Deimling, A.4
Figarella-Branger, D.5
Cavenee, W.K.6
Ohgaki, H.7
Wiestler, O.D.8
Kleihues, P.9
Ellison, D.W.10
-
5
-
-
84971281668
-
Gliomas genomics and epigenomics: Arriving at the start and knowing it for the first time
-
M. G. Filbin, M. L. Suva, Gliomas Genomics and Epigenomics: Arriving at the start and knowing it for the first time. Annu. Rev. Pathol. 11, 497-521 (2016).
-
(2016)
Annu. Rev. Pathol.
, vol.11
, pp. 497-521
-
-
Filbin, M.G.1
Suva, M.L.2
-
6
-
-
79960656490
-
6-methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: Enzyme activity, promoter methylation and immunohistochemistry
-
6-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: Enzyme activity, promoter methylation and immunohistochemistry. Biochim. Biophys. Acta 1816, 179-190 (2011).
-
(2011)
Biochim. Biophys. Acta
, vol.1816
, pp. 179-190
-
-
Christmann, M.1
Verbeek, B.2
Roos, W.P.3
Kaina, B.4
-
7
-
-
66249108601
-
Understanding the warburg effect: The metabolic requirements of cell proliferation
-
M. G. Vander Heiden, L. C. Cantley, C. B. Thompson, Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 324, 1029-1033 (2009).
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
8
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
D. Hanahan, R. A. Weinberg, Hallmarks of cancer: The next generation. Cell 144, 646-674 (2011).
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
10
-
-
84899940537
-
Addicted to secrete-novel concepts and targets in cancer therapy
-
N. Dejeans, S. Manie, C. Hetz, F. Bard, T. Hupp, P. Agostinis, A. Samali, E. Chevet, Addicted to secrete-Novel concepts and targets in cancer therapy. Trends Mol. Med. 20, 242-250 (2014).
-
(2014)
Trends Mol. Med.
, vol.20
, pp. 242-250
-
-
Dejeans, N.1
Manie, S.2
Hetz, C.3
Bard, F.4
Hupp, T.5
Agostinis, P.6
Samali, A.7
Chevet, E.8
-
11
-
-
84930958887
-
Stress-mediated translational control in cancer cells
-
G. Leprivier, B. Rotblat, D. Khan, E. Jan, P. H. Sorensen, Stress-mediated translational control in cancer cells. Biochim. Biophys. Acta 1849, 845-860 (2015).
-
(2015)
Biochim. Biophys. Acta
, vol.1849
, pp. 845-860
-
-
Leprivier, G.1
Rotblat, B.2
Khan, D.3
Jan, E.4
Sorensen, P.H.5
-
12
-
-
84907820400
-
Endoplasmic reticulum chaperones and oxidoreductases: Critical regulators of tumor cell survival and immunorecognition
-
T. Gutiérrez, T. Simmen, Endoplasmic reticulum chaperones and oxidoreductases: Critical regulators of tumor cell survival and immunorecognition. Front. Oncol. 4, 291 (2014).
-
(2014)
Front. Oncol.
, vol.4
, pp. 291
-
-
Gutiérrez, T.1
Simmen, T.2
-
13
-
-
33645154135
-
Cellular response to endoplasmic reticulum stress: A matter of life or death
-
M. Boyce, J. Yuan, Cellular response to endoplasmic reticulum stress: A matter of life or death. Cell Death Differ. 13, 363-373 (2006).
-
(2006)
Cell Death Differ.
, vol.13
, pp. 363-373
-
-
Boyce, M.1
Yuan, J.2
-
14
-
-
22244446505
-
The mammalian unfolded protein response
-
M. Schröder, R. J. Kaufman, The mammalian unfolded protein response. Annu. Rev. Biochem. 74, 739-789 (2005).
-
(2005)
Annu. Rev. Biochem.
, vol.74
, pp. 739-789
-
-
Schröder, M.1
Kaufman, R.J.2
-
15
-
-
0033782015
-
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
-
A. Bertolotti, Y. Zhang, L. M. Hendershot, H. P. Harding, D. Ron, Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol. 2, 326-332 (2000).
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 326-332
-
-
Bertolotti, A.1
Zhang, Y.2
Hendershot, L.M.3
Harding, H.P.4
Ron, D.5
-
16
-
-
59649111087
-
The unfolded protein response signals through high-order assembly of ire1
-
A. V. Korennykh, P. F. Egea, A. A. Korostelev, J. Finer-Moore, C. Zhang, K. M. Shokat, R. M. Stroud, P. Walter, The unfolded protein response signals through high-order assembly of Ire1. Nature 457, 687-693 (2009).
-
(2009)
Nature
, vol.457
, pp. 687-693
-
-
Korennykh, A.V.1
Egea, P.F.2
Korostelev, A.A.3
Finer-Moore, J.4
Zhang, C.5
Shokat, K.M.6
Stroud, R.M.7
Walter, P.8
-
17
-
-
84938212067
-
Targeting the IRE1α-XBP1 branch of the unfolded protein response in human diseases
-
D. Jiang, M. Niwa, A. C. Koong, Targeting the IRE1α-XBP1 branch of the unfolded protein response in human diseases. Semin. Cancer Biol. 33, 48-56 (2015).
-
(2015)
Semin. Cancer Biol.
, vol.33
, pp. 48-56
-
-
Jiang, D.1
Niwa, M.2
Koong, A.C.3
-
18
-
-
84899937866
-
Getting RIDD of RNA: IRE1 in cell fate regulation
-
M. Maurel, E. Chevet, J. Tavernier, S. Gerlo, Getting RIDD of RNA: IRE1 in cell fate regulation. Trends Biochem. Sci. 39, 245-254 (2014).
-
(2014)
Trends Biochem. Sci.
, vol.39
, pp. 245-254
-
-
Maurel, M.1
Chevet, E.2
Tavernier, J.3
Gerlo, S.4
-
19
-
-
82255173966
-
The unfolded protein response: From stress pathway to homeostatic regulation
-
P. Walter, D. Ron, The unfolded protein response: From stress pathway to homeostatic regulation. Science 334, 1081-1086 (2011).
-
(2011)
Science
, vol.334
, pp. 1081-1086
-
-
Walter, P.1
Ron, D.2
-
20
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
D. Ron, P. Walter, Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 8, 519-529 (2007).
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
21
-
-
79952264011
-
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
-
I. Tabas, D. Ron, Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat. Cell Biol. 13, 184-190 (2011).
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 184-190
-
-
Tabas, I.1
Ron, D.2
-
22
-
-
35448967382
-
The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas
-
P. Pyrko, A. H. Schönthal, F. M. Hofman, T. C. Chen, A. S. Lee, The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas. Cancer Res. 67, 9809-9816 (2007).
-
(2007)
Cancer Res.
, vol.67
, pp. 9809-9816
-
-
Pyrko, P.1
Schönthal, A.H.2
Hofman, F.M.3
Chen, T.C.4
Lee, A.S.5
-
23
-
-
84870546460
-
ER stress-mediated autophagy promotes myc-dependent transformation and tumor growth
-
L. S. Hart, J. T. Cunningham, T. Datta, S. Dey, F. Tameire, S. L. Lehman, B. Qiu, H. Zhang, G. Cerniglia, M. Bi, Y. Li, Y. Gao, H. Liu, C. Li, A. Maity, A. T. Tikhonenko, A. E. Perl, A. Koong, S. Y. Fuchs, J. A. Diehl, I. G. Mills, D. Ruggero, C. Koumenis, ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J. Clin. Invest. 122, 4621-4634 (2012).
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 4621-4634
-
-
Hart, L.S.1
Cunningham, J.T.2
Datta, T.3
Dey, S.4
Tameire, F.5
Lehman, S.L.6
Qiu, B.7
Zhang, H.8
Cerniglia, G.9
Bi, M.10
Li, Y.11
Gao, Y.12
Liu, H.13
Li, C.14
Maity, A.15
Tikhonenko, A.T.16
Perl, A.E.17
Koong, A.18
Fuchs, S.Y.19
Diehl, J.A.20
Mills, I.G.21
Ruggero, D.22
Koumenis, C.23
more..
-
24
-
-
77955486614
-
XBP1s levels are implicated in the biology and outcome of myeloma mediating different clinical outcomes to thalidomide-based treatments
-
T. Bagratuni, P. Wu, D. Gonzalez de Castro, E. L. Davenport, N. J. Dickens, B. A. Walker, K. Boyd, D. C. Johnson, W. Gregory, G. J. Morgan, F. E. Davies, XBP1s levels are implicated in the biology and outcome of myeloma mediating different clinical outcomes to thalidomide-based treatments. Blood 116, 250-253 (2010).
-
(2010)
Blood
, vol.116
, pp. 250-253
-
-
Bagratuni, T.1
Wu, P.2
Gonzalez De-Castro, D.3
Davenport, E.L.4
Dickens, N.J.5
Walker, B.A.6
Boyd, K.7
Johnson, D.C.8
Gregory, W.9
Morgan, G.J.10
Davies, F.E.11
-
25
-
-
0034021399
-
Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions
-
P. M. Fernandez, S. O. Tabbara, L. K. Jacobs, F. C. Manning, T. N. Tsangaris, A. M. Schwartz, K. A. Kennedy, S. R. Patierno, Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions. Breast Cancer Res. Treat. 59, 15-26 (2000).
-
(2000)
Breast Cancer Res. Treat.
, vol.59
, pp. 15-26
-
-
Fernandez, P.M.1
Tabbara, S.O.2
Jacobs, L.K.3
Manning, F.C.4
Tsangaris, T.N.5
Schwartz, A.M.6
Kennedy, K.A.7
Patierno, S.R.8
-
26
-
-
20444399528
-
Expression of endoplasmic reticulum molecular chaperone grp78 in human lung cancer and its clinical significance
-
H. Uramoto, K. Sugio, T. Oyama, S. Nakata, K. Ono, T. Yoshimastu, M. Morita, K. Yasumoto, Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance. Lung Cancer 49, 55-62 (2005).
-
(2005)
Lung Cancer
, vol.49
, pp. 55-62
-
-
Uramoto, H.1
Sugio, K.2
Oyama, T.3
Nakata, S.4
Ono, K.5
Yoshimastu, T.6
Morita, M.7
Yasumoto, K.8
-
27
-
-
0038216621
-
Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: A possible involvement of the ER stress pathway in hepatocarcinogenesis
-
M. Shuda, N. Kondoh, N. Imazeki, K. Tanaka, T. Okada, K. Mori, A. Hada, M. Arai, T. Wakatsuki, O. Matsubara, N. Yamamoto, M. Yamamoto, Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: A possible involvement of the ER stress pathway in hepatocarcinogenesis. J. Hepatol. 38, 605-614 (2003).
-
(2003)
J. Hepatol.
, vol.38
, pp. 605-614
-
-
Shuda, M.1
Kondoh, N.2
Imazeki, N.3
Tanaka, K.4
Okada, T.5
Mori, K.6
Hada, A.7
Arai, M.8
Wakatsuki, T.9
Matsubara, O.10
Yamamoto, N.11
Yamamoto, M.12
-
28
-
-
31044433349
-
Overexpression of glucose-regulated protein 78 in colon cancer
-
X. Xing, M. Lai, Y. Wang, E. Xu, Q. Huang, Overexpression of glucose-regulated protein 78 in colon cancer. Clin. Chim. Acta 364, 308-315 (2006).
-
(2006)
Clin. Chim. Acta
, vol.364
, pp. 308-315
-
-
Xing, X.1
Lai, M.2
Wang, Y.3
Xu, E.4
Huang, Q.5
-
29
-
-
84938198681
-
Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy
-
F. Tameire, I. I. Verginadis, C. Koumenis, Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy. Semin. Cancer Biol. 33, 3-15 (2015).
-
(2015)
Semin. Cancer Biol.
, vol.33
, pp. 3-15
-
-
Tameire, F.1
Verginadis, I.I.2
Koumenis, C.3
-
30
-
-
84946222789
-
Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer
-
Z. Niu, M. Wang, L. Zhou, L. Yao, Q. Liao, Y. Zhao, Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer. Sci. Rep. 5, 16067 (2015).
-
(2015)
Sci. Rep.
, vol.5
, pp. 16067
-
-
Niu, Z.1
Wang, M.2
Zhou, L.3
Yao, L.4
Liao, Q.5
Zhao, Y.6
-
31
-
-
80054969637
-
The expression of the endoplasmic reticulum stress sensor BiP/GRP78 predicts response to chemotherapy and determines the efficacy of proteasome inhibitors in diffuse large b-cell lymphoma
-
A. Mozos, G. Roué, A. Lopez-Guillermo, P. Jares, E. Campo, D. Colomer, A. Martinez, The expression of the endoplasmic reticulum stress sensor BiP/GRP78 predicts response to chemotherapy and determines the efficacy of proteasome inhibitors in diffuse large b-cell lymphoma. Am. J. Pathol. 179, 2601-2610 (2011).
-
(2011)
Am. J. Pathol.
, vol.179
, pp. 2601-2610
-
-
Mozos, A.1
Roué, G.2
Lopez-Guillermo, A.3
Jares, P.4
Campo, E.5
Colomer, D.6
Martinez, A.7
-
32
-
-
84873729773
-
The endoplasmic reticulum stress marker, glucoseregulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival
-
K. Matsuo, M. J. Gray, D. Y. Yang, S. A. Srivastava, P. B. Tripathi, L. A. Sonoda, E.-J. Yoo, L. Dubeau, A. S. Lee, Y. G. Lin, The endoplasmic reticulum stress marker, glucoseregulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival. Gynecol. Oncol. 128, 552-559 (2013).
-
(2013)
Gynecol. Oncol.
, vol.128
, pp. 552-559
-
-
Matsuo, K.1
Gray, M.J.2
Yang, D.Y.3
Srivastava, S.A.4
Tripathi, P.B.5
Sonoda, L.A.6
Yoo, E.-J.7
Dubeau, L.8
Lee, A.S.9
Lin, Y.G.10
-
33
-
-
84938211446
-
ER proteostasis addiction in cancer biology: Novel concepts
-
E. Dufey, H. Urra, C. Hetz, ER proteostasis addiction in cancer biology: Novel concepts. Semin. Cancer Biol. 33, 40-47 (2015).
-
(2015)
Semin. Cancer Biol.
, vol.33
, pp. 40-47
-
-
Dufey, E.1
Urra, H.2
Hetz, C.3
-
34
-
-
84968918504
-
Endoplasmic reticulum stress and the hallmarks of cancer
-
H. Urra, E. Dufey, T. Avril, E. Chevet, C. Hetz, Endoplasmic reticulum stress and the hallmarks of cancer. Trends Cancer 2, 252-262 (2016).
-
(2016)
Trends Cancer
, vol.2
, pp. 252-262
-
-
Urra, H.1
Dufey, E.2
Avril, T.3
Chevet, E.4
Hetz, C.5
-
35
-
-
84876998128
-
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response
-
J. Heijmans, J. F. van Lidth de Jeude, B.-K. Koo, S. L. Rosekrans, M. C. Wielenga, M. van de Wetering, M. Ferrante, A. S. Lee, J. J. M. Onderwater, J. C. Paton, A. W. Paton, A. M. Mommaas, L. L. Kodach, J. C. Hardwick, D. W. Hommes, H. Clevers, V. Muncan, G. R. van den Brink, ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell Rep. 3, 1128-1139 (2013).
-
(2013)
Cell Rep.
, vol.3
, pp. 1128-1139
-
-
Heijmans, J.1
Van Lidth-De-Jeude, J.F.2
Koo, B.-K.3
Rosekrans, S.L.4
Wielenga, M.C.5
Van De-Wetering, M.6
Ferrante, M.7
Lee, A.S.8
Onderwater, J.J.M.9
Paton, J.C.10
Paton, A.W.11
Mommaas, A.M.12
Kodach, L.L.13
Hardwick, J.C.14
Hommes, D.W.15
Clevers, H.16
Muncan, V.17
Van Den-Brink, G.R.18
-
36
-
-
84938203694
-
Novel roles of the unfolded protein response in the control of tumor development and aggressiveness
-
N. Dejeans, K. Barroso, M. E. Fernandez-Zapico, A. Samali, E. Chevet, Novel roles of the unfolded protein response in the control of tumor development and aggressiveness. Semin. Cancer Biol. 33, 67-73 (2015).
-
(2015)
Semin. Cancer Biol.
, vol.33
, pp. 67-73
-
-
Dejeans, N.1
Barroso, K.2
Fernandez-Zapico, M.E.3
Samali, A.4
Chevet, E.5
-
37
-
-
77954535031
-
PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage
-
E. Bobrovnikova-Marjon, C. Grigoriadou, D. Pytel, F. Zhang, J. Ye, C. Koumenis, D. Cavener, J. A. Diehl, PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage. Oncogene 29, 3881-3895 (2010).
-
(2010)
Oncogene
, vol.29
, pp. 3881-3895
-
-
Bobrovnikova-Marjon, E.1
Grigoriadou, C.2
Pytel, D.3
Zhang, F.4
Ye, J.5
Koumenis, C.6
Cavener, D.7
Diehl, J.A.8
-
38
-
-
80052342419
-
PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment
-
A. Avivar-Valderas, E. Salas, E. Bobrovnikova-Marjon, J. A. Diehl, C. Nagi, J. Debnath, J. A. Aguirre-Ghiso, PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment. Mol. Cell. Biol. 31, 3616-3629 (2011).
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 3616-3629
-
-
Avivar-Valderas, A.1
Salas, E.2
Bobrovnikova-Marjon, E.3
Diehl, J.A.4
Nagi, C.5
Debnath, J.6
Aguirre-Ghiso, J.A.7
-
39
-
-
32944478891
-
Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells
-
A. C. Ranganathan, L. Zhang, A. P. Adam, J. A. Aguirre-Ghiso, Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells. Cancer Res. 66, 1702-1711 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 1702-1711
-
-
Ranganathan, A.C.1
Zhang, L.2
Adam, A.P.3
Aguirre-Ghiso, J.A.4
-
40
-
-
84904053401
-
Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress
-
Y.-x. Feng, E. S. Sokol, C. A. Del Vecchio, S. Sanduja, J. H. L. Claessen, T. A. Proia, D. X. Jin, F. Reinhardt, H. L. Ploegh, Q. Wang, P. B. Gupta, Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress. Cancer Discov. 4, 702-715 (2014).
-
(2014)
Cancer Discov.
, vol.4
, pp. 702-715
-
-
Feng, Y.-X.1
Sokol, E.S.2
Del Vecchio, C.A.3
Sanduja, S.4
Claessen, J.H.L.5
Proia, T.A.6
Jin, D.X.7
Reinhardt, F.8
Ploegh, H.L.9
Wang, Q.10
Gupta, P.B.11
-
41
-
-
84888096859
-
Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3
-
H. Mujcic, A. Nagelkerke, K. M. Rouschop, S. Chung, N. Chaudary, P. N. Span, B. Clarke, M. Milosevic, J. Sykes, R. P. Hill, M. Koritzinsky, B. G. Wouters, Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3. Clin. Cancer Res. 19, 6126-6137 (2013).
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 6126-6137
-
-
Mujcic, H.1
Nagelkerke, A.2
Rouschop, K.M.3
Chung, S.4
Chaudary, N.5
Span, P.N.6
Clarke, B.7
Milosevic, M.8
Sykes, J.9
Hill, R.P.10
Koritzinsky, M.11
Wouters, B.G.12
-
42
-
-
84905241767
-
Activating transcription factor 4 promotes esophageal squamous cell carcinoma invasion and metastasis in mice and is associated with poor prognosis in human patients
-
H. Zhu, X. Chen, B. Chen, B. Chen, W. Song, D. Sun, Y. Zhao, Activating transcription factor 4 promotes esophageal squamous cell carcinoma invasion and metastasis in mice and is associated with poor prognosis in human patients. PLOS ONE 9, e103882 (2014).
-
(2014)
PLOS ONE
, vol.9
, pp. e103882
-
-
Zhu, H.1
Chen, X.2
Chen, B.3
Chen, B.4
Song, W.5
Sun, D.6
Zhao, Y.7
-
43
-
-
84867562151
-
The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway
-
Y. Wang, G. N. Alam, Y. Ning, F. Visioli, Z. Dong, J. E. Nor, P. J. Polverini, The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway. Cancer Res. 72, 5396-5406 (2012).
-
(2012)
Cancer Res.
, vol.72
, pp. 5396-5406
-
-
Wang, Y.1
Alam, G.N.2
Ning, Y.3
Visioli, F.4
Dong, Z.5
Nor, J.E.6
Polverini, P.J.7
-
44
-
-
84875235453
-
Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity
-
C. Atkins, Q. Liu, E. Minthorn, S.-Y. Zhang, D. J. Figueroa, K. Moss, T. B. Stanley, B. Sanders, A. Goetz, N. Gaul, A. E. Choudhry, H. Alsaid, B. M. Jucker, J. M. Axten, R. Kumar, Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res. 73, 1993-2002 (2013).
-
(2013)
Cancer Res.
, vol.73
, pp. 1993-2002
-
-
Atkins, C.1
Liu, Q.2
Minthorn, E.3
Zhang, S.-Y.4
Figueroa, D.J.5
Moss, K.6
Stanley, T.B.7
Sanders, B.8
Goetz, A.9
Gaul, N.10
Choudhry, A.E.11
Alsaid, H.12
Jucker, B.M.13
Axten, J.M.14
Kumar, R.15
-
45
-
-
0043133837
-
Phosphorylation of the α subunit of eukaryotic initiation factor 2 is required for activation of NF-κB in response to diverse cellular stresses
-
H.-Y. Jiang, S. A. Wek, B. C. McGrath, D. Scheuner, R. J. Kaufman, D. R. Cavener, R. C. Wek, Phosphorylation of the α subunit of eukaryotic initiation factor 2 is required for activation of NF-κB in response to diverse cellular stresses. Mol. Cell. Biol. 23, 5651-5663 (2003).
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 5651-5663
-
-
Jiang, H.-Y.1
Wek, S.A.2
McGrath, B.C.3
Scheuner, D.4
Kaufman, R.J.5
Cavener, D.R.6
Wek, R.C.7
-
46
-
-
33947101019
-
Patterns of somatic mutation in human cancer genomes
-
C. Greenman, P. Stephens, R. Smith, G. L. Dalgliesh, C. Hunter, G. Bignell, H. Davies, J. Teague, A. Butler, C. Stevens, S. Edkins, S. O'Meara, I. Vastrik, E. E. Schmidt, T. Avis, S. Barthorpe, G. Bhamra, G. Buck, B. Choudhury, J. Clements, J. Cole, E. Dicks, S. Forbes, K. Gray, K. Halliday, R. Harrison, K. Hills, J. Hinton, A. Jenkinson, D. Jones, A. Menzies, T. Mironenko, J. Perry, K. Raine, D. Richardson, R. Shepherd, A. Small, C. Tofts, J. Varian, T. Webb, S. West, S. Widaa, A. Yates, D. P. Cahill, D. N. Louis, P. Goldstraw, A. G. Nicholson, F. Brasseur, L. Looijenga, B. L. Weber, Y. E. Chiew, A. DeFazio, M. F. Greaves, A. R. Green, P. Campbell, E. Birney, D. F. Easton, G. Chenevix-Trench, M. H. Tan, S. K. Khoo, B. T. Teh, S. T. Yuen, S. Y. Leung, R. Wooster, P. A. Futreal, M. R. Stratton, Patterns of somatic mutation in human cancer genomes. Nature 446, 153-158 (2007).
-
(2007)
Nature
, vol.446
, pp. 153-158
-
-
Greenman, C.1
Stephens, P.2
Smith, R.3
Dalgliesh, G.L.4
Hunter, C.5
Bignell, G.6
Davies, H.7
Teague, J.8
Butler, A.9
Stevens, C.10
Edkins, S.11
O'Meara, S.12
Vastrik, I.13
Schmidt, E.E.14
Avis, T.15
Barthorpe, S.16
Bhamra, G.17
Buck, G.18
Choudhury, B.19
Clements, J.20
Cole, J.21
Dicks, E.22
Forbes, S.23
Gray, K.24
Halliday, K.25
Harrison, R.26
Hills, K.27
Hinton, J.28
Jenkinson, A.29
Jones, D.30
Menzies, A.31
Mironenko, T.32
Perry, J.33
Raine, K.34
Richardson, D.35
Shepherd, R.36
Small, A.37
Tofts, C.38
Varian, J.39
Webb, T.40
West, S.41
Widaa, S.42
Yates, A.43
Cahill, D.P.44
Louis, D.N.45
Goldstraw, P.46
Nicholson, A.G.47
Brasseur, F.48
Looijenga, L.49
Weber, B.L.50
Chiew, Y.E.51
DeFazio, A.52
Greaves, M.F.53
Green, A.R.54
Campbell, P.55
Birney, E.56
Easton, D.F.57
Chenevix-Trench, G.58
Tan, M.H.59
Khoo, S.K.60
Teh, B.T.61
Yuen, S.T.62
Leung, S.Y.63
Wooster, R.64
Futreal, P.A.65
Stratton, M.R.66
more..
-
47
-
-
80052227409
-
A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1α
-
Z. Xue, Y. He, K. Ye, Z. Gu, Y. Mao, L. Qi, A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1α. J. Biol. Chem. 286, 30859-30866 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 30859-30866
-
-
Xue, Z.1
He, Y.2
Ye, K.3
Gu, Z.4
Mao, Y.5
Qi, L.6
-
48
-
-
84975520156
-
Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia
-
H. Sun, D.-C. Lin, X. Guo, B. K. Masouleh, S. Gery, Q. Cao, S. Alkan, T. Ikezoe, C. Akiba, R. Paquette, W. Chien, C. Muller-Tidow, Y. Jing, K. Agelopoulos, M. Müschen, H. P. Koeffler, Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia. Oncotarget 7, 18736-18749 (2016).
-
(2016)
Oncotarget
, vol.7
, pp. 18736-18749
-
-
Sun, H.1
Lin, D.-C.2
Guo, X.3
Masouleh, B.K.4
Gery, S.5
Cao, Q.6
Alkan, S.7
Ikezoe, T.8
Akiba, C.9
Paquette, R.10
Chien, W.11
Muller-Tidow, C.12
Jing, Y.13
Agelopoulos, K.14
Müschen, M.15
Koeffler, H.P.16
-
49
-
-
4344660747
-
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth
-
L. Romero-Ramirez, H. Cao, D. Nelson, E. Hammond, A. H. Lee, H. Yoshida, K. Mori, L. H. Glimcher, N. C. Denko, A. J. Giaccia, Q.-T. Le, A. C. Koong, XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res. 64, 5943-5947 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 5943-5947
-
-
Romero-Ramirez, L.1
Cao, H.2
Nelson, D.3
Hammond, E.4
Lee, A.H.5
Yoshida, H.6
Mori, K.7
Glimcher, L.H.8
Denko, N.C.9
Giaccia, A.J.10
Le, Q.-T.11
Koong, A.C.12
-
50
-
-
84897541350
-
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
-
X. Chen, D. Iliopoulos, Q. Zhang, Q. Tang, M. B. Greenblatt, M. Hatziapostolou, E. Lim, W. L. Tam, M. Ni, Y. Chen, J. Mai, H. Shen, D. Z. Hu, S. Adoro, B. Hu, M. Song, C. Tan, M. D. Landis, M. Ferrari, S. J. Shin, M. Brown, J. C. Chang, X. S. Liu, L. H. Glimcher, XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. Nature 508, 103-107 (2014).
-
(2014)
Nature
, vol.508
, pp. 103-107
-
-
Chen, X.1
Iliopoulos, D.2
Zhang, Q.3
Tang, Q.4
Greenblatt, M.B.5
Hatziapostolou, M.6
Lim, E.7
Tam, W.L.8
Ni, M.9
Chen, Y.10
Mai, J.11
Shen, H.12
Hu, D.Z.13
Adoro, S.14
Hu, B.15
Song, M.16
Tan, C.17
Landis, M.D.18
Ferrari, M.19
Shin, S.J.20
Brown, M.21
Chang, J.C.22
Liu, X.S.23
Glimcher, L.H.24
more..
-
51
-
-
51049121572
-
Identification of genes that regulate epithelial cell migration using an siRNA screening approach
-
K. J. Simpson, L. M. Selfors, J. Bui, A. Reynolds, D. Leake, A. Khvorova, J. S. Brugge, Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Nat. Cell Biol. 10, 1027-1038 (2008).
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 1027-1038
-
-
Simpson, K.J.1
Selfors, L.M.2
Bui, J.3
Reynolds, A.4
Leake, D.5
Khvorova, A.6
Brugge, J.S.7
-
52
-
-
77957288028
-
Inositol-requiring enzyme 1α is a key regulator of angiogenesis and invasion in malignant glioma
-
G. Auf, A. Jabouille, S. Guerit, R. Pineau, M. Delugin, M. Bouchecareilh, N. Magnin, A. Favereaux, M. Maitre, T. Gaiser, A. von Deimling, M. Czabanka, P. Vajkoczy, E. Chevet, A. Bikfalvi, M. Moenner, Inositol-requiring enzyme 1α is a key regulator of angiogenesis and invasion in malignant glioma. Proc. Natl. Acad. Sci. U.S.A. 107, 15553-15558 (2010).
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 15553-15558
-
-
Auf, G.1
Jabouille, A.2
Guerit, S.3
Pineau, R.4
Delugin, M.5
Bouchecareilh, M.6
Magnin, N.7
Favereaux, A.8
Maitre, M.9
Gaiser, T.10
Von Deimling, A.11
Czabanka, M.12
Vajkoczy, P.13
Chevet, E.14
Bikfalvi, A.15
Moenner, M.16
-
53
-
-
33645815074
-
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expression
-
P. Hu, Z. Han, A. D. Couvillon, R. J. Kaufman, J. H. Exton, Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expression. Mol. Cell. Biol. 26, 3071-3084 (2006).
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 3071-3084
-
-
Hu, P.1
Han, Z.2
Couvillon, A.D.3
Kaufman, R.J.4
Exton, J.H.5
-
54
-
-
77958611209
-
Transcriptional and posttranscriptional regulation of proangiogenic factors by the unfolded protein response
-
E. R. Pereira, N. Liao, G. A. Neale, L. M. Hendershot, Transcriptional and posttranscriptional regulation of proangiogenic factors by the unfolded protein response. PLOS ONE 5, e12521 (2010).
-
(2010)
PLOS ONE
, vol.5
, pp. e12521
-
-
Pereira, E.R.1
Liao, N.2
Neale, G.A.3
Hendershot, L.M.4
-
55
-
-
34547114745
-
IRE1 signaling is essential for ischemiainduced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo
-
B. Drogat, P. Auguste, D. T. Nguyen, M. Bouchecareilh, R. Pineau, J. Nalbantoglu, R. J. Kaufman, E. Chevet, A. Bikfalvi, M. Moenner, IRE1 signaling is essential for ischemiainduced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo. Cancer Res. 67, 6700-6707 (2007).
-
(2007)
Cancer Res.
, vol.67
, pp. 6700-6707
-
-
Drogat, B.1
Auguste, P.2
Nguyen, D.T.3
Bouchecareilh, M.4
Pineau, R.5
Nalbantoglu, J.6
Kaufman, R.J.7
Chevet, E.8
Bikfalvi, A.9
Moenner, M.10
-
56
-
-
48749105093
-
ATF6α-rheb-mTOR signaling promotes survival of dormant tumor cells in vivo
-
D. M. Schewe, J. A. Aguirre-Ghiso, ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo. Proc. Natl. Acad. Sci. U.S.A. 105, 10519-10524 (2008).
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 10519-10524
-
-
Schewe, D.M.1
Aguirre-Ghiso, J.A.2
-
57
-
-
29344457845
-
Transformation-associated gene regulation by ATF6α during hepatocarcinogenesis
-
M. Arai, N. Kondoh, N. Imazeki, A. Hada, K. Hatsuse, F. Kimura, O. Matsubara, K. Mori, T. Wakatsuki, M. Yamamoto, Transformation-associated gene regulation by ATF6α during hepatocarcinogenesis. FEBS Lett. 580, 184-190 (2006).
-
(2006)
FEBS Lett.
, vol.580
, pp. 184-190
-
-
Arai, M.1
Kondoh, N.2
Imazeki, N.3
Hada, A.4
Hatsuse, K.5
Kimura, F.6
Matsubara, O.7
Mori, K.8
Wakatsuki, T.9
Yamamoto, M.10
-
58
-
-
84899139079
-
Endoplasmic reticulum stress-activated transcription factor ATF6α requires the disulfide isomerase PDIA5 to modulate chemoresistance
-
A. Higa, S. Taouji, S. Lhomond, D. Jensen, M. E. Fernandez-Zapico, J. C. Simpson, J.-M. Pasquet, R. Schekman, E. Chevet, Endoplasmic reticulum stress-activated transcription factor ATF6α requires the disulfide isomerase PDIA5 to modulate chemoresistance. Mol. Cell. Biol. 34, 1839-1849 (2014).
-
(2014)
Mol. Cell. Biol.
, vol.34
, pp. 1839-1849
-
-
Higa, A.1
Taouji, S.2
Lhomond, S.3
Jensen, D.4
Fernandez-Zapico, M.E.5
Simpson, J.C.6
Pasquet, J.-M.7
Schekman, R.8
Chevet, E.9
-
59
-
-
84901005666
-
VEGF signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress
-
E. Karali, S. Bellou, D. Stellas, A. Klinakis, C. Murphy, T. Fotsis, VEGF signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress. Mol. Cell 54, 559-572 (2014).
-
(2014)
Mol. Cell
, vol.54
, pp. 559-572
-
-
Karali, E.1
Bellou, S.2
Stellas, D.3
Klinakis, A.4
Murphy, C.5
Fotsis, T.6
-
60
-
-
85007146049
-
ATF6α regulates morphological changes associated with senescence in human fibroblasts
-
C. Druelle, C. Drullion, J. Desle, N. Martin, L. Saas, J. Cormenier, N. Malaquin, L. Huot, C. Slomianny, F. Bouali, C. Vercamer, D. Hot, A. Pourtier, E. Chevet, C. Abbadie, O. Pluquet, ATF6α regulates morphological changes associated with senescence in human fibroblasts. Oncotarget 7, 67699-67715 (2016).
-
(2016)
Oncotarget
, vol.7
, pp. 67699-67715
-
-
Druelle, C.1
Drullion, C.2
Desle, J.3
Martin, N.4
Saas, L.5
Cormenier, J.6
Malaquin, N.7
Huot, L.8
Slomianny, C.9
Bouali, F.10
Vercamer, C.11
Hot, D.12
Pourtier, A.13
Chevet, E.14
Abbadie, C.15
Pluquet, O.16
-
61
-
-
0035144493
-
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating bcl2 and perturbing the cellular redox state
-
K. D. McCullough, J. L. Martindale, L.-O. Klotz, T.-Y. Aw, N. J. Holbrook, Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol. Cell. Biol. 21, 1249-1259 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 1249-1259
-
-
McCullough, K.D.1
Martindale, J.L.2
Klotz, L.-O.3
Aw, T.-Y.4
Holbrook, N.J.5
-
62
-
-
1842843855
-
Roles of CHOP/GADD153 in endoplasmic reticulum stress
-
S. Oyadomari, M. Mori, Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 11, 381-389 (2004).
-
(2004)
Cell Death Differ.
, vol.11
, pp. 381-389
-
-
Oyadomari, S.1
Mori, M.2
-
63
-
-
10644233167
-
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
-
S. J. Marciniak, C. Y. Yun, S. Oyadomari, I. Novoa, Y. Zhang, R. Jungreis, K. Nagata, H. P. Harding, D. Ron, CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 18, 3066-3077 (2004).
-
(2004)
Genes Dev.
, vol.18
, pp. 3066-3077
-
-
Marciniak, S.J.1
Yun, C.Y.2
Oyadomari, S.3
Novoa, I.4
Zhang, Y.5
Jungreis, R.6
Nagata, K.7
Harding, H.P.8
Ron, D.9
-
64
-
-
84905392984
-
Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib
-
M. Edagawa, J. Kawauchi, M. Hirata, H. Goshima, M. Inoue, T. Okamoto, A. Murakami, Y. Maehara, S. Kitajima, Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib. J. Biol. Chem. 289, 21544-21561 (2014).
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 21544-21561
-
-
Edagawa, M.1
Kawauchi, J.2
Hirata, M.3
Goshima, H.4
Inoue, M.5
Okamoto, T.6
Murakami, A.7
Maehara, Y.8
Kitajima, S.9
-
65
-
-
38849191201
-
Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib
-
A. Kardosh, E. B. Golden, P. Pyrko, J. Uddin, F. M. Hofman, T. C. Chen, S. G. Louie, N. A. Petasis, A. H. Schönthal, Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib. Cancer Res. 68, 843-851 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 843-851
-
-
Kardosh, A.1
Golden, E.B.2
Pyrko, P.3
Uddin, J.4
Hofman, F.M.5
Chen, T.C.6
Louie, S.G.7
Petasis, N.A.8
Schönthal, A.H.9
-
66
-
-
67650456858
-
A ruthenium-containing organometallic compound reduces tumor growth through induction of the endoplasmic reticulum stress gene CHOP
-
X. Meng, M. L. Leyva, M. Jenny, I. Gross, S. Benosman, B. Fricker, S. Harlepp, P. Hebraud, A. Boos, P. Wlosik, P. Bischoff, C. Sirlin, M. Pfeffer, J.-P. Loeffler, C. Gaiddon, A ruthenium-containing organometallic compound reduces tumor growth through induction of the endoplasmic reticulum stress gene CHOP. Cancer Res. 69, 5458-5466 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 5458-5466
-
-
Meng, X.1
Leyva, M.L.2
Jenny, M.3
Gross, I.4
Benosman, S.5
Fricker, B.6
Harlepp, S.7
Hebraud, P.8
Boos, A.9
Wlosik, P.10
Bischoff, P.11
Sirlin, C.12
Pfeffer, M.13
Loeffler, J.-P.14
Gaiddon, C.15
-
67
-
-
80051686709
-
Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
-
X. Tian, J. Ye, M. Alonso-Basanta, S. M. Hahn, C. Koumenis, J. F. Dorsey, Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J. Biol. Chem. 286, 29408-29416 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 29408-29416
-
-
Tian, X.1
Ye, J.2
Alonso-Basanta, M.3
Hahn, S.M.4
Koumenis, C.5
Dorsey, J.F.6
-
68
-
-
80555149291
-
ATF3 inhibits PDX-1-stimulated transactivation
-
W. H. Kim, M. K. Jang, C. H. Kim, H. K. Shin, M. H. Jung, ATF3 inhibits PDX-1-stimulated transactivation. Biochem. Biophys. Res. Commun. 414, 681-687 (2011).
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.414
, pp. 681-687
-
-
Kim, W.H.1
Jang, M.K.2
Kim, C.H.3
Shin, H.K.4
Jung, M.H.5
-
69
-
-
33646491144
-
C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation
-
M. Endo, M. Mori, S. Akira, T. Gotoh, C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation. J. Immunol. 176, 6245-6253 (2006).
-
(2006)
J. Immunol.
, vol.176
, pp. 6245-6253
-
-
Endo, M.1
Mori, M.2
Akira, S.3
Gotoh, T.4
-
70
-
-
84890002163
-
High epiregulin expression in human U87 glioma cells relies on IRE1α and promotes autocrine growth through EGF receptor
-
G. Auf, A. Jabouille, M. Delugin, S. Guerit, R. Pineau, S. North, N. Platonova, M. Maitre, A. Favereaux, P. Vajkoczy, M. Seno, A. Bikfalvi, D. Minchenko, O. Minchenko, M. Moenner, High epiregulin expression in human U87 glioma cells relies on IRE1α and promotes autocrine growth through EGF receptor. BMC Cancer 13, 597 (2013).
-
(2013)
BMC Cancer
, vol.13
, pp. 597
-
-
Auf, G.1
Jabouille, A.2
Delugin, M.3
Guerit, S.4
Pineau, R.5
North, S.6
Platonova, N.7
Maitre, M.8
Favereaux, A.9
Vajkoczy, P.10
Seno, M.11
Bikfalvi, A.12
Minchenko, D.13
Minchenko, O.14
Moenner, M.15
-
71
-
-
84944474756
-
Glioblastoma invasion and cooption depend on IRE1α endoribonuclease activity
-
A. Jabouille, M. Delugin, R. Pineau, A. Dubrac, F. Soulet, S. Lhomond, N. Pallares-Lupon, H. Prats, A. Bikfalvi, E. Chevet, C. Touriol, M. Moenner, Glioblastoma invasion and cooption depend on IRE1α endoribonuclease activity. Oncotarget 6, 24922-24934 (2015).
-
(2015)
Oncotarget
, vol.6
, pp. 24922-24934
-
-
Jabouille, A.1
Delugin, M.2
Pineau, R.3
Dubrac, A.4
Soulet, F.5
Lhomond, S.6
Pallares-Lupon, N.7
Prats, H.8
Bikfalvi, A.9
Chevet, E.10
Touriol, C.11
Moenner, M.12
-
72
-
-
84872173393
-
Autocrine control of glioma cells adhesion and migration through IRE1α-mediated cleavage of SPARC mRNA
-
N. Dejeans, O. Pluquet, S. Lhomond, F. Grise, M. Bouchecareilh, A. Juin, M. Meynard-Cadars, A. Bidaud-Meynard, C. Gentil, V. Moreau, F. Saltel, E. Chevet, Autocrine control of glioma cells adhesion and migration through IRE1α-mediated cleavage of SPARC mRNA. J. Cell Sci. 125, 4278-4287 (2012).
-
(2012)
J. Cell Sci.
, vol.125
, pp. 4278-4287
-
-
Dejeans, N.1
Pluquet, O.2
Lhomond, S.3
Grise, F.4
Bouchecareilh, M.5
Juin, A.6
Meynard-Cadars, M.7
Bidaud-Meynard, A.8
Gentil, C.9
Moreau, V.10
Saltel, F.11
Chevet, E.12
-
73
-
-
0141752795
-
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
-
S. B. Cullinan, D. Zhang, M. Hannink, E. Arvisais, R. J. Kaufman, J. A. Diehl, Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol. Cell. Biol. 23, 7198-7209 (2003).
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 7198-7209
-
-
Cullinan, S.B.1
Zhang, D.2
Hannink, M.3
Arvisais, E.4
Kaufman, R.J.5
Diehl, J.A.6
-
74
-
-
76249095217
-
PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells
-
A. Yacoub, H. A. Hamed, J. Allegood, C. Mitchell, S. Spiegel, M. S. Lesniak, B. Ogretmen, R. Dash, D. Sarkar, W. C. Broaddus, S. Grant, D. T. Curiel, P. B. Fisher, P. Dent, PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells. Cancer Res. 70, 1120-1129 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 1120-1129
-
-
Yacoub, A.1
Hamed, H.A.2
Allegood, J.3
Mitchell, C.4
Spiegel, S.5
Lesniak, M.S.6
Ogretmen, B.7
Dash, R.8
Sarkar, D.9
Broaddus, W.C.10
Grant, S.11
Curiel, D.T.12
Fisher, P.B.13
Dent, P.14
-
75
-
-
84864865373
-
The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress
-
T. Rzymski, A. Petry, D. Kračun, F. Rieß, L. Pike, A. L. Harris, A. Görlach, The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress. Oncogene 31, 3621-3634 (2012).
-
(2012)
Oncogene
, vol.31
, pp. 3621-3634
-
-
Rzymski, T.1
Petry, A.2
Kračun, D.3
Rieß, F.4
Pike, L.5
Harris, A.L.6
Görlach, A.7
-
76
-
-
84929090723
-
Pancreatic endoplasmic reticulum kinase activation promotes medulloblastoma cell migration and invasion through induction of vascular endothelial growth factor A
-
S. Jamison, Y. Lin, W. Lin, Pancreatic endoplasmic reticulum kinase activation promotes medulloblastoma cell migration and invasion through induction of vascular endothelial growth factor A. PLOS ONE 10, e0120252 (2015).
-
(2015)
PLOS ONE
, vol.10
, pp. e0120252
-
-
Jamison, S.1
Lin, Y.2
Lin, W.3
-
77
-
-
84957649544
-
The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma
-
D. Y. A. Dadey, V. Kapoor, A. Khudanyan, F. Urano, A. H. Kim, D. Thotala, D. E. Hallahan, The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma. Oncotarget 7, 2080-2092 (2016).
-
(2016)
Oncotarget
, vol.7
, pp. 2080-2092
-
-
Dadey, D.Y.A.1
Kapoor, V.2
Khudanyan, A.3
Urano, F.4
Kim, A.H.5
Thotala, D.6
Hallahan, D.E.7
-
78
-
-
84952872645
-
Genome-wide CRISPR-cas9 screens reveal loss of redundancy between PKMYT1 and WEE1 in glioblastoma stem-like cells
-
C. M. Toledo, Y. Ding, P. Hoellerbauer, R. J. Davis, R. Basom, E. J. Girard, E. Lee, P. Corrin, T. Hart, H. Bolouri, J. Davison, Q. Zhang, J. Hardcastle, B. J. Aronow, C. L. Plaisier, N. S. Baliga, J. Moffat, Q. Lin, X. N. Li, D.-H. Nam, J. Lee, S. M. Pollard, J. Zhu, J. J. Delrow, B. E. Clurman, J. M. Olson, P. J. Paddison, Genome-wide CRISPR-Cas9 screens reveal loss of redundancy between PKMYT1 and WEE1 in Glioblastoma stem-like cells. Cell Rep. 13, 2425-2439 (2015).
-
(2015)
Cell Rep.
, vol.13
, pp. 2425-2439
-
-
Toledo, C.M.1
Ding, Y.2
Hoellerbauer, P.3
Davis, R.J.4
Basom, R.5
Girard, E.J.6
Lee, E.7
Corrin, P.8
Hart, T.9
Bolouri, H.10
Davison, J.11
Zhang, Q.12
Hardcastle, J.13
Aronow, B.J.14
Plaisier, C.L.15
Baliga, N.S.16
Moffat, J.17
Lin, Q.18
Li, X.N.19
Nam, D.-H.20
Lee, J.21
Pollard, S.M.22
Zhu, J.23
Delrow, J.J.24
Clurman, B.E.25
Olson, J.M.26
Paddison, P.J.27
more..
-
79
-
-
84867754321
-
ATF4-dependent regulation of the JMJD3 gene during amino acid deprivation can be rescued in ATF4-deficient cells by inhibition of deacetylation
-
J. Shan, L. Fu, M. N. Balasubramanian, T. Anthony, M. S. Kilberg, ATF4-dependent regulation of the JMJD3 gene during amino acid deprivation can be rescued in ATF4-deficient cells by inhibition of deacetylation. J. Biol. Chem. 287, 36393-36403 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 36393-36403
-
-
Shan, J.1
Fu, L.2
Balasubramanian, M.N.3
Anthony, T.4
Kilberg, M.S.5
-
80
-
-
84942550534
-
Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells
-
X. Liu, S. Guo, X. Liu, L. Su, Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells. Apoptosis 20, 1499-1507 (2015).
-
(2015)
Apoptosis
, vol.20
, pp. 1499-1507
-
-
Liu, X.1
Guo, S.2
Liu, X.3
Su, L.4
-
81
-
-
84907575515
-
Activating transcription factor 3-mediated chemo-intervention with cancer chemokines in a noncanonical pathway under endoplasmic reticulum stress
-
S.-H. Park, J. Kim, K. H. Do, J. Park, C. G. Oh, H. J. Choi, B. G. Song, S. J. Lee, Y. S. Kim, Y. Moon, Activating transcription factor 3-mediated chemo-intervention with cancer chemokines in a noncanonical pathway under endoplasmic reticulum stress. J. Biol. Chem. 289, 27118-27133 (2014).
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 27118-27133
-
-
Park, S.-H.1
Kim, J.2
Do, K.H.3
Park, J.4
Oh, C.G.5
Choi, H.J.6
Song, B.G.7
Lee, S.J.8
Kim, Y.S.9
Moon, Y.10
-
82
-
-
84891135307
-
HDAC4 protects cells from ER stress induced apoptosis through interaction with ATF4
-
P. Zhang, Q. Sun, C. Zhao, S. Ling, Q. Li, Y.-Z. Chang, Y. Li, HDAC4 protects cells from ER stress induced apoptosis through interaction with ATF4. Cell. Signal. 26, 556-563 (2014).
-
(2014)
Cell. Signal
, vol.26
, pp. 556-563
-
-
Zhang, P.1
Sun, Q.2
Zhao, C.3
Ling, S.4
Li, Q.5
Chang, Y.-Z.6
Li, Y.7
-
83
-
-
66849109082
-
Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor-induced apoptosis
-
P. Baumeister, D. Dong, Y. Fu, A. S. Lee, Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor-induced apoptosis. Mol. Cancer Ther. 8, 1086-1094 (2009).
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 1086-1094
-
-
Baumeister, P.1
Dong, D.2
Fu, Y.3
Lee, A.S.4
-
84
-
-
79551474362
-
Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation
-
F.-M. Wang, Y.-J. Chen, H.-J. Ouyang, Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation. Biochem. J. 433, 245-252 (2011).
-
(2011)
Biochem. J.
, vol.433
, pp. 245-252
-
-
Wang, F.-M.1
Chen, Y.-J.2
Ouyang, H.-J.3
-
85
-
-
62849096067
-
The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes
-
Z. Nagy, A. Riss, C. Romier, X. le Guezennec, A. R. Dongre, M. Orpinell, J. Han, H. Stunnenberg, L. Tora, The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes. Mol. Cell. Biol. 29, 1649-1660 (2009).
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 1649-1660
-
-
Nagy, Z.1
Riss, A.2
Romier, C.3
Le Guezennec, X.4
Dongre, A.R.5
Orpinell, M.6
Han, J.7
Stunnenberg, H.8
Tora, L.9
-
86
-
-
84863329769
-
Endoplasmic reticulum stress-responsive transcription factor ATF6α directs recruitment of the mediator of RNA polymerase II transcription and multiple histone acetyltransferase complexes
-
D. Sela, L. Chen, S. Martin-Brown, M. P. Washburn, L. Florens, J. W. Conaway, R. C. Conaway, Endoplasmic reticulum stress-responsive transcription factor ATF6α directs recruitment of the Mediator of RNA polymerase II transcription and multiple histone acetyltransferase complexes. J. Biol. Chem. 287, 23035-23045 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 23035-23045
-
-
Sela, D.1
Chen, L.2
Martin-Brown, S.3
Washburn, M.P.4
Florens, L.5
Conaway, J.W.6
Conaway, R.C.7
-
87
-
-
84883658620
-
Role for human mediator subunit MED25 in recruitment of mediator to promoters by endoplasmic reticulum stress-responsive transcription factor ATF6α
-
D. Sela, J. J. Conkright, L. Chen, J. Gilmore, M. P. Washburn, L. Florens, R. C. Conaway, J. W. Conaway, Role for human mediator subunit MED25 in recruitment of mediator to promoters by endoplasmic reticulum stress-responsive transcription factor ATF6α. J. Biol. Chem. 288, 26179-26187 (2013).
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 26179-26187
-
-
Sela, D.1
Conkright, J.J.2
Chen, L.3
Gilmore, J.4
Washburn, M.P.5
Florens, L.6
Conaway, R.C.7
Conaway, J.W.8
-
88
-
-
84880730339
-
A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation
-
A. W. Schram, R. Baas, P. W. T. C. Jansen, A. Riss, L. Tora, M. Vermeulen, H. T. M. Timmers, A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation. PLOS ONE 8, e70035 (2013).
-
(2013)
PLOS ONE
, vol.8
, pp. e70035
-
-
Schram, A.W.1
Baas, R.2
Jansen, P.W.T.C.3
Riss, A.4
Tora, L.5
Vermeulen, M.6
Timmers, H.T.M.7
-
89
-
-
79551500034
-
PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription
-
Q. J. Lew, K. L. Chu, J. Lee, P. L. Koh, V. Rajasegaran, J. Y. Teo, S.-H. Chao, PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription. Nucleic Acids Res. 39, 429-439 (2011).
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 429-439
-
-
Lew, Q.J.1
Chu, K.L.2
Lee, J.3
Koh, P.L.4
Rajasegaran, V.5
Teo, J.Y.6
Chao, S.-H.7
-
90
-
-
84921405901
-
GCN5 inhibits XBP-1S-mediated transcription by antagonizing PCAF action
-
Q. J. Lew, K. L. Chu, Y. L. Chia, B. Soo, J. P. Ho, C. H. Ng, H. S. Kwok, C.-M. Chiang, Y. Chang, S.-H. Chao, GCN5 inhibits XBP-1S-mediated transcription by antagonizing PCAF action. Oncotarget 6, 271-287 (2015).
-
(2015)
Oncotarget
, vol.6
, pp. 271-287
-
-
Lew, Q.J.1
Chu, K.L.2
Chia, Y.L.3
Soo, B.4
Ho, J.P.5
Ng, C.H.6
Kwok, H.S.7
Chiang, C.-M.8
Chang, Y.9
Chao, S.-H.10
-
91
-
-
29244491657
-
P300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain
-
I. Lassot, E. Estrabaud, S. Emiliani, M. Benkirane, R. Benarous, F. Margottin-Goguet, p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain. J. Biol. Chem. 280, 41537-41545 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 41537-41545
-
-
Lassot, I.1
Estrabaud, E.2
Emiliani, S.3
Benkirane, M.4
Benarous, R.5
Margottin-Goguet, F.6
-
92
-
-
34347230960
-
Reticulon-1C acts as a molecular switch between endoplasmic reticulum stress and genotoxic cell death pathway in human neuroblastoma cells
-
F. Di Sano, B. Fazi, R. Tufi, R. Nardacci, M. Piacentini, Reticulon-1C acts as a molecular switch between endoplasmic reticulum stress and genotoxic cell death pathway in human neuroblastoma cells. J. Neurochem. 102, 345-353 (2007).
-
(2007)
J. Neurochem.
, vol.102
, pp. 345-353
-
-
Di Sano, F.1
Fazi, B.2
Tufi, R.3
Nardacci, R.4
Piacentini, M.5
-
93
-
-
70350692123
-
Acetylation of RTN-1C regulates the induction of ER stress by the inhibition of HDAC activity in neuroectodermal tumors
-
B. Fazi, S. Melino, S. De Rubeis, C. Bagni, M. Paci, M. Piacentini, F. Di Sano, Acetylation of RTN-1C regulates the induction of ER stress by the inhibition of HDAC activity in neuroectodermal tumors. Oncogene 28, 3814-3824 (2009).
-
(2009)
Oncogene
, vol.28
, pp. 3814-3824
-
-
Fazi, B.1
Melino, S.2
De Rubeis, S.3
Bagni, C.4
Paci, M.5
Piacentini, M.6
Di Sano, F.7
-
94
-
-
84877836210
-
In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis
-
G. Gargiulo, M. Cesaroni, M. Serresi, N. de Vries, D. Hulsman, S. W. Bruggeman, C. Lancini, M. van Lohuizen, In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis. Cancer Cell 23, 660-676 (2013).
-
(2013)
Cancer Cell
, vol.23
, pp. 660-676
-
-
Gargiulo, G.1
Cesaroni, M.2
Serresi, M.3
De Vries, N.4
Hulsman, D.5
Bruggeman, S.W.6
Lancini, C.7
Van Lohuizen, M.8
-
95
-
-
84879155370
-
Endoplasmic reticulum stress signaling: The microRNA connection
-
M. Maurel, E. Chevet, Endoplasmic reticulum stress signaling: The microRNA connection. Am. J. Physiol. Cell Physiol. 304, C1117-C1126 (2013).
-
(2013)
Am. J. Physiol. Cell Physiol.
, vol.304
, pp. C1117-C1126
-
-
Maurel, M.1
Chevet, E.2
-
96
-
-
84868525253
-
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic caspase-2
-
J.-P. Upton, L. Wang, D. Han, E. S. Wang, N. E. Huskey, L. Lim, M. Truitt, M. T. McManus, D. Ruggero, A. Goga, F. R. Papa, S. A. Oakes, IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science 338, 818-822 (2012).
-
(2012)
Science
, vol.338
, pp. 818-822
-
-
Upton, J.-P.1
Wang, L.2
Han, D.3
Wang, E.S.4
Huskey, N.E.5
Lim, L.6
Truitt, M.7
McManus, M.T.8
Ruggero, D.9
Goga, A.10
Papa, F.R.11
Oakes, S.A.12
-
97
-
-
84975796689
-
Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis
-
E. Chevet, C. Hetz, A. Samali, Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis. Cancer Discov. 5, 586-597 (2015).
-
(2015)
Cancer Discov.
, vol.5
, pp. 586-597
-
-
Chevet, E.1
Hetz, C.2
Samali, A.3
-
98
-
-
84940094034
-
Reduced PTEN expression and overexpression of miR-17-5p, -19a-3p, -19b-3p, -21-5p, -130b-3p, -221-3p and -222-3p by glioblastoma stem-like cells following irradiation
-
T. Tokudome, A. Sasaki, M. Tsuji, Y. Udaka, H. Oyamada, H. Tsuchiya, K. Oguchi, Reduced PTEN expression and overexpression of miR-17-5p, -19a-3p, -19b-3p, -21-5p, -130b-3p, -221-3p and -222-3p by glioblastoma stem-like cells following irradiation. Oncol. Lett. 10, 2269-2272 (2015).
-
(2015)
Oncol. Lett.
, vol.10
, pp. 2269-2272
-
-
Tokudome, T.1
Sasaki, A.2
Tsuji, M.3
Udaka, Y.4
Oyamada, H.5
Tsuchiya, H.6
Oguchi, K.7
-
99
-
-
70350221952
-
MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes
-
Y. Li, F. Guessous, Y. Zhang, C. Dipierro, B. Kefas, E. Johnson, L. Marcinkiewicz, J. Jiang, Y. Yang, T. D. Schmittgen, B. Lopes, D. Schiff, B. Purow, R. Abounader, MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res. 69, 7569-7576 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 7569-7576
-
-
Li, Y.1
Guessous, F.2
Zhang, Y.3
Dipierro, C.4
Kefas, B.5
Johnson, E.6
Marcinkiewicz, L.7
Jiang, J.8
Yang, Y.9
Schmittgen, T.D.10
Lopes, B.11
Schiff, D.12
Purow, B.13
Abounader, R.14
-
100
-
-
84906269634
-
MiR-96/HBP1/Wnt/β-catenin regulatory circuitry promotes glioma growth
-
Z. Yan, J. Wang, C. Wang, Y. Jiao, W. Qi, S. Che, miR-96/HBP1/Wnt/β-catenin regulatory circuitry promotes glioma growth. FEBS Lett. 588, 3038-3046 (2014).
-
(2014)
FEBS Lett.
, vol.588
, pp. 3038-3046
-
-
Yan, Z.1
Wang, J.2
Wang, C.3
Jiao, Y.4
Qi, W.5
Che, S.6
-
101
-
-
33745893809
-
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response
-
J. Hollien, J. S. Weissman, Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science 313, 104-107 (2006).
-
(2006)
Science
, vol.313
, pp. 104-107
-
-
Hollien, J.1
Weissman, J.S.2
-
102
-
-
84881436099
-
Posttranscriptional regulation of PER1 underlies the oncogenic function of IREα
-
O. Pluquet, N. Dejeans, M. Bouchecareilh, S. Lhomond, R. Pineau, A. Higa, M. Delugin, C. Combe, S. Loriot, G. Cubel, N. Dugot-Senant, A. Vital, H. Loiseau, S. J. Gosline, S. Taouji, M. Hallett, J. N. Sarkaria, K. Anderson, W. Wu, F. J. Rodriguez, J. Rosenbaum, F. Saltel, M. E. Fernandez-Zapico, E. Chevet, Posttranscriptional regulation of PER1 underlies the oncogenic function of IREα. Cancer Res. 73, 4732-4743 (2013).
-
(2013)
Cancer Res.
, vol.73
, pp. 4732-4743
-
-
Pluquet, O.1
Dejeans, N.2
Bouchecareilh, M.3
Lhomond, S.4
Pineau, R.5
Higa, A.6
Delugin, M.7
Combe, C.8
Loriot, S.9
Cubel, G.10
Dugot-Senant, N.11
Vital, A.12
Loiseau, H.13
Gosline, S.J.14
Taouji, S.15
Hallett, M.16
Sarkaria, J.N.17
Anderson, K.18
Wu, W.19
Rodriguez, F.J.20
Rosenbaum, J.21
Saltel, F.22
Fernandez-Zapico, M.E.23
Chevet, E.24
more..
-
103
-
-
84934275896
-
Proteostasis control by the unfolded protein response
-
C. Hetz, E. Chevet, S. A. Oakes, Proteostasis control by the unfolded protein response. Nat. Cell Biol. 17, 829-838 (2015).
-
(2015)
Nat. Cell Biol.
, vol.17
, pp. 829-838
-
-
Hetz, C.1
Chevet, E.2
Oakes, S.A.3
-
104
-
-
33748532939
-
The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses
-
S. F. Hussain, D. Yang, D. Suki, K. Aldape, E. Grimm, A. B. Heimberger, The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. Neuro Oncol. 8, 261-279 (2006).
-
(2006)
Neuro Oncol.
, vol.8
, pp. 261-279
-
-
Hussain, S.F.1
Yang, D.2
Suki, D.3
Aldape, K.4
Grimm, E.5
Heimberger, A.B.6
-
105
-
-
33747178730
-
Characteristics of tumor-associated endothelial cells derived from glioblastoma multiforme
-
C. Charalambous, T. C. Chen, F. M. Hofman, Characteristics of tumor-associated endothelial cells derived from glioblastoma multiforme. Neurosurg. Focus 20, E22 (2006).
-
(2006)
Neurosurg. Focus
, vol.20
, pp. E22
-
-
Charalambous, C.1
Chen, T.C.2
Hofman, F.M.3
-
106
-
-
0034093158
-
Flow cytometric characterization of tumor-associated macrophages in experimental gliomas
-
B. Badie, J. M. Schartner, Flow cytometric characterization of tumor-associated macrophages in experimental gliomas. Neurosurgery 46, 957-961 (2000).
-
(2000)
Neurosurgery
, vol.46
, pp. 957-961
-
-
Badie, B.1
Schartner, J.M.2
-
107
-
-
50249144131
-
Possible involvement of the M2 antiinflammatory macrophage phenotype in growth of human gliomas
-
Y. Komohara, K. Ohnishi, J. Kuratsu, M. Takeya, Possible involvement of the M2 antiinflammatory macrophage phenotype in growth of human gliomas. J. Pathol. 216, 15-24 (2008).
-
(2008)
J. Pathol.
, vol.216
, pp. 15-24
-
-
Komohara, Y.1
Ohnishi, K.2
Kuratsu, J.3
Takeya, M.4
-
108
-
-
0036187615
-
The role of tumour-associated macrophages in tumour progression: Implications for new anticancer therapies
-
L. Bingle, N. J. Brown, C. E. Lewis, The role of tumour-associated macrophages in tumour progression: Implications for new anticancer therapies. J. Pathol. 196, 254-265 (2002).
-
(2002)
J. Pathol.
, vol.196
, pp. 254-265
-
-
Bingle, L.1
Brown, N.J.2
Lewis, C.E.3
-
109
-
-
84881504052
-
The controversial role of microglia in malignant gliomas
-
J. Wei, K. Gabrusiewicz, A. Heimberger, The controversial role of microglia in malignant gliomas. Clin. Dev. Immunol. 2013, 285246 (2013).
-
(2013)
Clin. Dev. Immunol.
, vol.2013
, pp. 285246
-
-
Wei, J.1
Gabrusiewicz, K.2
Heimberger, A.3
-
110
-
-
84855817522
-
Immunology in the clinic review series; focus on cancer: Tumour-associated macrophages: Undisputed stars of the inflammatory tumour microenvironment
-
P. Allavena, A. Mantovani, Immunology in the clinic review series; focus on cancer: Tumour-associated macrophages: Undisputed stars of the inflammatory tumour microenvironment. Clin. Exp. Immunol. 167, 195-205 (2012).
-
(2012)
Clin. Exp. Immunol.
, vol.167
, pp. 195-205
-
-
Allavena, P.1
Mantovani, A.2
-
111
-
-
0036839143
-
Macrophage polarization: Tumorassociated macrophages as a paradigm for polarized M2 mononuclear phagocytes
-
A. Mantovani, S. Sozzani, M. Locati, P. Allavena, A. Sica, Macrophage polarization: Tumorassociated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23, 549-555 (2002).
-
(2002)
Trends Immunol.
, vol.23
, pp. 549-555
-
-
Mantovani, A.1
Sozzani, S.2
Locati, M.3
Allavena, P.4
Sica, A.5
-
112
-
-
84875492465
-
Tumor associated macrophages and neutrophils in tumor progression
-
M. R. Galdiero, C. Garlanda, S. Jaillon, G. Marone, A. Mantovani, Tumor associated macrophages and neutrophils in tumor progression. J. Cell. Physiol. 228, 1404-1412 (2013).
-
(2013)
J. Cell. Physiol.
, vol.228
, pp. 1404-1412
-
-
Galdiero, M.R.1
Garlanda, C.2
Jaillon, S.3
Marone, G.4
Mantovani, A.5
-
113
-
-
84953747412
-
The role of microglia and macrophages in glioma maintenance and progression
-
D. Hambardzumyan, D. H. Gutmann, H. Kettenmann, The role of microglia and macrophages in glioma maintenance and progression. Nat. Neurosci. 19, 20-27 (2016).
-
(2016)
Nat. Neurosci.
, vol.19
, pp. 20-27
-
-
Hambardzumyan, D.1
Gutmann, D.H.2
Kettenmann, H.3
-
114
-
-
77951290227
-
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
-
F. Martinon, X. Chen, A.-H. Lee, L. H. Glimcher, TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat. Immunol. 11, 411-418 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 411-418
-
-
Martinon, F.1
Chen, X.2
Lee, A.-H.3
Glimcher, L.H.4
-
115
-
-
67349257146
-
HIV protease inhibitor lopinavir-induced TNF-α and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages
-
L. Chen, S. Jarujaron, X. Wu, L. Sun, W. Zha, G. Liang, X. Wang, E. C. Gurley, E. J. Studer, P. B. Hylemon, W. M. Pandak Jr., L. Zhang, G. Wang, X. Li, P. Dent, H. Zhou, HIV protease inhibitor lopinavir-induced TNF-α and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages. Biochem. Pharmacol. 78, 70-77 (2009).
-
(2009)
Biochem. Pharmacol.
, vol.78
, pp. 70-77
-
-
Chen, L.1
Jarujaron, S.2
Wu, X.3
Sun, L.4
Zha, W.5
Liang, G.6
Wang, X.7
Gurley, E.C.8
Studer, E.J.9
Hylemon, P.B.10
Pandak, W.M.11
Zhang, L.12
Wang, G.13
Li, X.14
Dent, P.15
Zhou, H.16
-
116
-
-
78049271424
-
Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression
-
J. C. Goodall, C. Wu, Y. Zhang, L. McNeill, L. Ellis, V. Saudek, J. S. Gaston, Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression. Proc. Natl. Acad. Sci. U.S.A. 107, 17698-17703 (2010).
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 17698-17703
-
-
Goodall, J.C.1
Wu, C.2
Zhang, Y.3
McNeill, L.4
Ellis, L.5
Saudek, V.6
Gaston, J.S.7
-
117
-
-
84892914407
-
Immune chaperone gp96 drives the contributions of macrophages to inflammatory colon tumorigenesis
-
C. Morales, S. Rachidi, F. Hong, S. Sun, X. Ouyang, C. Wallace, Y. Zhang, E. Garret-Mayer, J. Wu, B. Liu, Z. Li, Immune chaperone gp96 drives the contributions of macrophages to inflammatory colon tumorigenesis. Cancer Res. 74, 446-459 (2014).
-
(2014)
Cancer Res.
, vol.74
, pp. 446-459
-
-
Morales, C.1
Rachidi, S.2
Hong, F.3
Sun, S.4
Ouyang, X.5
Wallace, C.6
Zhang, Y.7
Garret-Mayer, E.8
Wu, J.9
Liu, B.10
Li, Z.11
-
118
-
-
79955632933
-
Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells
-
N. R. Mahadevan, J. Rodvold, H. Sepulveda, S. Rossi, A. F. Drew, M. Zanetti, Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells. Proc. Natl. Acad. Sci. U.S.A. 108, 6561-6566 (2011).
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 6561-6566
-
-
Mahadevan, N.R.1
Rodvold, J.2
Sepulveda, H.3
Rossi, S.4
Drew, A.F.5
Zanetti, M.6
-
120
-
-
47949100421
-
KDEL-retained antigen in B lymphocytes induces a proinflammatory response: A possible role for endoplasmic reticulum stress in adaptive T cell immunity
-
M. C. Wheeler, M. Rizzi, R. Sasik, G. Almanza, G. Hardiman, M. Zanetti, KDEL-retained antigen in B lymphocytes induces a proinflammatory response: A possible role for endoplasmic reticulum stress in adaptive T cell immunity. J. Immunol. 181, 256-264 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 256-264
-
-
Wheeler, M.C.1
Rizzi, M.2
Sasik, R.3
Almanza, G.4
Hardiman, G.5
Zanetti, M.6
-
121
-
-
63349100596
-
ER stress affects processing of MHC class I-associated peptides
-
D. P. Granados, P.-L. Tanguay, M.-P. Hardy, É. Caron, D. de Verteuil, S. Meloche, C. Perreault, ER stress affects processing of MHC class I-associated peptides. BMC Immunol. 10, 10 (2009).
-
(2009)
BMC Immunol.
, vol.10
, pp. 10
-
-
Granados, D.P.1
Tanguay, P.-L.2
Hardy, M.-P.3
Caron, É.4
De Verteuil, D.5
Meloche, S.6
Perreault, C.7
-
122
-
-
66149118659
-
+ T cell function via L-arginine metabolism
-
+ T cell function via L-arginine metabolism. Cancer Res. 69, 3086-3094 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 3086-3094
-
-
Norian, L.A.1
Rodriguez, P.C.2
O'Mara, L.A.3
Zabaleta, J.4
Ochoa, A.C.5
Cella, M.6
Allen, P.M.7
-
123
-
-
84894424803
-
+ dendritic cells
-
+ dendritic cells. Nat. Immunol. 15, 248-257 (2014).
-
(2014)
Nat. Immunol.
, vol.15
, pp. 248-257
-
-
Osorio, F.1
Tavernier, S.J.2
Hoffmann, E.3
Saeys, Y.4
Martens, L.5
Vetters, J.6
Delrue, I.7
De Rycke, R.8
Parthoens, E.9
Pouliot, P.10
Iwawaki, T.11
Janssens, S.12
Lambrecht, B.N.13
-
124
-
-
34948897411
-
The transcription factor XBP-1 is essential for the development and survival of dendritic cells
-
N. N. Iwakoshi, M. Pypaert, L. H. Glimcher, The transcription factor XBP-1 is essential for the development and survival of dendritic cells. J. Exp. Med. 204, 2267-2275 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2267-2275
-
-
Iwakoshi, N.N.1
Pypaert, M.2
Glimcher, L.H.3
-
125
-
-
84991706068
-
STAT3 and STAT6 signaling pathways synergize to promote cathepsin secretion from macrophages via IRE1α activation
-
D. Yan, H.-W. Wang, R. L. Bowman, J. A. Joyce, STAT3 and STAT6 signaling pathways synergize to promote cathepsin secretion from macrophages via IRE1α activation. Cell Rep. 16, 2914-2927 (2016).
-
(2016)
Cell Rep.
, vol.16
, pp. 2914-2927
-
-
Yan, D.1
Wang, H.-W.2
Bowman, R.L.3
Joyce, J.A.4
-
126
-
-
84979610111
-
Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the golgi apparatus during ER stress
-
C. M. Gallagher, P. Walter, Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress. eLife 5, e11880 (2016).
-
(2016)
ELife
, vol.5
, pp. e11880
-
-
Gallagher, C.M.1
Walter, P.2
-
127
-
-
84979623050
-
Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch
-
C. M. Gallagher, C. Garri, E. L. Cain, K. K. Ang, C. G. Wilson, S. Chen, B. R. Hearn, P. Jaishankar, A. Aranda-Diaz, M. R. Arkin, A. R. Renslo, P. Walter, Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. eLife 5, e11878 (2016).
-
(2016)
ELife
, vol.5
, pp. e11878
-
-
Gallagher, C.M.1
Garri, C.2
Cain, E.L.3
Ang, K.K.4
Wilson, C.G.5
Chen, S.6
Hearn, B.R.7
Jaishankar, P.8
Aranda-Diaz, A.9
Arkin, M.R.10
Renslo, A.R.11
Walter, P.12
-
128
-
-
84979515521
-
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
-
L. Plate, C. B. Cooley, J. J. Chen, R. J. Paxman, C. M. Gallagher, F. Madoux, J. C. Genereux, W. Dobbs, D. Garza, T. P. Spicer, L. Scampavia, S. J. Brown, H. Rosen, E. T. Powers, P. Walter, P. Hodder, R. L. Wiseman, J. W. Kelly, Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. eLife 5, e15550 (2016).
-
(2016)
ELife
, vol.5
, pp. e15550
-
-
Plate, L.1
Cooley, C.B.2
Chen, J.J.3
Paxman, R.J.4
Gallagher, C.M.5
Madoux, F.6
Genereux, J.C.7
Dobbs, W.8
Garza, D.9
Spicer, T.P.10
Scampavia, L.11
Brown, S.J.12
Rosen, H.13
Powers, E.T.14
Walter, P.15
Hodder, P.16
Wiseman, R.L.17
Kelly, J.W.18
-
129
-
-
84859587957
-
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule
-
B. C. Cross, P. J. Bond, P. G. Sadowski, B. K. Jha, J. Zak, J. M. Goodman, R. H. Silverman, T. A. Neubert, I. R. Baxendale, D. Ron, H. P. Harding, The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc. Natl. Acad. Sci. U.S.A. 109, E869-E878 (2012).
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. E869-E878
-
-
Cross, B.C.1
Bond, P.J.2
Sadowski, P.G.3
Jha, B.K.4
Zak, J.5
Goodman, J.M.6
Silverman, R.H.7
Neubert, T.A.8
Baxendale, I.R.9
Ron, D.10
Harding, H.P.11
-
130
-
-
79953319782
-
Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease
-
K. Volkmann, J. L. Lucas, D. Vuga, X. Wang, D. Brumm, C. Stiles, D. Kriebel, A. Der-Sarkissian, K. Krishnan, C. Schweitzer, Z. Liu, U. M. Malyankar, D. Chiovitti, M. Canny, D. Durocher, F. Sicheri, J. B. Patterson, Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease. J. Biol. Chem. 286, 12743-12755 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 12743-12755
-
-
Volkmann, K.1
Lucas, J.L.2
Vuga, D.3
Wang, X.4
Brumm, D.5
Stiles, C.6
Kriebel, D.7
Der-Sarkissian, A.8
Krishnan, K.9
Schweitzer, C.10
Liu, Z.11
Malyankar, U.M.12
Chiovitti, D.13
Canny, M.14
Durocher, D.15
Sicheri, F.16
Patterson, J.B.17
-
131
-
-
84862501186
-
Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma
-
N. Mimura, M. Fulciniti, G. Gorgun, Y.-T. Tai, D. Cirstea, L. Santo, Y. Hu, C. Fabre, J. Minami, H. Ohguchi, T. Kiziltepe, H. Ikeda, Y. Kawano, M. French, M. Blumenthal, V. Tam, N. L. Kertesz, U. M. Malyankar, M. Hokenson, T. Pham, Q. Zeng, J. B. Patterson, P. G. Richardson, N. C. Munshi, K. C. Anderson, Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma. Blood 119, 5772-5781 (2012).
-
(2012)
Blood
, vol.119
, pp. 5772-5781
-
-
Mimura, N.1
Fulciniti, M.2
Gorgun, G.3
Tai, Y.-T.4
Cirstea, D.5
Santo, L.6
Hu, Y.7
Fabre, C.8
Minami, J.9
Ohguchi, H.10
Kiziltepe, T.11
Ikeda, H.12
Kawano, Y.13
French, M.14
Blumenthal, M.15
Tam, V.16
Kertesz, N.L.17
Malyankar, U.M.18
Hokenson, M.19
Pham, T.20
Zeng, Q.21
Patterson, J.B.22
Richardson, P.G.23
Munshi, N.C.24
Anderson, K.C.25
more..
-
132
-
-
84907360215
-
Structure and mechanism of action of the hydroxy-arylaldehyde class of IRE1 endoribonuclease inhibitors
-
M. Sanches, N. M. Duffy, M. Talukdar, N. Thevakumaran, D. Chiovitti, M. D. Canny, K. Lee, I. Kurinov, D. Uehling, R. Al-awar, G. Poda, M. Prakesch, B. Wilson, V. Tam, C. Schweitzer, A. Toro, J. L. Lucas, D. Vuga, L. Lehmann, D. Durocher, Q. Zeng, J. B. Patterson, F. Sicheri, Structure and mechanism of action of the hydroxy-arylaldehyde class of IRE1 endoribonuclease inhibitors. Nat. Commun. 5, 4202 (2014).
-
(2014)
Nat. Commun.
, vol.5
, pp. 4202
-
-
Sanches, M.1
Duffy, N.M.2
Talukdar, M.3
Thevakumaran, N.4
Chiovitti, D.5
Canny, M.D.6
Lee, K.7
Kurinov, I.8
Uehling, D.9
Al-Awar, R.10
Poda, G.11
Prakesch, M.12
Wilson, B.13
Tam, V.14
Schweitzer, C.15
Toro, A.16
Lucas, J.L.17
Vuga, D.18
Lehmann, L.19
Durocher, D.20
Zeng, Q.21
Patterson, J.B.22
Sicheri, F.23
more..
-
133
-
-
84964290066
-
Adaptation of the secretory pathway in cancer through IRE1 signaling
-
S. Lhomond, N. Pallares, K. Barroso, K. Schmit, N. Dejeans, H. Fazli, S. Taouji, J. B. Patterson, E. Chevet, Adaptation of the secretory pathway in cancer through IRE1 signaling. Methods Mol. Biol. 1292, 177-194 (2015).
-
(2015)
Methods Mol. Biol.
, vol.1292
, pp. 177-194
-
-
Lhomond, S.1
Pallares, N.2
Barroso, K.3
Schmit, K.4
Dejeans, N.5
Fazli, H.6
Taouji, S.7
Patterson, J.B.8
Chevet, E.9
-
134
-
-
84905492694
-
Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress
-
R. Ghosh, L. Wang, E. S. Wang, B. G. Perera, A. Igbaria, S. Morita, K. Prado, M. Thamsen, D. Caswell, H. Macias, K. F. Weiberth, M. J. Gliedt, M. V. Alavi, S. B. Hari, A. K. Mitra, B. Bhhatarai, S. C. Schurer, E. L. Snapp, D. B. Gould, M. S. German, B. J. Backes, D. J. Maly, S. A. Oakes, F. R. Papa, Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress. Cell 158, 534-548 (2014).
-
(2014)
Cell
, vol.158
, pp. 534-548
-
-
Ghosh, R.1
Wang, L.2
Wang, E.S.3
Perera, B.G.4
Igbaria, A.5
Morita, S.6
Prado, K.7
Thamsen, M.8
Caswell, D.9
Macias, H.10
Weiberth, K.F.11
Gliedt, M.J.12
Alavi, M.V.13
Hari, S.B.14
Mitra, A.K.15
Bhhatarai, B.16
Schurer, S.C.17
Snapp, E.L.18
Gould, D.B.19
German, M.S.20
Backes, B.J.21
Maly, D.J.22
Oakes, S.A.23
Papa, F.R.24
more..
-
135
-
-
79251589342
-
Identification of an ire1α endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma
-
I. Papandreou, N. C. Denko, M. Olson, H. Van Melckebeke, S. Lust, A. Tam, D. E. Solow-Cordero, D. M. Bouley, F. Offner, M. Niwa, A. C. Koong, Identification of an Ire1α endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood 117, 1311-1314 (2011).
-
(2011)
Blood
, vol.117
, pp. 1311-1314
-
-
Papandreou, I.1
Denko, N.C.2
Olson, M.3
Van Melckebeke, H.4
Lust, S.5
Tam, A.6
Solow-Cordero, D.E.7
Bouley, D.M.8
Offner, F.9
Niwa, M.10
Koong, A.C.11
-
136
-
-
84870357261
-
Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors
-
L. Wang, B. G. Perera, S. B. Hari, B. Bhhatarai, B. J. Backes, M. A. Seeliger, S. C. Schurer, S. A. Oakes, F. R. Papa, D. J. Maly, Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nat. Chem. Biol. 8, 982-989 (2012).
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 982-989
-
-
Wang, L.1
Perera, B.G.2
Hari, S.B.3
Bhhatarai, B.4
Backes, B.J.5
Seeliger, M.A.6
Schurer, S.C.7
Oakes, S.A.8
Papa, F.R.9
Maly, D.J.10
-
137
-
-
84881530677
-
Pharmacological brakerelease of mRNA translation enhances cognitive memory
-
C. Sidrauski, D. Acosta-Alvear, A. Khoutorsky, P. Vedantham, B. R. Hearn, H. Li, K. Gamache, C. M. Gallagher, K. K. Ang, C. Wilson, V. Okreglak, A. Ashkenazi, B. Hann, K. Nader, M. R. Arkin, A. R. Renslo, N. Sonenberg, P. Walter, Pharmacological brakerelease of mRNA translation enhances cognitive memory. eLife 2, e00498 (2013).
-
(2013)
ELife
, vol.2
, pp. e00498
-
-
Sidrauski, C.1
Acosta-Alvear, D.2
Khoutorsky, A.3
Vedantham, P.4
Hearn, B.R.5
Li, H.6
Gamache, K.7
Gallagher, C.M.8
Ang, K.K.9
Wilson, C.10
Okreglak, V.11
Ashkenazi, A.12
Hann, B.13
Nader, K.14
Arkin, M.R.15
Renslo, A.R.16
Sonenberg, N.17
Walter, P.18
-
138
-
-
13644256191
-
A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress
-
M. Boyce, K. F. Bryant, C. Jousse, K. Long, H. P. Harding, D. Scheuner, R. J. Kaufman, D. Ma, D. M. Coen, D. Ron, J. Yuan, A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress. Science 307, 935-939 (2005).
-
(2005)
Science
, vol.307
, pp. 935-939
-
-
Boyce, M.1
Bryant, K.F.2
Jousse, C.3
Long, K.4
Harding, H.P.5
Scheuner, D.6
Kaufman, R.J.7
Ma, D.8
Coen, D.M.9
Ron, D.10
Yuan, J.11
-
139
-
-
79953288480
-
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis
-
P. Tsaytler, H. P. Harding, D. Ron, A. Bertolotti, Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. Science 332, 91-94 (2011).
-
(2011)
Science
, vol.332
, pp. 91-94
-
-
Tsaytler, P.1
Harding, H.P.2
Ron, D.3
Bertolotti, A.4
-
140
-
-
84927619395
-
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit
-
I. Das, A. Krzyzosiak, K. Schneider, L. Wrabetz, M. D'Antonio, N. Barry, A. Sigurdardottir, A. Bertolotti, Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science 348, 239-242 (2015).
-
(2015)
Science
, vol.348
, pp. 239-242
-
-
Das, I.1
Krzyzosiak, A.2
Schneider, K.3
Wrabetz, L.4
D'Antonio, M.5
Barry, N.6
Sigurdardottir, A.7
Bertolotti, A.8
-
141
-
-
84883387793
-
Targeting the unfolded protein response in disease
-
C. Hetz, E. Chevet, H. P. Harding, Targeting the unfolded protein response in disease. Nat. Rev. Drug Discov. 12, 703-719 (2013).
-
(2013)
Nat. Rev. Drug Discov.
, vol.12
, pp. 703-719
-
-
Hetz, C.1
Chevet, E.2
Harding, H.P.3
-
142
-
-
84866001506
-
Identification of toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing
-
M. Ri, E. Tashiro, D. Oikawa, S. Shinjo, M. Tokuda, Y. Yokouchi, T. Narita, A. Masaki, A. Ito, J. Ding, S. Kusumoto, T. Ishida, H. Komatsu, Y. Shiotsu, R. Ueda, T. Iwawaki, M. Imoto, S. Iida, Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood Cancer J. 2, e79 (2012).
-
(2012)
Blood Cancer J.
, vol.2
, pp. e79
-
-
Ri, M.1
Tashiro, E.2
Oikawa, D.3
Shinjo, S.4
Tokuda, M.5
Yokouchi, Y.6
Narita, T.7
Masaki, A.8
Ito, A.9
Ding, J.10
Kusumoto, S.11
Ishida, T.12
Komatsu, H.13
Shiotsu, Y.14
Ueda, R.15
Iwawaki, T.16
Imoto, M.17
Iida, S.18
-
143
-
-
54049093229
-
SAR study of a novel trieneansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress-induced XBP1 activation
-
T. Kawamura, E. Tashiro, K. Yamamoto, K. Shindo, M. Imoto, SAR study of a novel trieneansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress-induced XBP1 activation. J. Antibiot. 61, 303-311 (2008).
-
(2008)
J. Antibiot.
, vol.61
, pp. 303-311
-
-
Kawamura, T.1
Tashiro, E.2
Yamamoto, K.3
Shindo, K.4
Imoto, M.5
-
144
-
-
38449100448
-
Trierixin, a novel inhibitor of ER stress-induced XBP1 activation from streptomyces sp. II. Structure elucidation
-
Y. Futamura, E. Tashiro, N. Hironiwa, J. Kohno, M. Nishio, K. Shindo, M. Imoto, Trierixin, a novel Inhibitor of ER stress-induced XBP1 activation from Streptomyces sp. II. structure elucidation. J. Antibiot. 60, 582-585 (2007).
-
(2007)
J. Antibiot.
, vol.60
, pp. 582-585
-
-
Futamura, Y.1
Tashiro, E.2
Hironiwa, N.3
Kohno, J.4
Nishio, M.5
Shindo, K.6
Imoto, M.7
-
145
-
-
79952283168
-
Structure of the ire1 autophosphorylation complex and implications for the unfolded protein response
-
M. M. U. Ali, T. Bagratuni, E. L. Davenport, P. R. Nowak, M. C. Silva-Santisteban, A. Hardcastle, C. McAndrews, M. G. Rowlands, G. J. Morgan, W. Aherne, I. Collins, F. E. Davies, L. H. Pearl, Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response. EMBO J. 30, 894-905 (2011).
-
(2011)
EMBO J.
, vol.30
, pp. 894-905
-
-
Ali, M.M.U.1
Bagratuni, T.2
Davenport, E.L.3
Nowak, P.R.4
Silva-Santisteban, M.C.5
Hardcastle, A.6
McAndrews, C.7
Rowlands, M.G.8
Morgan, G.J.9
Aherne, W.10
Collins, I.11
Davies, F.E.12
Pearl, L.H.13
-
146
-
-
80052668828
-
Peptides derived from the bifunctional kinase/RNase enzyme IRE1α modulate IRE1α activity and protect cells from endoplasmic reticulum stress
-
M. Bouchecareilh, A. Higa, S. Fribourg, M. Moenner, E. Chevet, Peptides derived from the bifunctional kinase/RNase enzyme IRE1α modulate IRE1α activity and protect cells from endoplasmic reticulum stress. FASEB J. 25, 3115-3129 (2011).
-
(2011)
FASEB J.
, vol.25
, pp. 3115-3129
-
-
Bouchecareilh, M.1
Higa, A.2
Fribourg, S.3
Moenner, M.4
Chevet, E.5
-
147
-
-
84866905708
-
Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)
-
J. M. Axten, J. R. Medina, Y. Feng, A. Shu, S. P. Romeril, S. W. Grant, W. H. Li, D. A. Heerding, E. Minthorn, T. Mencken, C. Atkins, Q. Liu, S. Rabindran, R. Kumar, X. Hong, A. Goetz, T. Stanley, J. D. Taylor, S. D. Sigethy, G. H. Tomberlin, A. M. Hassell, K. M. Kahler, L. M. Shewchuk, R. T. Gampe, Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J. Med. Chem. 55, 7193-7207 (2012).
-
(2012)
J. Med. Chem.
, vol.55
, pp. 7193-7207
-
-
Axten, J.M.1
Medina, J.R.2
Feng, Y.3
Shu, A.4
Romeril, S.P.5
Grant, S.W.6
Li, W.H.7
Heerding, D.A.8
Minthorn, E.9
Mencken, T.10
Atkins, C.11
Liu, Q.12
Rabindran, S.13
Kumar, R.14
Hong, X.15
Goetz, A.16
Stanley, T.17
Taylor, J.D.18
Sigethy, S.D.19
Tomberlin, G.H.20
Hassell, A.M.21
Kahler, K.M.22
Shewchuk, L.M.23
Gampe, R.T.24
more..
-
148
-
-
84928141313
-
Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response
-
C. Sidrauski, J. C. Tsai, M. Kampmann, B. R. Hearn, P. Vedantham, P. Jaishankar, M. Sokabe, A. S. Mendez, B. W. Newton, E. L. Tang, E. Verschueren, J. R. Johnson, N. J. Krogan, C. S. Fraser, J. S. Weissman, A. R. Renslo, P. Walter, Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife 4, e07314 (2015).
-
(2015)
Elife
, vol.4
, pp. e07314
-
-
Sidrauski, C.1
Tsai, J.C.2
Kampmann, M.3
Hearn, B.R.4
Vedantham, P.5
Jaishankar, P.6
Sokabe, M.7
Mendez, A.S.8
Newton, B.W.9
Tang, E.L.10
Verschueren, E.11
Johnson, J.R.12
Krogan, N.J.13
Fraser, C.S.14
Weissman, J.S.15
Renslo, A.R.16
Walter, P.17
-
149
-
-
84962034543
-
Signaling the unfolded protein response in primary brain cancers
-
P. J. Le Reste, T. Avril, V. Quillien, X. Morandi, E. Chevet, Signaling the unfolded protein response in primary brain cancers. Brain Res. 1642, 59-69 (2016).
-
(2016)
Brain Res.
, vol.1642
, pp. 59-69
-
-
Le Reste, P.J.1
Avril, T.2
Quillien, V.3
Morandi, X.4
Chevet, E.5
-
150
-
-
84964258008
-
The endoplasmic reticulum stress/unfolded protein response in gliomagenesis, tumor progression and as a therapeutic target in glioblastoma
-
N. M. Peñaranda Fajardo, C. Meijer, F. A. E. Kruyt, The endoplasmic reticulum stress/unfolded protein response in gliomagenesis, tumor progression and as a therapeutic target in glioblastoma. Biochem. Pharmacol. 118, 1-8 (2016).
-
(2016)
Biochem. Pharmacol.
, vol.118
, pp. 1-8
-
-
Peñaranda Fajardo, N.M.1
Meijer, C.2
Kruyt, F.A.E.3
-
151
-
-
77949714264
-
Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature
-
J. J. Virrey, Z. Liu, H.-Y. Cho, A. Kardosh, E. B. Golden, S. G. Louie, K. J. Gaffney, N. A. Petasis, A. H. Schönthal, T. C. Chen, F. M. Hofman, Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature. Mol. Cancer Ther. 9, 631-641 (2010).
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 631-641
-
-
Virrey, J.J.1
Liu, Z.2
Cho, H.-Y.3
Kardosh, A.4
Golden, E.B.5
Louie, S.G.6
Gaffney, K.J.7
Petasis, N.A.8
Schönthal, A.H.9
Chen, T.C.10
Hofman, F.M.11
-
152
-
-
66449115318
-
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
-
M. Salazar, A. Carracedo, I. J. Salanueva, S. Hernández-Tiedra, M. Lorente, A. Egia, P. Vazquez, C. Blázquez, S. Torres, S. Garcia, J. Nowak, G. M. Fimia, M. Piacentini, F. Cecconi, P. P. Pandolfi, L. González-Feria, J. L. Iovanna, M. Guzman, P. Boya, G. Velasco, Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J. Clin. Invest. 119, 1359-1372 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 1359-1372
-
-
Salazar, M.1
Carracedo, A.2
Salanueva, I.J.3
Hernández-Tiedra, S.4
Lorente, M.5
Egia, A.6
Vazquez, P.7
Blázquez, C.8
Torres, S.9
Garcia, S.10
Nowak, J.11
Fimia, G.M.12
Piacentini, M.13
Cecconi, F.14
Pandolfi, P.P.15
González-Feria, L.16
Iovanna, J.L.17
Guzman, M.18
Boya, P.19
Velasco, G.20
more..
-
153
-
-
33745929641
-
9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
-
9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. Br. J. Cancer 95, 197-203 (2006).
-
(2006)
Br. J. Cancer
, vol.95
, pp. 197-203
-
-
Guzmán, M.1
Duarte, M.J.2
Blázquez, C.3
Ravina, J.4
Rosa, M.C.5
Galve-Roperh, I.6
Sánchez, C.7
Velasco, G.8
González-Feria, L.9
-
154
-
-
84945199647
-
Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cells both in vitro and in vivo
-
C. V. Kavitha, A. K. Jain, C. Agarwal, A. Pierce, A. Keating, K. M. Huber, N. J. Serkova, M. F. Wempe, R. Agarwal, G. Deep, Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cells both in vitro and in vivo. Mol. Carcinog. 54, 1417-1429 (2015).
-
(2015)
Mol. Carcinog.
, vol.54
, pp. 1417-1429
-
-
Kavitha, C.V.1
Jain, A.K.2
Agarwal, C.3
Pierce, A.4
Keating, A.5
Huber, K.M.6
Serkova, N.J.7
Wempe, M.F.8
Agarwal, R.9
Deep, G.10
-
155
-
-
79951577565
-
Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models
-
T. C. Chen, W. Wang, E. B. Golden, S. Thomas, W. Sivakumar, F. M. Hofman, S. G. Louie, A. H. Schönthal, Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models. Cancer Lett. 302, 100-108 (2011).
-
(2011)
Cancer Lett.
, vol.302
, pp. 100-108
-
-
Chen, T.C.1
Wang, W.2
Golden, E.B.3
Thomas, S.4
Sivakumar, W.5
Hofman, F.M.6
Louie, S.G.7
Schönthal, A.H.8
-
156
-
-
84905663623
-
NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas
-
H.-Y. Cho, W. Wang, N. Jhaveri, D. J. Lee, N. Sharma, L. Dubeau, A. H. Schönthal, F. M. Hofman, T. C. Chen, NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas. Mol. Cancer Ther. 13, 2004-2017 (2014).
-
(2014)
Mol. Cancer Ther.
, vol.13
, pp. 2004-2017
-
-
Cho, H.-Y.1
Wang, W.2
Jhaveri, N.3
Lee, D.J.4
Sharma, N.5
Dubeau, L.6
Schönthal, A.H.7
Hofman, F.M.8
Chen, T.C.9
-
157
-
-
84869227959
-
Perillyl alcohol for the treatment of temozolomide-resistant gliomas
-
H.-Y. Cho, W. Wang, N. Jhaveri, S. Torres, J. Tseng, M. N. Leong, D. J. Lee, A. Goldkorn, T. Xu, N. A. Petasis, S. G. Louie, A. H. Schönthal, F. M. Hofman, T. C. Chen, Perillyl alcohol for the treatment of temozolomide-resistant gliomas. Mol. Cancer Ther. 11, 2462-2472 (2012).
-
(2012)
Mol. Cancer Ther.
, vol.11
, pp. 2462-2472
-
-
Cho, H.-Y.1
Wang, W.2
Jhaveri, N.3
Torres, S.4
Tseng, J.5
Leong, M.N.6
Lee, D.J.7
Goldkorn, A.8
Xu, T.9
Petasis, N.A.10
Louie, S.G.11
Schönthal, A.H.12
Hofman, F.M.13
Chen, T.C.14
-
158
-
-
84891424146
-
Long-term outcome in patients with recurrent malignant glioma treated with perillyl alcohol inhalation
-
C. O. Da Fonseca, I. Petrone Soares, D. S. Clemençon, S. Rochlin, L. Cardeman, T. Quirico-Santos, Long-term outcome in patients with recurrent malignant glioma treated with Perillyl alcohol inhalation. Anticancer Res. 33, 5625-5631 (2013).
-
(2013)
Anticancer Res.
, vol.33
, pp. 5625-5631
-
-
Da Fonseca, C.O.1
Petrone Soares, I.2
Clemençon, D.S.3
Rochlin, S.4
Cardeman, L.5
Quirico-Santos, T.6
-
159
-
-
84906302724
-
Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells
-
T. H. Kim, J. Song, S.-H. Kim, A. K. Parikh, X. Mo, K. Palanichamy, B. Kaur, J. Yu, S. O. Yoon, I. Nakano, C.-H. Kwon, Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells. Neuro Oncol. 16, 1354-1364 (2014).
-
(2014)
Neuro Oncol.
, vol.16
, pp. 1354-1364
-
-
Kim, T.H.1
Song, J.2
Kim, S.-H.3
Parikh, A.K.4
Mo, X.5
Palanichamy, K.6
Kaur, B.7
Yu, J.8
Yoon, S.O.9
Nakano, I.10
Kwon, C.-H.11
-
160
-
-
84916881536
-
Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy
-
E. B. Golden, H.-Y. Cho, A. Jahanian, F. M. Hofman, S. G. Louie, A. H. Schönthal, T. C. Chen, Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy. Neurosurg. Focus 37, E12 (2014).
-
(2014)
Neurosurg. Focus
, vol.37
, pp. E12
-
-
Golden, E.B.1
Cho, H.-Y.2
Jahanian, A.3
Hofman, F.M.4
Louie, S.G.5
Schönthal, A.H.6
Chen, T.C.7
-
161
-
-
33746238112
-
OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells
-
A. Yacoub, M. A. Park, D. Hanna, Y. Hong, C. Mitchell, A. P. Pandya, H. Harada, G. Powis, C.-S. Chen, C. Koumenis, S. Grant, P. Dent, OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells. Mol. Pharmacol. 70, 589-603 (2006).
-
(2006)
Mol. Pharmacol.
, vol.70
, pp. 589-603
-
-
Yacoub, A.1
Park, M.A.2
Hanna, D.3
Hong, Y.4
Mitchell, C.5
Pandya, A.P.6
Harada, H.7
Powis, G.8
Chen, C.-S.9
Koumenis, C.10
Grant, S.11
Dent, P.12
-
162
-
-
84921695231
-
PDE5 inhibitors enhance celecoxib killing in multiple tumor types
-
L. Booth, J. L. Roberts, N. Cruickshanks, S. Tavallai, T. Webb, P. Samuel, A. Conley, B. Binion, H. F. Young, A. Poklepovic, S. Spiegel, P. Dent, PDE5 inhibitors enhance celecoxib killing in multiple tumor types. J. Cell. Physiol. 230, 1115-1127 (2015).
-
(2015)
J. Cell. Physiol.
, vol.230
, pp. 1115-1127
-
-
Booth, L.1
Roberts, J.L.2
Cruickshanks, N.3
Tavallai, S.4
Webb, T.5
Samuel, P.6
Conley, A.7
Binion, B.8
Young, H.F.9
Poklepovic, A.10
Spiegel, S.11
Dent, P.12
-
163
-
-
63049126568
-
Differential genomic and proteomic profiling of glioblastoma cells exposed to terpyridineplatinum(II) complexes
-
S. Koncarevic, S. Urig, K. Steiner, S. Rahlfs, C. Herold-Mende, H. Sueltmann, K. Becker, Differential genomic and proteomic profiling of glioblastoma cells exposed to terpyridineplatinum(II) complexes. Free Radic. Biol. Med. 46, 1096-1108 (2009).
-
(2009)
Free Radic. Biol. Med.
, vol.46
, pp. 1096-1108
-
-
Koncarevic, S.1
Urig, S.2
Steiner, K.3
Rahlfs, S.4
Herold-Mende, C.5
Sueltmann, H.6
Becker, K.7
-
164
-
-
84927755659
-
A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy
-
J. Noack, J. Choi, K. Richter, A. Kopp-Schneider, A. Régnier-Vigouroux, A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy. Cell Death Dis. 5, e1425 (2014).
-
(2014)
Cell Death Dis.
, vol.5
, pp. e1425
-
-
Noack, J.1
Choi, J.2
Richter, K.3
Kopp-Schneider, A.4
Régnier-Vigouroux, A.5
-
165
-
-
85032065520
-
ET-71 the antitumor effects of withaferin a in glioblastoma stem cells
-
B. Zhang, S. Shah, J. Prince, W. Walters, A. Bregy, Y. Guo, R. J. Komatar, R. M. Graham, ET-71 the antitumor effects of withaferin a in glioblastoma stem cells. Neuro Oncol. 16, v94-v95 (2014).
-
(2014)
Neuro Oncol.
, vol.16
, pp. v94-v95
-
-
Zhang, B.1
Shah, S.2
Prince, J.3
Walters, W.4
Bregy, A.5
Guo, Y.6
Komatar, R.J.7
Graham, R.M.8
-
166
-
-
33751173430
-
Altered gene expression induced by ionizing radiation and glycolytic inhibitor 2-deoxy-glucose in a human glioma cell line: Implications for radio sensitization
-
K. Heminger, V. Jain, M. Kadakia, B. Dwarakanath, S. J. Berberich, Altered gene expression induced by ionizing radiation and glycolytic inhibitor 2-deoxy-glucose in a human glioma cell line: Implications for radio sensitization. Cancer Biol. Ther. 5, 815-823 (2006).
-
(2006)
Cancer Biol. Ther.
, vol.5
, pp. 815-823
-
-
Heminger, K.1
Jain, V.2
Kadakia, M.3
Dwarakanath, B.4
Berberich, S.J.5
-
167
-
-
84974792533
-
Synergistic increase in efficacy of a combination of 2-deoxy-D-glucose and cisplatin in normoxia and hypoxia: Switch from autophagy to apoptosis
-
A. Jalota, M. Kumar, B. C. Das, A. K. Yadav, K. Chosdol, S. Sinha, Synergistic increase in efficacy of a combination of 2-deoxy-D-glucose and cisplatin in normoxia and hypoxia: Switch from autophagy to apoptosis. Tumour Biol. 37, 12347-12358 (2016).
-
(2016)
Tumour Biol.
, vol.37
, pp. 12347-12358
-
-
Jalota, A.1
Kumar, M.2
Das, B.C.3
Yadav, A.K.4
Chosdol, K.5
Sinha, S.6
-
168
-
-
84868145921
-
2-hydroxyoleic acid induces ER stress and autophagy in various human glioma cell lines
-
A. Marcilla-Etxenike, M. L. Martin, M. A. Noguera-Salvà, J. M. García-Verdugo, M. Soriano-Navarro, I. Dey, P. V. Escribà, X. Busquets, 2-Hydroxyoleic acid induces ER stress and autophagy in various human glioma cell lines. PLOS ONE 7, e48235 (2012).
-
(2012)
PLOS ONE
, vol.7
, pp. e48235
-
-
Marcilla-Etxenike, A.1
Martin, M.L.2
Noguera-Salvà, M.A.3
García-Verdugo, J.M.4
Soriano-Navarro, M.5
Dey, I.6
Escribà, P.V.7
Busquets, X.8
-
169
-
-
78149282077
-
The neuro-steroid, 5-androstene 3β,17α diol; induces endoplasmic reticulum stress and autophagy through PERK/eIF2α signaling in malignant glioma cells and transformed fibroblasts
-
W. Jia, R. M. Loria, M. A. Park, A. Yacoub, P. Dent, M. R. Graf, The neuro-steroid, 5-androstene 3β,17α diol; induces endoplasmic reticulum stress and autophagy through PERK/eIF2α signaling in malignant glioma cells and transformed fibroblasts. Int. J. Biochem. Cell Biol. 42, 2019-2029 (2010).
-
(2010)
Int. J. Biochem. Cell Biol.
, vol.42
, pp. 2019-2029
-
-
Jia, W.1
Loria, R.M.2
Park, M.A.3
Yacoub, A.4
Dent, P.5
Graf, M.R.6
-
170
-
-
79955762933
-
Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation
-
I. Y. Kim, Y. J. Kang, M. J. Yoon, E. H. Kim, S. U. Kim, T. K. Kwon, I. A. Kim, K. S. Choi, Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 13, 267-279 (2011).
-
(2011)
Neuro Oncol.
, vol.13
, pp. 267-279
-
-
Kim, I.Y.1
Kang, Y.J.2
Yoon, M.J.3
Kim, E.H.4
Kim, S.U.5
Kwon, T.K.6
Kim, I.A.7
Choi, K.S.8
-
171
-
-
84865180666
-
Molecular mechanism of cytotoxicity induced by hsp90-targeted antp-TPR hybrid peptide in glioblastoma cells
-
T. Horibe, A. Torisawa, M. Kohno, K. Kawakami, Molecular mechanism of cytotoxicity induced by Hsp90-targeted Antp-TPR hybrid peptide in glioblastoma cells. Mol. Cancer 11, 59 (2012).
-
(2012)
Mol. Cancer
, vol.11
, pp. 59
-
-
Horibe, T.1
Torisawa, A.2
Kohno, M.3
Kawakami, K.4
-
172
-
-
77957998671
-
Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction
-
K. S. Eom, H.-J. Kim, H. S. So, R. Park, T. Y. Kim, Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction. Biol. Pharm. Bull. 33, 1644-1649 (2010).
-
(2010)
Biol. Pharm. Bull.
, vol.33
, pp. 1644-1649
-
-
Eom, K.S.1
Kim, H.-J.2
So, H.S.3
Park, R.4
Kim, T.Y.5
-
173
-
-
67649415924
-
Involvement of reactive oxygen species and caspasedependent pathway in berberine-induced cell cycle arrest and apoptosis in C6 rat glioma cells
-
T.-C. Chen, K.-C. Lai, J.-S. Yang, C.-L. Liao, T.-C. Hsia, G.-W. Chen, J.-J. Lin, H.-J. Lin, T.-H. Chiu, Y.-J. Tang, J.-G. Chung, Involvement of reactive oxygen species and caspasedependent pathway in berberine-induced cell cycle arrest and apoptosis in C6 rat glioma cells. Int. J. Oncol. 34, 1681-1690 (2009).
-
(2009)
Int. J. Oncol.
, vol.34
, pp. 1681-1690
-
-
Chen, T.-C.1
Lai, K.-C.2
Yang, J.-S.3
Liao, C.-L.4
Hsia, T.-C.5
Chen, G.-W.6
Lin, J.-J.7
Lin, H.-J.8
Chiu, T.-H.9
Tang, Y.-J.10
Chung, J.-G.11
-
174
-
-
84896721859
-
Bufalin induces the interplay between apoptosis and autophagy in glioma cells through endoplasmic reticulum stress
-
S. Shen, Y. Zhang, Z. Wang, R. Liu, X. Gong, Bufalin induces the interplay between apoptosis and autophagy in glioma cells through endoplasmic reticulum stress. Int. J. Biol. Sci. 10, 212-224 (2014).
-
(2014)
Int. J. Biol. Sci.
, vol.10
, pp. 212-224
-
-
Shen, S.1
Zhang, Y.2
Wang, Z.3
Liu, R.4
Gong, X.5
-
175
-
-
51749085130
-
Induction of apoptosis in human cancer cells by candidaspongiolide, a novel sponge polyketide
-
D. Trisciuoglio, B. Uranchimeg, J. H. Cardellina, T. L. Meragelman, S. Matsunaga, N. Fusetani, D. Del Bufalo, R. H. Shoemaker, G. Melillo, Induction of apoptosis in human cancer cells by candidaspongiolide, a novel sponge polyketide. J. Natl. Cancer Inst. 100, 1233-1246 (2008).
-
(2008)
J. Natl. Cancer Inst.
, vol.100
, pp. 1233-1246
-
-
Trisciuoglio, D.1
Uranchimeg, B.2
Cardellina, J.H.3
Meragelman, T.L.4
Matsunaga, S.5
Fusetani, N.6
Del Bufalo, D.7
Shoemaker, R.H.8
Melillo, G.9
-
176
-
-
84901012573
-
Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells
-
S. Boridy, P. U. Le, K. Petrecca, D. Maysinger, Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells. Cell Death Dis. 5, e1216 (2014).
-
(2014)
Cell Death Dis.
, vol.5
, pp. e1216
-
-
Boridy, S.1
Le, P.U.2
Petrecca, K.3
Maysinger, D.4
-
177
-
-
84883183250
-
Celecoxib enhances radiosensitivity of hypoxic glioblastoma cells through endoplasmic reticulum stress
-
K. Suzuki, A. Gerelchuluun, Z. Hong, L. Sun, J. Zenkoh, T. Moritake, K. Tsuboi, Celecoxib enhances radiosensitivity of hypoxic glioblastoma cells through endoplasmic reticulum stress. Neuro Oncol. 15, 1186-1199 (2013).
-
(2013)
Neuro Oncol.
, vol.15
, pp. 1186-1199
-
-
Suzuki, K.1
Gerelchuluun, A.2
Hong, Z.3
Sun, L.4
Zenkoh, J.5
Moritake, T.6
Tsuboi, K.7
-
178
-
-
17044407040
-
Differential profiles of copper-induced ROS generation in human neuroblastoma and astrocytoma cells
-
Y. Qian, Y. Zheng, L. Abraham, K. S. Ramos, E. Tiffany-Castiglioni, Differential profiles of copper-induced ROS generation in human neuroblastoma and astrocytoma cells. Brain Res. Mol. Brain Res. 134, 323-332 (2005).
-
(2005)
Brain Res. Mol. Brain Res.
, vol.134
, pp. 323-332
-
-
Qian, Y.1
Zheng, Y.2
Abraham, L.3
Ramos, K.S.4
Tiffany-Castiglioni, E.5
-
179
-
-
80052715123
-
Synthetic triterpenoid cyano enone of methyl boswellate activates intrinsic, extrinsic, and endoplasmic reticulum stress cell death pathways in tumor cell lines
-
P. Ravanan, R. Sano, P. Talwar, S. Ogasawara, S.-i. Matsuzawa, M. Cuddy, S. K. Singh, G. S. R. Rao, P. Kondaiah, J. C. Reed, Synthetic triterpenoid cyano enone of methyl boswellate activates intrinsic, extrinsic, and endoplasmic reticulum stress cell death pathways in tumor cell lines. Mol. Cancer Ther. 10, 1635-1643 (2011).
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 1635-1643
-
-
Ravanan, P.1
Sano, R.2
Talwar, P.3
Ogasawara, S.4
Matsuzawa, S.-I.5
Cuddy, M.6
Singh, S.K.7
Rao, G.S.R.8
Kondaiah, P.9
Reed, J.C.10
-
180
-
-
84922318940
-
Fatsioside A inhibits the growth of glioma cells via the induction of endoplasmic reticulum stress-mediated apoptosis
-
J.-M. Pan, L. Zhou, G.-B. Wang, G.-W. Xia, K. Xue, X.-G. Cui, H.-Z. Shi, J. H. Liu, J. Hu, Fatsioside A inhibits the growth of glioma cells via the induction of endoplasmic reticulum stress-mediated apoptosis. Mol. Med. Rep. 11, 3493-3498 (2015).
-
(2015)
Mol. Med. Rep.
, vol.11
, pp. 3493-3498
-
-
Pan, J.-M.1
Zhou, L.2
Wang, G.-B.3
Xia, G.-W.4
Xue, K.5
Cui, X.-G.6
Shi, H.-Z.7
Liu, J.H.8
Hu, J.9
-
181
-
-
84976467592
-
Fluoxetine synergizes with temozolomide to induce the CHOP-dependent endoplasmic reticulum stress-related apoptosis pathway in glioma cells
-
J. Ma, Y.-R. Yang, W. Chen, M.-H. Chen, H. Wang, X.-D. Wang, L.-L. Sun, F.-Z. Wang, D.-C. Wang, Fluoxetine synergizes with temozolomide to induce the CHOP-dependent endoplasmic reticulum stress-related apoptosis pathway in glioma cells. Oncol. Rep. 36, 676-684 (2016).
-
(2016)
Oncol. Rep.
, vol.36
, pp. 676-684
-
-
Ma, J.1
Yang, Y.-R.2
Chen, W.3
Chen, M.-H.4
Wang, H.5
Wang, X.-D.6
Sun, L.-L.7
Wang, F.-Z.8
Wang, D.-C.9
-
182
-
-
77955578557
-
Glucosamine induces autophagic cell death through the stimulation of ER stress in human glioma cancer cells
-
M.-S. Hwang, W.-K. Baek, Glucosamine induces autophagic cell death through the stimulation of ER stress in human glioma cancer cells. Biochem. Biophys. Res. Commun. 399, 111-116 (2010).
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.399
, pp. 111-116
-
-
Hwang, M.-S.1
Baek, W.-K.2
-
183
-
-
36348961452
-
HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress
-
P. Pyrko, A. Kardosh, W. Wang, W. Xiong, A. H. Schönthal, T. C. Chen, HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress. Cancer Res. 67, 10920-10928 (2007).
-
(2007)
Cancer Res.
, vol.67
, pp. 10920-10928
-
-
Pyrko, P.1
Kardosh, A.2
Wang, W.3
Xiong, W.4
Schönthal, A.H.5
Chen, T.C.6
-
184
-
-
84883194899
-
Inhibition of glioma growth by minocycline is mediated through endoplasmic reticulum stress-induced apoptosis and autophagic cell death
-
W.-T. Liu, C.-Y. Huang, I.-C. Lu, P.-W. Gean, Inhibition of glioma growth by minocycline is mediated through endoplasmic reticulum stress-induced apoptosis and autophagic cell death. Neuro Oncol. 15, 1127-1141 (2013).
-
(2013)
Neuro Oncol.
, vol.15
, pp. 1127-1141
-
-
Liu, W.-T.1
Huang, C.-Y.2
Lu, I.-C.3
Gean, P.-W.4
-
185
-
-
84922359898
-
PEITC induces apoptosis of human brain glioblastoma GBM8401 cells through the extrinsic- and intrinsic-signaling pathways
-
Y.-C. Chou, M.-Y. Chang, M.-J. Wang, T. Harnod, C.-H. Hung, H.-T. Lee, C.-C. Shen, J.-G. Chung, PEITC induces apoptosis of Human Brain Glioblastoma GBM8401 Cells through the extrinsic- and intrinsic-signaling pathways. Neurochem. Int. 81, 32-40 (2015).
-
(2015)
Neurochem. Int.
, vol.81
, pp. 32-40
-
-
Chou, Y.-C.1
Chang, M.-Y.2
Wang, M.-J.3
Harnod, T.4
Hung, C.-H.5
Lee, H.-T.6
Shen, C.-C.7
Chung, J.-G.8
-
186
-
-
84951849798
-
Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells
-
Y.-C. Chou, M.-Y. Chang, M.-J. Wang, H.-C. Liu, S.-J. Chang, T. Harnod, C.-H. Hung, H.-T. Lee, C.-C. Shen, J.-G. Chung, Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells. Environ. Toxicol. 32, 176-187 (2015).
-
(2015)
Environ. Toxicol.
, vol.32
, pp. 176-187
-
-
Chou, Y.-C.1
Chang, M.-Y.2
Wang, M.-J.3
Liu, H.-C.4
Chang, S.-J.5
Harnod, T.6
Hung, C.-H.7
Lee, H.-T.8
Shen, C.-C.9
Chung, J.-G.10
-
187
-
-
84941958209
-
PEITC inhibits human brain glioblastoma GBM 8401 cell migration and invasion through the inhibition of uPA, rho A, and ras with inhibition of MMP-2, -7 and -9 gene expression
-
Y.-C. Chou, M.-Y. Chang, M.-J. Wang, F.-S. Yu, H.-C. Liu, T. Harnod, C.-H. Hung, H.-T. Lee, J.-G. Chung, PEITC inhibits human brain glioblastoma GBM 8401 cell migration and invasion through the inhibition of uPA, Rho A, and Ras with inhibition of MMP-2, -7 and -9 gene expression. Oncol. Rep. 34, 2489-2496 (2015).
-
(2015)
Oncol. Rep.
, vol.34
, pp. 2489-2496
-
-
Chou, Y.-C.1
Chang, M.-Y.2
Wang, M.-J.3
Yu, F.-S.4
Liu, H.-C.5
Harnod, T.6
Hung, C.-H.7
Lee, H.-T.8
Chung, J.-G.9
-
188
-
-
84881531214
-
Monensin, a polyether ionophore antibiotic, overcomes TRAIL resistance in glioma cells via endoplasmic reticulum stress, DR5 upregulation and c-FLIP downregulation
-
M. J. Yoon, Y. J. Kang, I. Y. Kim, E. H. Kim, J. A. Lee, J. H. Lim, T. K. Kwon, K. S. Choi, Monensin, a polyether ionophore antibiotic, overcomes TRAIL resistance in glioma cells via endoplasmic reticulum stress, DR5 upregulation and c-FLIP downregulation. Carcinogenesis 34, 1918-1928 (2013).
-
(2013)
Carcinogenesis
, vol.34
, pp. 1918-1928
-
-
Yoon, M.J.1
Kang, Y.J.2
Kim, I.Y.3
Kim, E.H.4
Lee, J.A.5
Lim, J.H.6
Kwon, T.K.7
Choi, K.S.8
-
189
-
-
84866415246
-
The novel phloroglucinol derivative BFP induces apoptosis of glioma cancer through reactive oxygen species and endoplasmic reticulum stress pathways
-
D.-Y. Lu, C.-S. Chang, W.-L. Yeh, C.-H. Tang, C.-W. Cheung, Y.-M. Leung, J.-F. Liu, K.-L. Wong, The novel phloroglucinol derivative BFP induces apoptosis of glioma cancer through reactive oxygen species and endoplasmic reticulum stress pathways. Phytomedicine 19, 1093-1100 (2012).
-
(2012)
Phytomedicine
, vol.19
, pp. 1093-1100
-
-
Lu, D.-Y.1
Chang, C.-S.2
Yeh, W.-L.3
Tang, C.-H.4
Cheung, C.-W.5
Leung, Y.-M.6
Liu, J.-F.7
Wong, K.-L.8
-
190
-
-
84929648600
-
Quinoline-based antimalarial drugs: A novel class of autophagy inhibitors
-
E. B. Golden, H.-Y. Cho, F. M. Hofman, S. G. Louie, A. H. Schönthal, T. C. Chen, Quinoline-based antimalarial drugs: A novel class of autophagy inhibitors. Neurosurg. Focus 38, E12 (2015).
-
(2015)
Neurosurg. Focus
, vol.38
, pp. E12
-
-
Golden, E.B.1
Cho, H.-Y.2
Hofman, F.M.3
Louie, S.G.4
Schönthal, A.H.5
Chen, T.C.6
-
191
-
-
84863101358
-
The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2/Beclin 1 interaction in human glioma U251 cells
-
J.-t. Zhong, Y. Xu, H.-w. Yi, J. Su, H.-m. Yu, X.-y. Xiang, X.-n. Li, Z.-c. Zhang, L.-k. Sun, The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2/Beclin 1 interaction in human glioma U251 cells. Cancer Lett. 323, 180-187 (2012).
-
(2012)
Cancer Lett.
, vol.323
, pp. 180-187
-
-
Zhong, J.-T.1
Xu, Y.2
Yi, H.-W.3
Su, J.4
Yu, H.-M.5
Xiang, X.-Y.6
Li, X.-N.7
Zhang, Z.-C.8
Sun, L.-K.9
-
192
-
-
84862570792
-
Functional evaluation of a fluorescent schweinfurthin: Mechanism of cytotoxicity and intracellular quantification
-
C. H. Kuder, R. M. Sheehy, J. D. Neighbors, D. F. Wiemer, R. J. Hohl, Functional evaluation of a fluorescent schweinfurthin: Mechanism of cytotoxicity and intracellular quantification. Mol. Pharmacol. 82, 9-16 (2012).
-
(2012)
Mol. Pharmacol.
, vol.82
, pp. 9-16
-
-
Kuder, C.H.1
Sheehy, R.M.2
Neighbors, J.D.3
Wiemer, D.F.4
Hohl, R.J.5
-
193
-
-
84872607629
-
2+ ATPase, induces endoplasmic reticulum stress response, and exerts toxicity in glioma cells: Relevant similarities to and important differences from celecoxib
-
2+ ATPase, induces endoplasmic reticulum stress response, and exerts toxicity in glioma cells: Relevant similarities to and important differences from celecoxib. J. Neurosci. Res. 91, 393-406 (2013).
-
(2013)
J. Neurosci. Res.
, vol.91
, pp. 393-406
-
-
White, M.C.1
Johnson, G.G.2
Zhang, W.3
Hobrath, J.V.4
Piazza, G.A.5
Grimaldi, M.6
-
194
-
-
84908161732
-
Combination of unsaturated fatty acids and ionizing radiation on human glioma cells: Cellular, biochemical and gene expression analysis
-
O. Antal, L. Hackler Jr., J. Shen, I. Mán, K. Hideghéty, K. Kitajka, L. G. Puskás, Combination of unsaturated fatty acids and ionizing radiation on human glioma cells: Cellular, biochemical and gene expression analysis. Lipids Health Dis. 13, 142 (2014).
-
(2014)
Lipids Health Dis.
, vol.13
, pp. 142
-
-
Antal, O.1
Hackler, L.2
Shen, J.3
Mán, I.4
Hideghéty, K.5
Kitajka, K.6
Puskás, L.G.7
-
195
-
-
84949492494
-
Zoledronic acid induces apoptosis via stimulating the expressions of ERN1, TLR2, and IRF5 genes in glioma cells
-
C. Biray Avci, C. C. Kurt, B. E. Tepedelen, O. Ozalp, B. Goker, Z. Mutlu, Y. Dodurga, L. Elmas, C. Gunduz, Zoledronic acid induces apoptosis via stimulating the expressions of ERN1, TLR2, and IRF5 genes in glioma cells. Tumour Biol. 37, 6673-6679 (2016).
-
(2016)
Tumour Biol.
, vol.37
, pp. 6673-6679
-
-
Biray Avci, C.1
Kurt, C.C.2
Tepedelen, B.E.3
Ozalp, O.4
Goker, B.5
Mutlu, Z.6
Dodurga, Y.7
Elmas, L.8
Gunduz, C.9
-
196
-
-
84901062374
-
Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress
-
S. Shen, Y. Zhang, R. Zhang, X. Tu, X. Gong, Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress. Chem. Biol. Interact. 218, 28-41 (2014).
-
(2014)
Chem. Biol. Interact.
, vol.218
, pp. 28-41
-
-
Shen, S.1
Zhang, Y.2
Zhang, R.3
Tu, X.4
Gong, X.5
-
197
-
-
84893493393
-
Down-modulation of SEL1L, an unfolded protein response and endoplasmic reticulum-associated degradation protein, sensitizes glioma stem cells to the cytotoxic effect of valproic acid
-
M. Cattaneo, S. Baronchelli, D. Schiffer, M. Mellai, V. Caldera, G. J. Saccani, L. Dalpra, A. Daga, R. Orlandi, P. DeBlasio, I. Biunno, Down-modulation of SEL1L, an unfolded protein response and endoplasmic reticulum-associated degradation protein, sensitizes glioma stem cells to the cytotoxic effect of valproic acid. J. Biol. Chem. 289, 2826-2838 (2014).
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 2826-2838
-
-
Cattaneo, M.1
Baronchelli, S.2
Schiffer, D.3
Mellai, M.4
Caldera, V.5
Saccani, G.J.6
Dalpra, L.7
Daga, A.8
Orlandi, R.9
DeBlasio, P.10
Biunno, I.11
-
198
-
-
0033845743
-
Increased expression of endoplasmic reticulum stress proteins following chronic valproate treatment of rat C6 glioma cells
-
C. D. Bown, J.-F. Wang, L. T. Young, Increased expression of endoplasmic reticulum stress proteins following chronic valproate treatment of rat C6 glioma cells. Neuropharmacology 39, 2162-2169 (2000).
-
(2000)
Neuropharmacology
, vol.39
, pp. 2162-2169
-
-
Bown, C.D.1
Wang, J.-F.2
Young, L.T.3
-
199
-
-
84864989279
-
Wogonin induces reactive oxygen species production and cell apoptosis in human glioma cancer cells
-
C. F. Tsai, W. L. Yeh, S. M. Huang, T. W. Tan, D. Y. Lu, Wogonin induces reactive oxygen species production and cell apoptosis in human glioma cancer cells. Int. J. Mol. Sci. 13, 9877-9892 (2012).
-
(2012)
Int. J. Mol. Sci.
, vol.13
, pp. 9877-9892
-
-
Tsai, C.F.1
Yeh, W.L.2
Huang, S.M.3
Tan, T.W.4
Lu, D.Y.5
-
200
-
-
84890861050
-
Yessotoxin induces ER-stress followed by autophagic cell death in glioma cells mediated by mTOR and BNIP3
-
J. A. Rubiolo, H. López-Alonso, P. Martinez, A. Millán, E. Cagide, M. R. Vieytes, F. V. Vega, L. M. Botana, Yessotoxin induces ER-stress followed by autophagic cell death in glioma cells mediated by mTOR and BNIP3. Cell Signal. 26, 419-432 (2013).
-
(2013)
Cell Signal
, vol.26
, pp. 419-432
-
-
Rubiolo, J.A.1
López-Alonso, H.2
Martinez, P.3
Millán, A.4
Cagide, E.5
Vieytes, M.R.6
Vega, F.V.7
Botana, L.M.8
-
201
-
-
0033050865
-
Differential display PCR reveals novel targets for the mood-stabilizing drug valproate including the molecular chaperone GRP78
-
J.-F. Wang, C. Bown, L. T. Young, Differential display PCR reveals novel targets for the mood-stabilizing drug valproate including the molecular chaperone GRP78. Mol. Pharmacol. 55, 521-527 (1999).
-
(1999)
Mol. Pharmacol.
, vol.55
, pp. 521-527
-
-
Wang, J.-F.1
Bown, C.2
Young, L.T.3
-
202
-
-
84867280871
-
ER stress and autophagy contribute to CsA-induced death of malignant glioma cells
-
I. A. Ciechomska, B. Kaminska, ER stress and autophagy contribute to CsA-induced death of malignant glioma cells. Autophagy 8, 1526-1528 (2012).
-
(2012)
Autophagy
, vol.8
, pp. 1526-1528
-
-
Ciechomska, I.A.1
Kaminska, B.2
-
203
-
-
84884213364
-
Endoplasmic reticulum stress triggers autophagy in malignant glioma cells undergoing cyclosporine A-induced cell death
-
I. A. Ciechomska, K. Gabrusiewicz, A. A. Szczepankiewicz, B. Kaminska, Endoplasmic reticulum stress triggers autophagy in malignant glioma cells undergoing cyclosporine A-induced cell death. Oncogene 32, 1518-1529 (2013).
-
(2013)
Oncogene
, vol.32
, pp. 1518-1529
-
-
Ciechomska, I.A.1
Gabrusiewicz, K.2
Szczepankiewicz, A.A.3
Kaminska, B.4
-
204
-
-
84876706245
-
Antidepressant desipramine leads to C6 glioma cell autophagy: Implication for the adjuvant therapy of cancer
-
J. Ma, L.-N. Hou, Z.-X. Rong, P. Liang, C. Fang, H.-F. Li, H. Qi, H.-Z. Chen, Antidepressant desipramine leads to C6 glioma cell autophagy: Implication for the adjuvant therapy of cancer. Anticancer Agents Med Chem. 13, 254-260 (2013).
-
(2013)
Anticancer Agents Med Chem.
, vol.13
, pp. 254-260
-
-
Ma, J.1
Hou, L.-N.2
Rong, Z.-X.3
Liang, P.4
Fang, C.5
Li, H.-F.6
Qi, H.7
Chen, H.-Z.8
-
205
-
-
78651298891
-
Desipramine induces apoptosis in rat glioma cells via endoplasmic reticulum stress-dependent CHOP pathway
-
J. Ma, Y. Qiu, L. Yang, L. Peng, Z. Xia, L.-N. Hou, C. Fang, H. Qi, H.-Z. Chen, Desipramine induces apoptosis in rat glioma cells via endoplasmic reticulum stress-dependent CHOP pathway. J. Neurooncol. 101, 41-48 (2011).
-
(2011)
J. Neurooncol.
, vol.101
, pp. 41-48
-
-
Ma, J.1
Qiu, Y.2
Yang, L.3
Peng, L.4
Xia, Z.5
Hou, L.-N.6
Fang, C.7
Qi, H.8
Chen, H.-Z.9
-
206
-
-
0030028531
-
Interaction of ethanol with inducers of glucose-regulated stress proteins. Ethanol potentiates inducers of grp78 transcription
-
K.-P. Hsieh, N. Wilke, A. Harris, M. F. Miles, Interaction of ethanol with inducers of glucose-regulated stress proteins. Ethanol potentiates inducers of grp78 transcription. J. Biol. Chem. 271, 2709-2716 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 2709-2716
-
-
Hsieh, K.-P.1
Wilke, N.2
Harris, A.3
Miles, M.F.4
-
207
-
-
0028061921
-
Ethanol-responsive genes in neural cells include the 78-kilodalton glucose-regulated protein (GRP78) and 94-kilodalton glucose-regulated protein (GRP94) molecular chaperones
-
M. F. Miles, N. Wilke, M. Elliot, W. Tanner, S. Shah, Ethanol-responsive genes in neural cells include the 78-kilodalton glucose-regulated protein (GRP78) and 94-kilodalton glucose-regulated protein (GRP94) molecular chaperones. Mol. Pharmacol. 46, 873-879 (1994).
-
(1994)
Mol. Pharmacol.
, vol.46
, pp. 873-879
-
-
Miles, M.F.1
Wilke, N.2
Elliot, M.3
Tanner, W.4
Shah, S.5
-
208
-
-
13844265748
-
GRP78 compartmentalized redistribution in Pb-treated glia: Role of GRP78 in lead-induced oxidative stress
-
Y. Qian, Y. Zheng, K. S. Ramos, E. Tiffany-Castiglioni, GRP78 compartmentalized redistribution in Pb-treated glia: Role of GRP78 in lead-induced oxidative stress. Neurotoxicology 26, 267-275 (2005).
-
(2005)
Neurotoxicology
, vol.26
, pp. 267-275
-
-
Qian, Y.1
Zheng, Y.2
Ramos, K.S.3
Tiffany-Castiglioni, E.4
-
209
-
-
0035199528
-
Induction of 78 kD glucose-regulated protein (GRP78) expression and redox-regulated transcription factor activity by lead and mercury in C6 rat glioma cells
-
Y. Qian, M. H. Falahatpisheh, Y. Zheng, K. S. Ramos, E. Tiffany-Castiglioni, Induction of 78 kD glucose-regulated protein (GRP78) expression and redox-regulated transcription factor activity by lead and mercury in C6 rat glioma cells. Neurotox. Res. 3, 581-589 (2001).
-
(2001)
Neurotox. Res.
, vol.3
, pp. 581-589
-
-
Qian, Y.1
Falahatpisheh, M.H.2
Zheng, Y.3
Ramos, K.S.4
Tiffany-Castiglioni, E.5
-
210
-
-
84940591663
-
New oleyl glycoside as anti-cancer agent that targets on neutral sphingomyelinase
-
L. Romero-Ramírez, I. García-Álvarez, J. Casas, M. A. Barreda-Manso, N. Yanguas-Casás, M. Nieto-Sampedro, A. Fernández-Mayoralas, New oleyl glycoside as anti-cancer agent that targets on neutral sphingomyelinase. Biochem. Pharmacol. 97, 158-172 (2015).
-
(2015)
Biochem. Pharmacol.
, vol.97
, pp. 158-172
-
-
Romero-Ramírez, L.1
García-Álvarez, I.2
Casas, J.3
Barreda-Manso, M.A.4
Yanguas-Casás, N.5
Nieto-Sampedro, M.6
Fernández-Mayoralas, A.7
-
211
-
-
84925441663
-
DAW22, a natural sesquiterpene coumarin isolated from ferula ferulaeoides (Steud.) korov. That induces C6 glioma cell apoptosis and endoplasmic reticulum (ER) stress
-
L. Zhang, X. Tong, J. Zhang, J. Huang, J. Wang, DAW22, a natural sesquiterpene coumarin isolated from Ferula ferulaeoides (Steud.) Korov. that induces C6 glioma cell apoptosis and endoplasmic reticulum (ER) stress. Fitoterapia 103, 46-54 (2015).
-
(2015)
Fitoterapia
, vol.103
, pp. 46-54
-
-
Zhang, L.1
Tong, X.2
Zhang, J.3
Huang, J.4
Wang, J.5
-
212
-
-
65349121788
-
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
-
National Cancer Institute of Canada Clinical Trials Group
-
R. Stupp, M. E. Hegi, W. P. Mason, M. J. van den Bent, M. J. Taphoorn, R. C. Janzer, S. K. Ludwin, A. Allgeier, B. Fisher, K. Belanger, P. Hau, A. A. Brandes, J. Gijtenbeek, C. Marosi, C. J. Vecht, K. Mokhtari, P. Wesseling, S. Villa, E. Eisenhauer, T. Gorlia, M. Weller, D. Lacombe, J. G. Cairncross, R.-O. Mirimanoff; European Organisation for Research and Treatment of Cancer Brain Tumour and Radiation Oncology Groups, National Cancer Institute of Canada Clinical Trials Group, Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 10, 459-466 (2009).
-
(2009)
Lancet Oncol.
, vol.10
, pp. 459-466
-
-
Stupp, R.1
Hegi, M.E.2
Mason, W.P.3
Van Den-Bent, M.J.4
Taphoorn, M.J.5
Janzer, R.C.6
Ludwin, S.K.7
Allgeier, A.8
Fisher, B.9
Belanger, K.10
Hau, P.11
Brandes, A.A.12
Gijtenbeek, J.13
Marosi, C.14
Vecht, C.J.15
Mokhtari, K.16
Wesseling, P.17
Villa, S.18
Eisenhauer, E.19
Gorlia, T.20
Weller, M.21
Lacombe, D.22
Cairncross, J.G.23
Mirimanoff, R.-O.24
more..
-
213
-
-
84877129262
-
Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways
-
S. Sun, D. Lee, A. S. W. Ho, J. K. S. Pu, X. Q. Zhang, N. P. Lee, P. J. R. Day, W. M. Lui, C. F. Fung, G. K. K. Leung, Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways. Neuro Oncol. 15, 562-577 (2013).
-
(2013)
Neuro Oncol.
, vol.15
, pp. 562-577
-
-
Sun, S.1
Lee, D.2
Ho, A.S.W.3
Pu, J.K.S.4
Zhang, X.Q.5
Lee, N.P.6
Day, P.J.R.7
Lui, W.M.8
Fung, C.F.9
Leung, G.K.K.10
-
214
-
-
84930033325
-
SEL1L SNP rs12435998, a predictor of glioblastoma survival and response to radio-chemotherapy
-
M. Mellai, M. Cattaneo, A. M. Storaci, L. Annovazzi, P. Cassoni, A. Melcarne, P. De Blasio, D. Schiffer, I. Biunno, SEL1L SNP rs12435998, a predictor of glioblastoma survival and response to radio-chemotherapy. Oncotarget 6, 12452-12467 (2015).
-
(2015)
Oncotarget
, vol.6
, pp. 12452-12467
-
-
Mellai, M.1
Cattaneo, M.2
Storaci, A.M.3
Annovazzi, L.4
Cassoni, P.5
Melcarne, A.6
De Blasio, P.7
Schiffer, D.8
Biunno, I.9
-
215
-
-
33748996534
-
Calreticulin, a molecular chaperone in the endoplasmic reticulum, modulates radiosensitivity of human glioblastoma U251MG cells
-
T. Okunaga, Y. Urata, S. Goto, T. Matsuo, S. Mizota, K. Tsutsumi, I. Nagata, T. Kondo, Y. Ihara, Calreticulin, a molecular chaperone in the endoplasmic reticulum, modulates radiosensitivity of human glioblastoma U251MG cells. Cancer Res. 66, 8662-8671 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 8662-8671
-
-
Okunaga, T.1
Urata, Y.2
Goto, S.3
Matsuo, T.4
Mizota, S.5
Tsutsumi, K.6
Nagata, I.7
Kondo, T.8
Ihara, Y.9
-
216
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
Cancer Genome Atlas Research Network, Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455, 1061-1068 (2008).
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
-
217
-
-
84982124664
-
Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and rad51
-
E. Xipell, T. Aragón, N. Martínez-Velez, B. Vera, M. A. Idoate, J. J. Martínez-Irujo, A. G. Garzón, M. Gonzalez-Huarriz, A. M. Acanda, C. Jones, F. F. Lang, J. Fueyo, C. Gomez-Manzano, M. M. Alonso, Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51. Neuro Oncol. 18, 1109-1119 (2016).
-
(2016)
Neuro Oncol.
, vol.18
, pp. 1109-1119
-
-
Xipell, E.1
Aragón, T.2
Martínez-Velez, N.3
Vera, B.4
Idoate, M.A.5
Martínez-Irujo, J.J.6
Garzón, A.G.7
Gonzalez-Huarriz, M.8
Acanda, A.M.9
Jones, C.10
Lang, F.F.11
Fueyo, J.12
Gomez-Manzano, C.13
Alonso, M.M.14
-
218
-
-
84875811673
-
IPK-mediated attenuation of the proapoptotic PERK-CHOP pathway allows malignant progression upon low glucose
-
IPK-mediated attenuation of the proapoptotic PERK-CHOP pathway allows malignant progression upon low glucose. Mol. Cell 49, 1049-1059 (2013).
-
(2013)
Mol. Cell
, vol.49
, pp. 1049-1059
-
-
Huber, A.-L.1
Lebeau, J.2
Guillaumot, P.3
Pétrilli, V.4
Malek, M.5
Chilloux, J.6
Fauvet, F.7
Payen, L.8
Kfoury, A.9
Renno, T.10
Chevet, E.11
Manié, S.N.12
-
219
-
-
84960193866
-
Adaptive preconditioning in neurological diseases-therapeutic insights from proteostatic perturbations
-
B. Mollereau, N. M. Rzechorzek, B. D. Roussel, M. Sedru, D. M. Van den Brink, B. Bailly-Maitre, F. Palladino, D. B. Medinas, P. M. Domingos, S. Hunot, S. Chandran, S. Birman, T. Baron, D. Vivien, C. B. Duarte, H. D. Ryoo, H. Steller, F. Urano, E. Chevet, G. Kroemer, A. Ciechanover, E. J. Calabrese, R. J. Kaufman, C. Hetz, Adaptive preconditioning in neurological diseases-Therapeutic insights from proteostatic perturbations. Brain Res. 1648, 603-616 (2016).
-
(2016)
Brain Res.
, vol.1648
, pp. 603-616
-
-
Mollereau, B.1
Rzechorzek, N.M.2
Roussel, B.D.3
Sedru, M.4
Van Den-Brink, D.M.5
Bailly-Maitre, B.6
Palladino, F.7
Medinas, D.B.8
Domingos, P.M.9
Hunot, S.10
Chandran, S.11
Birman, S.12
Baron, T.13
Vivien, D.14
Duarte, C.B.15
Ryoo, H.D.16
Steller, H.17
Urano, F.18
Chevet, E.19
Kroemer, G.20
Ciechanover, A.21
Calabrese, E.J.22
Kaufman, R.J.23
Hetz, C.24
more..
|