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Volumn 10, Issue 470, 2017, Pages

Endoplasmic reticulum proteostasis in glioblastoma - From molecular mechanisms to therapeutic perspectives

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ANTINEOPLASTIC AGENT; PROTEIN IRE1; PROTEIN KINASE R; PROTEIN KINASE R LIKE ER KINASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 85016301922     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.aal2323     Document Type: Review
Times cited : (104)

References (219)
  • 3
    • 84881156635 scopus 로고    scopus 로고
    • Prospective evaluation of health-related quality of life in patients with glioblastoma multiforme treated on a phase II trial of hypofractionated IMRT with temozolomide
    • K. Reddy, L. E. Gaspar, B. D. Kavanagh, A. Waziri, D. M. Damek, D. Ney, K. O. Lillehei, C. Chen, Prospective evaluation of health-related quality of life in patients with glioblastoma multiforme treated on a phase II trial of hypofractionated IMRT with temozolomide. J. Neurooncol. 114, 111-116 (2013).
    • (2013) J. Neurooncol. , vol.114 , pp. 111-116
    • Reddy, K.1    Gaspar, L.E.2    Kavanagh, B.D.3    Waziri, A.4    Damek, D.M.5    Ney, D.6    Lillehei, K.O.7    Chen, C.8
  • 5
    • 84971281668 scopus 로고    scopus 로고
    • Gliomas genomics and epigenomics: Arriving at the start and knowing it for the first time
    • M. G. Filbin, M. L. Suva, Gliomas Genomics and Epigenomics: Arriving at the start and knowing it for the first time. Annu. Rev. Pathol. 11, 497-521 (2016).
    • (2016) Annu. Rev. Pathol. , vol.11 , pp. 497-521
    • Filbin, M.G.1    Suva, M.L.2
  • 6
    • 79960656490 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: Enzyme activity, promoter methylation and immunohistochemistry
    • 6-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: Enzyme activity, promoter methylation and immunohistochemistry. Biochim. Biophys. Acta 1816, 179-190 (2011).
    • (2011) Biochim. Biophys. Acta , vol.1816 , pp. 179-190
    • Christmann, M.1    Verbeek, B.2    Roos, W.P.3    Kaina, B.4
  • 7
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the warburg effect: The metabolic requirements of cell proliferation
    • M. G. Vander Heiden, L. C. Cantley, C. B. Thompson, Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 324, 1029-1033 (2009).
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 8
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • D. Hanahan, R. A. Weinberg, Hallmarks of cancer: The next generation. Cell 144, 646-674 (2011).
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 12
    • 84907820400 scopus 로고    scopus 로고
    • Endoplasmic reticulum chaperones and oxidoreductases: Critical regulators of tumor cell survival and immunorecognition
    • T. Gutiérrez, T. Simmen, Endoplasmic reticulum chaperones and oxidoreductases: Critical regulators of tumor cell survival and immunorecognition. Front. Oncol. 4, 291 (2014).
    • (2014) Front. Oncol. , vol.4 , pp. 291
    • Gutiérrez, T.1    Simmen, T.2
  • 13
    • 33645154135 scopus 로고    scopus 로고
    • Cellular response to endoplasmic reticulum stress: A matter of life or death
    • M. Boyce, J. Yuan, Cellular response to endoplasmic reticulum stress: A matter of life or death. Cell Death Differ. 13, 363-373 (2006).
    • (2006) Cell Death Differ. , vol.13 , pp. 363-373
    • Boyce, M.1    Yuan, J.2
  • 14
    • 22244446505 scopus 로고    scopus 로고
    • The mammalian unfolded protein response
    • M. Schröder, R. J. Kaufman, The mammalian unfolded protein response. Annu. Rev. Biochem. 74, 739-789 (2005).
    • (2005) Annu. Rev. Biochem. , vol.74 , pp. 739-789
    • Schröder, M.1    Kaufman, R.J.2
  • 15
    • 0033782015 scopus 로고    scopus 로고
    • Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
    • A. Bertolotti, Y. Zhang, L. M. Hendershot, H. P. Harding, D. Ron, Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol. 2, 326-332 (2000).
    • (2000) Nat. Cell Biol. , vol.2 , pp. 326-332
    • Bertolotti, A.1    Zhang, Y.2    Hendershot, L.M.3    Harding, H.P.4    Ron, D.5
  • 17
    • 84938212067 scopus 로고    scopus 로고
    • Targeting the IRE1α-XBP1 branch of the unfolded protein response in human diseases
    • D. Jiang, M. Niwa, A. C. Koong, Targeting the IRE1α-XBP1 branch of the unfolded protein response in human diseases. Semin. Cancer Biol. 33, 48-56 (2015).
    • (2015) Semin. Cancer Biol. , vol.33 , pp. 48-56
    • Jiang, D.1    Niwa, M.2    Koong, A.C.3
  • 19
    • 82255173966 scopus 로고    scopus 로고
    • The unfolded protein response: From stress pathway to homeostatic regulation
    • P. Walter, D. Ron, The unfolded protein response: From stress pathway to homeostatic regulation. Science 334, 1081-1086 (2011).
    • (2011) Science , vol.334 , pp. 1081-1086
    • Walter, P.1    Ron, D.2
  • 20
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • D. Ron, P. Walter, Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 8, 519-529 (2007).
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 21
    • 79952264011 scopus 로고    scopus 로고
    • Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
    • I. Tabas, D. Ron, Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat. Cell Biol. 13, 184-190 (2011).
    • (2011) Nat. Cell Biol. , vol.13 , pp. 184-190
    • Tabas, I.1    Ron, D.2
  • 22
    • 35448967382 scopus 로고    scopus 로고
    • The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas
    • P. Pyrko, A. H. Schönthal, F. M. Hofman, T. C. Chen, A. S. Lee, The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas. Cancer Res. 67, 9809-9816 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 9809-9816
    • Pyrko, P.1    Schönthal, A.H.2    Hofman, F.M.3    Chen, T.C.4    Lee, A.S.5
  • 26
    • 20444399528 scopus 로고    scopus 로고
    • Expression of endoplasmic reticulum molecular chaperone grp78 in human lung cancer and its clinical significance
    • H. Uramoto, K. Sugio, T. Oyama, S. Nakata, K. Ono, T. Yoshimastu, M. Morita, K. Yasumoto, Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance. Lung Cancer 49, 55-62 (2005).
    • (2005) Lung Cancer , vol.49 , pp. 55-62
    • Uramoto, H.1    Sugio, K.2    Oyama, T.3    Nakata, S.4    Ono, K.5    Yoshimastu, T.6    Morita, M.7    Yasumoto, K.8
  • 28
    • 31044433349 scopus 로고    scopus 로고
    • Overexpression of glucose-regulated protein 78 in colon cancer
    • X. Xing, M. Lai, Y. Wang, E. Xu, Q. Huang, Overexpression of glucose-regulated protein 78 in colon cancer. Clin. Chim. Acta 364, 308-315 (2006).
    • (2006) Clin. Chim. Acta , vol.364 , pp. 308-315
    • Xing, X.1    Lai, M.2    Wang, Y.3    Xu, E.4    Huang, Q.5
  • 29
    • 84938198681 scopus 로고    scopus 로고
    • Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy
    • F. Tameire, I. I. Verginadis, C. Koumenis, Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy. Semin. Cancer Biol. 33, 3-15 (2015).
    • (2015) Semin. Cancer Biol. , vol.33 , pp. 3-15
    • Tameire, F.1    Verginadis, I.I.2    Koumenis, C.3
  • 30
    • 84946222789 scopus 로고    scopus 로고
    • Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer
    • Z. Niu, M. Wang, L. Zhou, L. Yao, Q. Liao, Y. Zhao, Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer. Sci. Rep. 5, 16067 (2015).
    • (2015) Sci. Rep. , vol.5 , pp. 16067
    • Niu, Z.1    Wang, M.2    Zhou, L.3    Yao, L.4    Liao, Q.5    Zhao, Y.6
  • 31
    • 80054969637 scopus 로고    scopus 로고
    • The expression of the endoplasmic reticulum stress sensor BiP/GRP78 predicts response to chemotherapy and determines the efficacy of proteasome inhibitors in diffuse large b-cell lymphoma
    • A. Mozos, G. Roué, A. Lopez-Guillermo, P. Jares, E. Campo, D. Colomer, A. Martinez, The expression of the endoplasmic reticulum stress sensor BiP/GRP78 predicts response to chemotherapy and determines the efficacy of proteasome inhibitors in diffuse large b-cell lymphoma. Am. J. Pathol. 179, 2601-2610 (2011).
    • (2011) Am. J. Pathol. , vol.179 , pp. 2601-2610
    • Mozos, A.1    Roué, G.2    Lopez-Guillermo, A.3    Jares, P.4    Campo, E.5    Colomer, D.6    Martinez, A.7
  • 32
    • 84873729773 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress marker, glucoseregulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival
    • K. Matsuo, M. J. Gray, D. Y. Yang, S. A. Srivastava, P. B. Tripathi, L. A. Sonoda, E.-J. Yoo, L. Dubeau, A. S. Lee, Y. G. Lin, The endoplasmic reticulum stress marker, glucoseregulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival. Gynecol. Oncol. 128, 552-559 (2013).
    • (2013) Gynecol. Oncol. , vol.128 , pp. 552-559
    • Matsuo, K.1    Gray, M.J.2    Yang, D.Y.3    Srivastava, S.A.4    Tripathi, P.B.5    Sonoda, L.A.6    Yoo, E.-J.7    Dubeau, L.8    Lee, A.S.9    Lin, Y.G.10
  • 33
    • 84938211446 scopus 로고    scopus 로고
    • ER proteostasis addiction in cancer biology: Novel concepts
    • E. Dufey, H. Urra, C. Hetz, ER proteostasis addiction in cancer biology: Novel concepts. Semin. Cancer Biol. 33, 40-47 (2015).
    • (2015) Semin. Cancer Biol. , vol.33 , pp. 40-47
    • Dufey, E.1    Urra, H.2    Hetz, C.3
  • 34
    • 84968918504 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the hallmarks of cancer
    • H. Urra, E. Dufey, T. Avril, E. Chevet, C. Hetz, Endoplasmic reticulum stress and the hallmarks of cancer. Trends Cancer 2, 252-262 (2016).
    • (2016) Trends Cancer , vol.2 , pp. 252-262
    • Urra, H.1    Dufey, E.2    Avril, T.3    Chevet, E.4    Hetz, C.5
  • 36
    • 84938203694 scopus 로고    scopus 로고
    • Novel roles of the unfolded protein response in the control of tumor development and aggressiveness
    • N. Dejeans, K. Barroso, M. E. Fernandez-Zapico, A. Samali, E. Chevet, Novel roles of the unfolded protein response in the control of tumor development and aggressiveness. Semin. Cancer Biol. 33, 67-73 (2015).
    • (2015) Semin. Cancer Biol. , vol.33 , pp. 67-73
    • Dejeans, N.1    Barroso, K.2    Fernandez-Zapico, M.E.3    Samali, A.4    Chevet, E.5
  • 39
    • 32944478891 scopus 로고    scopus 로고
    • Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells
    • A. C. Ranganathan, L. Zhang, A. P. Adam, J. A. Aguirre-Ghiso, Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells. Cancer Res. 66, 1702-1711 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 1702-1711
    • Ranganathan, A.C.1    Zhang, L.2    Adam, A.P.3    Aguirre-Ghiso, J.A.4
  • 42
    • 84905241767 scopus 로고    scopus 로고
    • Activating transcription factor 4 promotes esophageal squamous cell carcinoma invasion and metastasis in mice and is associated with poor prognosis in human patients
    • H. Zhu, X. Chen, B. Chen, B. Chen, W. Song, D. Sun, Y. Zhao, Activating transcription factor 4 promotes esophageal squamous cell carcinoma invasion and metastasis in mice and is associated with poor prognosis in human patients. PLOS ONE 9, e103882 (2014).
    • (2014) PLOS ONE , vol.9 , pp. e103882
    • Zhu, H.1    Chen, X.2    Chen, B.3    Chen, B.4    Song, W.5    Sun, D.6    Zhao, Y.7
  • 43
    • 84867562151 scopus 로고    scopus 로고
    • The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway
    • Y. Wang, G. N. Alam, Y. Ning, F. Visioli, Z. Dong, J. E. Nor, P. J. Polverini, The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway. Cancer Res. 72, 5396-5406 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 5396-5406
    • Wang, Y.1    Alam, G.N.2    Ning, Y.3    Visioli, F.4    Dong, Z.5    Nor, J.E.6    Polverini, P.J.7
  • 45
    • 0043133837 scopus 로고    scopus 로고
    • Phosphorylation of the α subunit of eukaryotic initiation factor 2 is required for activation of NF-κB in response to diverse cellular stresses
    • H.-Y. Jiang, S. A. Wek, B. C. McGrath, D. Scheuner, R. J. Kaufman, D. R. Cavener, R. C. Wek, Phosphorylation of the α subunit of eukaryotic initiation factor 2 is required for activation of NF-κB in response to diverse cellular stresses. Mol. Cell. Biol. 23, 5651-5663 (2003).
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 5651-5663
    • Jiang, H.-Y.1    Wek, S.A.2    McGrath, B.C.3    Scheuner, D.4    Kaufman, R.J.5    Cavener, D.R.6    Wek, R.C.7
  • 47
    • 80052227409 scopus 로고    scopus 로고
    • A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1α
    • Z. Xue, Y. He, K. Ye, Z. Gu, Y. Mao, L. Qi, A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1α. J. Biol. Chem. 286, 30859-30866 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 30859-30866
    • Xue, Z.1    He, Y.2    Ye, K.3    Gu, Z.4    Mao, Y.5    Qi, L.6
  • 51
    • 51049121572 scopus 로고    scopus 로고
    • Identification of genes that regulate epithelial cell migration using an siRNA screening approach
    • K. J. Simpson, L. M. Selfors, J. Bui, A. Reynolds, D. Leake, A. Khvorova, J. S. Brugge, Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Nat. Cell Biol. 10, 1027-1038 (2008).
    • (2008) Nat. Cell Biol. , vol.10 , pp. 1027-1038
    • Simpson, K.J.1    Selfors, L.M.2    Bui, J.3    Reynolds, A.4    Leake, D.5    Khvorova, A.6    Brugge, J.S.7
  • 53
    • 33645815074 scopus 로고    scopus 로고
    • Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expression
    • P. Hu, Z. Han, A. D. Couvillon, R. J. Kaufman, J. H. Exton, Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expression. Mol. Cell. Biol. 26, 3071-3084 (2006).
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 3071-3084
    • Hu, P.1    Han, Z.2    Couvillon, A.D.3    Kaufman, R.J.4    Exton, J.H.5
  • 54
    • 77958611209 scopus 로고    scopus 로고
    • Transcriptional and posttranscriptional regulation of proangiogenic factors by the unfolded protein response
    • E. R. Pereira, N. Liao, G. A. Neale, L. M. Hendershot, Transcriptional and posttranscriptional regulation of proangiogenic factors by the unfolded protein response. PLOS ONE 5, e12521 (2010).
    • (2010) PLOS ONE , vol.5 , pp. e12521
    • Pereira, E.R.1    Liao, N.2    Neale, G.A.3    Hendershot, L.M.4
  • 55
  • 56
    • 48749105093 scopus 로고    scopus 로고
    • ATF6α-rheb-mTOR signaling promotes survival of dormant tumor cells in vivo
    • D. M. Schewe, J. A. Aguirre-Ghiso, ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo. Proc. Natl. Acad. Sci. U.S.A. 105, 10519-10524 (2008).
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 10519-10524
    • Schewe, D.M.1    Aguirre-Ghiso, J.A.2
  • 59
    • 84901005666 scopus 로고    scopus 로고
    • VEGF signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress
    • E. Karali, S. Bellou, D. Stellas, A. Klinakis, C. Murphy, T. Fotsis, VEGF signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress. Mol. Cell 54, 559-572 (2014).
    • (2014) Mol. Cell , vol.54 , pp. 559-572
    • Karali, E.1    Bellou, S.2    Stellas, D.3    Klinakis, A.4    Murphy, C.5    Fotsis, T.6
  • 61
    • 0035144493 scopus 로고    scopus 로고
    • Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating bcl2 and perturbing the cellular redox state
    • K. D. McCullough, J. L. Martindale, L.-O. Klotz, T.-Y. Aw, N. J. Holbrook, Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol. Cell. Biol. 21, 1249-1259 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1249-1259
    • McCullough, K.D.1    Martindale, J.L.2    Klotz, L.-O.3    Aw, T.-Y.4    Holbrook, N.J.5
  • 62
    • 1842843855 scopus 로고    scopus 로고
    • Roles of CHOP/GADD153 in endoplasmic reticulum stress
    • S. Oyadomari, M. Mori, Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 11, 381-389 (2004).
    • (2004) Cell Death Differ. , vol.11 , pp. 381-389
    • Oyadomari, S.1    Mori, M.2
  • 64
    • 84905392984 scopus 로고    scopus 로고
    • Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib
    • M. Edagawa, J. Kawauchi, M. Hirata, H. Goshima, M. Inoue, T. Okamoto, A. Murakami, Y. Maehara, S. Kitajima, Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib. J. Biol. Chem. 289, 21544-21561 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 21544-21561
    • Edagawa, M.1    Kawauchi, J.2    Hirata, M.3    Goshima, H.4    Inoue, M.5    Okamoto, T.6    Murakami, A.7    Maehara, Y.8    Kitajima, S.9
  • 65
    • 38849191201 scopus 로고    scopus 로고
    • Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib
    • A. Kardosh, E. B. Golden, P. Pyrko, J. Uddin, F. M. Hofman, T. C. Chen, S. G. Louie, N. A. Petasis, A. H. Schönthal, Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib. Cancer Res. 68, 843-851 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 843-851
    • Kardosh, A.1    Golden, E.B.2    Pyrko, P.3    Uddin, J.4    Hofman, F.M.5    Chen, T.C.6    Louie, S.G.7    Petasis, N.A.8    Schönthal, A.H.9
  • 67
    • 80051686709 scopus 로고    scopus 로고
    • Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
    • X. Tian, J. Ye, M. Alonso-Basanta, S. M. Hahn, C. Koumenis, J. F. Dorsey, Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J. Biol. Chem. 286, 29408-29416 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 29408-29416
    • Tian, X.1    Ye, J.2    Alonso-Basanta, M.3    Hahn, S.M.4    Koumenis, C.5    Dorsey, J.F.6
  • 69
    • 33646491144 scopus 로고    scopus 로고
    • C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation
    • M. Endo, M. Mori, S. Akira, T. Gotoh, C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation. J. Immunol. 176, 6245-6253 (2006).
    • (2006) J. Immunol. , vol.176 , pp. 6245-6253
    • Endo, M.1    Mori, M.2    Akira, S.3    Gotoh, T.4
  • 75
    • 84864865373 scopus 로고    scopus 로고
    • The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress
    • T. Rzymski, A. Petry, D. Kračun, F. Rieß, L. Pike, A. L. Harris, A. Görlach, The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress. Oncogene 31, 3621-3634 (2012).
    • (2012) Oncogene , vol.31 , pp. 3621-3634
    • Rzymski, T.1    Petry, A.2    Kračun, D.3    Rieß, F.4    Pike, L.5    Harris, A.L.6    Görlach, A.7
  • 76
    • 84929090723 scopus 로고    scopus 로고
    • Pancreatic endoplasmic reticulum kinase activation promotes medulloblastoma cell migration and invasion through induction of vascular endothelial growth factor A
    • S. Jamison, Y. Lin, W. Lin, Pancreatic endoplasmic reticulum kinase activation promotes medulloblastoma cell migration and invasion through induction of vascular endothelial growth factor A. PLOS ONE 10, e0120252 (2015).
    • (2015) PLOS ONE , vol.10 , pp. e0120252
    • Jamison, S.1    Lin, Y.2    Lin, W.3
  • 77
    • 84957649544 scopus 로고    scopus 로고
    • The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma
    • D. Y. A. Dadey, V. Kapoor, A. Khudanyan, F. Urano, A. H. Kim, D. Thotala, D. E. Hallahan, The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma. Oncotarget 7, 2080-2092 (2016).
    • (2016) Oncotarget , vol.7 , pp. 2080-2092
    • Dadey, D.Y.A.1    Kapoor, V.2    Khudanyan, A.3    Urano, F.4    Kim, A.H.5    Thotala, D.6    Hallahan, D.E.7
  • 79
    • 84867754321 scopus 로고    scopus 로고
    • ATF4-dependent regulation of the JMJD3 gene during amino acid deprivation can be rescued in ATF4-deficient cells by inhibition of deacetylation
    • J. Shan, L. Fu, M. N. Balasubramanian, T. Anthony, M. S. Kilberg, ATF4-dependent regulation of the JMJD3 gene during amino acid deprivation can be rescued in ATF4-deficient cells by inhibition of deacetylation. J. Biol. Chem. 287, 36393-36403 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 36393-36403
    • Shan, J.1    Fu, L.2    Balasubramanian, M.N.3    Anthony, T.4    Kilberg, M.S.5
  • 80
    • 84942550534 scopus 로고    scopus 로고
    • Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells
    • X. Liu, S. Guo, X. Liu, L. Su, Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells. Apoptosis 20, 1499-1507 (2015).
    • (2015) Apoptosis , vol.20 , pp. 1499-1507
    • Liu, X.1    Guo, S.2    Liu, X.3    Su, L.4
  • 81
    • 84907575515 scopus 로고    scopus 로고
    • Activating transcription factor 3-mediated chemo-intervention with cancer chemokines in a noncanonical pathway under endoplasmic reticulum stress
    • S.-H. Park, J. Kim, K. H. Do, J. Park, C. G. Oh, H. J. Choi, B. G. Song, S. J. Lee, Y. S. Kim, Y. Moon, Activating transcription factor 3-mediated chemo-intervention with cancer chemokines in a noncanonical pathway under endoplasmic reticulum stress. J. Biol. Chem. 289, 27118-27133 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 27118-27133
    • Park, S.-H.1    Kim, J.2    Do, K.H.3    Park, J.4    Oh, C.G.5    Choi, H.J.6    Song, B.G.7    Lee, S.J.8    Kim, Y.S.9    Moon, Y.10
  • 82
    • 84891135307 scopus 로고    scopus 로고
    • HDAC4 protects cells from ER stress induced apoptosis through interaction with ATF4
    • P. Zhang, Q. Sun, C. Zhao, S. Ling, Q. Li, Y.-Z. Chang, Y. Li, HDAC4 protects cells from ER stress induced apoptosis through interaction with ATF4. Cell. Signal. 26, 556-563 (2014).
    • (2014) Cell. Signal , vol.26 , pp. 556-563
    • Zhang, P.1    Sun, Q.2    Zhao, C.3    Ling, S.4    Li, Q.5    Chang, Y.-Z.6    Li, Y.7
  • 83
    • 66849109082 scopus 로고    scopus 로고
    • Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor-induced apoptosis
    • P. Baumeister, D. Dong, Y. Fu, A. S. Lee, Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor-induced apoptosis. Mol. Cancer Ther. 8, 1086-1094 (2009).
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 1086-1094
    • Baumeister, P.1    Dong, D.2    Fu, Y.3    Lee, A.S.4
  • 84
    • 79551474362 scopus 로고    scopus 로고
    • Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation
    • F.-M. Wang, Y.-J. Chen, H.-J. Ouyang, Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation. Biochem. J. 433, 245-252 (2011).
    • (2011) Biochem. J. , vol.433 , pp. 245-252
    • Wang, F.-M.1    Chen, Y.-J.2    Ouyang, H.-J.3
  • 85
    • 62849096067 scopus 로고    scopus 로고
    • The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes
    • Z. Nagy, A. Riss, C. Romier, X. le Guezennec, A. R. Dongre, M. Orpinell, J. Han, H. Stunnenberg, L. Tora, The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes. Mol. Cell. Biol. 29, 1649-1660 (2009).
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 1649-1660
    • Nagy, Z.1    Riss, A.2    Romier, C.3    Le Guezennec, X.4    Dongre, A.R.5    Orpinell, M.6    Han, J.7    Stunnenberg, H.8    Tora, L.9
  • 86
    • 84863329769 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-responsive transcription factor ATF6α directs recruitment of the mediator of RNA polymerase II transcription and multiple histone acetyltransferase complexes
    • D. Sela, L. Chen, S. Martin-Brown, M. P. Washburn, L. Florens, J. W. Conaway, R. C. Conaway, Endoplasmic reticulum stress-responsive transcription factor ATF6α directs recruitment of the Mediator of RNA polymerase II transcription and multiple histone acetyltransferase complexes. J. Biol. Chem. 287, 23035-23045 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 23035-23045
    • Sela, D.1    Chen, L.2    Martin-Brown, S.3    Washburn, M.P.4    Florens, L.5    Conaway, J.W.6    Conaway, R.C.7
  • 87
    • 84883658620 scopus 로고    scopus 로고
    • Role for human mediator subunit MED25 in recruitment of mediator to promoters by endoplasmic reticulum stress-responsive transcription factor ATF6α
    • D. Sela, J. J. Conkright, L. Chen, J. Gilmore, M. P. Washburn, L. Florens, R. C. Conaway, J. W. Conaway, Role for human mediator subunit MED25 in recruitment of mediator to promoters by endoplasmic reticulum stress-responsive transcription factor ATF6α. J. Biol. Chem. 288, 26179-26187 (2013).
    • (2013) J. Biol. Chem. , vol.288 , pp. 26179-26187
    • Sela, D.1    Conkright, J.J.2    Chen, L.3    Gilmore, J.4    Washburn, M.P.5    Florens, L.6    Conaway, R.C.7    Conaway, J.W.8
  • 88
    • 84880730339 scopus 로고    scopus 로고
    • A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation
    • A. W. Schram, R. Baas, P. W. T. C. Jansen, A. Riss, L. Tora, M. Vermeulen, H. T. M. Timmers, A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation. PLOS ONE 8, e70035 (2013).
    • (2013) PLOS ONE , vol.8 , pp. e70035
    • Schram, A.W.1    Baas, R.2    Jansen, P.W.T.C.3    Riss, A.4    Tora, L.5    Vermeulen, M.6    Timmers, H.T.M.7
  • 91
    • 29244491657 scopus 로고    scopus 로고
    • P300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain
    • I. Lassot, E. Estrabaud, S. Emiliani, M. Benkirane, R. Benarous, F. Margottin-Goguet, p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain. J. Biol. Chem. 280, 41537-41545 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 41537-41545
    • Lassot, I.1    Estrabaud, E.2    Emiliani, S.3    Benkirane, M.4    Benarous, R.5    Margottin-Goguet, F.6
  • 92
    • 34347230960 scopus 로고    scopus 로고
    • Reticulon-1C acts as a molecular switch between endoplasmic reticulum stress and genotoxic cell death pathway in human neuroblastoma cells
    • F. Di Sano, B. Fazi, R. Tufi, R. Nardacci, M. Piacentini, Reticulon-1C acts as a molecular switch between endoplasmic reticulum stress and genotoxic cell death pathway in human neuroblastoma cells. J. Neurochem. 102, 345-353 (2007).
    • (2007) J. Neurochem. , vol.102 , pp. 345-353
    • Di Sano, F.1    Fazi, B.2    Tufi, R.3    Nardacci, R.4    Piacentini, M.5
  • 93
    • 70350692123 scopus 로고    scopus 로고
    • Acetylation of RTN-1C regulates the induction of ER stress by the inhibition of HDAC activity in neuroectodermal tumors
    • B. Fazi, S. Melino, S. De Rubeis, C. Bagni, M. Paci, M. Piacentini, F. Di Sano, Acetylation of RTN-1C regulates the induction of ER stress by the inhibition of HDAC activity in neuroectodermal tumors. Oncogene 28, 3814-3824 (2009).
    • (2009) Oncogene , vol.28 , pp. 3814-3824
    • Fazi, B.1    Melino, S.2    De Rubeis, S.3    Bagni, C.4    Paci, M.5    Piacentini, M.6    Di Sano, F.7
  • 94
    • 84877836210 scopus 로고    scopus 로고
    • In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis
    • G. Gargiulo, M. Cesaroni, M. Serresi, N. de Vries, D. Hulsman, S. W. Bruggeman, C. Lancini, M. van Lohuizen, In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis. Cancer Cell 23, 660-676 (2013).
    • (2013) Cancer Cell , vol.23 , pp. 660-676
    • Gargiulo, G.1    Cesaroni, M.2    Serresi, M.3    De Vries, N.4    Hulsman, D.5    Bruggeman, S.W.6    Lancini, C.7    Van Lohuizen, M.8
  • 95
    • 84879155370 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress signaling: The microRNA connection
    • M. Maurel, E. Chevet, Endoplasmic reticulum stress signaling: The microRNA connection. Am. J. Physiol. Cell Physiol. 304, C1117-C1126 (2013).
    • (2013) Am. J. Physiol. Cell Physiol. , vol.304 , pp. C1117-C1126
    • Maurel, M.1    Chevet, E.2
  • 97
    • 84975796689 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis
    • E. Chevet, C. Hetz, A. Samali, Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis. Cancer Discov. 5, 586-597 (2015).
    • (2015) Cancer Discov. , vol.5 , pp. 586-597
    • Chevet, E.1    Hetz, C.2    Samali, A.3
  • 98
    • 84940094034 scopus 로고    scopus 로고
    • Reduced PTEN expression and overexpression of miR-17-5p, -19a-3p, -19b-3p, -21-5p, -130b-3p, -221-3p and -222-3p by glioblastoma stem-like cells following irradiation
    • T. Tokudome, A. Sasaki, M. Tsuji, Y. Udaka, H. Oyamada, H. Tsuchiya, K. Oguchi, Reduced PTEN expression and overexpression of miR-17-5p, -19a-3p, -19b-3p, -21-5p, -130b-3p, -221-3p and -222-3p by glioblastoma stem-like cells following irradiation. Oncol. Lett. 10, 2269-2272 (2015).
    • (2015) Oncol. Lett. , vol.10 , pp. 2269-2272
    • Tokudome, T.1    Sasaki, A.2    Tsuji, M.3    Udaka, Y.4    Oyamada, H.5    Tsuchiya, H.6    Oguchi, K.7
  • 100
    • 84906269634 scopus 로고    scopus 로고
    • MiR-96/HBP1/Wnt/β-catenin regulatory circuitry promotes glioma growth
    • Z. Yan, J. Wang, C. Wang, Y. Jiao, W. Qi, S. Che, miR-96/HBP1/Wnt/β-catenin regulatory circuitry promotes glioma growth. FEBS Lett. 588, 3038-3046 (2014).
    • (2014) FEBS Lett. , vol.588 , pp. 3038-3046
    • Yan, Z.1    Wang, J.2    Wang, C.3    Jiao, Y.4    Qi, W.5    Che, S.6
  • 101
    • 33745893809 scopus 로고    scopus 로고
    • Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response
    • J. Hollien, J. S. Weissman, Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science 313, 104-107 (2006).
    • (2006) Science , vol.313 , pp. 104-107
    • Hollien, J.1    Weissman, J.S.2
  • 103
    • 84934275896 scopus 로고    scopus 로고
    • Proteostasis control by the unfolded protein response
    • C. Hetz, E. Chevet, S. A. Oakes, Proteostasis control by the unfolded protein response. Nat. Cell Biol. 17, 829-838 (2015).
    • (2015) Nat. Cell Biol. , vol.17 , pp. 829-838
    • Hetz, C.1    Chevet, E.2    Oakes, S.A.3
  • 104
    • 33748532939 scopus 로고    scopus 로고
    • The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses
    • S. F. Hussain, D. Yang, D. Suki, K. Aldape, E. Grimm, A. B. Heimberger, The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. Neuro Oncol. 8, 261-279 (2006).
    • (2006) Neuro Oncol. , vol.8 , pp. 261-279
    • Hussain, S.F.1    Yang, D.2    Suki, D.3    Aldape, K.4    Grimm, E.5    Heimberger, A.B.6
  • 105
    • 33747178730 scopus 로고    scopus 로고
    • Characteristics of tumor-associated endothelial cells derived from glioblastoma multiforme
    • C. Charalambous, T. C. Chen, F. M. Hofman, Characteristics of tumor-associated endothelial cells derived from glioblastoma multiforme. Neurosurg. Focus 20, E22 (2006).
    • (2006) Neurosurg. Focus , vol.20 , pp. E22
    • Charalambous, C.1    Chen, T.C.2    Hofman, F.M.3
  • 106
    • 0034093158 scopus 로고    scopus 로고
    • Flow cytometric characterization of tumor-associated macrophages in experimental gliomas
    • B. Badie, J. M. Schartner, Flow cytometric characterization of tumor-associated macrophages in experimental gliomas. Neurosurgery 46, 957-961 (2000).
    • (2000) Neurosurgery , vol.46 , pp. 957-961
    • Badie, B.1    Schartner, J.M.2
  • 107
    • 50249144131 scopus 로고    scopus 로고
    • Possible involvement of the M2 antiinflammatory macrophage phenotype in growth of human gliomas
    • Y. Komohara, K. Ohnishi, J. Kuratsu, M. Takeya, Possible involvement of the M2 antiinflammatory macrophage phenotype in growth of human gliomas. J. Pathol. 216, 15-24 (2008).
    • (2008) J. Pathol. , vol.216 , pp. 15-24
    • Komohara, Y.1    Ohnishi, K.2    Kuratsu, J.3    Takeya, M.4
  • 108
    • 0036187615 scopus 로고    scopus 로고
    • The role of tumour-associated macrophages in tumour progression: Implications for new anticancer therapies
    • L. Bingle, N. J. Brown, C. E. Lewis, The role of tumour-associated macrophages in tumour progression: Implications for new anticancer therapies. J. Pathol. 196, 254-265 (2002).
    • (2002) J. Pathol. , vol.196 , pp. 254-265
    • Bingle, L.1    Brown, N.J.2    Lewis, C.E.3
  • 109
    • 84881504052 scopus 로고    scopus 로고
    • The controversial role of microglia in malignant gliomas
    • J. Wei, K. Gabrusiewicz, A. Heimberger, The controversial role of microglia in malignant gliomas. Clin. Dev. Immunol. 2013, 285246 (2013).
    • (2013) Clin. Dev. Immunol. , vol.2013 , pp. 285246
    • Wei, J.1    Gabrusiewicz, K.2    Heimberger, A.3
  • 110
    • 84855817522 scopus 로고    scopus 로고
    • Immunology in the clinic review series; focus on cancer: Tumour-associated macrophages: Undisputed stars of the inflammatory tumour microenvironment
    • P. Allavena, A. Mantovani, Immunology in the clinic review series; focus on cancer: Tumour-associated macrophages: Undisputed stars of the inflammatory tumour microenvironment. Clin. Exp. Immunol. 167, 195-205 (2012).
    • (2012) Clin. Exp. Immunol. , vol.167 , pp. 195-205
    • Allavena, P.1    Mantovani, A.2
  • 111
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumorassociated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • A. Mantovani, S. Sozzani, M. Locati, P. Allavena, A. Sica, Macrophage polarization: Tumorassociated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23, 549-555 (2002).
    • (2002) Trends Immunol. , vol.23 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 113
    • 84953747412 scopus 로고    scopus 로고
    • The role of microglia and macrophages in glioma maintenance and progression
    • D. Hambardzumyan, D. H. Gutmann, H. Kettenmann, The role of microglia and macrophages in glioma maintenance and progression. Nat. Neurosci. 19, 20-27 (2016).
    • (2016) Nat. Neurosci. , vol.19 , pp. 20-27
    • Hambardzumyan, D.1    Gutmann, D.H.2    Kettenmann, H.3
  • 114
    • 77951290227 scopus 로고    scopus 로고
    • TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
    • F. Martinon, X. Chen, A.-H. Lee, L. H. Glimcher, TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat. Immunol. 11, 411-418 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 411-418
    • Martinon, F.1    Chen, X.2    Lee, A.-H.3    Glimcher, L.H.4
  • 116
    • 78049271424 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression
    • J. C. Goodall, C. Wu, Y. Zhang, L. McNeill, L. Ellis, V. Saudek, J. S. Gaston, Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression. Proc. Natl. Acad. Sci. U.S.A. 107, 17698-17703 (2010).
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 17698-17703
    • Goodall, J.C.1    Wu, C.2    Zhang, Y.3    McNeill, L.4    Ellis, L.5    Saudek, V.6    Gaston, J.S.7
  • 120
    • 47949100421 scopus 로고    scopus 로고
    • KDEL-retained antigen in B lymphocytes induces a proinflammatory response: A possible role for endoplasmic reticulum stress in adaptive T cell immunity
    • M. C. Wheeler, M. Rizzi, R. Sasik, G. Almanza, G. Hardiman, M. Zanetti, KDEL-retained antigen in B lymphocytes induces a proinflammatory response: A possible role for endoplasmic reticulum stress in adaptive T cell immunity. J. Immunol. 181, 256-264 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 256-264
    • Wheeler, M.C.1    Rizzi, M.2    Sasik, R.3    Almanza, G.4    Hardiman, G.5    Zanetti, M.6
  • 124
    • 34948897411 scopus 로고    scopus 로고
    • The transcription factor XBP-1 is essential for the development and survival of dendritic cells
    • N. N. Iwakoshi, M. Pypaert, L. H. Glimcher, The transcription factor XBP-1 is essential for the development and survival of dendritic cells. J. Exp. Med. 204, 2267-2275 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 2267-2275
    • Iwakoshi, N.N.1    Pypaert, M.2    Glimcher, L.H.3
  • 125
    • 84991706068 scopus 로고    scopus 로고
    • STAT3 and STAT6 signaling pathways synergize to promote cathepsin secretion from macrophages via IRE1α activation
    • D. Yan, H.-W. Wang, R. L. Bowman, J. A. Joyce, STAT3 and STAT6 signaling pathways synergize to promote cathepsin secretion from macrophages via IRE1α activation. Cell Rep. 16, 2914-2927 (2016).
    • (2016) Cell Rep. , vol.16 , pp. 2914-2927
    • Yan, D.1    Wang, H.-W.2    Bowman, R.L.3    Joyce, J.A.4
  • 126
    • 84979610111 scopus 로고    scopus 로고
    • Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the golgi apparatus during ER stress
    • C. M. Gallagher, P. Walter, Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress. eLife 5, e11880 (2016).
    • (2016) ELife , vol.5 , pp. e11880
    • Gallagher, C.M.1    Walter, P.2
  • 139
    • 79953288480 scopus 로고    scopus 로고
    • Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis
    • P. Tsaytler, H. P. Harding, D. Ron, A. Bertolotti, Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. Science 332, 91-94 (2011).
    • (2011) Science , vol.332 , pp. 91-94
    • Tsaytler, P.1    Harding, H.P.2    Ron, D.3    Bertolotti, A.4
  • 141
    • 84883387793 scopus 로고    scopus 로고
    • Targeting the unfolded protein response in disease
    • C. Hetz, E. Chevet, H. P. Harding, Targeting the unfolded protein response in disease. Nat. Rev. Drug Discov. 12, 703-719 (2013).
    • (2013) Nat. Rev. Drug Discov. , vol.12 , pp. 703-719
    • Hetz, C.1    Chevet, E.2    Harding, H.P.3
  • 143
    • 54049093229 scopus 로고    scopus 로고
    • SAR study of a novel trieneansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress-induced XBP1 activation
    • T. Kawamura, E. Tashiro, K. Yamamoto, K. Shindo, M. Imoto, SAR study of a novel trieneansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress-induced XBP1 activation. J. Antibiot. 61, 303-311 (2008).
    • (2008) J. Antibiot. , vol.61 , pp. 303-311
    • Kawamura, T.1    Tashiro, E.2    Yamamoto, K.3    Shindo, K.4    Imoto, M.5
  • 144
    • 38449100448 scopus 로고    scopus 로고
    • Trierixin, a novel inhibitor of ER stress-induced XBP1 activation from streptomyces sp. II. Structure elucidation
    • Y. Futamura, E. Tashiro, N. Hironiwa, J. Kohno, M. Nishio, K. Shindo, M. Imoto, Trierixin, a novel Inhibitor of ER stress-induced XBP1 activation from Streptomyces sp. II. structure elucidation. J. Antibiot. 60, 582-585 (2007).
    • (2007) J. Antibiot. , vol.60 , pp. 582-585
    • Futamura, Y.1    Tashiro, E.2    Hironiwa, N.3    Kohno, J.4    Nishio, M.5    Shindo, K.6    Imoto, M.7
  • 146
    • 80052668828 scopus 로고    scopus 로고
    • Peptides derived from the bifunctional kinase/RNase enzyme IRE1α modulate IRE1α activity and protect cells from endoplasmic reticulum stress
    • M. Bouchecareilh, A. Higa, S. Fribourg, M. Moenner, E. Chevet, Peptides derived from the bifunctional kinase/RNase enzyme IRE1α modulate IRE1α activity and protect cells from endoplasmic reticulum stress. FASEB J. 25, 3115-3129 (2011).
    • (2011) FASEB J. , vol.25 , pp. 3115-3129
    • Bouchecareilh, M.1    Higa, A.2    Fribourg, S.3    Moenner, M.4    Chevet, E.5
  • 149
    • 84962034543 scopus 로고    scopus 로고
    • Signaling the unfolded protein response in primary brain cancers
    • P. J. Le Reste, T. Avril, V. Quillien, X. Morandi, E. Chevet, Signaling the unfolded protein response in primary brain cancers. Brain Res. 1642, 59-69 (2016).
    • (2016) Brain Res. , vol.1642 , pp. 59-69
    • Le Reste, P.J.1    Avril, T.2    Quillien, V.3    Morandi, X.4    Chevet, E.5
  • 150
    • 84964258008 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress/unfolded protein response in gliomagenesis, tumor progression and as a therapeutic target in glioblastoma
    • N. M. Peñaranda Fajardo, C. Meijer, F. A. E. Kruyt, The endoplasmic reticulum stress/unfolded protein response in gliomagenesis, tumor progression and as a therapeutic target in glioblastoma. Biochem. Pharmacol. 118, 1-8 (2016).
    • (2016) Biochem. Pharmacol. , vol.118 , pp. 1-8
    • Peñaranda Fajardo, N.M.1    Meijer, C.2    Kruyt, F.A.E.3
  • 155
    • 79951577565 scopus 로고    scopus 로고
    • Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models
    • T. C. Chen, W. Wang, E. B. Golden, S. Thomas, W. Sivakumar, F. M. Hofman, S. G. Louie, A. H. Schönthal, Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models. Cancer Lett. 302, 100-108 (2011).
    • (2011) Cancer Lett. , vol.302 , pp. 100-108
    • Chen, T.C.1    Wang, W.2    Golden, E.B.3    Thomas, S.4    Sivakumar, W.5    Hofman, F.M.6    Louie, S.G.7    Schönthal, A.H.8
  • 156
    • 84905663623 scopus 로고    scopus 로고
    • NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas
    • H.-Y. Cho, W. Wang, N. Jhaveri, D. J. Lee, N. Sharma, L. Dubeau, A. H. Schönthal, F. M. Hofman, T. C. Chen, NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas. Mol. Cancer Ther. 13, 2004-2017 (2014).
    • (2014) Mol. Cancer Ther. , vol.13 , pp. 2004-2017
    • Cho, H.-Y.1    Wang, W.2    Jhaveri, N.3    Lee, D.J.4    Sharma, N.5    Dubeau, L.6    Schönthal, A.H.7    Hofman, F.M.8    Chen, T.C.9
  • 159
    • 84906302724 scopus 로고    scopus 로고
    • Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells
    • T. H. Kim, J. Song, S.-H. Kim, A. K. Parikh, X. Mo, K. Palanichamy, B. Kaur, J. Yu, S. O. Yoon, I. Nakano, C.-H. Kwon, Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells. Neuro Oncol. 16, 1354-1364 (2014).
    • (2014) Neuro Oncol. , vol.16 , pp. 1354-1364
    • Kim, T.H.1    Song, J.2    Kim, S.-H.3    Parikh, A.K.4    Mo, X.5    Palanichamy, K.6    Kaur, B.7    Yu, J.8    Yoon, S.O.9    Nakano, I.10    Kwon, C.-H.11
  • 164
    • 84927755659 scopus 로고    scopus 로고
    • A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy
    • J. Noack, J. Choi, K. Richter, A. Kopp-Schneider, A. Régnier-Vigouroux, A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy. Cell Death Dis. 5, e1425 (2014).
    • (2014) Cell Death Dis. , vol.5 , pp. e1425
    • Noack, J.1    Choi, J.2    Richter, K.3    Kopp-Schneider, A.4    Régnier-Vigouroux, A.5
  • 166
    • 33751173430 scopus 로고    scopus 로고
    • Altered gene expression induced by ionizing radiation and glycolytic inhibitor 2-deoxy-glucose in a human glioma cell line: Implications for radio sensitization
    • K. Heminger, V. Jain, M. Kadakia, B. Dwarakanath, S. J. Berberich, Altered gene expression induced by ionizing radiation and glycolytic inhibitor 2-deoxy-glucose in a human glioma cell line: Implications for radio sensitization. Cancer Biol. Ther. 5, 815-823 (2006).
    • (2006) Cancer Biol. Ther. , vol.5 , pp. 815-823
    • Heminger, K.1    Jain, V.2    Kadakia, M.3    Dwarakanath, B.4    Berberich, S.J.5
  • 167
    • 84974792533 scopus 로고    scopus 로고
    • Synergistic increase in efficacy of a combination of 2-deoxy-D-glucose and cisplatin in normoxia and hypoxia: Switch from autophagy to apoptosis
    • A. Jalota, M. Kumar, B. C. Das, A. K. Yadav, K. Chosdol, S. Sinha, Synergistic increase in efficacy of a combination of 2-deoxy-D-glucose and cisplatin in normoxia and hypoxia: Switch from autophagy to apoptosis. Tumour Biol. 37, 12347-12358 (2016).
    • (2016) Tumour Biol. , vol.37 , pp. 12347-12358
    • Jalota, A.1    Kumar, M.2    Das, B.C.3    Yadav, A.K.4    Chosdol, K.5    Sinha, S.6
  • 169
    • 78149282077 scopus 로고    scopus 로고
    • The neuro-steroid, 5-androstene 3β,17α diol; induces endoplasmic reticulum stress and autophagy through PERK/eIF2α signaling in malignant glioma cells and transformed fibroblasts
    • W. Jia, R. M. Loria, M. A. Park, A. Yacoub, P. Dent, M. R. Graf, The neuro-steroid, 5-androstene 3β,17α diol; induces endoplasmic reticulum stress and autophagy through PERK/eIF2α signaling in malignant glioma cells and transformed fibroblasts. Int. J. Biochem. Cell Biol. 42, 2019-2029 (2010).
    • (2010) Int. J. Biochem. Cell Biol. , vol.42 , pp. 2019-2029
    • Jia, W.1    Loria, R.M.2    Park, M.A.3    Yacoub, A.4    Dent, P.5    Graf, M.R.6
  • 170
    • 79955762933 scopus 로고    scopus 로고
    • Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation
    • I. Y. Kim, Y. J. Kang, M. J. Yoon, E. H. Kim, S. U. Kim, T. K. Kwon, I. A. Kim, K. S. Choi, Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 13, 267-279 (2011).
    • (2011) Neuro Oncol. , vol.13 , pp. 267-279
    • Kim, I.Y.1    Kang, Y.J.2    Yoon, M.J.3    Kim, E.H.4    Kim, S.U.5    Kwon, T.K.6    Kim, I.A.7    Choi, K.S.8
  • 171
    • 84865180666 scopus 로고    scopus 로고
    • Molecular mechanism of cytotoxicity induced by hsp90-targeted antp-TPR hybrid peptide in glioblastoma cells
    • T. Horibe, A. Torisawa, M. Kohno, K. Kawakami, Molecular mechanism of cytotoxicity induced by Hsp90-targeted Antp-TPR hybrid peptide in glioblastoma cells. Mol. Cancer 11, 59 (2012).
    • (2012) Mol. Cancer , vol.11 , pp. 59
    • Horibe, T.1    Torisawa, A.2    Kohno, M.3    Kawakami, K.4
  • 172
    • 77957998671 scopus 로고    scopus 로고
    • Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction
    • K. S. Eom, H.-J. Kim, H. S. So, R. Park, T. Y. Kim, Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction. Biol. Pharm. Bull. 33, 1644-1649 (2010).
    • (2010) Biol. Pharm. Bull. , vol.33 , pp. 1644-1649
    • Eom, K.S.1    Kim, H.-J.2    So, H.S.3    Park, R.4    Kim, T.Y.5
  • 174
    • 84896721859 scopus 로고    scopus 로고
    • Bufalin induces the interplay between apoptosis and autophagy in glioma cells through endoplasmic reticulum stress
    • S. Shen, Y. Zhang, Z. Wang, R. Liu, X. Gong, Bufalin induces the interplay between apoptosis and autophagy in glioma cells through endoplasmic reticulum stress. Int. J. Biol. Sci. 10, 212-224 (2014).
    • (2014) Int. J. Biol. Sci. , vol.10 , pp. 212-224
    • Shen, S.1    Zhang, Y.2    Wang, Z.3    Liu, R.4    Gong, X.5
  • 176
    • 84901012573 scopus 로고    scopus 로고
    • Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells
    • S. Boridy, P. U. Le, K. Petrecca, D. Maysinger, Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells. Cell Death Dis. 5, e1216 (2014).
    • (2014) Cell Death Dis. , vol.5 , pp. e1216
    • Boridy, S.1    Le, P.U.2    Petrecca, K.3    Maysinger, D.4
  • 177
    • 84883183250 scopus 로고    scopus 로고
    • Celecoxib enhances radiosensitivity of hypoxic glioblastoma cells through endoplasmic reticulum stress
    • K. Suzuki, A. Gerelchuluun, Z. Hong, L. Sun, J. Zenkoh, T. Moritake, K. Tsuboi, Celecoxib enhances radiosensitivity of hypoxic glioblastoma cells through endoplasmic reticulum stress. Neuro Oncol. 15, 1186-1199 (2013).
    • (2013) Neuro Oncol. , vol.15 , pp. 1186-1199
    • Suzuki, K.1    Gerelchuluun, A.2    Hong, Z.3    Sun, L.4    Zenkoh, J.5    Moritake, T.6    Tsuboi, K.7
  • 178
    • 17044407040 scopus 로고    scopus 로고
    • Differential profiles of copper-induced ROS generation in human neuroblastoma and astrocytoma cells
    • Y. Qian, Y. Zheng, L. Abraham, K. S. Ramos, E. Tiffany-Castiglioni, Differential profiles of copper-induced ROS generation in human neuroblastoma and astrocytoma cells. Brain Res. Mol. Brain Res. 134, 323-332 (2005).
    • (2005) Brain Res. Mol. Brain Res. , vol.134 , pp. 323-332
    • Qian, Y.1    Zheng, Y.2    Abraham, L.3    Ramos, K.S.4    Tiffany-Castiglioni, E.5
  • 179
    • 80052715123 scopus 로고    scopus 로고
    • Synthetic triterpenoid cyano enone of methyl boswellate activates intrinsic, extrinsic, and endoplasmic reticulum stress cell death pathways in tumor cell lines
    • P. Ravanan, R. Sano, P. Talwar, S. Ogasawara, S.-i. Matsuzawa, M. Cuddy, S. K. Singh, G. S. R. Rao, P. Kondaiah, J. C. Reed, Synthetic triterpenoid cyano enone of methyl boswellate activates intrinsic, extrinsic, and endoplasmic reticulum stress cell death pathways in tumor cell lines. Mol. Cancer Ther. 10, 1635-1643 (2011).
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 1635-1643
    • Ravanan, P.1    Sano, R.2    Talwar, P.3    Ogasawara, S.4    Matsuzawa, S.-I.5    Cuddy, M.6    Singh, S.K.7    Rao, G.S.R.8    Kondaiah, P.9    Reed, J.C.10
  • 180
    • 84922318940 scopus 로고    scopus 로고
    • Fatsioside A inhibits the growth of glioma cells via the induction of endoplasmic reticulum stress-mediated apoptosis
    • J.-M. Pan, L. Zhou, G.-B. Wang, G.-W. Xia, K. Xue, X.-G. Cui, H.-Z. Shi, J. H. Liu, J. Hu, Fatsioside A inhibits the growth of glioma cells via the induction of endoplasmic reticulum stress-mediated apoptosis. Mol. Med. Rep. 11, 3493-3498 (2015).
    • (2015) Mol. Med. Rep. , vol.11 , pp. 3493-3498
    • Pan, J.-M.1    Zhou, L.2    Wang, G.-B.3    Xia, G.-W.4    Xue, K.5    Cui, X.-G.6    Shi, H.-Z.7    Liu, J.H.8    Hu, J.9
  • 181
    • 84976467592 scopus 로고    scopus 로고
    • Fluoxetine synergizes with temozolomide to induce the CHOP-dependent endoplasmic reticulum stress-related apoptosis pathway in glioma cells
    • J. Ma, Y.-R. Yang, W. Chen, M.-H. Chen, H. Wang, X.-D. Wang, L.-L. Sun, F.-Z. Wang, D.-C. Wang, Fluoxetine synergizes with temozolomide to induce the CHOP-dependent endoplasmic reticulum stress-related apoptosis pathway in glioma cells. Oncol. Rep. 36, 676-684 (2016).
    • (2016) Oncol. Rep. , vol.36 , pp. 676-684
    • Ma, J.1    Yang, Y.-R.2    Chen, W.3    Chen, M.-H.4    Wang, H.5    Wang, X.-D.6    Sun, L.-L.7    Wang, F.-Z.8    Wang, D.-C.9
  • 182
    • 77955578557 scopus 로고    scopus 로고
    • Glucosamine induces autophagic cell death through the stimulation of ER stress in human glioma cancer cells
    • M.-S. Hwang, W.-K. Baek, Glucosamine induces autophagic cell death through the stimulation of ER stress in human glioma cancer cells. Biochem. Biophys. Res. Commun. 399, 111-116 (2010).
    • (2010) Biochem. Biophys. Res. Commun. , vol.399 , pp. 111-116
    • Hwang, M.-S.1    Baek, W.-K.2
  • 183
    • 36348961452 scopus 로고    scopus 로고
    • HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress
    • P. Pyrko, A. Kardosh, W. Wang, W. Xiong, A. H. Schönthal, T. C. Chen, HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress. Cancer Res. 67, 10920-10928 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 10920-10928
    • Pyrko, P.1    Kardosh, A.2    Wang, W.3    Xiong, W.4    Schönthal, A.H.5    Chen, T.C.6
  • 184
    • 84883194899 scopus 로고    scopus 로고
    • Inhibition of glioma growth by minocycline is mediated through endoplasmic reticulum stress-induced apoptosis and autophagic cell death
    • W.-T. Liu, C.-Y. Huang, I.-C. Lu, P.-W. Gean, Inhibition of glioma growth by minocycline is mediated through endoplasmic reticulum stress-induced apoptosis and autophagic cell death. Neuro Oncol. 15, 1127-1141 (2013).
    • (2013) Neuro Oncol. , vol.15 , pp. 1127-1141
    • Liu, W.-T.1    Huang, C.-Y.2    Lu, I.-C.3    Gean, P.-W.4
  • 185
    • 84922359898 scopus 로고    scopus 로고
    • PEITC induces apoptosis of human brain glioblastoma GBM8401 cells through the extrinsic- and intrinsic-signaling pathways
    • Y.-C. Chou, M.-Y. Chang, M.-J. Wang, T. Harnod, C.-H. Hung, H.-T. Lee, C.-C. Shen, J.-G. Chung, PEITC induces apoptosis of Human Brain Glioblastoma GBM8401 Cells through the extrinsic- and intrinsic-signaling pathways. Neurochem. Int. 81, 32-40 (2015).
    • (2015) Neurochem. Int. , vol.81 , pp. 32-40
    • Chou, Y.-C.1    Chang, M.-Y.2    Wang, M.-J.3    Harnod, T.4    Hung, C.-H.5    Lee, H.-T.6    Shen, C.-C.7    Chung, J.-G.8
  • 186
    • 84951849798 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells
    • Y.-C. Chou, M.-Y. Chang, M.-J. Wang, H.-C. Liu, S.-J. Chang, T. Harnod, C.-H. Hung, H.-T. Lee, C.-C. Shen, J.-G. Chung, Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells. Environ. Toxicol. 32, 176-187 (2015).
    • (2015) Environ. Toxicol. , vol.32 , pp. 176-187
    • Chou, Y.-C.1    Chang, M.-Y.2    Wang, M.-J.3    Liu, H.-C.4    Chang, S.-J.5    Harnod, T.6    Hung, C.-H.7    Lee, H.-T.8    Shen, C.-C.9    Chung, J.-G.10
  • 187
    • 84941958209 scopus 로고    scopus 로고
    • PEITC inhibits human brain glioblastoma GBM 8401 cell migration and invasion through the inhibition of uPA, rho A, and ras with inhibition of MMP-2, -7 and -9 gene expression
    • Y.-C. Chou, M.-Y. Chang, M.-J. Wang, F.-S. Yu, H.-C. Liu, T. Harnod, C.-H. Hung, H.-T. Lee, J.-G. Chung, PEITC inhibits human brain glioblastoma GBM 8401 cell migration and invasion through the inhibition of uPA, Rho A, and Ras with inhibition of MMP-2, -7 and -9 gene expression. Oncol. Rep. 34, 2489-2496 (2015).
    • (2015) Oncol. Rep. , vol.34 , pp. 2489-2496
    • Chou, Y.-C.1    Chang, M.-Y.2    Wang, M.-J.3    Yu, F.-S.4    Liu, H.-C.5    Harnod, T.6    Hung, C.-H.7    Lee, H.-T.8    Chung, J.-G.9
  • 188
    • 84881531214 scopus 로고    scopus 로고
    • Monensin, a polyether ionophore antibiotic, overcomes TRAIL resistance in glioma cells via endoplasmic reticulum stress, DR5 upregulation and c-FLIP downregulation
    • M. J. Yoon, Y. J. Kang, I. Y. Kim, E. H. Kim, J. A. Lee, J. H. Lim, T. K. Kwon, K. S. Choi, Monensin, a polyether ionophore antibiotic, overcomes TRAIL resistance in glioma cells via endoplasmic reticulum stress, DR5 upregulation and c-FLIP downregulation. Carcinogenesis 34, 1918-1928 (2013).
    • (2013) Carcinogenesis , vol.34 , pp. 1918-1928
    • Yoon, M.J.1    Kang, Y.J.2    Kim, I.Y.3    Kim, E.H.4    Lee, J.A.5    Lim, J.H.6    Kwon, T.K.7    Choi, K.S.8
  • 189
    • 84866415246 scopus 로고    scopus 로고
    • The novel phloroglucinol derivative BFP induces apoptosis of glioma cancer through reactive oxygen species and endoplasmic reticulum stress pathways
    • D.-Y. Lu, C.-S. Chang, W.-L. Yeh, C.-H. Tang, C.-W. Cheung, Y.-M. Leung, J.-F. Liu, K.-L. Wong, The novel phloroglucinol derivative BFP induces apoptosis of glioma cancer through reactive oxygen species and endoplasmic reticulum stress pathways. Phytomedicine 19, 1093-1100 (2012).
    • (2012) Phytomedicine , vol.19 , pp. 1093-1100
    • Lu, D.-Y.1    Chang, C.-S.2    Yeh, W.-L.3    Tang, C.-H.4    Cheung, C.-W.5    Leung, Y.-M.6    Liu, J.-F.7    Wong, K.-L.8
  • 191
    • 84863101358 scopus 로고    scopus 로고
    • The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2/Beclin 1 interaction in human glioma U251 cells
    • J.-t. Zhong, Y. Xu, H.-w. Yi, J. Su, H.-m. Yu, X.-y. Xiang, X.-n. Li, Z.-c. Zhang, L.-k. Sun, The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2/Beclin 1 interaction in human glioma U251 cells. Cancer Lett. 323, 180-187 (2012).
    • (2012) Cancer Lett. , vol.323 , pp. 180-187
    • Zhong, J.-T.1    Xu, Y.2    Yi, H.-W.3    Su, J.4    Yu, H.-M.5    Xiang, X.-Y.6    Li, X.-N.7    Zhang, Z.-C.8    Sun, L.-K.9
  • 192
    • 84862570792 scopus 로고    scopus 로고
    • Functional evaluation of a fluorescent schweinfurthin: Mechanism of cytotoxicity and intracellular quantification
    • C. H. Kuder, R. M. Sheehy, J. D. Neighbors, D. F. Wiemer, R. J. Hohl, Functional evaluation of a fluorescent schweinfurthin: Mechanism of cytotoxicity and intracellular quantification. Mol. Pharmacol. 82, 9-16 (2012).
    • (2012) Mol. Pharmacol. , vol.82 , pp. 9-16
    • Kuder, C.H.1    Sheehy, R.M.2    Neighbors, J.D.3    Wiemer, D.F.4    Hohl, R.J.5
  • 193
    • 84872607629 scopus 로고    scopus 로고
    • 2+ ATPase, induces endoplasmic reticulum stress response, and exerts toxicity in glioma cells: Relevant similarities to and important differences from celecoxib
    • 2+ ATPase, induces endoplasmic reticulum stress response, and exerts toxicity in glioma cells: Relevant similarities to and important differences from celecoxib. J. Neurosci. Res. 91, 393-406 (2013).
    • (2013) J. Neurosci. Res. , vol.91 , pp. 393-406
    • White, M.C.1    Johnson, G.G.2    Zhang, W.3    Hobrath, J.V.4    Piazza, G.A.5    Grimaldi, M.6
  • 194
    • 84908161732 scopus 로고    scopus 로고
    • Combination of unsaturated fatty acids and ionizing radiation on human glioma cells: Cellular, biochemical and gene expression analysis
    • O. Antal, L. Hackler Jr., J. Shen, I. Mán, K. Hideghéty, K. Kitajka, L. G. Puskás, Combination of unsaturated fatty acids and ionizing radiation on human glioma cells: Cellular, biochemical and gene expression analysis. Lipids Health Dis. 13, 142 (2014).
    • (2014) Lipids Health Dis. , vol.13 , pp. 142
    • Antal, O.1    Hackler, L.2    Shen, J.3    Mán, I.4    Hideghéty, K.5    Kitajka, K.6    Puskás, L.G.7
  • 196
    • 84901062374 scopus 로고    scopus 로고
    • Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress
    • S. Shen, Y. Zhang, R. Zhang, X. Tu, X. Gong, Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress. Chem. Biol. Interact. 218, 28-41 (2014).
    • (2014) Chem. Biol. Interact. , vol.218 , pp. 28-41
    • Shen, S.1    Zhang, Y.2    Zhang, R.3    Tu, X.4    Gong, X.5
  • 197
    • 84893493393 scopus 로고    scopus 로고
    • Down-modulation of SEL1L, an unfolded protein response and endoplasmic reticulum-associated degradation protein, sensitizes glioma stem cells to the cytotoxic effect of valproic acid
    • M. Cattaneo, S. Baronchelli, D. Schiffer, M. Mellai, V. Caldera, G. J. Saccani, L. Dalpra, A. Daga, R. Orlandi, P. DeBlasio, I. Biunno, Down-modulation of SEL1L, an unfolded protein response and endoplasmic reticulum-associated degradation protein, sensitizes glioma stem cells to the cytotoxic effect of valproic acid. J. Biol. Chem. 289, 2826-2838 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 2826-2838
    • Cattaneo, M.1    Baronchelli, S.2    Schiffer, D.3    Mellai, M.4    Caldera, V.5    Saccani, G.J.6    Dalpra, L.7    Daga, A.8    Orlandi, R.9    DeBlasio, P.10    Biunno, I.11
  • 198
    • 0033845743 scopus 로고    scopus 로고
    • Increased expression of endoplasmic reticulum stress proteins following chronic valproate treatment of rat C6 glioma cells
    • C. D. Bown, J.-F. Wang, L. T. Young, Increased expression of endoplasmic reticulum stress proteins following chronic valproate treatment of rat C6 glioma cells. Neuropharmacology 39, 2162-2169 (2000).
    • (2000) Neuropharmacology , vol.39 , pp. 2162-2169
    • Bown, C.D.1    Wang, J.-F.2    Young, L.T.3
  • 199
    • 84864989279 scopus 로고    scopus 로고
    • Wogonin induces reactive oxygen species production and cell apoptosis in human glioma cancer cells
    • C. F. Tsai, W. L. Yeh, S. M. Huang, T. W. Tan, D. Y. Lu, Wogonin induces reactive oxygen species production and cell apoptosis in human glioma cancer cells. Int. J. Mol. Sci. 13, 9877-9892 (2012).
    • (2012) Int. J. Mol. Sci. , vol.13 , pp. 9877-9892
    • Tsai, C.F.1    Yeh, W.L.2    Huang, S.M.3    Tan, T.W.4    Lu, D.Y.5
  • 201
    • 0033050865 scopus 로고    scopus 로고
    • Differential display PCR reveals novel targets for the mood-stabilizing drug valproate including the molecular chaperone GRP78
    • J.-F. Wang, C. Bown, L. T. Young, Differential display PCR reveals novel targets for the mood-stabilizing drug valproate including the molecular chaperone GRP78. Mol. Pharmacol. 55, 521-527 (1999).
    • (1999) Mol. Pharmacol. , vol.55 , pp. 521-527
    • Wang, J.-F.1    Bown, C.2    Young, L.T.3
  • 202
    • 84867280871 scopus 로고    scopus 로고
    • ER stress and autophagy contribute to CsA-induced death of malignant glioma cells
    • I. A. Ciechomska, B. Kaminska, ER stress and autophagy contribute to CsA-induced death of malignant glioma cells. Autophagy 8, 1526-1528 (2012).
    • (2012) Autophagy , vol.8 , pp. 1526-1528
    • Ciechomska, I.A.1    Kaminska, B.2
  • 203
    • 84884213364 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress triggers autophagy in malignant glioma cells undergoing cyclosporine A-induced cell death
    • I. A. Ciechomska, K. Gabrusiewicz, A. A. Szczepankiewicz, B. Kaminska, Endoplasmic reticulum stress triggers autophagy in malignant glioma cells undergoing cyclosporine A-induced cell death. Oncogene 32, 1518-1529 (2013).
    • (2013) Oncogene , vol.32 , pp. 1518-1529
    • Ciechomska, I.A.1    Gabrusiewicz, K.2    Szczepankiewicz, A.A.3    Kaminska, B.4
  • 204
    • 84876706245 scopus 로고    scopus 로고
    • Antidepressant desipramine leads to C6 glioma cell autophagy: Implication for the adjuvant therapy of cancer
    • J. Ma, L.-N. Hou, Z.-X. Rong, P. Liang, C. Fang, H.-F. Li, H. Qi, H.-Z. Chen, Antidepressant desipramine leads to C6 glioma cell autophagy: Implication for the adjuvant therapy of cancer. Anticancer Agents Med Chem. 13, 254-260 (2013).
    • (2013) Anticancer Agents Med Chem. , vol.13 , pp. 254-260
    • Ma, J.1    Hou, L.-N.2    Rong, Z.-X.3    Liang, P.4    Fang, C.5    Li, H.-F.6    Qi, H.7    Chen, H.-Z.8
  • 205
    • 78651298891 scopus 로고    scopus 로고
    • Desipramine induces apoptosis in rat glioma cells via endoplasmic reticulum stress-dependent CHOP pathway
    • J. Ma, Y. Qiu, L. Yang, L. Peng, Z. Xia, L.-N. Hou, C. Fang, H. Qi, H.-Z. Chen, Desipramine induces apoptosis in rat glioma cells via endoplasmic reticulum stress-dependent CHOP pathway. J. Neurooncol. 101, 41-48 (2011).
    • (2011) J. Neurooncol. , vol.101 , pp. 41-48
    • Ma, J.1    Qiu, Y.2    Yang, L.3    Peng, L.4    Xia, Z.5    Hou, L.-N.6    Fang, C.7    Qi, H.8    Chen, H.-Z.9
  • 206
    • 0030028531 scopus 로고    scopus 로고
    • Interaction of ethanol with inducers of glucose-regulated stress proteins. Ethanol potentiates inducers of grp78 transcription
    • K.-P. Hsieh, N. Wilke, A. Harris, M. F. Miles, Interaction of ethanol with inducers of glucose-regulated stress proteins. Ethanol potentiates inducers of grp78 transcription. J. Biol. Chem. 271, 2709-2716 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 2709-2716
    • Hsieh, K.-P.1    Wilke, N.2    Harris, A.3    Miles, M.F.4
  • 207
    • 0028061921 scopus 로고
    • Ethanol-responsive genes in neural cells include the 78-kilodalton glucose-regulated protein (GRP78) and 94-kilodalton glucose-regulated protein (GRP94) molecular chaperones
    • M. F. Miles, N. Wilke, M. Elliot, W. Tanner, S. Shah, Ethanol-responsive genes in neural cells include the 78-kilodalton glucose-regulated protein (GRP78) and 94-kilodalton glucose-regulated protein (GRP94) molecular chaperones. Mol. Pharmacol. 46, 873-879 (1994).
    • (1994) Mol. Pharmacol. , vol.46 , pp. 873-879
    • Miles, M.F.1    Wilke, N.2    Elliot, M.3    Tanner, W.4    Shah, S.5
  • 208
    • 13844265748 scopus 로고    scopus 로고
    • GRP78 compartmentalized redistribution in Pb-treated glia: Role of GRP78 in lead-induced oxidative stress
    • Y. Qian, Y. Zheng, K. S. Ramos, E. Tiffany-Castiglioni, GRP78 compartmentalized redistribution in Pb-treated glia: Role of GRP78 in lead-induced oxidative stress. Neurotoxicology 26, 267-275 (2005).
    • (2005) Neurotoxicology , vol.26 , pp. 267-275
    • Qian, Y.1    Zheng, Y.2    Ramos, K.S.3    Tiffany-Castiglioni, E.4
  • 209
    • 0035199528 scopus 로고    scopus 로고
    • Induction of 78 kD glucose-regulated protein (GRP78) expression and redox-regulated transcription factor activity by lead and mercury in C6 rat glioma cells
    • Y. Qian, M. H. Falahatpisheh, Y. Zheng, K. S. Ramos, E. Tiffany-Castiglioni, Induction of 78 kD glucose-regulated protein (GRP78) expression and redox-regulated transcription factor activity by lead and mercury in C6 rat glioma cells. Neurotox. Res. 3, 581-589 (2001).
    • (2001) Neurotox. Res. , vol.3 , pp. 581-589
    • Qian, Y.1    Falahatpisheh, M.H.2    Zheng, Y.3    Ramos, K.S.4    Tiffany-Castiglioni, E.5
  • 211
    • 84925441663 scopus 로고    scopus 로고
    • DAW22, a natural sesquiterpene coumarin isolated from ferula ferulaeoides (Steud.) korov. That induces C6 glioma cell apoptosis and endoplasmic reticulum (ER) stress
    • L. Zhang, X. Tong, J. Zhang, J. Huang, J. Wang, DAW22, a natural sesquiterpene coumarin isolated from Ferula ferulaeoides (Steud.) Korov. that induces C6 glioma cell apoptosis and endoplasmic reticulum (ER) stress. Fitoterapia 103, 46-54 (2015).
    • (2015) Fitoterapia , vol.103 , pp. 46-54
    • Zhang, L.1    Tong, X.2    Zhang, J.3    Huang, J.4    Wang, J.5
  • 213
    • 84877129262 scopus 로고    scopus 로고
    • Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways
    • S. Sun, D. Lee, A. S. W. Ho, J. K. S. Pu, X. Q. Zhang, N. P. Lee, P. J. R. Day, W. M. Lui, C. F. Fung, G. K. K. Leung, Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways. Neuro Oncol. 15, 562-577 (2013).
    • (2013) Neuro Oncol. , vol.15 , pp. 562-577
    • Sun, S.1    Lee, D.2    Ho, A.S.W.3    Pu, J.K.S.4    Zhang, X.Q.5    Lee, N.P.6    Day, P.J.R.7    Lui, W.M.8    Fung, C.F.9    Leung, G.K.K.10
  • 215
    • 33748996534 scopus 로고    scopus 로고
    • Calreticulin, a molecular chaperone in the endoplasmic reticulum, modulates radiosensitivity of human glioblastoma U251MG cells
    • T. Okunaga, Y. Urata, S. Goto, T. Matsuo, S. Mizota, K. Tsutsumi, I. Nagata, T. Kondo, Y. Ihara, Calreticulin, a molecular chaperone in the endoplasmic reticulum, modulates radiosensitivity of human glioblastoma U251MG cells. Cancer Res. 66, 8662-8671 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 8662-8671
    • Okunaga, T.1    Urata, Y.2    Goto, S.3    Matsuo, T.4    Mizota, S.5    Tsutsumi, K.6    Nagata, I.7    Kondo, T.8    Ihara, Y.9
  • 216
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network, Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455, 1061-1068 (2008).
    • (2008) Nature , vol.455 , pp. 1061-1068


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