ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

EMBO Journal

Volumn 24, Issue 19, 2005, Pages 3470-3481

  Bi, Meixia ^a   Naczki, Christine ^a   Koritzinsky, Marianne ^b   Fels, Diane ^a   Blais, Jaime ^c   Hu, Nianping ^a   Harding, Heather ^d   Novoa, Isabelle ^d   Varia, Mahesh ^e   Raleigh, James ^e   Scheuner, Donalyn ^f   Kaufman, Randal J ^f   Bell, John ^c   Ron, David ^d   Wouters, Bradly G ^b   Koumenis, Constantinos ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c OTTAWA REGIONAL CANCER CENTRE   (Canada)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Apoptosis; ATF4; Endoplasmic reticulum; Hypoxia; PERK

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; HYPOXIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA TRANSLATION; SIGNAL TRANSDUCTION; TUMOR BIOPSY; TUMOR CELL; TUMOR GROWTH; UPREGULATION;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; ANOXIA; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; EIF-2 KINASE; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR-2; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, NUDE; MUTATION; NEOPLASMS; SIGNAL TRANSDUCTION; STRESS; TRANSCRIPTION FACTOR CHOP;

ANIMALIA;

EID: 27144458505     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600777     Document Type: Article

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