Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development

Cell

Volumn 107, Issue 7, 2001, Pages 893-903

  Shen, Xiaohua ^a   Ellis, Ronald E ^b   Lee, Kyungho ^a   Liu, Chuan Yin ^a   Yang, Kun ^a   Solomon, Aaron ^c   Yoshida, Hiderou ^d   Morimoto, Rick ^c   Kurnit, David M ^a   Mori, Kazutoshi ^d   Kaufman, Randal J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c Rice Institute for Biomedical Research   (United States)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; PROTEIN IRE1; PROTEIN KINASE; PROTEIN PEK1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CELL STRAIN COS1; CONTROLLED STUDY; EGG; ENDOPLASMIC RETICULUM; FEMALE; GENETIC MODEL; HOMEOSTASIS; HUMAN; INTESTINE CELL; LARVA; LARVAL DEVELOPMENT; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FOLDING; REGULATORY MECHANISM; RNA SPLICING; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TRANSLATION REGULATION;

ANIMALIA; CAENORHABDITIS; CAENORHABDITIS ELEGANS; METAZOA; NEMATODA;

EID: 18244405070     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(01)00612-2     Document Type: Article

References (53)

1. Integration of endoplasmic reticulum signaling in health and disease
2. The genetics of Caenorhabditis elegans
3. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
4. Increased sensitivity to dextran sodium sulfate colitis in IRE1β-deficient mice
5. A novel member of the Tob Family of proteins controls sexual fate in Caenorhabditis elegans germ cells
6. Translational attenuation mediated by an mRNA intron
7. The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core
8. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase
9. A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response
10. EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with wolcott-rallison syndrome
11. Potent and specific genetic interference by double-stranded RNA in C. elegans
12. Neuropathology of degenerative cell death in Caenorhabditis elegans
13. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
14. Perk is essential for translational regulation and cell survival during the unfolded protein response
15. Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival
16. Real time quantitative PCR
17. Translation control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress
18. Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun
19. Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translation controls
20. Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response
21. Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response
22. A comparison of the different DNA binding specificities of the bZip proteins C/EBP and GCN4
23. Conformational disease
24. IRE-1 mediated nonconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
25. Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum
26. Targeted disruption of CRE-binding factor TREB5 gene leads to cellular necrosis in cardiac myocytes at the embryonic stage
27. A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus
28. Tripartite management of unfolded proteins in the endoplasmic reticulum
29. mRNA splicing-mediated C-terminal replacement of transcription factor Hac1p is required for efficient activation of the unfolded protein response
30. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
31. IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae
32. An essential role in liver development for transcription factor XBP-1
33. Plasma cell differentiation requires the transcription factor XBP-1
34. Block of HAC1 mRNA translation by long-range base pairing is released by cytoplasmic splicing upon induction of the unfolded protein response
35. Translational control is required for the unfolded protein response and in vivo glucose homeostasis
36. The unfolded protein response represses nitrogen-starvation induced developmental differentiation in yeast
37. Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control
38. tRNA ligase is required for regulated mRNA splicing in the unfolded protein response
39. The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response
40. Caenorhabditis elegans deficiency mapping
41. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
42. The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response
43. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
44. IRE1 and efferent signaling from the endoplasmic reticulum
45. Cloning of mammalian Ire1 reveals diversity in the ER stress responses
46. Cell death: A new classification separating apoptosis from necrosis
47. Necrotic cell death in C. elegans requires the function of clareticulin and regulators of Ca(2+) release from the endoplasmic reticulum
48. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
49. Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress
50. Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors
51. ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
52. Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6α and 6β that activates the mammalian unfolded protein response
53. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor