Translation Attenuation through eIF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β Cells

Cell Metabolism

Volumn 10, Issue 1, 2009, Pages 13-26

  Back, Sung Hoon ^a   Scheuner, Donalyn ^a   Han, Jaeseok ^a   Song, Benbo ^a   Ribick, Mark ^a   Wang, Junying ^a   Gildersleeve, Robert D ^a   Pennathur, Subramaniam ^b   Kaufman, Randal J ^a,b  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

HUMDISEASE

Indexed keywords

ANTIOXIDANT; CARRIER PROTEIN; GLUCOSE; INITIATION FACTOR 2ALPHA; INSULIN; MESSENGER RNA; PROINSULIN; INITIATION FACTOR 2; MUTANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; GLUCOSE INTOLERANCE; HOMOZYGOTE; INSULIN RESISTANCE; INSULIN SYNTHESIS; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; TRANSLATION REGULATION; ANIMAL; CELL CULTURE; FEMALE; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROTEIN SYNTHESIS; SECRETION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

EUKARYOTA; MUS;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR-2; FEMALE; HOMOZYGOTE; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, TRANSGENIC; MUTANT PROTEINS; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN FOLDING; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

EID: 67649450485     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2009.06.002     Document Type: Article

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