pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response

Journal of Cell Biology

Volumn 172, Issue 4, 2006, Pages 565-575

  Yoshida, Hiderou ^a,b   Oku, Masaya ^a   Suzuki, Mie ^a   Mori, Kazutoshi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; MESSENGER RNA PRECURSOR; PROTEASOME; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ARTICLE; BIOACCUMULATION; CELL NUCLEUS; COMPLEX FORMATION; CONTROLLED STUDY; CYTOPLASM; ENDOPLASMIC RETICULUM; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN MOTIF; RNA SPLICING; SIGNAL TRANSDUCTION; STRESS; TRANSCRIPTION INITIATION;

ANIMALS; CELL NUCLEUS; CELLS, CULTURED; CYCLOHEXIMIDE; CYTOPLASM; DITHIOTHREITOL; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; FEEDBACK, BIOCHEMICAL; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; NUCLEAR PROTEINS; PROTEIN FOLDING; PROTEIN SPLICING; PROTEIN TRANSPORT; RNA PRECURSORS; RNA, MESSENGER;

MAMMALIA;

EID: 32644432826     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200508145     Document Type: Article

References (30)

1. Calfon, M., H. Zeng, F. Urano, J.H. Till, S.R. Hubbard, H.P. Harding, S.G. Clark, and D. Ron. 2002. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature. 415:92-96.
2. Chapman, R.E., and P. Walter. 1997. Translational attenuation mediated by an mRNA intron. Curr. Biol. 7:850-859.
3. Cox, J.S., and P. Walter. 1996. A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell. 87:391-404.
4. Cox, J.S., C.E. Shamu, and P. Walter. 1993. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell. 73:1197-1206.
5. Fornerod, M., M. Ohno, M. Yoshida, and I.W. Mattaj. 1997. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell. 90:1051-1060.
6. Harding, H.P., Y. Zhang, and D. Ron. 1999. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature. 397:271-274.
7. Harding, H.P., I.I. Novoa, Y. Zhang, H. Zeng, R. Wek, M. Schapira, and D. Ron. 2000. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell. 6:1099-1108.
8. Haze, K., T. Okada, H. Yoshida, H. Yanagi, T. Yura, M. Negishi, and K. Mori. 2001. Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. Biochem. J. 355:19-28.
9. Iwawaki, T., A. Hosoda, T. Okuda, Y. Kamigori, C. Nomura-Furuwatari, Y. Kimata, A. Tsuru, and K. Kohno. 2001. Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress. Nat. Cell Biol. 3:158-164.
10. Kaufman, R.J. 1999. Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev. 13:1211-1233.
11. Kawahara, T., H. Yanagi, T. Yura, and K. Mori. 1997. Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response. Mol. Biol. Cell. 8:1845-1862.
12. la Cour, T., R. Gupta, K. Rapacki, K. Skriver, F.M. Poulsen, and S. Brunak. 2003. NESbase version 1.0: a database of nuclear export signals. Nucleic Acids Res. 31:393-396.
13. Lee, A.H., N.N. Iwakoshi, K.C. Anderson, and L.H. Glimcher. 2003. Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. Proc. Natl. Acad. Sci. USA. 100:9946-9951.
14. Mori, K. 2000. Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell. 101:451-454.
15. Mori, K., W. Ma, M.J. Gething, and J. Sambrook. 1993. A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus. Cell. 74:743-756.
16. Mori, K., T. Kawahara, H. Yoshida, H. Yanagi, and T. Yura. 1996. Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway. Genes Cells. 1:803-817.
17. Newman, J.R., and A.E. Keating. 2003. Comprehensive identification of human bZIP interactions with coiled-coil arrays. Science. 300:2097-2101.
18. Niwa, M., C. Sidrauski, R.J. Kaufman, and P. Walter. 1999. A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response. Cell. 99:691-702.
19. Patil, C., and P. Walter. 2001. Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr. Opin. Cell Biol. 13:349-355.
20. Ruegsegger, U., J.H. Leber, and P. Walter. 2001. Block of HAC1 mRNA translation by long-range base pairing is released by cytoplasmic splicing upon induction of the unfolded protein response. Cell. 107:103-114.
21. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. Second Edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
22. Tirasophon, W., A.A. Welihinda, and R.J. Kaufman. 1998. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev. 12:1812-1824.
23. Urano, F., A. Bertolotti, and D. Ron. 2000. IRE1 and efferent signaling from the endoplasmic reticulum. J. Cell Sci. 113:3697-3702.
24. Wang, X.Z., H.P. Harding, Y. Zhang, E.M. Jolicoeur, M. Kuroda, and D. Ron. 1998. Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J. 17:5708-5717.
25. Ye, J., R.B. Rawson, R. Komuro, X. Chen, U.P. Dave, R. Prywes, M.S. Brown, and J.L. Goldstein. 2000. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol. Cell. 6:1355-1364.
26. Yoshida, H., K. Haze, H. Yanagi, T. Yura, and K. Mori. 1998. Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors. J. Biol. Chem. 273:33741-33749.
27. Yoshida, H., T. Okada, K. Haze, H. Yanagi, T. Yura, M. Negishi, and K. Mori. 2000. ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol. Cell. Biol. 20:6755-6767.
28. Yoshida, H., T. Matsui, A. Yamamoto, T. Okada, and K. Mori. 2001a. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell. 107:881-891.
29. Yoshida, H., T. Okada, K. Haze, H. Yanagi, T. Yura, M. Negishi, and K. Mori. 2001b. Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response. Mol. Cell. Biol. 21:1239-1248.
30. Yoshida, H., T. Matsui, N. Hosokawa, R.J. Kaufman, K. Nagata, and K. Mori. 2003. A time-dependent phase shift in the mammalian unfolded protein response. Dev. Cell. 4:265-271.