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Volumn 19, Issue 12, 2008, Pages 5373-5386

CCAAT/enhancer-binding protein β promotes osteoblast differentiation by enhancing Runx2 activity with ATF4

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CCAAT ENHANCER BINDING PROTEIN BETA; COLLAGEN TYPE 10; HETERODIMER; HOMODIMER; LEUCINE ZIPPER PROTEIN; TRANSCRIPTION FACTOR RUNX2;

EID: 59449103777     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E08-03-0329     Document Type: Article
Times cited : (93)

References (35)
  • 2
    • 34248504550 scopus 로고    scopus 로고
    • Bone formation: Maturation and function activities of osteoblast lineage cells
    • 6th ed, ed. J. Favus, Washington: American Society for Bone and Mineral Research
    • Aubin, J. E., Lian, J. B., and Stein, G. S. (2006). Bone formation: maturation and function activities of osteoblast lineage cells. In: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 6th ed., ed. J. Favus, Washington: American Society for Bone and Mineral Research, 20-29.
    • (2006) Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism , pp. 20-29
    • Aubin, J.E.1    Lian, J.B.2    Stein, G.S.3
  • 3
    • 0031760438 scopus 로고    scopus 로고
    • Bmp-2 downstream targets in mesenchymal development identified by subtractive cloning from recombinant mesenchymal progenitors (C3H10T1/2)
    • Bachner, D., Ahrens, M., Schroder, D., Hoffmann, A., Lauber, J., Betat, N., Steinert, P., Flohe, L., and Gross, G. (1998). Bmp-2 downstream targets in mesenchymal development identified by subtractive cloning from recombinant mesenchymal progenitors (C3H10T1/2). Dev. Dyn. 213, 398-411.
    • (1998) Dev. Dyn , vol.213 , pp. 398-411
    • Bachner, D.1    Ahrens, M.2    Schroder, D.3    Hoffmann, A.4    Lauber, J.5    Betat, N.6    Steinert, P.7    Flohe, L.8    Gross, G.9
  • 5
    • 0026491183 scopus 로고
    • Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo
    • Conlon, R. A., and Rossant, J. (1992). Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo. Development 116, 357-368.
    • (1992) Development , vol.116 , pp. 357-368
    • Conlon, R.A.1    Rossant, J.2
  • 7
    • 0028927556 scopus 로고
    • Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene
    • Ducy, P., and Karsenty, G. (1995). Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene. Mol. Cell. Biol. 15, 1858-1869.
    • (1995) Mol. Cell. Biol , vol.15 , pp. 1858-1869
    • Ducy, P.1    Karsenty, G.2
  • 8
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1, a transcriptional activator of osteoblast differentiation
    • Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., and Karsenty, G. (1997). Osf2/Cbfa1, a transcriptional activator of osteoblast differentiation. Cell 89, 747-754.
    • (1997) Cell , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.L.4    Karsenty, G.5
  • 9
    • 0035918274 scopus 로고    scopus 로고
    • Smurf1 interacts with transforming growth factor-β type I receptor through Smad7 and induces receptor degradation
    • Ebisawa, T., Fukuchi, M., Murakami, G., Chiba, T., Tanaka, K., Imamura, T., and Miyazono, K. (2001). Smurf1 interacts with transforming growth factor-β type I receptor through Smad7 and induces receptor degradation. J. Biol. Chem. 276, 12477-12480.
    • (2001) J. Biol. Chem , vol.276 , pp. 12477-12480
    • Ebisawa, T.1    Fukuchi, M.2    Murakami, G.3    Chiba, T.4    Tanaka, K.5    Imamura, T.6    Miyazono, K.7
  • 10
    • 0037059765 scopus 로고    scopus 로고
    • CCAAT/enhancer-binding proteins (C/EBP) β and δ activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression
    • Gutierrez, S., Javed, A., Tennant, D. K., van Rees, M., Montecino, M., Stein, G. S., Stein, J. L., and Lian, J. B. (2002). CCAAT/enhancer-binding proteins (C/EBP) β and δ activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression. J. Biol. Chem. 277, 1316-1323.
    • (2002) J. Biol. Chem , vol.277 , pp. 1316-1323
    • Gutierrez, S.1    Javed, A.2    Tennant, D.K.3    van Rees, M.4    Montecino, M.5    Stein, G.S.6    Stein, J.L.7    Lian, J.B.8
  • 11
    • 14844283748 scopus 로고    scopus 로고
    • Col1a1 promoter-targeted expression of p20 CCAAT enhancer-binding protein β (C/EBPβ), a truncated C/EBPβ isoform, causes osteopenia in transgenic mice
    • Harrison, J. R., Huang, Y. F., Wilson, K. A., Kelly, P. L., Adams, D. J., Gronowicz, G. A., and Clark, S. H. (2005). Col1a1 promoter-targeted expression of p20 CCAAT enhancer-binding protein β (C/EBPβ), a truncated C/EBPβ isoform, causes osteopenia in transgenic mice. J. Biol. Chem. 280, 8117-8124.
    • (2005) J. Biol. Chem , vol.280 , pp. 8117-8124
    • Harrison, J.R.1    Huang, Y.F.2    Wilson, K.A.3    Kelly, P.L.4    Adams, D.J.5    Gronowicz, G.A.6    Clark, S.H.7
  • 12
    • 20044370269 scopus 로고    scopus 로고
    • A CCAAT/enhancer binding protein β isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes
    • Hata, K., Nishimura, R., Ueda, M., Ikeda, F., Matsubara, T., Ichida, F., Hisada, K., Nokubi, T., Yamaguchi, A., and Yoneda, T. (2005). A CCAAT/enhancer binding protein β isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes. Mol. Cell. Biol. 25, 1971-1979.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 1971-1979
    • Hata, K.1    Nishimura, R.2    Ueda, M.3    Ikeda, F.4    Matsubara, T.5    Ichida, F.6    Hisada, K.7    Nokubi, T.8    Yamaguchi, A.9    Yoneda, T.10
  • 13
    • 33846010529 scopus 로고    scopus 로고
    • An integrated map of p53-binding sites and histone modification in the human ENCODE regions
    • Kaneshiro, K., Tsutsumi, S., Tsuji, S., Shirahige, K., and Aburatani, H. (2007). An integrated map of p53-binding sites and histone modification in the human ENCODE regions. Genomics 89, 178-188.
    • (2007) Genomics , vol.89 , pp. 178-188
    • Kaneshiro, K.1    Tsutsumi, S.2    Tsuji, S.3    Shirahige, K.4    Aburatani, H.5
  • 14
    • 0030684749 scopus 로고    scopus 로고
    • Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    • Komori, T. et al. (1997). Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89, 755-764.
    • (1997) Cell , vol.89 , pp. 755-764
    • Komori, T.1
  • 15
    • 15444351110 scopus 로고    scopus 로고
    • Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia
    • Mundlos, S. et al. (1997). Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell 89, 773-779.
    • (1997) Cell , vol.89 , pp. 773-779
    • Mundlos, S.1
  • 16
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    • Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., and de Crombrugghe, B. (2002). The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108, 17-29.
    • (2002) Cell , vol.108 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5    Behringer, R.R.6    de Crombrugghe, B.7
  • 17
    • 0035831513 scopus 로고    scopus 로고
    • Fluid shear stress-induced cyclooxygenase-2 expression is mediated by C/EBP β, cAMP-response element-binding protein, and AP-1 in osteoblastic MC3T3-E1 cells
    • Ogasawara, A., Arakawa, T., Kaneda, T., Takuma, T., Sato, T., Kaneko, H., Kumegawa, M., and Hakeda, Y. (2001). Fluid shear stress-induced cyclooxygenase-2 expression is mediated by C/EBP β, cAMP-response element-binding protein, and AP-1 in osteoblastic MC3T3-E1 cells. J. Biol. Chem. 276, 7048-7054.
    • (2001) J. Biol. Chem , vol.276 , pp. 7048-7054
    • Ogasawara, A.1    Arakawa, T.2    Kaneda, T.3    Takuma, T.4    Sato, T.5    Kaneko, H.6    Kumegawa, M.7    Hakeda, Y.8
  • 18
    • 0030666372 scopus 로고    scopus 로고
    • Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
    • Otto, F. et al. (1997). Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89, 765-771.
    • (1997) Cell , vol.89 , pp. 765-771
    • Otto, F.1
  • 19
    • 0036256989 scopus 로고    scopus 로고
    • Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: Correlation with CCAAT-enhancer binding protein expression
    • Pereira, R. C., Delany, A. M., and Canalis, E. (2002). Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: correlation with CCAAT-enhancer binding protein expression. Bone 30, 685-691.
    • (2002) Bone , vol.30 , pp. 685-691
    • Pereira, R.C.1    Delany, A.M.2    Canalis, E.3
  • 20
    • 0035808380 scopus 로고    scopus 로고
    • Crystal structure of the CCAAT box/enhancer-binding protein β activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA
    • Podust, L. M., Krezel, A. M., and Kim, Y. (2001). Crystal structure of the CCAAT box/enhancer-binding protein β activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA. J. Biol. Chem. 276, 505-513.
    • (2001) J. Biol. Chem , vol.276 , pp. 505-513
    • Podust, L.M.1    Krezel, A.M.2    Kim, Y.3
  • 21
    • 0029024113 scopus 로고
    • Lymphoproliferative disorder and imbalanced T-helper response in C/EBP β-deficient mice
    • Screpanti, I. et al. (1995). Lymphoproliferative disorder and imbalanced T-helper response in C/EBP β-deficient mice. EMBO J. 14, 1932-1941.
    • (1995) EMBO J , vol.14 , pp. 1932-1941
    • Screpanti, I.1
  • 22
    • 33745189426 scopus 로고    scopus 로고
    • CCAAT/enhancer-binding protein δ activates the Runx2-mediated transcription of mouse osteocalcin II promoter
    • Shin, C. S., Jeon, M. J., Yang, J. Y., Her, S. J., Kim, D., Kim, S. W., and Kim, S. Y. (2006). CCAAT/enhancer-binding protein δ activates the Runx2-mediated transcription of mouse osteocalcin II promoter. J. Mol. Endocrinol. 36, 531-546.
    • (2006) J. Mol. Endocrinol , vol.36 , pp. 531-546
    • Shin, C.S.1    Jeon, M.J.2    Yang, J.Y.3    Her, S.J.4    Kim, D.5    Kim, S.W.6    Kim, S.Y.7
  • 23
    • 33746947885 scopus 로고    scopus 로고
    • CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation
    • Shirakawa, K. et al. (2006). CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation. Mol. Cell. Biol. 26, 6105-6116.
    • (2006) Mol. Cell. Biol , vol.26 , pp. 6105-6116
    • Shirakawa, K.1
  • 24
    • 0035118709 scopus 로고    scopus 로고
    • Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice
    • Takeda, S., Bonnamy, J. P., Owen, M. J., Ducy, P., and Karsenty, G. (2001). Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice. Genes Dev. 15, 467-481.
    • (2001) Genes Dev , vol.15 , pp. 467-481
    • Takeda, S.1    Bonnamy, J.P.2    Owen, M.J.3    Ducy, P.4    Karsenty, G.5
  • 25
  • 26
    • 0031435337 scopus 로고    scopus 로고
    • Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBPδ gene
    • Tanaka, T., Yoshida, N., Kishimoto, T., and Akira, S. (1997). Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBPδ gene. EMBO J. 16, 7432-7443.
    • (1997) EMBO J , vol.16 , pp. 7432-7443
    • Tanaka, T.1    Yoshida, N.2    Kishimoto, T.3    Akira, S.4
  • 27
    • 0035795405 scopus 로고    scopus 로고
    • Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes
    • Ueta, C. et al. (2001). Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J. Cell Biol. 153, 87-100.
    • (2001) J. Cell Biol , vol.153 , pp. 87-100
    • Ueta, C.1
  • 28
    • 0027155881 scopus 로고
    • C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements
    • Vallejo, M., Ron, D., Miller, C. P., and Habener, J. F. (1993). C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. Proc. Natl. Acad. Sci. USA 90, 4679-4683.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 4679-4683
    • Vallejo, M.1    Ron, D.2    Miller, C.P.3    Habener, J.F.4
  • 29
    • 0028971225 scopus 로고
    • Conditional ectopic expression of C/EBP β in NIH-3T3 cells induces PPAR γ and stimulates adipogenesis
    • Wu, Z., Xie, Y., Bucher, N. L., and Farmer, S. R. (1995). Conditional ectopic expression of C/EBP β in NIH-3T3 cells induces PPAR γ and stimulates adipogenesis. Genes Dev. 9, 2350-2363.
    • (1995) Genes Dev , vol.9 , pp. 2350-2363
    • Wu, Z.1    Xie, Y.2    Bucher, N.L.3    Farmer, S.R.4
  • 30
    • 24744458827 scopus 로고    scopus 로고
    • Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression
    • Xiao, G., Jiang, D., Ge, C., Zhao, Z., Lai, Y., Boules, H., Phimphilai, M., Yang, X., Karsenty, G., and Franceschi, R. T. (2005). Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression. J. Biol. Chem. 280, 30689-30696.
    • (2005) J. Biol. Chem , vol.280 , pp. 30689-30696
    • Xiao, G.1    Jiang, D.2    Ge, C.3    Zhao, Z.4    Lai, Y.5    Boules, H.6    Phimphilai, M.7    Yang, X.8    Karsenty, G.9    Franceschi, R.T.10
  • 31
    • 11144357428 scopus 로고    scopus 로고
    • ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome
    • Yang, X. et al. (2004). ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell 117, 387-398.
    • (2004) Cell , vol.117 , pp. 387-398
    • Yang, X.1
  • 32
    • 41949123120 scopus 로고    scopus 로고
    • General transcription factor IIA-γ increases osteoblast-specific Osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2
    • Yu, S., Jiang, Y., Galson, D. L., Luo, M., Lai, Y., Lu, Y., Ouyang, H. J., Zhang, J., and Xiao, G. (2008). General transcription factor IIA-γ increases osteoblast-specific Osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2. J. Biol. Chem. 283, 5542-5553.
    • (2008) J. Biol. Chem , vol.283 , pp. 5542-5553
    • Yu, S.1    Jiang, Y.2    Galson, D.L.3    Luo, M.4    Lai, Y.5    Lu, Y.6    Ouyang, H.J.7    Zhang, J.8    Xiao, G.9
  • 34
    • 0041845297 scopus 로고    scopus 로고
    • E3 ubiquitin ligase Smurf1 mediates core-binding factor α1/Runx2 degradation and plays a specific role in osteoblast differentiation
    • Zhao, M., Qiao, M., Oyajobi, B. O., Mundy, G. R., and Chen, D. (2003). E3 ubiquitin ligase Smurf1 mediates core-binding factor α1/Runx2 degradation and plays a specific role in osteoblast differentiation. J. Biol. Chem. 278, 27939-27944.
    • (2003) J. Biol. Chem , vol.278 , pp. 27939-27944
    • Zhao, M.1    Qiao, M.2    Oyajobi, B.O.3    Mundy, G.R.4    Chen, D.5
  • 35
    • 0042887424 scopus 로고    scopus 로고
    • Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo
    • Zheng, Q., Zhou, G., Morello, R., Chen, Y., Garcia-Rojas, X., and Lee, B. (2003). Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo. J. Cell Biol. 162, 833-842.
    • (2003) J. Cell Biol , vol.162 , pp. 833-842
    • Zheng, Q.1    Zhou, G.2    Morello, R.3    Chen, Y.4    Garcia-Rojas, X.5    Lee, B.6


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