The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress

Nature

Volumn 510, Issue 7504, 2014, Pages 268-272

  Van Galen, Peter ^a,b   Kreso, Antonija ^a,b   Mbong, Nathan ^a,b   Kent, David G ^c   Fitzmaurice, Timothy ^d   Chambers, Joseph E ^c   Xie, Stephanie ^a,b   Laurenti, Elisa ^a,b   Hermans, Karin ^a,b   Eppert, Kolja ^e   Marciniak, Stefan J ^c   Goodall, Jane C ^d   Green, Anthony R ^c   Wouters, Bradly G ^a   Wienholds, Erno ^a,b   Dick, John E ^a,b  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CHAPERONE; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; PROTEIN ERDJ4; PROTEIN IRE1; PROTEIN KINASE; PROTEIN PERK; THAPSIGARGIN; TUNICAMYCIN; UNCLASSIFIED DRUG;

BIOACCUMULATION; CELL ORGANELLE; GENETIC ANALYSIS; PHYSIOLOGICAL RESPONSE; PROTEIN; SIGNALING;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL FUNCTION; CELL SURVIVAL; CELL VIABILITY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; APOPTOSIS; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-2; HEMATOPOIETIC STEM CELLS; HETEROGRAFTS; HSP40 HEAT-SHOCK PROTEINS; HUMANS; MALE; MEMBRANE PROTEINS; MICE; MOLECULAR CHAPERONES; PROTEIN FOLDING; PROTEIN PHOSPHATASE 1; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP; TUNICAMYCIN; UNFOLDED PROTEIN RESPONSE;

EID: 84902343044     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13228     Document Type: Article

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