Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis

Diabetologia

Volumn 53, Issue 6, 2010, Pages 1120-1130

  Allagnat, F ^a   Christulia, F ^a,c   Ortis, F ^a   Pirot, P ^a,d   Lortz, S ^b   Lenzen, S ^b   Eizirik, D L ^a   Cardozo, A K ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c MEK Consulting   (Greece)

^d UNIVERSITY OF COLORADO DENVER   (United States)

Author keywords

Apoptosis; Beta cell; ER stress; Insulin; PDX 1; Secretion; Unfolded protein response; UPR; XBP 1

Indexed keywords

CYTOKINE; GLUCOSE; INSULIN; MESSENGER RNA; PROTEIN DERIVATIVE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FIBROBLAST; GENE OVEREXPRESSION; GENE TARGETING; INSULIN RELEASE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RAT;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL COUNT; CELL SURVIVAL; CELLS, CULTURED; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; FLUORESCENT ANTIBODY TECHNIQUE; HOMEODOMAIN PROTEINS; INDOLES; INSULIN; INSULIN-SECRETING CELLS; INTERFERON-GAMMA; INTERLEUKIN-8; MAF TRANSCRIPTION FACTORS; MALE; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 77952093535     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1699-7     Document Type: Article

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