-
1
-
-
34250794495
-
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks
-
Acosta-Alvear D., Zhou Y., Blais A., Tsikitis M., Lents N.H., Arias C., Lennon C.J., Kluger Y., Dynlacht B.D. XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks. Mol. Cell 2007, 27:53-66.
-
(2007)
Mol. Cell
, vol.27
, pp. 53-66
-
-
Acosta-Alvear, D.1
Zhou, Y.2
Blais, A.3
Tsikitis, M.4
Lents, N.H.5
Arias, C.6
Lennon, C.J.7
Kluger, Y.8
Dynlacht, B.D.9
-
2
-
-
77950677297
-
Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development
-
Alexaki V.I., Notas G., Pelekanou V., Kampa M., Valkanou M., Theodoropoulos P., Stathopoulos E.N., Tsapis A., Castanas E. Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development. J. Immunol. 2009, 183:5948-5956.
-
(2009)
J. Immunol.
, vol.183
, pp. 5948-5956
-
-
Alexaki, V.I.1
Notas, G.2
Pelekanou, V.3
Kampa, M.4
Valkanou, M.5
Theodoropoulos, P.6
Stathopoulos, E.N.7
Tsapis, A.8
Castanas, E.9
-
3
-
-
0034952995
-
Enhanced accumulation of BiP in transgenic plants confers tolerance to water stress
-
Alvim F.C., Carolino S.M., Cascardo J.C., Nunes C.C., Martinez C.A., Otoni W.C., Fontes E.P. Enhanced accumulation of BiP in transgenic plants confers tolerance to water stress. Plant Physiol. 2001, 126:1042-1054.
-
(2001)
Plant Physiol.
, vol.126
, pp. 1042-1054
-
-
Alvim, F.C.1
Carolino, S.M.2
Cascardo, J.C.3
Nunes, C.C.4
Martinez, C.A.5
Otoni, W.C.6
Fontes, E.P.7
-
4
-
-
67649450485
-
Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells
-
Back S.H., Scheuner D., Han J., Song B., Ribick M., Wang J., Gildersleeve R.D., Pennathur S., Kaufman R.J. Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metab. 2009, 10:13-26.
-
(2009)
Cell Metab.
, vol.10
, pp. 13-26
-
-
Back, S.H.1
Scheuner, D.2
Han, J.3
Song, B.4
Ribick, M.5
Wang, J.6
Gildersleeve, R.D.7
Pennathur, S.8
Kaufman, R.J.9
-
5
-
-
35848940511
-
Transmembrane bZIP transcription factors in ER stress signaling and the unfolded protein response
-
Bailey D., O'Hare P. Transmembrane bZIP transcription factors in ER stress signaling and the unfolded protein response. Antioxid. Redox Signal. 2007, 9:2305-2321.
-
(2007)
Antioxid. Redox Signal.
, vol.9
, pp. 2305-2321
-
-
Bailey, D.1
O'Hare, P.2
-
6
-
-
68949214283
-
The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response
-
Basseri S., Lhotak S., Sharma A.M., Austin R.C. The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response. J. Lipid Res. 2009, 50:2486-2501.
-
(2009)
J. Lipid Res.
, vol.50
, pp. 2486-2501
-
-
Basseri, S.1
Lhotak, S.2
Sharma, A.M.3
Austin, R.C.4
-
7
-
-
0033782015
-
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
-
Bertolotti A., Zhang Y., Hendershot L.M., Harding H.P., Ron D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol. 2000, 2:326-332.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 326-332
-
-
Bertolotti, A.1
Zhang, Y.2
Hendershot, L.M.3
Harding, H.P.4
Ron, D.5
-
8
-
-
55849112292
-
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation
-
Bobrovnikova-Marjon E., Hatzivassiliou G., Grigoriadou C., Romero M., Cavener D.R., Thompson C.B., Diehl J.A. PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation. Proc. Natl. Acad. Sci. USA 2008, 105:16314-16319.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 16314-16319
-
-
Bobrovnikova-Marjon, E.1
Hatzivassiliou, G.2
Grigoriadou, C.3
Romero, M.4
Cavener, D.R.5
Thompson, C.B.6
Diehl, J.A.7
-
9
-
-
52749091008
-
Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals
-
Boden G., Duan X., Homko C., Molina E.J., Song W., Perez O., Cheung P., Merali S. Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Diabetes 2008, 57:2438-2444.
-
(2008)
Diabetes
, vol.57
, pp. 2438-2444
-
-
Boden, G.1
Duan, X.2
Homko, C.3
Molina, E.J.4
Song, W.5
Perez, O.6
Cheung, P.7
Merali, S.8
-
10
-
-
33845575826
-
Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death
-
Borradaile N.M., Han X., Harp J.D., Gale S.E., Ory D.S., Schaffer J.E. Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J. Lipid Res. 2006, 47:2726-2737.
-
(2006)
J. Lipid Res.
, vol.47
, pp. 2726-2737
-
-
Borradaile, N.M.1
Han, X.2
Harp, J.D.3
Gale, S.E.4
Ory, D.S.5
Schaffer, J.E.6
-
11
-
-
13644256191
-
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress
-
Boyce M., Bryant K.F., Jousse C., Long K., Harding H.P., Scheuner D., Kaufman R.J., Ma D., Coen D.M., Ron D., et al. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 2005, 307:935-939.
-
(2005)
Science
, vol.307
, pp. 935-939
-
-
Boyce, M.1
Bryant, K.F.2
Jousse, C.3
Long, K.4
Harding, H.P.5
Scheuner, D.6
Kaufman, R.J.7
Ma, D.8
Coen, D.M.9
Ron, D.10
-
12
-
-
0034681260
-
Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
-
Brown M.S., Ye J., Rawson R.B., Goldstein J.L. Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans. Cell 2000, 100:391-398.
-
(2000)
Cell
, vol.100
, pp. 391-398
-
-
Brown, M.S.1
Ye, J.2
Rawson, R.B.3
Goldstein, J.L.4
-
13
-
-
0037011917
-
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
-
Calfon M., Zeng H., Urano F., Till J.H., Hubbard S.R., Harding H.P., Clark S.G., Ron D. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 2002, 415:92-96.
-
(2002)
Nature
, vol.415
, pp. 92-96
-
-
Calfon, M.1
Zeng, H.2
Urano, F.3
Till, J.H.4
Hubbard, S.R.5
Harding, H.P.6
Clark, S.G.7
Ron, D.8
-
14
-
-
51549107903
-
Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism
-
Cao H., Gerhold K., Mayers J.R., Wiest M.M., Watkins S.M., Hotamisligil G.S. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 2008, 134:933-944.
-
(2008)
Cell
, vol.134
, pp. 933-944
-
-
Cao, H.1
Gerhold, K.2
Mayers, J.R.3
Wiest, M.M.4
Watkins, S.M.5
Hotamisligil, G.S.6
-
15
-
-
0037066741
-
The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi
-
Chen X., Shen J., Prywes R. The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi. J. Biol. Chem. 2002, 277:13045-13052.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 13045-13052
-
-
Chen, X.1
Shen, J.2
Prywes, R.3
-
16
-
-
33947510911
-
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis
-
Cnop M., Ladriere L., Hekerman P., Ortis F., Cardozo A.K., Dogusan Z., Flamez D., Boyce M., Yuan J., Eizirik D.L. Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. J. Biol. Chem. 2007, 282:3989-3997.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 3989-3997
-
-
Cnop, M.1
Ladriere, L.2
Hekerman, P.3
Ortis, F.4
Cardozo, A.K.5
Dogusan, Z.6
Flamez, D.7
Boyce, M.8
Yuan, J.9
Eizirik, D.L.10
-
17
-
-
29244462498
-
Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway
-
Cullinan S.B., Diehl J.A. Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway. Int. J. Biochem. Cell Biol. 2006, 38:317-332.
-
(2006)
Int. J. Biochem. Cell Biol.
, vol.38
, pp. 317-332
-
-
Cullinan, S.B.1
Diehl, J.A.2
-
18
-
-
0141752795
-
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
-
Cullinan S.B., Zhang D., Hannink M., Arvisais E., Kaufman R.J., Diehl J.A. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol. Cell. Biol. 2003, 23:7198-7209.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 7198-7209
-
-
Cullinan, S.B.1
Zhang, D.2
Hannink, M.3
Arvisais, E.4
Kaufman, R.J.5
Diehl, J.A.6
-
19
-
-
24944438230
-
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
-
De Souza C.T., Araujo E.P., Bordin S., Ashimine R., Zollner R.L., Boschero A.C., Saad M.J., Velloso L.A. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 2005, 146:4192-4199.
-
(2005)
Endocrinology
, vol.146
, pp. 4192-4199
-
-
De Souza, C.T.1
Araujo, E.P.2
Bordin, S.3
Ashimine, R.4
Zollner, R.L.5
Boschero, A.C.6
Saad, M.J.7
Velloso, L.A.8
-
20
-
-
8644282751
-
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2
-
Deng J., Lu P.D., Zhang Y., Scheuner D., Kaufman R.J., Sonenberg N., Harding H.P., Ron D. Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol. Cell. Biol. 2004, 24:10161-10168.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 10161-10168
-
-
Deng, J.1
Lu, P.D.2
Zhang, Y.3
Scheuner, D.4
Kaufman, R.J.5
Sonenberg, N.6
Harding, H.P.7
Ron, D.8
-
21
-
-
26444524411
-
Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor
-
Devries-Seimon T., Li Y., Yao P.M., Stone E., Wang Y., Davis R.J., Flavell R., Tabas I. Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. J. Cell Biol. 2005, 171:61-73.
-
(2005)
J. Cell Biol.
, vol.171
, pp. 61-73
-
-
Devries-Seimon, T.1
Li, Y.2
Yao, P.M.3
Stone, E.4
Wang, Y.5
Davis, R.J.6
Flavell, R.7
Tabas, I.8
-
22
-
-
33750071414
-
NF-kappaB activation represses tumor necrosis factor-alpha-induced autophagy
-
Djavaheri-Mergny M., Amelotti M., Mathieu J., Besancon F., Bauvy C., Souquere S., Pierron G., Codogno P. NF-kappaB activation represses tumor necrosis factor-alpha-induced autophagy. J. Biol. Chem. 2006, 281:30373-30382.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 30373-30382
-
-
Djavaheri-Mergny, M.1
Amelotti, M.2
Mathieu, J.3
Besancon, F.4
Bauvy, C.5
Souquere, S.6
Pierron, G.7
Codogno, P.8
-
23
-
-
67651227289
-
Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress
-
DuRose J.B., Scheuner D., Kaufman R.J., Rothblum L.I., Niwa M. Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress. Mol. Cell. Biol. 2009, 29:4295-4307.
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 4295-4307
-
-
DuRose, J.B.1
Scheuner, D.2
Kaufman, R.J.3
Rothblum, L.I.4
Niwa, M.5
-
24
-
-
52749093177
-
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet
-
Ebato C., Uchida T., Arakawa M., Komatsu M., Ueno T., Komiya K., Azuma K., Hirose T., Tanaka K., Kominami E., et al. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab. 2008, 8:325-332.
-
(2008)
Cell Metab.
, vol.8
, pp. 325-332
-
-
Ebato, C.1
Uchida, T.2
Arakawa, M.3
Komatsu, M.4
Ueno, T.5
Komiya, K.6
Azuma, K.7
Hirose, T.8
Tanaka, K.9
Kominami, E.10
-
25
-
-
71549152580
-
Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis
-
Erbay E., Babaev V.R., Mayers J.R., Makowski L., Charles K.N., Snitow M.E., Fazio S., Wiest M.M., Watkins S.M., Linton M.F., et al. Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nat. Med. 2009, 15:1383-1391.
-
(2009)
Nat. Med.
, vol.15
, pp. 1383-1391
-
-
Erbay, E.1
Babaev, V.R.2
Mayers, J.R.3
Makowski, L.4
Charles, K.N.5
Snitow, M.E.6
Fazio, S.7
Wiest, M.M.8
Watkins, S.M.9
Linton, M.F.10
-
26
-
-
68349148211
-
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
-
Feuerer M., Herrero L., Cipolletta D., Naaz A., Wong J., Nayer A., Lee J., Goldfine A.B., Benoist C., Shoelson S., et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med. 2009, 15:930-939.
-
(2009)
Nat. Med.
, vol.15
, pp. 930-939
-
-
Feuerer, M.1
Herrero, L.2
Cipolletta, D.3
Naaz, A.4
Wong, J.5
Nayer, A.6
Lee, J.7
Goldfine, A.B.8
Benoist, C.9
Shoelson, S.10
-
27
-
-
28244435870
-
WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells
-
Fonseca S.G., Fukuma M., Lipson K.L., Nguyen L.X., Allen J.R., Oka Y., Urano F. WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells. J. Biol. Chem. 2005, 280:39609-39615.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 39609-39615
-
-
Fonseca, S.G.1
Fukuma, M.2
Lipson, K.L.3
Nguyen, L.X.4
Allen, J.R.5
Oka, Y.6
Urano, F.7
-
28
-
-
44449118921
-
Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets
-
Furuhashi M., Hotamisligil G.S. Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat. Rev. Drug Discov. 2008, 7:489-503.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 489-503
-
-
Furuhashi, M.1
Hotamisligil, G.S.2
-
29
-
-
33745962325
-
Nitric oxide and endoplasmic reticulum stress
-
Gotoh T., Mori M. Nitric oxide and endoplasmic reticulum stress. Arterioscler. Thromb. Vasc. Biol. 2006, 26:1439-1446.
-
(2006)
Arterioscler. Thromb. Vasc. Biol.
, vol.26
, pp. 1439-1446
-
-
Gotoh, T.1
Mori, M.2
-
30
-
-
62749178966
-
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss
-
Gregor M.F., Yang L., Fabbrini E., Mohammed B.S., Eagon J.C., Hotamisligil G.S., Klein S. Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes 2009, 58:693-700.
-
(2009)
Diabetes
, vol.58
, pp. 693-700
-
-
Gregor, M.F.1
Yang, L.2
Fabbrini, E.3
Mohammed, B.S.4
Eagon, J.C.5
Hotamisligil, G.S.6
Klein, S.7
-
31
-
-
34548419344
-
Adipocyte stress: The endoplasmic reticulum and metabolic disease
-
Gregor M.G., Hotamisligil G.S. Adipocyte stress: The endoplasmic reticulum and metabolic disease. J. Lipid Res. 2007, 48:1905-1914.
-
(2007)
J. Lipid Res.
, vol.48
, pp. 1905-1914
-
-
Gregor, M.G.1
Hotamisligil, G.S.2
-
32
-
-
33846627302
-
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
-
Hampe J., Franke A., Rosenstiel P., Till A., Teuber M., Huse K., Albrecht M., Mayr G., De La Vega F.M., Briggs J., et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat. Genet. 2007, 39:207-211.
-
(2007)
Nat. Genet.
, vol.39
, pp. 207-211
-
-
Hampe, J.1
Franke, A.2
Rosenstiel, P.3
Till, A.4
Teuber, M.5
Huse, K.6
Albrecht, M.7
Mayr, G.8
De La Vega, F.M.9
Briggs, J.10
-
33
-
-
68049110633
-
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates
-
Han D., Lerner A.G., Vande Walle L., Upton J.P., Xu W., Hagen A., Backes B.J., Oakes S.A., Papa F.R. IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell 2009, 138:562-575.
-
(2009)
Cell
, vol.138
, pp. 562-575
-
-
Han, D.1
Lerner, A.G.2
Vande Walle, L.3
Upton, J.P.4
Xu, W.5
Hagen, A.6
Backes, B.J.7
Oakes, S.A.8
Papa, F.R.9
-
34
-
-
20144374658
-
Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex
-
Hao S., Sharp J.W., Ross-Inta C.M., McDaniel B.J., Anthony T.G., Wek R.C., Cavener D.R., McGrath B.C., Rudell J.B., Koehnle T.J., et al. Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science 2005, 307:1776-1778.
-
(2005)
Science
, vol.307
, pp. 1776-1778
-
-
Hao, S.1
Sharp, J.W.2
Ross-Inta, C.M.3
McDaniel, B.J.4
Anthony, T.G.5
Wek, R.C.6
Cavener, D.R.7
McGrath, B.C.8
Rudell, J.B.9
Koehnle, T.J.10
-
35
-
-
0033590451
-
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
-
Harding H.P., Zhang Y., Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 1999, 397:271-274.
-
(1999)
Nature
, vol.397
, pp. 271-274
-
-
Harding, H.P.1
Zhang, Y.2
Ron, D.3
-
36
-
-
0033634654
-
Regulated translation initiation controls stress-induced gene expression in mammalian cells
-
Harding H.P., Novoa I., Zhang Y., Zeng H., Wek R., Schapira M., Ron D. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell 2000, 6:1099-1108.
-
(2000)
Mol. Cell
, vol.6
, pp. 1099-1108
-
-
Harding, H.P.1
Novoa, I.2
Zhang, Y.3
Zeng, H.4
Wek, R.5
Schapira, M.6
Ron, D.7
-
37
-
-
0033634641
-
Perk is essential for translational regulation and cell survival during the unfolded protein response
-
Harding H.P., Zhang Y., Bertolotti A., Zeng H., Ron D. Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol. Cell 2000, 5:897-904.
-
(2000)
Mol. Cell
, vol.5
, pp. 897-904
-
-
Harding, H.P.1
Zhang, Y.2
Bertolotti, A.3
Zeng, H.4
Ron, D.5
-
38
-
-
0034968330
-
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival
-
Harding H.P., Zeng H., Zhang Y., Jungries R., Chung P., Plesken H., Sabatini D.D., Ron D. Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol. Cell 2001, 7:1153-1163.
-
(2001)
Mol. Cell
, vol.7
, pp. 1153-1163
-
-
Harding, H.P.1
Zeng, H.2
Zhang, Y.3
Jungries, R.4
Chung, P.5
Plesken, H.6
Sabatini, D.D.7
Ron, D.8
-
39
-
-
3342958797
-
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
-
Harrington L.S., Findlay G.M., Gray A., Tolkacheva T., Wigfield S., Rebholz H., Barnett J., Leslie N.R., Cheng S., Shepherd P.R., et al. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J. Cell Biol. 2004, 166:213-223.
-
(2004)
J. Cell Biol.
, vol.166
, pp. 213-223
-
-
Harrington, L.S.1
Findlay, G.M.2
Gray, A.3
Tolkacheva, T.4
Wigfield, S.5
Rebholz, H.6
Barnett, J.7
Leslie, N.R.8
Cheng, S.9
Shepherd, P.R.10
-
40
-
-
34548700401
-
T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis
-
Harris J., De Haro S.A., Master S.S., Keane J., Roberts E.A., Delgado M., Deretic V. T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis. Immunity 2007, 27:505-517.
-
(2007)
Immunity
, vol.27
, pp. 505-517
-
-
Harris, J.1
De Haro, S.A.2
Master, S.S.3
Keane, J.4
Roberts, E.A.5
Delgado, M.6
Deretic, V.7
-
41
-
-
4444265582
-
Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death
-
Haynes C.M., Titus E.A., Cooper A.A. Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death. Mol. Cell 2004, 15:767-776.
-
(2004)
Mol. Cell
, vol.15
, pp. 767-776
-
-
Haynes, C.M.1
Titus, E.A.2
Cooper, A.A.3
-
42
-
-
33646237823
-
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha
-
Hetz C., Bernasconi P., Fisher J., Lee A.H., Bassik M.C., Antonsson B., Brandt G.S., Iwakoshi N.N., Schinzel A., Glimcher L.H., et al. Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science 2006, 312:572-576.
-
(2006)
Science
, vol.312
, pp. 572-576
-
-
Hetz, C.1
Bernasconi, P.2
Fisher, J.3
Lee, A.H.4
Bassik, M.C.5
Antonsson, B.6
Brandt, G.S.7
Iwakoshi, N.N.8
Schinzel, A.9
Glimcher, L.H.10
-
43
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J., Tuncman G., Chang L., Gorgun C.Z., Uysal K.T., Maeda K., Karin M., Hotamisligil G.S. A central role for JNK in obesity and insulin resistance. Nature 2002, 420:333-336.
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Gorgun, C.Z.4
Uysal, K.T.5
Maeda, K.6
Karin, M.7
Hotamisligil, G.S.8
-
44
-
-
33745893809
-
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response
-
Hollien J., Weissman J.S. Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science 2006, 313:104-107.
-
(2006)
Science
, vol.313
, pp. 104-107
-
-
Hollien, J.1
Weissman, J.S.2
-
45
-
-
68549092781
-
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells
-
Hollien J., Lin J.H., Li H., Stevens N., Walter P., Weissman J.S. Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J. Cell Biol. 2009, 186:323-331.
-
(2009)
J. Cell Biol.
, vol.186
, pp. 323-331
-
-
Hollien, J.1
Lin, J.H.2
Li, H.3
Stevens, N.4
Walter, P.5
Weissman, J.S.6
-
46
-
-
34047119110
-
Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation
-
Hosogai N., Fukuhara A., Oshima K., Miyata Y., Tanaka S., Segawa K., Furukawa S., Tochino Y., Komuro R., Matsuda M., et al. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 2007, 56:901-911.
-
(2007)
Diabetes
, vol.56
, pp. 901-911
-
-
Hosogai, N.1
Fukuhara, A.2
Oshima, K.3
Miyata, Y.4
Tanaka, S.5
Segawa, K.6
Furukawa, S.7
Tochino, Y.8
Komuro, R.9
Matsuda, M.10
-
47
-
-
56749112559
-
Endoplasmic reticulum stress induces leptin resistance
-
Hosoi T., Sasaki M., Miyahara T., Hashimoto C., Matsuo S., Yoshii M., Ozawa K. Endoplasmic reticulum stress induces leptin resistance. Mol. Pharmacol. 2008, 74:1610-1619.
-
(2008)
Mol. Pharmacol.
, vol.74
, pp. 1610-1619
-
-
Hosoi, T.1
Sasaki, M.2
Miyahara, T.3
Hashimoto, C.4
Matsuo, S.5
Yoshii, M.6
Ozawa, K.7
-
48
-
-
33846422032
-
Obesity and diabetes in the developing world-a growing challenge
-
Hossain P., Kawar B., El Nahas M. Obesity and diabetes in the developing world-a growing challenge. N. Engl. J. Med. 2007, 356:213-215.
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 213-215
-
-
Hossain, P.1
Kawar, B.2
El Nahas, M.3
-
49
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil G.S. Inflammation and metabolic disorders. Nature 2006, 444:860-867.
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
50
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
-
Hotamisligil G.S., Shargill N.S., Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259:87-91.
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
51
-
-
33645860825
-
Reactive oxygen species have a causal role in multiple forms of insulin resistance
-
Houstis N., Rosen E.D., Lander E.S. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006, 440:944-948.
-
(2006)
Nature
, vol.440
, pp. 944-948
-
-
Houstis, N.1
Rosen, E.D.2
Lander, E.S.3
-
52
-
-
33645815074
-
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression
-
Hu P., Han Z., Couvillon A.D., Kaufman R.J., Exton J.H. Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol. Cell. Biol. 2006, 26:3071-3084.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 3071-3084
-
-
Hu, P.1
Han, Z.2
Couvillon, A.D.3
Kaufman, R.J.4
Exton, J.H.5
-
53
-
-
37149012111
-
Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide
-
Huang C.J., Haataja L., Gurlo T., Butler A.E., Wu X., Soeller W.C., Butler P.C. Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide. Am. J. Physiol. Endocrinol. Metab. 2007, 293:E1656-E1662.
-
(2007)
Am. J. Physiol. Endocrinol. Metab.
, vol.293
-
-
Huang, C.J.1
Haataja, L.2
Gurlo, T.3
Butler, A.E.4
Wu, X.5
Soeller, W.C.6
Butler, P.C.7
-
54
-
-
0043133837
-
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappa B in response to diverse cellular stresses
-
Jiang H.Y., Wek S.A., McGrath B.C., Scheuner D., Kaufman R.J., Cavener D.R., Wek R.C. Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappa B in response to diverse cellular stresses. Mol. Cell. Biol. 2003, 23:5651-5663.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 5651-5663
-
-
Jiang, H.Y.1
Wek, S.A.2
McGrath, B.C.3
Scheuner, D.4
Kaufman, R.J.5
Cavener, D.R.6
Wek, R.C.7
-
55
-
-
52749094770
-
Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia
-
Jung H.S., Chung K.W., Won Kim J., Kim J., Komatsu M., Tanaka K., Nguyen Y.H., Kang T.M., Yoon K.H., Kim J.W., et al. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab. 2008, 8:318-324.
-
(2008)
Cell Metab.
, vol.8
, pp. 318-324
-
-
Jung, H.S.1
Chung, K.W.2
Won Kim, J.3
Kim, J.4
Komatsu, M.5
Tanaka, K.6
Nguyen, Y.H.7
Kang, T.M.8
Yoon, K.H.9
Kim, J.W.10
-
56
-
-
66449137379
-
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
-
Kammoun H.L., Chabanon H., Hainault I., Luquet S., Magnan C., Koike T., Ferre P., Foufelle F. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J. Clin. Invest. 2009, 119:1201-1215.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 1201-1215
-
-
Kammoun, H.L.1
Chabanon, H.2
Hainault, I.3
Luquet, S.4
Magnan, C.5
Koike, T.6
Ferre, P.7
Foufelle, F.8
-
57
-
-
1442321303
-
Activation signal of nuclear factor-kappa B in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2
-
Kaneko M., Niinuma Y., Nomura Y. Activation signal of nuclear factor-kappa B in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2. Biol. Pharm. Bull. 2003, 26:931-935.
-
(2003)
Biol. Pharm. Bull.
, vol.26
, pp. 931-935
-
-
Kaneko, M.1
Niinuma, Y.2
Nomura, Y.3
-
58
-
-
14244256097
-
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance
-
Khamzina L., Veilleux A., Bergeron S., Marette A. Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. Endocrinology 2005, 146:1473-1481.
-
(2005)
Endocrinology
, vol.146
, pp. 1473-1481
-
-
Khamzina, L.1
Veilleux, A.2
Bergeron, S.3
Marette, A.4
-
59
-
-
9244231766
-
Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress
-
Kharroubi I., Ladriere L., Cardozo A.K., Dogusan Z., Cnop M., Eizirik D.L. Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Endocrinology 2004, 145:5087-5096.
-
(2004)
Endocrinology
, vol.145
, pp. 5087-5096
-
-
Kharroubi, I.1
Ladriere, L.2
Cardozo, A.K.3
Dogusan, Z.4
Cnop, M.5
Eizirik, D.L.6
-
60
-
-
0035937721
-
Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response
-
Kokame K., Kato H., Miyata T. Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response. J. Biol. Chem. 2001, 276:9199-9205.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 9199-9205
-
-
Kokame, K.1
Kato, H.2
Miyata, T.3
-
61
-
-
33846211417
-
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation
-
Kouroku Y., Fujita E., Tanida I., Ueno T., Isoai A., Kumagai H., Ogawa S., Kaufman R.J., Kominami E., Momoi T. ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ. 2007, 14:230-239.
-
(2007)
Cell Death Differ.
, vol.14
, pp. 230-239
-
-
Kouroku, Y.1
Fujita, E.2
Tanida, I.3
Ueno, T.4
Isoai, A.5
Kumagai, H.6
Ogawa, S.7
Kaufman, R.J.8
Kominami, E.9
Momoi, T.10
-
62
-
-
0036319579
-
Polymorphisms in the oxygen-regulated protein 150 gene (ORP150) are associated with insulin resistance in Pima Indians
-
Kovacs P., Yang X., Permana P.A., Bogardus C., Baier L.J. Polymorphisms in the oxygen-regulated protein 150 gene (ORP150) are associated with insulin resistance in Pima Indians. Diabetes 2002, 51:1618-1621.
-
(2002)
Diabetes
, vol.51
, pp. 1618-1621
-
-
Kovacs, P.1
Yang, X.2
Permana, P.A.3
Bogardus, C.4
Baier, L.J.5
-
63
-
-
27744588780
-
Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways
-
Kwiatkowski D.J., Manning B.D. Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. Hum. Mol. Genet. 2005, 14 Spec No. 2:R251-R258.
-
(2005)
Hum. Mol. Genet.
-
-
Kwiatkowski, D.J.1
Manning, B.D.2
-
64
-
-
20144386666
-
Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK
-
Ladiges W.C., Knoblaugh S.E., Morton J.F., Korth M.J., Sopher B.L., Baskin C.R., MacAuley A., Goodman A.G., LeBoeuf R.C., Katze M.G. Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK. Diabetes 2005, 54:1074-1081.
-
(2005)
Diabetes
, vol.54
, pp. 1074-1081
-
-
Ladiges, W.C.1
Knoblaugh, S.E.2
Morton, J.F.3
Korth, M.J.4
Sopher, B.L.5
Baskin, C.R.6
MacAuley, A.7
Goodman, A.G.8
LeBoeuf, R.C.9
Katze, M.G.10
-
65
-
-
0142059951
-
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
-
Lee A.H., Iwakoshi N.N., Glimcher L.H. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol. Cell. Biol. 2003, 23:7448-7459.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 7448-7459
-
-
Lee, A.H.1
Iwakoshi, N.N.2
Glimcher, L.H.3
-
66
-
-
45849137877
-
Regulation of hepatic lipogenesis by the transcription factor XBP1
-
Lee A.H., Scapa E.F., Cohen D.E., Glimcher L.H. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 2008, 320:1492-1496.
-
(2008)
Science
, vol.320
, pp. 1492-1496
-
-
Lee, A.H.1
Scapa, E.F.2
Cohen, D.E.3
Glimcher, L.H.4
-
67
-
-
34547605613
-
IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway
-
Lee D.F., Kuo H.P., Chen C.T., Hsu J.M., Chou C.K., Wei Y., Sun H.L., Li L.Y., Ping B., Huang W.C., et al. IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell 2007, 130:440-455.
-
(2007)
Cell
, vol.130
, pp. 440-455
-
-
Lee, D.F.1
Kuo, H.P.2
Chen, C.T.3
Hsu, J.M.4
Chou, C.K.5
Wei, Y.6
Sun, H.L.7
Li, L.Y.8
Ping, B.9
Huang, W.C.10
-
68
-
-
33947134377
-
Autophagy-dependent viral recognition by plasmacytoid dendritic cells
-
Lee H.K., Lund J.M., Ramanathan B., Mizushima N., Iwasaki A. Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 2007, 315:1398-1401.
-
(2007)
Science
, vol.315
, pp. 1398-1401
-
-
Lee, H.K.1
Lund, J.M.2
Ramanathan, B.3
Mizushima, N.4
Iwasaki, A.5
-
69
-
-
34548700796
-
Unveiling the roles of autophagy in innate and adaptive immunity
-
Levine B., Deretic V. Unveiling the roles of autophagy in innate and adaptive immunity. Nat. Rev. Immunol. 2007, 7:767-777.
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 767-777
-
-
Levine, B.1
Deretic, V.2
-
70
-
-
20444461628
-
Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis
-
Li Y., Schwabe R.F., DeVries-Seimon T., Yao P.M., Gerbod-Giannone M.C., Tall A.R., Davis R.J., Flavell R., Brenner D.A., Tabas I. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J. Biol. Chem. 2005, 280:21763-21772.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 21763-21772
-
-
Li, Y.1
Schwabe, R.F.2
DeVries-Seimon, T.3
Yao, P.M.4
Gerbod-Giannone, M.C.5
Tall, A.R.6
Davis, R.J.7
Flavell, R.8
Brenner, D.A.9
Tabas, I.10
-
71
-
-
36049049392
-
IRE1 signaling affects cell fate during the unfolded protein response
-
Lin J.H., Li H., Yasumura D., Cohen H.R., Zhang C., Panning B., Shokat K.M., Lavail M.M., Walter P. IRE1 signaling affects cell fate during the unfolded protein response. Science 2007, 318:944-949.
-
(2007)
Science
, vol.318
, pp. 944-949
-
-
Lin, J.H.1
Li, H.2
Yasumura, D.3
Cohen, H.R.4
Zhang, C.5
Panning, B.6
Shokat, K.M.7
Lavail, M.M.8
Walter, P.9
-
72
-
-
33747849846
-
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1
-
Lipson K.L., Fonseca S.G., Ishigaki S., Nguyen L.X., Foss E., Bortell R., Rossini A.A., Urano F. Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. Cell Metab. 2006, 4:245-254.
-
(2006)
Cell Metab.
, vol.4
, pp. 245-254
-
-
Lipson, K.L.1
Fonseca, S.G.2
Ishigaki, S.3
Nguyen, L.X.4
Foss, E.5
Bortell, R.6
Rossini, A.A.7
Urano, F.8
-
73
-
-
68349160704
-
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice
-
Liu J., Divoux A., Sun J., Zhang J., Clement K., Glickman J.N., Sukhova G.K., Wolters P.J., Du J., Gorgun C.Z., et al. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat. Med. 2009, 15:940-945.
-
(2009)
Nat. Med.
, vol.15
, pp. 940-945
-
-
Liu, J.1
Divoux, A.2
Sun, J.3
Zhang, J.4
Clement, K.5
Glickman, J.N.6
Sukhova, G.K.7
Wolters, P.J.8
Du, J.9
Gorgun, C.Z.10
-
74
-
-
0036314984
-
Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response
-
Ma Y., Brewer J.W., Diehl J.A., Hendershot L.M. Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response. J. Mol. Biol. 2002, 318:1351-1365.
-
(2002)
J. Mol. Biol.
, vol.318
, pp. 1351-1365
-
-
Ma, Y.1
Brewer, J.W.2
Diehl, J.A.3
Hendershot, L.M.4
-
75
-
-
0034959752
-
Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis
-
Makowski L., Boord J.B., Maeda K., Babaev V.R., Uysal K.T., Morgan M.A., Parker R.A., Suttles J., Fazio S., Hotamisligil G.S., et al. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nat. Med. 2001, 7:699-705.
-
(2001)
Nat. Med.
, vol.7
, pp. 699-705
-
-
Makowski, L.1
Boord, J.B.2
Maeda, K.3
Babaev, V.R.4
Uysal, K.T.5
Morgan, M.A.6
Parker, R.A.7
Suttles, J.8
Fazio, S.9
Hotamisligil, G.S.10
-
76
-
-
70449927247
-
Autophagy is required to maintain muscle mass
-
Masiero E., Agatea L., Mammucari C., Blaauw B., Loro E., Komatsu M., Metzger D., Reggiani C., Schiaffino S., Sandri M. Autophagy is required to maintain muscle mass. Cell Metab. 2009, 10:507-515.
-
(2009)
Cell Metab.
, vol.10
, pp. 507-515
-
-
Masiero, E.1
Agatea, L.2
Mammucari, C.3
Blaauw, B.4
Loro, E.5
Komatsu, M.6
Metzger, D.7
Reggiani, C.8
Schiaffino, S.9
Sandri, M.10
-
77
-
-
20144387009
-
The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores
-
Maurin A.C., Jousse C., Averous J., Parry L., Bruhat A., Cherasse Y., Zeng H., Zhang Y., Harding H.P., Ron D., et al. The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores. Cell Metab. 2005, 1:273-277.
-
(2005)
Cell Metab.
, vol.1
, pp. 273-277
-
-
Maurin, A.C.1
Jousse, C.2
Averous, J.3
Parry, L.4
Bruhat, A.5
Cherasse, Y.6
Zeng, H.7
Zhang, Y.8
Harding, H.P.9
Ron, D.10
-
78
-
-
28444479505
-
Role of cholesterol and lipid organization in disease
-
Maxfield F.R., Tabas I. Role of cholesterol and lipid organization in disease. Nature 2005, 438:612-621.
-
(2005)
Nature
, vol.438
, pp. 612-621
-
-
Maxfield, F.R.1
Tabas, I.2
-
79
-
-
70349652275
-
Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation
-
Murakami T., Saito A., Hino S., Kondo S., Kanemoto S., Chihara K., Sekiya H., Tsumagari K., Ochiai K., Yoshinaga K., et al. Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation. Nat. Cell Biol. 2009, 11:1205-1211.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1205-1211
-
-
Murakami, T.1
Saito, A.2
Hino, S.3
Kondo, S.4
Kanemoto, S.5
Chihara, K.6
Sekiya, H.7
Tsumagari, K.8
Ochiai, K.9
Yoshinaga, K.10
-
80
-
-
33846223428
-
Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress
-
Nadanaka S., Okada T., Yoshida H., Mori K. Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress. Mol. Cell. Biol. 2007, 27:1027-1043.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 1027-1043
-
-
Nadanaka, S.1
Okada, T.2
Yoshida, H.3
Mori, K.4
-
81
-
-
75749108288
-
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis
-
Nakamura T., Furuhashi M., Li P., Cao H., Tuncman G., Sonenberg N., Gorgun C.Z., Hotamisligil G.S. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell 2010, 140:338-348.
-
(2010)
Cell
, vol.140
, pp. 338-348
-
-
Nakamura, T.1
Furuhashi, M.2
Li, P.3
Cao, H.4
Tuncman, G.5
Sonenberg, N.6
Gorgun, C.Z.7
Hotamisligil, G.S.8
-
82
-
-
19944430402
-
Involvement of endoplasmic reticulum stress in insulin resistance and diabetes
-
Nakatani Y., Kaneto H., Kawamori D., Yoshiuchi K., Hatazaki M., Matsuoka T.A., Ozawa K., Ogawa S., Hori M., Yamasaki Y., et al. Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. J. Biol. Chem. 2005, 280:847-851.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 847-851
-
-
Nakatani, Y.1
Kaneto, H.2
Kawamori, D.3
Yoshiuchi, K.4
Hatazaki, M.5
Matsuoka, T.A.6
Ozawa, K.7
Ogawa, S.8
Hori, M.9
Yamasaki, Y.10
-
83
-
-
70349687405
-
Discovery of Atg5/Atg7-independent alternative macroautophagy
-
Nishida Y., Arakawa S., Fujitani K., Yamaguchi H., Mizuta T., Kanaseki T., Komatsu M., Otsu K., Tsujimoto Y., Shimizu S. Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature 2009, 461:654-658.
-
(2009)
Nature
, vol.461
, pp. 654-658
-
-
Nishida, Y.1
Arakawa, S.2
Fujitani, K.3
Yamaguchi, H.4
Mizuta, T.5
Kanaseki, T.6
Komatsu, M.7
Otsu, K.8
Tsujimoto, Y.9
Shimizu, S.10
-
84
-
-
68349150756
-
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
-
Nishimura S., Manabe I., Nagasaki M., Eto K., Yamashita H., Ohsugi M., Otsu M., Hara K., Ueki K., Sugiura S., et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med. 2009, 15:914-920.
-
(2009)
Nat. Med.
, vol.15
, pp. 914-920
-
-
Nishimura, S.1
Manabe, I.2
Nagasaki, M.3
Eto, K.4
Yamashita, H.5
Ohsugi, M.6
Otsu, M.7
Hara, K.8
Ueki, K.9
Sugiura, S.10
-
85
-
-
33845459165
-
Autophagy is activated for cell survival after endoplasmic reticulum stress
-
Ogata M., Hino S., Saito A., Morikawa K., Kondo S., Kanemoto S., Murakami T., Taniguchi M., Tanii I., Yoshinaga K., et al. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol. Cell. Biol. 2006, 26:9220-9231.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 9220-9231
-
-
Ogata, M.1
Hino, S.2
Saito, A.3
Morikawa, K.4
Kondo, S.5
Kanemoto, S.6
Murakami, T.7
Taniguchi, M.8
Tanii, I.9
Yoshinaga, K.10
-
86
-
-
74549159752
-
Prevelance of high body mass index in US children and adolescents
-
Ogden C.L., Carroll M.D., Curtin L.R., Lamb M.M., Flegal K.M. Prevelance of high body mass index in US children and adolescents. JAMA 2010, 303:242-249.
-
(2010)
JAMA
, vol.303
, pp. 242-249
-
-
Ogden, C.L.1
Carroll, M.D.2
Curtin, L.R.3
Lamb, M.M.4
Flegal, K.M.5
-
87
-
-
34249707984
-
Self-association and BiP dissociation are not sufficient for activation of the ER stress sensor Ire1
-
Oikawa D., Kimata Y., Kohno K. Self-association and BiP dissociation are not sufficient for activation of the ER stress sensor Ire1. J. Cell Sci. 2007, 120:1681-1688.
-
(2007)
J. Cell Sci.
, vol.120
, pp. 1681-1688
-
-
Oikawa, D.1
Kimata, Y.2
Kohno, K.3
-
88
-
-
38149136598
-
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents
-
Ota T., Gayet C., Ginsberg H.N. Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents. J. Clin. Invest. 2008, 118:316-332.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 316-332
-
-
Ota, T.1
Gayet, C.2
Ginsberg, H.N.3
-
89
-
-
0036175128
-
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
-
Oyadomari S., Koizumi A., Takeda K., Gotoh T., Akira S., Araki E., Mori M. Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J. Clin. Invest. 2002, 109:525-532.
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 525-532
-
-
Oyadomari, S.1
Koizumi, A.2
Takeda, K.3
Gotoh, T.4
Akira, S.5
Araki, E.6
Mori, M.7
-
90
-
-
44349163999
-
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice
-
Oyadomari S., Harding H.P., Zhang Y., Oyadomari M., Ron D. Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab. 2008, 7:520-532.
-
(2008)
Cell Metab.
, vol.7
, pp. 520-532
-
-
Oyadomari, S.1
Harding, H.P.2
Zhang, Y.3
Oyadomari, M.4
Ron, D.5
-
91
-
-
14644397903
-
The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes
-
Ozawa K., Miyazaki M., Matsuhisa M., Takano K., Nakatani Y., Hatazaki M., Tamatani T., Yamagata K., Miyagawa J., Kitao Y., et al. The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes. Diabetes 2005, 54:657-663.
-
(2005)
Diabetes
, vol.54
, pp. 657-663
-
-
Ozawa, K.1
Miyazaki, M.2
Matsuhisa, M.3
Takano, K.4
Nakatani, Y.5
Hatazaki, M.6
Tamatani, T.7
Yamagata, K.8
Miyagawa, J.9
Kitao, Y.10
-
92
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan U., Cao Q., Yilmaz E., Lee A.H., Iwakoshi N.N., Ozdelen E., Tuncman G., Gorgun C., Glimcher L.H., Hotamisligil G.S. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004, 306:457-461.
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Gorgun, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
93
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
Ozcan U., Yilmaz E., Ozcan L., Furuhashi M., Vaillancourt E., Smith R.O., Gorgun C.Z., Hotamisligil G.S. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006, 313:1137-1140.
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
Furuhashi, M.4
Vaillancourt, E.5
Smith, R.O.6
Gorgun, C.Z.7
Hotamisligil, G.S.8
-
94
-
-
40649104735
-
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis
-
Ozcan U., Ozcan L., Yilmaz E., Duvel K., Sahin M., Manning B.D., Hotamisligil G.S. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol. Cell 2008, 29:541-551.
-
(2008)
Mol. Cell
, vol.29
, pp. 541-551
-
-
Ozcan, U.1
Ozcan, L.2
Yilmaz, E.3
Duvel, K.4
Sahin, M.5
Manning, B.D.6
Hotamisligil, G.S.7
-
95
-
-
57849115277
-
Endoplasmic reticulum stress plays a central role in development of leptin resistance
-
Ozcan L., Ergin A.S., Lu A., Chung J., Sarkar S., Nie D., Myers M.G., Ozcan U. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab. 2009, 9:35-51.
-
(2009)
Cell Metab.
, vol.9
, pp. 35-51
-
-
Ozcan, L.1
Ergin, A.S.2
Lu, A.3
Chung, J.4
Sarkar, S.5
Nie, D.6
Myers, M.G.7
Ozcan, U.8
-
96
-
-
0035881317
-
Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor gamma and mediated by inhibition of translation initiation
-
Palakurthi S.S., Aktas H., Grubissich L.M., Mortensen R.M., Halperin J.A. Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor gamma and mediated by inhibition of translation initiation. Cancer Res. 2001, 61:6213-6218.
-
(2001)
Cancer Res.
, vol.61
, pp. 6213-6218
-
-
Palakurthi, S.S.1
Aktas, H.2
Grubissich, L.M.3
Mortensen, R.M.4
Halperin, J.A.5
-
97
-
-
34347338690
-
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
-
Parkes M., Barrett J.C., Prescott N.J., Tremelling M., Anderson C.A., Fisher S.A., Roberts R.G., Nimmo E.R., Cummings F.R., Soars D., et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat. Genet. 2007, 39:830-832.
-
(2007)
Nat. Genet.
, vol.39
, pp. 830-832
-
-
Parkes, M.1
Barrett, J.C.2
Prescott, N.J.3
Tremelling, M.4
Anderson, C.A.5
Fisher, S.A.6
Roberts, R.G.7
Nimmo, E.R.8
Cummings, F.R.9
Soars, D.10
-
98
-
-
0035370949
-
Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals
-
Patil C., Walter P. Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr. Opin. Cell Biol. 2001, 13:349-355.
-
(2001)
Curr. Opin. Cell Biol.
, vol.13
, pp. 349-355
-
-
Patil, C.1
Walter, P.2
-
99
-
-
34147106529
-
Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs
-
Pirot P., Naamane N., Libert F., Magnusson N.E., Orntoft T.F., Cardozo A.K., Eizirik D.L. Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs. Diabetologia 2007, 50:1006-1014.
-
(2007)
Diabetologia
, vol.50
, pp. 1006-1014
-
-
Pirot, P.1
Naamane, N.2
Libert, F.3
Magnusson, N.E.4
Orntoft, T.F.5
Cardozo, A.K.6
Eizirik, D.L.7
-
100
-
-
63749105226
-
MTOR and the control of whole body metabolism
-
Polak P., Hall M.N. mTOR and the control of whole body metabolism. Curr. Opin. Cell Biol. 2009, 21:209-218.
-
(2009)
Curr. Opin. Cell Biol.
, vol.21
, pp. 209-218
-
-
Polak, P.1
Hall, M.N.2
-
101
-
-
50049116472
-
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
-
Porstmann T., Santos C.R., Griffiths B., Cully M., Wu M., Leevers S., Griffiths J.R., Chung Y.L., Schulze A. SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab. 2008, 8:224-236.
-
(2008)
Cell Metab.
, vol.8
, pp. 224-236
-
-
Porstmann, T.1
Santos, C.R.2
Griffiths, B.3
Cully, M.4
Wu, M.5
Leevers, S.6
Griffiths, J.R.7
Chung, Y.L.8
Schulze, A.9
-
102
-
-
52049106904
-
Cell growth control: mTOR takes on fat
-
Powers T. Cell growth control: mTOR takes on fat. Mol. Cell 2008, 31:775-776.
-
(2008)
Mol. Cell
, vol.31
, pp. 775-776
-
-
Powers, T.1
-
103
-
-
1842843860
-
Coupling endoplasmic reticulum stress to the cell death program
-
Rao R.V., Ellerby H.M., Bredesen D.E. Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ. 2004, 11:372-380.
-
(2004)
Cell Death Differ.
, vol.11
, pp. 372-380
-
-
Rao, R.V.1
Ellerby, H.M.2
Bredesen, D.E.3
-
104
-
-
0018246851
-
Rates of protein synthesis by hepatocytes isolated from rats of various ages
-
Ricca G.A., Liu D.S., Coniglio J.J., Richardson A. Rates of protein synthesis by hepatocytes isolated from rats of various ages. J. Cell. Physiol. 1978, 97:137-146.
-
(1978)
J. Cell. Physiol.
, vol.97
, pp. 137-146
-
-
Ricca, G.A.1
Liu, D.S.2
Coniglio, J.J.3
Richardson, A.4
-
105
-
-
33644629034
-
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62
-
Rodriguez A., Duran A., Selloum M., Champy M.F., Diez-Guerra F.J., Flores J.M., Serrano M., Auwerx J., Diaz-Meco M.T., Moscat J. Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. Cell Metab. 2006, 3:211-222.
-
(2006)
Cell Metab.
, vol.3
, pp. 211-222
-
-
Rodriguez, A.1
Duran, A.2
Selloum, M.3
Champy, M.F.4
Diez-Guerra, F.J.5
Flores, J.M.6
Serrano, M.7
Auwerx, J.8
Diaz-Meco, M.T.9
Moscat, J.10
-
106
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
Ron D., Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 2007, 8:519-529.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
107
-
-
33845864967
-
Adipocytes as regulators of energy balance and glucose homeostasis
-
Rosen E.D., Spiegelman B.M. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 2006, 444:847-853.
-
(2006)
Nature
, vol.444
, pp. 847-853
-
-
Rosen, E.D.1
Spiegelman, B.M.2
-
108
-
-
57049111040
-
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators
-
Rutkowski D.T., Wu J., Back S.H., Callaghan M.U., Ferris S.P., Iqbal J., Clark R., Miao H., Hassler J.R., Fornek J., et al. UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev. Cell 2008, 15:829-840.
-
(2008)
Dev. Cell
, vol.15
, pp. 829-840
-
-
Rutkowski, D.T.1
Wu, J.2
Back, S.H.3
Callaghan, M.U.4
Ferris, S.P.5
Iqbal, J.6
Clark, R.7
Miao, H.8
Hassler, J.R.9
Fornek, J.10
-
109
-
-
56249090667
-
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
-
Saitoh T., Fujita N., Jang M.H., Uematsu S., Yang B.G., Satoh T., Omori H., Noda T., Yamamoto N., Komatsu M., et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 2008, 456:264-268.
-
(2008)
Nature
, vol.456
, pp. 264-268
-
-
Saitoh, T.1
Fujita, N.2
Jang, M.H.3
Uematsu, S.4
Yang, B.G.5
Satoh, T.6
Omori, H.7
Noda, T.8
Yamamoto, N.9
Komatsu, M.10
-
110
-
-
33747356154
-
Adipose tissue: from lipid storage compartment to endocrine organ
-
Scherer P.E. Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes 2006, 55:1537-1545.
-
(2006)
Diabetes
, vol.55
, pp. 1537-1545
-
-
Scherer, P.E.1
-
111
-
-
0034973982
-
Translational control is required for the unfolded protein response and in vivo glucose homeostasis
-
Scheuner D., Song B., McEwen E., Liu C., Laybutt R., Gillespie P., Saunders T., Bonner-Weir S., Kaufman R.J. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol. Cell 2001, 7:1165-1176.
-
(2001)
Mol. Cell
, vol.7
, pp. 1165-1176
-
-
Scheuner, D.1
Song, B.2
McEwen, E.3
Liu, C.4
Laybutt, R.5
Gillespie, P.6
Saunders, T.7
Bonner-Weir, S.8
Kaufman, R.J.9
-
112
-
-
57349110829
-
Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects
-
Sharma N.K., Das S.K., Mondal A.K., Hackney O.G., Chu W.S., Kern P.A., Rasouli N., Spencer H.J., Yao-Borengasser A., Elbein S.C. Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects. J. Clin. Endocrinol. Metab. 2008, 93:4532-4541.
-
(2008)
J. Clin. Endocrinol. Metab.
, vol.93
, pp. 4532-4541
-
-
Sharma, N.K.1
Das, S.K.2
Mondal, A.K.3
Hackney, O.G.4
Chu, W.S.5
Kern, P.A.6
Rasouli, N.7
Spencer, H.J.8
Yao-Borengasser, A.9
Elbein, S.C.10
-
113
-
-
0036069980
-
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals
-
Shen J., Chen X., Hendershot L., Prywes R. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev. Cell 2002, 3:99-111.
-
(2002)
Dev. Cell
, vol.3
, pp. 99-111
-
-
Shen, J.1
Chen, X.2
Hendershot, L.3
Prywes, R.4
-
114
-
-
0031755020
-
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control
-
Shi Y., Vattem K.M., Sood R., An J., Liang J., Stramm L., Wek R.C. Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Mol. Cell. Biol. 1998, 18:7499-7509.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 7499-7509
-
-
Shi, Y.1
Vattem, K.M.2
Sood, R.3
An, J.4
Liang, J.5
Stramm, L.6
Wek, R.C.7
-
116
-
-
0030954870
-
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response
-
Sidrauski C., Walter P. The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 1997, 90:1031-1039.
-
(1997)
Cell
, vol.90
, pp. 1031-1039
-
-
Sidrauski, C.1
Walter, P.2
-
117
-
-
34249857603
-
Salicylates trigger protein synthesis inhibition in a protein kinase R-like endoplasmic reticulum kinase-dependent manner
-
Silva A.M., Wang D., Komar A.A., Castilho B.A., Williams B.R. Salicylates trigger protein synthesis inhibition in a protein kinase R-like endoplasmic reticulum kinase-dependent manner. J. Biol. Chem. 2007, 282:10164-10171.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 10164-10171
-
-
Silva, A.M.1
Wang, D.2
Komar, A.A.3
Castilho, B.A.4
Williams, B.R.5
-
118
-
-
65949095803
-
Autophagy regulates lipid metabolism
-
Singh R., Kaushik S., Wang Y., Xiang Y., Novak I., Komatsu M., Tanaka K., Cuervo A.M., Czaja M.J. Autophagy regulates lipid metabolism. Nature 2009, 458:1131-1135.
-
(2009)
Nature
, vol.458
, pp. 1131-1135
-
-
Singh, R.1
Kaushik, S.2
Wang, Y.3
Xiang, Y.4
Novak, I.5
Komatsu, M.6
Tanaka, K.7
Cuervo, A.M.8
Czaja, M.J.9
-
119
-
-
70449448312
-
Autophagy regulates adipose mass and differentiation in mice
-
Singh R., Xiang Y., Wang Y., Baikati K., Cuervo A.M., Luu Y.K., Tang Y., Pessin J.E., Schwartz G.J., Czaja M.J. Autophagy regulates adipose mass and differentiation in mice. J. Clin. Invest. 2009, 119:3329-3339.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3329-3339
-
-
Singh, R.1
Xiang, Y.2
Wang, Y.3
Baikati, K.4
Cuervo, A.M.5
Luu, Y.K.6
Tang, Y.7
Pessin, J.E.8
Schwartz, G.J.9
Czaja, M.J.10
-
120
-
-
33846577831
-
Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain
-
Sokka A.L., Putkonen N., Mudo G., Pryazhnikov E., Reijonen S., Khiroug L., Belluardo N., Lindholm D., Korhonen L. Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain. J. Neurosci. 2007, 27:901-908.
-
(2007)
J. Neurosci.
, vol.27
, pp. 901-908
-
-
Sokka, A.L.1
Putkonen, N.2
Mudo, G.3
Pryazhnikov, E.4
Reijonen, S.5
Khiroug, L.6
Belluardo, N.7
Lindholm, D.8
Korhonen, L.9
-
121
-
-
55849096988
-
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes
-
Song B., Scheuner D., Ron D., Pennathur S., Kaufman R.J. Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J. Clin. Invest. 2008, 118:3378-3389.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3378-3389
-
-
Song, B.1
Scheuner, D.2
Ron, D.3
Pennathur, S.4
Kaufman, R.J.5
-
122
-
-
70350435712
-
Macrophage apoptosis in advanced atherosclerosis
-
Tabas I., Seimon T., Timmins J., Li G., Lim W. Macrophage apoptosis in advanced atherosclerosis. Ann. N Y Acad. Sci. 2009, 1173(Suppl 1):E40-E45.
-
(2009)
Ann. N Y Acad. Sci.
, vol.1173
, Issue.1 SUPPL.
-
-
Tabas, I.1
Seimon, T.2
Timmins, J.3
Li, G.4
Lim, W.5
-
123
-
-
33644774734
-
Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians
-
Thameem F., Farook V.S., Bogardus C., Prochazka M. Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians. Diabetes 2006, 55:839-842.
-
(2006)
Diabetes
, vol.55
, pp. 839-842
-
-
Thameem, F.1
Farook, V.S.2
Bogardus, C.3
Prochazka, M.4
-
124
-
-
33846569938
-
Targeting mammalian target of rapamycin (mTOR) for health and diseases
-
Tsang C.K., Qi H., Liu L.F., Zheng X.F. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov. Today 2007, 12:112-124.
-
(2007)
Drug Discov. Today
, vol.12
, pp. 112-124
-
-
Tsang, C.K.1
Qi, H.2
Liu, L.F.3
Zheng, X.F.4
-
125
-
-
33746101818
-
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance
-
Tuncman G., Hirosumi J., Solinas G., Chang L., Karin M., Hotamisligil G.S. Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc. Natl. Acad. Sci. USA 2006, 103:10741-10746.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 10741-10746
-
-
Tuncman, G.1
Hirosumi, J.2
Solinas, G.3
Chang, L.4
Karin, M.5
Hotamisligil, G.S.6
-
126
-
-
33644886769
-
Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
-
Tzatsos A., Kandror K.V. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol. Cell. Biol. 2006, 26:63-76.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 63-76
-
-
Tzatsos, A.1
Kandror, K.V.2
-
127
-
-
33745315287
-
S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration
-
Uehara T., Nakamura T., Yao D., Shi Z.Q., Gu Z., Ma Y., Masliah E., Nomura Y., Lipton S.A. S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature 2006, 441:513-517.
-
(2006)
Nature
, vol.441
, pp. 513-517
-
-
Uehara, T.1
Nakamura, T.2
Yao, D.3
Shi, Z.Q.4
Gu, Z.5
Ma, Y.6
Masliah, E.7
Nomura, Y.8
Lipton, S.A.9
-
128
-
-
4544220704
-
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
-
Um S.H., Frigerio F., Watanabe M., Picard F., Joaquin M., Sticker M., Fumagalli S., Allegrini P.R., Kozma S.C., Auwerx J., et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 2004, 431:200-205.
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.H.1
Frigerio, F.2
Watanabe, M.3
Picard, F.4
Joaquin, M.5
Sticker, M.6
Fumagalli, S.7
Allegrini, P.R.8
Kozma, S.C.9
Auwerx, J.10
-
129
-
-
0034723235
-
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
-
Urano F., Wang X., Bertolotti A., Zhang Y., Chung P., Harding H.P., Ron D. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000, 287:664-666.
-
(2000)
Science
, vol.287
, pp. 664-666
-
-
Urano, F.1
Wang, X.2
Bertolotti, A.3
Zhang, Y.4
Chung, P.5
Harding, H.P.6
Ron, D.7
-
130
-
-
52349105273
-
A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity
-
Vallerie S.N., Furuhashi M., Fucho R., Hotamisligil G.S. A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity. PLoS ONE 2008, 3:e3151.
-
(2008)
PLoS ONE
, vol.3
-
-
Vallerie, S.N.1
Furuhashi, M.2
Fucho, R.3
Hotamisligil, G.S.4
-
131
-
-
68949220321
-
ER stress controls iron metabolism through induction of hepcidin
-
Vecchi C., Montosi G., Zhang K., Lamberti I., Duncan S.A., Kaufman R.J., Pietrangelo A. ER stress controls iron metabolism through induction of hepcidin. Science 2009, 325:877-880.
-
(2009)
Science
, vol.325
, pp. 877-880
-
-
Vecchi, C.1
Montosi, G.2
Zhang, K.3
Lamberti, I.4
Duncan, S.A.5
Kaufman, R.J.6
Pietrangelo, A.7
-
132
-
-
67749135249
-
The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis
-
Wang Y., Vera L., Fischer W.H., Montminy M. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 2009, 460:534-537.
-
(2009)
Nature
, vol.460
, pp. 534-537
-
-
Wang, Y.1
Vera, L.2
Fischer, W.H.3
Montminy, M.4
-
133
-
-
33745828301
-
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells
-
Wei Y., Wang D., Topczewski F., Pagliassotti M.J. Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am. J. Physiol. Endocrinol. Metab. 2006, 291:E275-E281.
-
(2006)
Am. J. Physiol. Endocrinol. Metab.
, vol.291
-
-
Wei, Y.1
Wang, D.2
Topczewski, F.3
Pagliassotti, M.J.4
-
135
-
-
68349137821
-
Normalization of obesity-associated insulin resistance through immunotherapy
-
Winer S., Chan Y., Paltser G., Truong D., Tsui H., Bahrami J., Dorfman R., Wang Y., Zielenski J., Mastronardi F., et al. Normalization of obesity-associated insulin resistance through immunotherapy. Nat. Med. 2009, 15:921-929.
-
(2009)
Nat. Med.
, vol.15
, pp. 921-929
-
-
Winer, S.1
Chan, Y.2
Paltser, G.3
Truong, D.4
Tsui, H.5
Bahrami, J.6
Dorfman, R.7
Wang, Y.8
Zielenski, J.9
Mastronardi, F.10
-
136
-
-
33749058310
-
A proposed model of fat packaging by exchangeable lipid droplet proteins
-
Wolins N.E., Brasaemle D.L., Bickel P.E. A proposed model of fat packaging by exchangeable lipid droplet proteins. FEBS Lett. 2006, 580:5484-5491.
-
(2006)
FEBS Lett.
, vol.580
, pp. 5484-5491
-
-
Wolins, N.E.1
Brasaemle, D.L.2
Bickel, P.E.3
-
137
-
-
34548189283
-
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress
-
Wu J., Rutkowski D.T., Dubois M., Swathirajan J., Saunders T., Wang J., Song B., Yau G.D., Kaufman R.J. ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress. Dev. Cell 2007, 13:351-364.
-
(2007)
Dev. Cell
, vol.13
, pp. 351-364
-
-
Wu, J.1
Rutkowski, D.T.2
Dubois, M.3
Swathirajan, J.4
Saunders, T.5
Wang, J.6
Song, B.7
Yau, G.D.8
Kaufman, R.J.9
-
138
-
-
34848886914
-
Autophagosome formation: core machinery and adaptations
-
Xie Z., Klionsky D.J. Autophagosome formation: core machinery and adaptations. Nat. Cell Biol. 2007, 9:1102-1109.
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 1102-1109
-
-
Xie, Z.1
Klionsky, D.J.2
-
139
-
-
26644450729
-
Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha
-
Xue X., Piao J.H., Nakajima A., Sakon-Komazawa S., Kojima Y., Mori K., Yagita H., Okumura K., Harding H., Nakano H. Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha. J. Biol. Chem. 2005, 280:33917-33925.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 33917-33925
-
-
Xue, X.1
Piao, J.H.2
Nakajima, A.3
Sakon-Komazawa, S.4
Kojima, Y.5
Mori, K.6
Yagita, H.7
Okumura, K.8
Harding, H.9
Nakano, H.10
-
140
-
-
34548172495
-
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1
-
Yamamoto K., Sato T., Matsui T., Sato M., Okada T., Yoshida H., Harada A., Mori K. Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1. Dev. Cell 2007, 13:365-376.
-
(2007)
Dev. Cell
, vol.13
, pp. 365-376
-
-
Yamamoto, K.1
Sato, T.2
Matsui, T.3
Sato, M.4
Okada, T.5
Yoshida, H.6
Harada, A.7
Mori, K.8
-
141
-
-
69849109361
-
Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response
-
Yamazaki H., Hiramatsu N., Hayakawa K., Tagawa Y., Okamura M., Ogata R., Huang T., Nakajima S., Yao J., Paton A.W., et al. Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response. J. Immunol. 2009, 183:1480-1487.
-
(2009)
J. Immunol.
, vol.183
, pp. 1480-1487
-
-
Yamazaki, H.1
Hiramatsu, N.2
Hayakawa, K.3
Tagawa, Y.4
Okamura, M.5
Ogata, R.6
Huang, T.7
Nakajima, S.8
Yao, J.9
Paton, A.W.10
-
142
-
-
27644484061
-
Autophagy: molecular machinery for self-eating
-
Yorimitsu T., Klionsky D.J. Autophagy: molecular machinery for self-eating. Cell Death Differ. 2005, 12(Suppl 2):1542-1552.
-
(2005)
Cell Death Differ.
, vol.12
, Issue.2 SUPPL.
, pp. 1542-1552
-
-
Yorimitsu, T.1
Klionsky, D.J.2
-
143
-
-
0032509216
-
Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors
-
Yoshida H., Haze K., Yanagi H., Yura T., Mori K. Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors. J. Biol. Chem. 1998, 273:33741-33749.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 33741-33749
-
-
Yoshida, H.1
Haze, K.2
Yanagi, H.3
Yura, T.4
Mori, K.5
-
144
-
-
0033815971
-
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
-
Yoshida H., Okada T., Haze K., Yanagi H., Yura T., Negishi M., Mori K. ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol. Cell. Biol. 2000, 20:6755-6767.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 6755-6767
-
-
Yoshida, H.1
Okada, T.2
Haze, K.3
Yanagi, H.4
Yura, T.5
Negishi, M.6
Mori, K.7
-
145
-
-
33750448469
-
GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress
-
Yusta B., Baggio L.L., Estall J.L., Koehler J.A., Holland D.P., Li H., Pipeleers D., Ling Z., Drucker D.J. GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress. Cell Metab. 2006, 4:391-406.
-
(2006)
Cell Metab.
, vol.4
, pp. 391-406
-
-
Yusta, B.1
Baggio, L.L.2
Estall, J.L.3
Koehler, J.A.4
Holland, D.P.5
Li, H.6
Pipeleers, D.7
Ling, Z.8
Drucker, D.J.9
-
146
-
-
65349177200
-
AMPK: An emerging drug target for diabetes and the metabolic syndrome
-
Zhang B.B., Zhou G., Li C. AMPK: An emerging drug target for diabetes and the metabolic syndrome. Cell Metab. 2009, 9:407-416.
-
(2009)
Cell Metab.
, vol.9
, pp. 407-416
-
-
Zhang, B.B.1
Zhou, G.2
Li, C.3
-
147
-
-
67650523945
-
Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway
-
Zhang H.H., Huang J., Duvel K., Boback B., Wu S., Squillace R.M., Wu C.L., Manning B.D. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PLoS ONE 2009, 4:e6189.
-
(2009)
PLoS ONE
, vol.4
-
-
Zhang, H.H.1
Huang, J.2
Duvel, K.3
Boback, B.4
Wu, S.5
Squillace, R.M.6
Wu, C.L.7
Manning, B.D.8
-
148
-
-
32044453080
-
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
-
Zhang K., Shen X., Wu J., Sakaki K., Saunders T., Rutkowski D.T., Back S.H., Kaufman R.J. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 2006, 124:587-599.
-
(2006)
Cell
, vol.124
, pp. 587-599
-
-
Zhang, K.1
Shen, X.2
Wu, J.3
Sakaki, K.4
Saunders, T.5
Rutkowski, D.T.6
Back, S.H.7
Kaufman, R.J.8
-
149
-
-
0036091476
-
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas
-
Zhang P., McGrath B., Li S., Frank A., Zambito F., Reinert J., Gannon M., Ma K., McNaughton K., Cavener D.R. The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol. Cell. Biol. 2002, 22:3864-3874.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 3864-3874
-
-
Zhang, P.1
McGrath, B.2
Li, S.3
Frank, A.4
Zambito, F.5
Reinert, J.6
Gannon, M.7
Ma, K.8
McNaughton, K.9
Cavener, D.R.10
-
150
-
-
33751430251
-
PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis
-
Zhang W., Feng D., Li Y., Iida K., McGrath B., Cavener D.R. PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. Cell Metab. 2006, 4:491-497.
-
(2006)
Cell Metab.
, vol.4
, pp. 491-497
-
-
Zhang, W.1
Feng, D.2
Li, Y.3
Iida, K.4
McGrath, B.5
Cavener, D.R.6
-
151
-
-
52949096557
-
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
-
Zhang X., Zhang G., Zhang H., Karin M., Bai H., Cai D. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 2008, 135:61-73.
-
(2008)
Cell
, vol.135
, pp. 61-73
-
-
Zhang, X.1
Zhang, G.2
Zhang, H.3
Karin, M.4
Bai, H.5
Cai, D.6
-
152
-
-
33749233991
-
The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response
-
Zhou J., Liu C.Y., Back S.H., Clark R.L., Peisach D., Xu Z., Kaufman R.J. The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc. Natl. Acad. Sci. USA 2006, 103:14343-14348.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 14343-14348
-
-
Zhou, J.1
Liu, C.Y.2
Back, S.H.3
Clark, R.L.4
Peisach, D.5
Xu, Z.6
Kaufman, R.J.7
|